BS7962

antibody from Bioworld Technology, Inc
Targeting: FANCG FAG, XRCC9
Provider product page for BS7962
Western blot
Immunohistochemistry

Antibody data

Product number
BS7962 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FANCG polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human FANCG.
Description
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F, and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF-Ï« signaling. Phosphorylation of FANC (fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. Phosphorylation of serine 7 in FANCG is functionally important in the FA pathway. FANCG is localized majorly in the nucleus and minorly in the cytoplasm, and is highly expressed in testis and thymus.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FANCG protein structure - BS7962 shown in red.