13683-1-AP

antibody from Proteintech Group

Targeting: CHMP4B C20orf178, dJ553F4.4, Shax1, SNF7-2, VPS32B

Provider product page for 13683-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [82]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 13683-1-AP - Provider product page
Provider: Proteintech Group
Product name: CHMP4B antibody
Antibody type: Polyclonal
Description: KD/KO validated CHMP4B antibody (Cat. #13683-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CHMP4B protein structure - 13683-1-AP shown in red.

Submitted references Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair.

Chen D, Fearns A, Peddie CJ, Gutierrez MG
The EMBO journal 2026 May;45(9):3022-3055

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei.

Chen Y, Norman RX, Toufektchan E, Luan X, Shim A, Rosenberg H, Kovacs MT, Nichols A, Hickling J, Cifani P, Kentsis A, Zhou W, Maciejowski J
Molecular cell 2026 Mar 19;86(6):1099-1115.e10

Inhibition of ESCRT-III activates alternative pathways for protein degradation and secretion.

Fujiwara M, Sakai R, Takahashi M, Matsumoto G, Hashimoto T, Kabuta T
Neurochemistry international 2026 Jun;196:106153

Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes.

Langejürgen A, Schmidt G, Unsöld L, Tatge H, Oyson E, Gerhard R
Toxins 2026 Apr 15;18(4)

Molecular and subcellular mechanisms of vital macrophage extracellular trap formation.

Lee Y, Brenner M, Aziz M, Wang P
Frontiers in immunology 2025;16:1608428

Evaluation of pyroptosis-associated genes in endometrial cancer utilizing a 101-combination machine learning framework and multi-omics data.

Huang LJ, Liu C, Chen L, Tang M, Zhan ST, Chen F, Teng AY, Zhou LN, Sang WL, Yang Y
Frontiers in medicine 2025;12:1590405

ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI.

Tian Z, Wu Y, Yi B, Li L, Liu Y, Zhang H, Li A
Autophagy 2025 Sep;21(9):1927-1944

Coordination of autophagosome closure and release by the Alzheimer's disease-associated protein BIN1.

Palmer JE, Puri C, O'Rourke RS, Son SM, Sang C, Huang YA, Rubinsztein DC
Cell reports 2025 Sep 23;44(9):116266

α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation.

Sitron CS, Trinkaus VA, Galesic A, Garhammer M, Yuste-Checa P, Dransfeld U, Feigenbutz D, Zhang J, Ivashko L, Dudanova I, Harper JW, Hartl FU
Molecular cell 2025 Sep 18;85(18):3505-3523.e17

Polystyrene nanoplastics-induced methuosis in brain microvascular endothelial cells: Rescue via ESCRT membrane repair system.

Yin S, Kang Y, Du W, Tan X, Wang Z, Shao L, Liu J
Ecotoxicology and environmental safety 2025 Sep 15;303:118800

KIF4A Inhibits Ferroptosis in Glioblastoma via the CHMP4B/GPX4 Axis and Promotes Temozolomide Resistance.

Shen X, Cheng H, Zheng J, Xia Y, Li Y, Guo Q, Zhang Z, Yin N, Liu Y, Dong J, Shen Y
Molecular carcinogenesis 2025 Oct;64(10):1650-1666

Glucocorticoids regulate small extracellular vesicle (sEV) release via activation of nSMase2.

Burke M, Waites C
bioRxiv : the preprint server for biology 2025 Oct 7;

IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cells.

Zhao Y, Zheng M, Li P, Zhao C, Chen R, Qian B, Cui X, Ren Y, Su C, Shi L, Hao J, Yao Z, Gao X, Yang J
Journal of advanced research 2025 Oct 31;

Endosome maturation during ER stress relies on the ubiquitin-binding domain of histone deacetylase 6.

Piscopo KM, Larson B, Christiansen AM, Perry JM, Hollien J
Molecular biology of the cell 2025 Oct 1;36(10):ar120

Loss of CHMP2A implicates an ordered assembly of ESCRT-III proteins during cytokinetic abscission.

Kamenetsky N, Nachmias D, Khan S, Avinoam O, Hazan I, Upcher A, Elia N
Molecular biology of the cell 2025 Nov 1;36(11):ar143

Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration.

Liu S, Hu Y, Xu W, Liu W, Wang B, Zeng X, Shao Z, Yang C, Xiong L, Cai X
Autophagy 2025 May;21(5):979-995

Cytoskeleton disruption and plasma membrane damage determine methuosis of normal and malignant cells.

