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- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [1]
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- Product number
- 17495-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17495-1-AP, RRID:AB_1939754
- Product name
- SPAG4L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SPAG4L antibody (Cat. #17495-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Genetic mutation of Cep76 results in male infertility due to abnormal sperm tail composition.
A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility.
The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.
Nuclear Membrane Protein SUN5 Is Highly Expressed and Promotes Proliferation and Migration in Colorectal Cancer by Regulating the ERK Pathway.
Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome.
SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice.
Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa.
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.
Biallelic mutations in PMFBP1 cause acephalic spermatozoa.
Patients with acephalic spermatozoa syndrome linked to SUN5 mutations have a favorable pregnancy outcome from ICSI.
Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome.
Essential role for SUN5 in anchoring sperm head to the tail.
Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome.
Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.
SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.
Houston BJ, Merriner DJ, Stathatos GG, Nguyen JH, O'Connor AE, Lopes AM, Conrad DF, Baker M, Dunleavy JE, O'Bryan MK
Life science alliance 2024 Jun;7(6)
Life science alliance 2024 Jun;7(6)
A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility.
Meindl K, Issler N, Afonso S, Cebrian-Serrano A, Müller K, Sterner C, Othmen H, Tegtmeier I, Witzgall R, Klootwijk E, Davies B, Kleta R, Warth R
Frontiers in cell and developmental biology 2023;11:1240558
Frontiers in cell and developmental biology 2023;11:1240558
The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.
Dunleavy JEM, Graffeo M, Wozniak K, O'Connor AE, Merriner DJ, Nguyen J, Schittenhelm RB, Houston BJ, O'Bryan MK
Development (Cambridge, England) 2023 Nov 15;150(22)
Development (Cambridge, England) 2023 Nov 15;150(22)
Nuclear Membrane Protein SUN5 Is Highly Expressed and Promotes Proliferation and Migration in Colorectal Cancer by Regulating the ERK Pathway.
Song X, Li R, Liu G, Huang L, Li P, Feng W, Gao Q, Xing X
Cancers 2022 Oct 31;14(21)
Cancers 2022 Oct 31;14(21)
Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome.
Xiang M, Wang Y, Wang K, Kong S, Lu M, Zhang J, Duan Z, Zha X, Shi X, Wang F, Cao Y, Zhu F
Reproductive sciences (Thousand Oaks, Calif.) 2022 Feb;29(2):646-651
Reproductive sciences (Thousand Oaks, Calif.) 2022 Feb;29(2):646-651
SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice.
Zhang Y, Yang L, Huang L, Liu G, Nie X, Zhang X, Xing X
Frontiers in cell and developmental biology 2021;9:684826
Frontiers in cell and developmental biology 2021;9:684826
Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa.
Cazin C, Boumerdassi Y, Martinez G, Fourati Ben Mustapha S, Whitfield M, Coutton C, Thierry-Mieg N, Di Pizio P, Rives N, Arnoult C, Touré A, Ray PF, Zouari R, Sifer C, Kherraf ZE
International journal of molecular sciences 2021 Feb 22;22(4)
International journal of molecular sciences 2021 Feb 22;22(4)
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.
Zhang Y, Liu C, Wu B, Li L, Li W, Yuan L
Nature communications 2021 Aug 13;12(1):4926
Nature communications 2021 Aug 13;12(1):4926
Biallelic mutations in PMFBP1 cause acephalic spermatozoa.
Sha YW, Wang X, Xu X, Ding L, Liu WS, Li P, Su ZY, Chen J, Mei LB, Zheng LK, Wang HL, Kong SB, You M, Wu JF
Clinical genetics 2019 Feb;95(2):277-286
Clinical genetics 2019 Feb;95(2):277-286
Patients with acephalic spermatozoa syndrome linked to SUN5 mutations have a favorable pregnancy outcome from ICSI.
Fang J, Zhang J, Zhu F, Yang X, Cui Y, Liu J
Human reproduction (Oxford, England) 2018 Mar 1;33(3):372-377
Human reproduction (Oxford, England) 2018 Mar 1;33(3):372-377
Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome.
Zhu F, Liu C, Wang F, Yang X, Zhang J, Wu H, Zhang Z, He X, Zhang Z, Zhou P, Wei Z, Shang Y, Wang L, Zhang R, Ouyang YC, Sun QY, Cao Y, Li W
American journal of human genetics 2018 Aug 2;103(2):188-199
American journal of human genetics 2018 Aug 2;103(2):188-199
Essential role for SUN5 in anchoring sperm head to the tail.
Shang Y, Zhu F, Wang L, Ouyang YC, Dong MZ, Liu C, Zhao H, Cui X, Ma D, Zhang Z, Yang X, Guo Y, Liu F, Yuan L, Gao F, Guo X, Sun QY, Cao Y, Li W
eLife 2017 Sep 25;6
eLife 2017 Sep 25;6
Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome.
Zhu F, Wang F, Yang X, Zhang J, Wu H, Zhang Z, Zhang Z, He X, Zhou P, Wei Z, Gecz J, Cao Y
American journal of human genetics 2016 Oct 6;99(4):942-949
American journal of human genetics 2016 Oct 6;99(4):942-949
Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.
Yassine S, Escoffier J, Abi Nahed R, Pierre V, Karaouzene T, Ray PF, Arnoult C
PloS one 2015;10(3):e0118698
PloS one 2015;10(3):e0118698
SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis.
Jiang XZ, Yang MG, Huang LH, Li CQ, Xing XW
DNA and cell biology 2011 Nov;30(11):875-82
DNA and cell biology 2011 Nov;30(11):875-82
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPAG4L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SPAG4L. This antibody recognizes human,mouse,rat antigen. The SPAG4L antibody has been validated for the following applications: ELISA, WB analysis.
