17958-1-AP

antibody from Proteintech Group

Targeting: LOX

Provider product page for 17958-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [50]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 17958-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17958-1-AP, RRID:AB_2234541
Product name: LOX antibody
Antibody type: Polyclonal
Description: LOX antibody (Cat. #17958-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LOX protein structure - 17958-1-AP shown in red.

Submitted references Integrating multi-omics and machine learning to unravel mechanisms of lymph node metastasis in papillary carcinoma with and without thyroiditis.

Chen S, Yang W, Liu Y, Li A
Frontiers in immunology 2026;17:1708330

Hydrogen sulfide generated by cystathionine gamma lyase inhibits lysyl oxidase and protects against calcific tendinopathy.

Faure E, Bernabei I, Ehirchiou D, Michel P, Kronenberg D, Pap T, Cirino G, Stange R, Busso N, Nasi S
Journal of orthopaedic translation 2026 Mar;57:101082

Protocol to study the contribution of biomechanics in osteoarthritis development using a cartilage-on-chip model.

Faure E, Chobaz V, de Haro D, Lauwers E, Busso N, Paggi CA, Nasi S
STAR protocols 2026 Mar 20;7(1):104365

Tannic Acid Achieves Rapid Scar-Free Corneal Healing by Chelating Excess Copper to Suppress Aberrant LOX-Mediated Fibrosis.

Cai M, Wang X, Sun S, Yuan Z, Wang Y, Hua X, Yuan X
Investigative ophthalmology & visual science 2026 Mar 2;67(3):13

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress.

Guan H, Huang L, Liu Y, Zhu E, Chen L, Li W, Wu H, Zhang X, Qin R, Zheng J, Mo Y, Zhong M, Xu B, Dai X, Wei Q, Chen Y, Wang Q, Zheng Z, Ma K, Tang C
Journal of inflammation research 2025;18:11521-11538

Mechanistic study on electroacupuncture-regulated circadian autophagy for inhibiting ferroptosis in hippocampal neurons and alleviating depression-like behaviors in adulthood induced by early chronic sleep deprivation.

Wu Y, Chen X, Liu F, Feng Y, Liao Z, Bu X, Fu W, Gao J, Wu L, Fan L, Yang Q, Yue P, Wang M
Frontiers in neurology 2025;16:1680606

DDIT4 knockdown suppresses venous malformation progression by inhibiting NF-κB signaling as a potential therapeutic target.

He Y, Lin J, Li Y, Cheng X, Wang T, Wang W, Zeng W, Li Y
Microvascular research 2025 Sep;161:104833

The Wnt/β-Catenin Inhibitor HC-1 Suppresses Liver Fibrosis by Inhibiting Activated Hepatic Stellate Cells and Inducing Matrix Metalloproteinase-1.

Hatakeyama D, Itaba N, Shimizu H, Morimoto M, Shiota G
Yonago acta medica 2025 May;68(2):131-143

Enhanced Vascular Smooth Muscle Cell and Extracellular Matrix Repair Using a Metal-Organic Framework-Based Co-Delivery System for Abdominal Aortic Aneurysm Therapy.

Lei J, Dong X, Huang Y, Wu Z, Peng Z, Li B, Wang R, Pan Y, Zheng X, Zhao Z, Lu X
Advanced healthcare materials 2025 Mar;14(6):e2402937

Periostin mediates collagen production, ECM remodeling and myofibroblast differentiation in breast prosthesis capsule formation.

Yang Y, Li S, Bian L, Dai X, Hu J, Ma Y, Wang Z
Scientific reports 2025 Jul 15;15(1):25649

COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression.

Wang Y, Zhang B, Fan F, Zhao F, Xu J, Zheng Y, Sun C, Hu Y
Biomedicines 2025 Feb 4;13(2)

High-Throughput Proteomics and Immunohistochemistry of Orbital Connective Tissue in Graves' Orbitopathy.

Hai Y, Ma Q, Fang S, Bahramimehr F, Song C, Duan Y, Yu G, Lu X, Jin C, Wang X, Liu L, Guo H, Wang Y, Zhou H, Efferth T, Kahaly GJ, Shen J
The Journal of clinical endocrinology and metabolism 2025 Dec 18;111(1):199-208

Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.

