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- Antibody Data
- Antigen structure
- References [37]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14363-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14363-1-AP, RRID:AB_2269266
- Product name
- RBM3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RBM3 antibody (Cat. #14363-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Validation of a new model of selective antegrade cerebral perfusion with circulatory arrest in rats.
Alternative 3'UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner.
RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment.
Mild and deep hypothermia differentially affect cerebral neuroinflammatory and cold shock response following cardiopulmonary bypass in rat.
SMYD5 is a regulator of the mild hypothermia response.
Mild hypothermia promotes neuronal differentiation of human neural stem cells via RBM3-SOX11 signaling pathway.
ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo.
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.
LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury.
RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
RNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial-Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma.
Cold shock protein RBM3 is upregulated in the autophagy-deficient brain.
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
mRNA microarray analysis for the identification of potential biomarkers for vital reaction in burned skin: a preliminary pilot study.
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia.
Hypothermic Shock Applied After Perinatal Asphyxia Prevents Retinal Damage in Rats.
Long non‑coding RNA MIR4435‑2HG promotes the progression of head and neck squamous cell carcinoma by regulating the miR‑383‑5p/RBM3 axis.
Inhibition of cell proliferation and radioresistance by miR-383-5p through targeting RNA binding protein motif (RBM3) in nasopharyngeal carcinoma.
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
RNA Binding Protein Motif 3 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis Through Promoting Stress Granules Formation in PC12 Cells and Rat Primary Cortical Neurons.
Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.
The RNA-Binding Protein RBM3 Promotes Neural Stem Cell (NSC) Proliferation Under Hypoxia.
The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production.
Robust RBM3 and β-klotho expression in developing neurons in the human brain.
RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain.
Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress.
iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications.
Neuroprotection via RNA-binding protein RBM3 expression is regulated by hypothermia but not by hypoxia in human SK-N-SH neurons.
Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.
Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons.
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices.
The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection.
Linardi D, Mani R, Di Nicola V, Perrone F, Martinazzi S, Tessari M, Faggian G, Luciani GB, Rungatscher A
Perfusion 2024 Sep;39(6):1179-1189
Perfusion 2024 Sep;39(6):1179-1189
Alternative 3'UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner.
Blake D, Gazzara MR, Breuer I, Ferretti M, Lynch KW
Scientific reports 2024 May 14;14(1):10987
Scientific reports 2024 May 14;14(1):10987
RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment.
Ding Y, Lin M, Wang J, Shang X
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119738
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119738
Mild and deep hypothermia differentially affect cerebral neuroinflammatory and cold shock response following cardiopulmonary bypass in rat.
Stern M, Kok WF, Doorduin J, Jongman RM, Jainandunsing J, Nieuwenhuijs-Moeke GJ, Absalom AR, Henning RH, Bosch DJ
Brain, behavior, and immunity 2024 Jul;119:96-104
Brain, behavior, and immunity 2024 Jul;119:96-104
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
bioRxiv : the preprint server for biology 2024 Jul 12;
bioRxiv : the preprint server for biology 2024 Jul 12;
Mild hypothermia promotes neuronal differentiation of human neural stem cells via RBM3-SOX11 signaling pathway.
Ma Y, He Z, Wang J, Zheng P, Ma Z, Liang Q, Zhang Q, Zhao X, Huang J, Weng W, Jiang J, Feng J
iScience 2024 Apr 19;27(4):109435
iScience 2024 Apr 19;27(4):109435
ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo.
Preußner M, Smith HL, Hughes D, Zhang M, Emmerichs AK, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR, Heyd F
EMBO molecular medicine 2023 May 8;15(5):e17157
EMBO molecular medicine 2023 May 8;15(5):e17157
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.
Feng X, Wang L, Zhou R, Zhou R, Chen L, Peng H, Huang Y, Guo Q, Luo X, Zhou H
Nature communications 2023 Jun 2;14(1):3208
Nature communications 2023 Jun 2;14(1):3208
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.
