PIP4K2A

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

Description

Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Tissue specificity

Tissue enriched (brain)

Subcell location

Golgi apparatus, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (22534854 - 22714578)

Ensembl ID

ENSG00000150867  (ver. 103.38)

Orthologs

Mouse Pip4k2a: ENSMUSG00000026737

UniProt

P48426

neXtProt

NX_P48426

Human splice variants
Mouse splice variants

Protein structure