Sato K, Yang M, Nakamura K, Tanaka H, Hori M, Nishio M, Suzuki A, Hibi H, Toyokuni S
Oral diseases 2024 Sep;30(6):3912-3924

A respiratory Streptococcus strain inhibits Acinetobacter baumannii from causing inflammatory damage through ferroptosis.

Sun Y, Li S, Che Y, Liang H, Guo Y, Xiao C
BMC microbiology 2024 Oct 28;24(1):437

2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.

Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, Zou L, Chen S, Zhu L, Zhao Q, Zhan G, Ouyang L, Peng C, Han B, Zhang J, Fu L
Signal transduction and targeted therapy 2024 May 15;9(1):133

Identification of TFR2 as a novel ferroptosis‑related gene that serves an important role in prognosis and progression of triple‑negative breast cancer.

Yang Y, Du J, Huang YF, He W, Liu L, Li D, Chen R
Oncology letters 2024 Feb;27(2):43

Procyanidin B2 alleviates oxidized low-density lipoprotein-induced cell injury, inflammation, monocyte chemotaxis, and oxidative stress by inhibiting the nuclear factor kappa-B pathway in human umbilical vein endothelial cells.

Yuan L, Fan L, Zhang Z, Huang X, Liu Q, Zhang Z
BMC cardiovascular disorders 2024 Apr 29;24(1):231

The response and resistance to drugs in ovarian cancer cell lines in 2D monolayers and 3D spheroids.

Świerczewska M, Sterzyńska K, Ruciński M, Andrzejewska M, Nowicki M, Januchowski R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115152

Molecular characterization of ferroptosis in soft tissue sarcoma constructs a prognostic and immunotherapeutic signature through experimental and bioinformatics analyses.

Yang ZQ, Guo LY, Xiao KW, Zhang C, Wu MH, Yan FF, Cai L
Aging 2023 Oct 20;15(20):11412-11447

Molecular Phenotyping and Mechanisms of Myocardial Fibrosis in Advanced Chronic Kidney Disease.

Narayanan G, Halim A, Hu A, Avin KG, Lu T, Zehnder D, Hato T, Chen NX, Moe SM, Lim K
Kidney360 2023 Nov 1;4(11):1562-1579

Increased renal uptake and urine excretion of oxidized LDL is possibly associated with formation of large calcium oxalate nephrolithiasis: a preliminary study.

Liu CJ, Ho KT, Tsai YS, Huang HS
World journal of urology 2023 May;41(5):1423-1430

The characterization of the sensitive ovarian cancer cell lines A2780 and W1 in response to ovarian CAFs.

Wojtowicz K, Nowicki M
Biochemical and biophysical research communications 2023 Jun 25;662:1-7

Qin S, Li L, Liu D
Aging 2023 Jul 25;15(14):7219-7236

Adenosine kinase promotes post-infarction cardiac repair by epigenetically maintaining reparative macrophage phenotype.

Zhang M, Wang C, Wang R, Xu J, Wang Z, Yan J, Cai Y, Li L, Huo Y, Dong S
Journal of molecular and cellular cardiology 2023 Jan;174:88-100

Anti-Apoptosis Therapy for Meniscal Avascular Zone Repair: A Proof-of-Concept Study in a Lapine Model.

Yan W, Wu Y, Zhao F, Dai R, Zhou Y, Liu D, Cheng J, Hu X, Ao Y
Bioengineering (Basel, Switzerland) 2023 Dec 14;10(12)

Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.

Zhao H, Li R, Chen Y, Yang X, Shang Z
Oncogene 2023 Apr;42(15):1166-1180

Lysyl oxidase promotes anaplastic thyroid carcinoma cell proliferation and metastasis mediated via BMP1.

Liu Y, Zhang Y, Tan Z, Wang J, Hu Y, Sun J, Bao M, Huang P, Ge M, Chai YJ, Zheng C
Gland surgery 2022 Jan;11(1):245-257

Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer.

Lu D, Lin Z, Wang R, Chen Z, Zhuo J, Xu L, Pan L, Li H, Yang X, He C, Shen W, Yang M, Li H, Chen H, Tan W, Wei X, Zheng S, Xu X
Redox biology 2022 Dec;58:102538

Expression of LOX Suggests Poor Prognosis in Gastric Cancer.

