Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS9265 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL 11RÏ« (D361) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 330-380 of Human IL-11RÏ«.
- Description
- The pleiotropic cytokine, IL-11, has been shown to have proliferative and differentiation effects on lymphopoietic, myeloid and erythroid cells. IL-11 also has the inhibiting effect of repressing adipogenesis in vitro. The IL-11Ï« receptor, IL-11RÏ«, is a member of the class 1 subgroup of the cytokine receptor family and exhibits structural similarity to the Ï« subunits of the human ciliary neurotrophic factor (CNTF) and the mouse IL-6 receptor. It is speculated that the IL-11RÏ« regulates the proliferation and/or differentiation of skeletogenic progenitor and mesenchymal cells. Coexpression of gp130 and IL-11Ï« is necessary for high-affinity binding of IL-11 to IL-11RÏ«. It has also been found that coexpression of IL-11RÏ« and gp130 is required for proper stimulation of Ba/F3 cells to differentiate into macrophage in response to IL-11.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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