Lin JQ, Khuperkar D, Pavlou S, Makarchuk S, Patikas N, Lee FC, Zbiegly JM, Kang J, Field SF, Bailey DM, Freeman JL, Ule J, Metzakopian E, Ruepp MD, Mallucci GR
The EMBO journal 2023 Jul 17;42(14):e113168
The EMBO journal 2023 Jul 17;42(14):e113168
LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.
Chen QW, Cai QQ, Yang Y, Dong S, Liu YY, Chen ZY, Kang CL, Qi B, Dong YW, Wu W, Zhuang LP, Shen YH, Meng ZQ, Wu XZ
Clinical and translational medicine 2023 Jan;13(1):e1129
Clinical and translational medicine 2023 Jan;13(1):e1129
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury.
Wang N, Wang L, Li C, Rao P, Wang X, Xu Y, Yang L, Sun L, Lu D
Journal of physiology and biochemistry 2023 Feb;79(1):47-57
Journal of physiology and biochemistry 2023 Feb;79(1):47-57
RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
Long F, Hu L, Chen Y, Duan X, Xie K, Feng J, Wang M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Apr;72(4):731-744
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Apr;72(4):731-744
RNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial-Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma.
Zhang L, Zhang Y, Shen D, Chen Y, Feng J, Wang X, Ma L, Liao Y, Tang L
Journal of hepatocellular carcinoma 2022;9:405-422
Journal of hepatocellular carcinoma 2022;9:405-422
Cold shock protein RBM3 is upregulated in the autophagy-deficient brain.
Nakamura J, Aihara T, Chiba T, Tsuruta F
microPublication biology 2022;2022
microPublication biology 2022;2022
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Li C, Pan Y, Tan Y, Wang Y, Sun X
Frontiers in cell and developmental biology 2022;10:896014
Frontiers in cell and developmental biology 2022;10:896014
mRNA microarray analysis for the identification of potential biomarkers for vital reaction in burned skin: a preliminary pilot study.
Liu JL, Zheng YH, Chen LJ, Zhang KK, Li JH, Yang JZ, Li XW, Zhao D, Xie XL, Wang Q
Forensic science, medicine, and pathology 2022 Sep;18(3):319-328
Forensic science, medicine, and pathology 2022 Sep;18(3):319-328
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Xiao Q, Liu Y, Zhang X, Liu Z, Xiao J, Ye Q, Fu B
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia.
Lücht J, Rolfs N, Wowro SJ, Berger F, Schmitt KRL, Tong G
Mediators of inflammation 2021;2021:8906561
Mediators of inflammation 2021;2021:8906561
Hypothermic Shock Applied After Perinatal Asphyxia Prevents Retinal Damage in Rats.
Rey-Funes M, Contartese DS, Peláez R, García-Sanmartín J, Narro-Íñiguez J, Soliño M, Fernández JC, Sarotto A, Ciranna NS, López-Costa JJ, Dorfman VB, Larrayoz IM, Loidl CF, Martínez A
Frontiers in pharmacology 2021;12:651599
Frontiers in pharmacology 2021;12:651599
Long non‑coding RNA MIR4435‑2HG promotes the progression of head and neck squamous cell carcinoma by regulating the miR‑383‑5p/RBM3 axis.
Wang S, Chen X, Qiao T
Oncology reports 2021 Jun;45(6)
Oncology reports 2021 Jun;45(6)
Inhibition of cell proliferation and radioresistance by miR-383-5p through targeting RNA binding protein motif (RBM3) in nasopharyngeal carcinoma.
Ma R, Gao P, Yang H, Hu J, Xiao JJ, Shi M, Zhao LN
Annals of translational medicine 2021 Jan;9(2):123
Annals of translational medicine 2021 Jan;9(2):123
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
Peretti D, Smith HL, Verity N, Humoud I, de Weerd L, Swinden DP, Hayes J, Mallucci GR
Life science alliance 2021 Apr;4(4)
Life science alliance 2021 Apr;4(4)
RNA Binding Protein Motif 3 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis Through Promoting Stress Granules Formation in PC12 Cells and Rat Primary Cortical Neurons.