Zhu J, Luo C, Zhao J, Zhu X, Lin K, Bu F, Yu Z, Zou F, Zhu Z
Frontiers in medicine 2021;8:718986

Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.

Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819

Drug resistance evaluation in novel 3D in vitro model.

Nowacka M, Sterzynska K, Andrzejewska M, Nowicki M, Januchowski R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111536

Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis.

Li RF, Chen XY, Xu Y, Feng FC, He HL, Zhou XM
Journal of ethnopharmacology 2021 Apr 6;269:113761

Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition.

Cai Q, Wang X, Wang S, Jin L, Ding J, Zhou D, Ma F
International journal of nanomedicine 2020;15:253-262

Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.

Liu B, Zhang S, Wang W, Yun Z, Lv L, Chai M, Wu Z, Zhu Y, Ma J, Leng L
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733

Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis.

Monga J, Subramani D, Bharathan A, Ghosh J
Scientific reports 2020 Apr 20;10(1):6649

Markers of the pre-metastatic niche "knock on the door" of metastasis-free cervical lymph nodes in patients with oral cancer.

Vered M, Shnaiderman-Shapiro A, Schiby G, Zlotogorski-Hurvitz A, Salo T, Yahalom R
Acta histochemica 2019 Nov;121(8):151447

Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma.

Saito T, Uzawa K, Terajima M, Shiiba M, Amelio AL, Tanzawa H, Yamauchi M
Journal of dental research 2019 May;98(5):517-525

Involvement of miR-30b in kynurenine-mediated lysyl oxidase expression.

Duan Z, Li L, Li Y
Journal of physiology and biochemistry 2019 Jun;75(2):135-142

The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.

Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243

Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription.

Ding Y, Xu H, Li L, Yuan Y, Xu Y
Biochemical and biophysical research communications 2019 Feb 12;509(3):633-640

Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.

Zlatic SA, Vrailas-Mortimer A, Gokhale A, Carey LJ, Scott E, Burch R, McCall MM, Rudin-Rush S, Davis JB, Hartwig C, Werner E, Li L, Petris M, Faundez V
Cell systems 2018 Mar 28;6(3):368-380.e6

Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis.

Liu Y, Wang G, Liang Z, Mei Z, Wu T, Cui A, Liu C, Cui L
Thoracic cancer 2018 Jul;9(7):785-793

Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development.

Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Nowacka M, Kaźmierczak D, Andrzejewska M, Rusek D, Brązert M, Brązert J, Nowicki M, Januchowski R
International journal of molecular sciences 2018 Dec 23;20(1)

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.

Li C, Zhang J, Wu H, Li L, Yang C, Song S, Peng P, Shao M, Zhang M, Zhao J, Zhao R, Wu W, Ruan Y, Wang L, Gu J
Scientific reports 2017 Mar 27;7:45275

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells.

Franzetti GA, Laud-Duval K, van der Ent W, Brisac A, Irondelle M, Aubert S, Dirksen U, Bouvier C, de Pinieux G, Snaar-Jagalska E, Chavrier P, Delattre O
Oncogene 2017 Jun 22;36(25):3505-3514

Suppression for lung metastasis by depletion of collagen I and lysyl oxidase via losartan assisted with paclitaxel-loaded pH-sensitive liposomes in breast cancer.

Zhang L, Wang Y, Xia T, Yu Q, Zhang Q, Yang Y, Cun X, Lu L, Gao H, Zhang Z, He Q
Drug delivery 2016 Oct;23(8):2970-2979

Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages.

Liu F, Wang Y, Xu J, Liu F, Hu R, Deng H
Archives of medical science : AMS 2016 Oct 1;12(5):959-967

Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis.

Jiang J, Sun A, Wang Y, Deng Y
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2016 Jun;32(6):469-72

Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse.

Cowling RT, Yeo SJ, Kim IJ, Park JI, Gu Y, Dalton ND, Peterson KL, Greenberg BH
American journal of physiology. Heart and circulatory physiology 2014 Sep 1;307(5):H773-81

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.

Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, Li Y, Chen L, Deng X
Toxicology letters 2013 Oct 24;222(2):91-101

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 17958-1-AP(LOX antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human placenta using 17958-1-AP(LOX antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The LOX antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LOX. This antibody recognizes human, mouse antigen. The LOX antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 17958-1-AP.pdf

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