Antibody data
- Antibody Data
- Antigen structure
- References [29]
- Comments [0]
- Validations [0]
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- Product number
- 13975-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13975-1-AP, RRID:AB_10638441
- Product name
- MKS3 antibody
- Antibody type
- Polyclonal
- Description
- MKS3 antibody (Cat. #13975-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells.
Expansion Microscopy of Mouse Photoreceptor Cilia.
Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers.
Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in Caenorhabditis elegans.
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone.
Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Ceglowski J, Hoffman HK, Neumann AJ, Hoff KJ, McCurdy BL, Moore JK, Prekeris R
EMBO reports 2024 Jan;25(1):198-227
EMBO reports 2024 Jan;25(1):198-227
Expansion Microscopy of Mouse Photoreceptor Cilia.
Moye AR, Robichaux MA, Wensel T
Advances in experimental medicine and biology 2023;1415:395-402
Advances in experimental medicine and biology 2023;1415:395-402
Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers.
Bahar-Shany K, Barnabas GD, Deutsch L, Deutsch N, Glick-Saar E, Dominissini D, Sapoznik S, Helpman L, Perri T, Blecher A, Katz G, Yagel I, Rosenblatt O, Shai D, Brandt B, Meyer R, Mohr-Sasson A, Volodarsky-Perel A, Zilberman I, Armon S, Jakobson-Setton A, Eitan R, Kadan Y, Beiner M, Josephy D, Brodsky M, Friedman E, Anafi L, Molchanov Y, Korach J, Geiger T, Levanon K
International journal of cancer 2023 Feb 15;152(4):781-793
International journal of cancer 2023 Feb 15;152(4):781-793
Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in Caenorhabditis elegans.
Lange KI, Best S, Tsiropoulou S, Berry I, Johnson CA, Blacque OE
Human molecular genetics 2022 May 19;31(10):1574-1587
Human molecular genetics 2022 May 19;31(10):1574-1587
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Schembs L, Willems A, Hasenpusch-Theil K, Cooper JD, Whiting K, Burr K, Bøstrand SMK, Selvaraj BT, Chandran S, Theil T
Cell reports 2022 May 17;39(7):110811
Cell reports 2022 May 17;39(7):110811
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Shen XL, Yuan JF, Qin XH, Song GP, Hu HB, Tu HQ, Song ZQ, Li PY, Xu YL, Li S, Jian XX, Li JN, He CY, Yu XP, Liang LY, Wu M, Han QY, Wang K, Li AL, Zhou T, Zhang YC, Wang N, Li HY
The Journal of cell biology 2022 Jan 3;221(1)
The Journal of cell biology 2022 Jan 3;221(1)
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Wang J, Thomas HR, Thompson RG, Waldrep SC, Fogerty J, Song P, Li Z, Ma Y, Santra P, Hoover JD, Yeo NC, Drummond IA, Yoder BK, Amack JD, Perkins B, Parant JM
Disease models & mechanisms 2022 Dec 1;15(12)
Disease models & mechanisms 2022 Dec 1;15(12)
Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone.
Conduit SE, Davies EM, Fulcher AJ, Oorschot V, Mitchell CA
Frontiers in cell and developmental biology 2021;9:634649
Frontiers in cell and developmental biology 2021;9:634649
Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.
Luo M, Lin Z, Zhu T, Jin M, Meng D, He R, Cao Z, Shen Y, Lu C, Cai R, Zhao Y, Wang X, Li H, Wu S, Zou X, Luo G, Cao L, Huang M, Jiao H, Gao H, Sui R, Zhao C, Ma X, Cao M
Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jun;23(6):1041-1049
Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jun;23(6):1041-1049
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5
Developmental cell 2020 May 4;53(3):287-299.e5
Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.
Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA
Scientific reports 2019 Jul 25;9(1):10828
Scientific reports 2019 Jul 25;9(1):10828
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ
Nature communications 2019 Jan 25;10(1):428
Nature communications 2019 Jan 25;10(1):428
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ
eLife 2018 Oct 16;7
eLife 2018 Oct 16;7
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
Jeong AL, Ka HI, Han S, Lee S, Lee EW, Soh SJ, Joo HJ, Sumiyasuren B, Park JY, Lim JS, Park JH, Lee MS, Yang Y
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier JM, Zobel T, Dahmen S, Leu T, Struchtrup A, Legendre F, Vesque C, Schneider-Maunoury S, Saunier S, Rüther U, Gerhardt C
The EMBO journal 2018 May 15;37(10)
The EMBO journal 2018 May 15;37(10)
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Weng RR, Yang TT, Huang CE, Chang CW, Wang WJ, Liao JC
Biophysical journal 2018 Jul 17;115(2):263-275
Biophysical journal 2018 Jul 17;115(2):263-275
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277
Nature communications 2018 Dec 11;9(1):5277
The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.
Loukil A, Tormanen K, Sütterlin C
The Journal of cell biology 2017 May 1;216(5):1287-1300
The Journal of cell biology 2017 May 1;216(5):1287-1300
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A
Cell reports 2017 Jul 11;20(2):384-396
Cell reports 2017 Jul 11;20(2):384-396
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.
Yang TT, Su J, Wang WJ, Craige B, Witman GB, Tsou MF, Liao JC
Scientific reports 2015 Sep 14;5:14096
Scientific reports 2015 Sep 14;5:14096
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ
Nature cell biology 2015 Mar;17(3):228-240
Nature cell biology 2015 Mar;17(3):228-240
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Ran J, Yang Y, Li D, Liu M, Zhou J
Scientific reports 2015 Aug 6;5:12917
Scientific reports 2015 Aug 6;5:12917
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ
Nature cell biology 2015 Apr;17(4):531
Nature cell biology 2015 Apr;17(4):531
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
Barbelanne M, Hossain D, Chan DP, Peränen J, Tsang WY
Human molecular genetics 2015 Apr 15;24(8):2185-200
Human molecular genetics 2015 Apr 15;24(8):2185-200
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF
The Journal of cell biology 2015 Apr 13;209(1):129-42
The Journal of cell biology 2015 Apr 13;209(1):129-42
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J
Cell research 2014 Nov;24(11):1342-53
Cell research 2014 Nov;24(11):1342-53
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF
Nature cell biology 2013 Jun;15(6):591-601
Nature cell biology 2013 Jun;15(6):591-601
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
Goetz SC, Liem KF Jr, Anderson KV
Cell 2012 Nov 9;151(4):847-858
Cell 2012 Nov 9;151(4):847-858
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF
Nature genetics 2011 Jul 3;43(8):776-84
Nature genetics 2011 Jul 3;43(8):776-84
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