Si W, Li Z, Huang Z, Ye S, Li X, Li Y, Kuang W, Chen D, Zhu M
Frontiers in cellular neuroscience 2020;14:559384
Frontiers in cellular neuroscience 2020;14:559384
Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.
Miao X, Zhang N
Experimental and molecular pathology 2020 Dec;117:104546
Experimental and molecular pathology 2020 Dec;117:104546
The RNA-Binding Protein RBM3 Promotes Neural Stem Cell (NSC) Proliferation Under Hypoxia.
Yan J, Goerne T, Zelmer A, Guzman R, Kapfhammer JP, Wellmann S, Zhu X
Frontiers in cell and developmental biology 2019;7:288
Frontiers in cell and developmental biology 2019;7:288
The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production.
Dong W, Dai ZH, Liu FC, Guo XG, Ge CM, Ding J, Liu H, Yang F
EBioMedicine 2019 Jul;45:155-167
EBioMedicine 2019 Jul;45:155-167
Robust RBM3 and β-klotho expression in developing neurons in the human brain.
Jackson TC, Janesko-Feldman K, Carlson SW, Kotermanski SE, Kochanek PM
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2019 Dec;39(12):2355-2367
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2019 Dec;39(12):2355-2367
RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
Chen P, Yue X, Xiong H, Lu X, Ji Z
International journal of oncology 2019 Apr;54(4):1387-1397
International journal of oncology 2019 Apr;54(4):1387-1397
Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain.
Jackson TC, Kotermanski SE, Kochanek PM
Developmental neuroscience 2018;40(4):325-336
Developmental neuroscience 2018;40(4):325-336
Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress.
Xia W, Su L, Jiao J
The Journal of cell biology 2018 Oct 1;217(10):3464-3479
The Journal of cell biology 2018 Oct 1;217(10):3464-3479
iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications.
Ou J, Ball JM, Luan Y, Zhao T, Miyagishima KJ, Xu Y, Zhou H, Chen J, Merriman DK, Xie Z, Mallon BS, Li W
Cell 2018 May 3;173(4):851-863.e16
Cell 2018 May 3;173(4):851-863.e16
Neuroprotection via RNA-binding protein RBM3 expression is regulated by hypothermia but not by hypoxia in human SK-N-SH neurons.
Rosenthal LM, Tong G, Walker C, Wowro SJ, Krech J, Pfitzer C, Justus G, Berger F, Schmitt KRL
Hypoxia (Auckland, N.Z.) 2017;5:33-43
Hypoxia (Auckland, N.Z.) 2017;5:33-43
Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.
Zhu X, Zelmer A, Kapfhammer JP, Wellmann S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):624-34
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):624-34
Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons.
Jackson TC, Manole MD, Kotermanski SE, Jackson EK, Clark RS, Kochanek PM
Neuroscience 2015 Oct 1;305:268-78
Neuroscience 2015 Oct 1;305:268-78
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Peretti D, Bastide A, Radford H, Verity N, Molloy C, Martin MG, Moreno JA, Steinert JR, Smith T, Dinsdale D, Willis AE, Mallucci GR
Nature 2015 Feb 12;518(7538):236-9
Nature 2015 Feb 12;518(7538):236-9
Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices.
Tong G, Endersfelder S, Rosenthal LM, Wollersheim S, Sauer IM, Bührer C, Berger F, Schmitt KR
Brain research 2013 Apr 4;1504:74-84
Brain research 2013 Apr 4;1504:74-84
The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection.
Chip S, Zelmer A, Ogunshola OO, Felderhoff-Mueser U, Nitsch C, Bührer C, Wellmann S
Neurobiology of disease 2011 Aug;43(2):388-96
Neurobiology of disease 2011 Aug;43(2):388-96
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14363-1-AP(RBM3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 14363-1-AP(RBM3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RBM3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RBM3. This antibody recognizes human, mouse, rat antigen. The RBM3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