Dong B, Xiao J, Wang J, Song X, Ji H, Peng J, Weng X, Guo D, Jiang S, Gao X
Cell & bioscience 2025 Jul 5;15(1):96

Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection.

Augenstreich J, Phan AT, Allen CNS, Poddar A, Chen H, Srinivasan L, Briken V
PLoS pathogens 2025 Jan;21(1):e1012830

Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.

Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes.

Swift KA, Pustova I, Kasberg W, Bowman J, Gopinath K, Voss E, Nelson H, Audhya A
The Journal of cell biology 2025 Dec 1;224(12)

Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies.

Yeat NY, Liu LH, Chang YH, Lai CP, Chen RH
Developmental cell 2025 Aug 4;60(15):2114-2130.e9

TDCPP disrupts ALG-2/ALIX-mediated ESCRT-III recruitment: Implications for lysosomal membrane repair and neurotoxicity.

Li T, Zhang Y, Ding X, Liu L, Ma R, Qin W, Yan C, Wang C, Zhang J, Keerman M, Niu Q
Environmental pollution (Barking, Essex : 1987) 2025 Aug 15;379:126535

The Rubicon-WIPI axis regulates exosome biogenesis during ageing.

Yanagawa K, Kuma A, Hamasaki M, Kita S, Yamamuro T, Nishino K, Nakamura S, Omori H, Kaminishi T, Oikawa S, Kato Y, Edahiro R, Kawagoe R, Taniguchi T, Tanaka Y, Shima T, Tabata K, Iwatani M, Bekku N, Hanayama R, Okada Y, Akimoto T, Kosako H, Takahashi A, Shimomura I, Sakata Y, Yoshimori T
Nature cell biology 2024 Sep;26(9):1558-1570

NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency.

Cendrowski J, Wrobel M, Mazur M, Jary B, Maurya R, Wang S, Korostynski M, Dziewulska A, Rohm M, Kuropka P, Pudelko-Malik N, Mlynarz P, Dobrzyn A, Zeigerer A, Miaczynska M
Cellular and molecular life sciences : CMLS 2024 Nov 19;81(1):458

Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche.

Rasheed A, Robichaud S, Dennison T, Nguyen MA, Geoffrion M, Reed JN, Wyatt HJ, Marouf Y, Baxi A, Lee R, Kazan H, Civelek M, van Solingen C, Ouimet M, Rayner KJ
Nature cardiovascular research 2024 May;3(5):594-611

3-MCPD Induces Renal Cell Pyroptosis and Inflammation by Inhibiting ESCRT-III-Mediated Cell Repair and Mitophagy.

Zhang R, Guan S, Meng Z, Deng X, Lu J
Journal of agricultural and food chemistry 2024 Jun 10;

Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis.

Chen J, Singh N, Ye X, Theune EV, Wang K
Cancer gene therapy 2024 Jul;31(7):1007-1017

TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress.

Jeong E, Willett R, Rissone A, La Spina M, Puertollano R
Nature communications 2024 Jan 2;15(1):93

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma.

Wu Z, Omura I, Saito A, Imaizumi K, Kamikawa Y
Nucleus (Austin, Tex.) 2024 Dec;15(1):2423660

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.

Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S
Science (New York, N.Y.) 2024 Aug 30;385(6712):eadj7446

The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a unique function in regulating mammalian cytokinesis abscission.

Dvilansky I, Altaras Y, Kamenetsky N, Nachmias D, Elia N
PLoS biology 2024 Apr;22(4):e3002327

Annexin A7 mediates lysosome repair independently of ESCRT-III.

Ebstrup ML, Sønder SL, Fogde DL, Heitmann ASB, Dietrich TN, Dias C, Jäättelä M, Maeda K, Nylandsted J
Frontiers in cell and developmental biology 2023;11:1211498

Lysosomal Function and Intracellular Position Determine the Malignant Phenotype in Malignant Melanoma.

Eriksson I, Vainikka L, Wäster P, Öllinger K
The Journal of investigative dermatology 2023 Sep;143(9):1769-1778.e12

TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

Chae CW, Yoon JH, Lim JR, Park JY, Cho JH, Jung YH, Choi GE, Lee HJ, Han HJ
Autophagy 2023 Oct;19(10):2752-2768

Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy.

Nozawa T, Toh H, Iibushi J, Kogai K, Minowa-Nozawa A, Satoh J, Ito S, Murase K, Nakagawa I
Nature communications 2023 Oct 6;14(1):6230

An oocyte meiotic midbody cap is required for developmental competence in mice.

Schindler K, Jung GI, Londoño-Vásquez D, Park S, Skop A, Balboula A
Research square 2023 Oct 5;

Stress granules plug and stabilize damaged endolysosomal membranes.

Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG
Nature 2023 Nov;623(7989):1062-1069

Vps60 initiates alternative ESCRT-III filaments.

Pfitzner AK, Zivkovic H, Bernat-Silvestre C, West M, Peltier T, Humbert F, Odorizzi G, Roux A
The Journal of cell biology 2023 Nov 6;222(11)

An oocyte meiotic midbody cap is required for developmental competence in mice.

Jung GI, Londoño-Vásquez D, Park S, Skop AR, Balboula AZ, Schindler K
Nature communications 2023 Nov 16;14(1):7419

ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion.

Wang F, Peters R, Jia J, Mudd M, Salemi M, Allers L, Javed R, Duque TLA, Paddar MA, Trosdal ES, Phinney B, Deretic V
Developmental cell 2023 May 22;58(10):866-884.e8

Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis.

Jun YW, Lee S, Ban BK, Lee JA, Gao FB
Autophagy 2023 Jul;19(7):2045-2061

DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.

Kumar R, Francis V, Ioannou MS, Aguila A, Khan M, Banks E, Kulasekaran G, McPherson PS
Cell reports 2023 Jul 25;42(7):112795

Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.

Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.

Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A, Hamasaki M, Kosako H, Yoshimori T, Nakamura S
EMBO reports 2023 Dec 6;24(12):e57300

The role of midbody-associated mRNAs in regulating abscission.

Farmer T, Vaeth KF, Han KJ, Goering R, Taliaferro MJ, Prekeris R
The Journal of cell biology 2023 Dec 4;222(12)

Polymyxin B Reduces Brain Injury in Ischemic Stroke Rat Through a Mechanism Involving Targeting ESCRT-III Machinery and RIPK1/RIPK3/MLKL Pathway.

Tian J, Zhang YY, Peng YW, Liu B, Zhang XJ, Hu ZY, Hu CP, Luo XJ, Peng J
Journal of cardiovascular translational research 2022 Oct;15(5):1129-1142

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.

Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron 2022 Mar 16;110(6):967-976.e8

Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome.

Dong H, Zhao B, Chen J, Liu Z, Li X, Li L, Wen H
Proceedings of the National Academy of Sciences of the United States of America 2022 Jun 28;119(26):e2123247119

Long noncoding RNA Sh2d3c promotes manganese-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax axis.

Lu W, Li D, Wei S, Yang J, Tang C, Ma X, Zou Y
Toxicology letters 2022 Jul 15;365:24-35

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission.

Luessing J, Okowa CC, Brennan E, Voisin M, Lowndes NF
iScience 2022 Jul 15;25(7):104536

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection.

Liu CC, Liu YY, Zhou JF, Chen X, Chen H, Hu JH, Chen J, Zhang J, Sun RC, Wei JC, Go YY, Morita E, Zhou B
PLoS pathogens 2022 Feb;18(2):e1010294

The Obligate Intracellular Bacterial Pathogen Anaplasma phagocytophilum Exploits Host Cell Multivesicular Body Biogenesis for Proliferation and Dissemination.

Read CB, Lind MCH, Chiarelli TJ, Izac JR, Adcox HE, Marconi RT, Carlyon JA
mBio 2022 Dec 20;13(6):e0296122

BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding.

Wang M, Zhao K, Liu M, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T, Wang H, Jiang C, Gao S, Chen J
Protein & cell 2022 Aug;13(8):580-601

Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair.

Yim WW, Yamamoto H, Mizushima N
FEBS letters 2022 Apr;596(8):991-1003

Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair.

Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Südhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM
Nature communications 2022 Apr 6;13(1):1875

Caveolae promote successful abscission by controlling intercellular bridge tension during cytokinesis.

Andrade V, Bai J, Gupta-Rossi N, Jimenez AJ, Delevoye C, Lamaze C, Echard A
Science advances 2022 Apr 15;8(15):eabm5095

Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.

Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V
Cell 2021 Nov 24;184(24):5950-5969.e22

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

Kazan JM, Desrochers G, Martin CE, Jeong H, Kharitidi D, Apaja PM, Roldan A, St Denis N, Gingras AC, Lukacs GL, Pause A
iScience 2021 Nov 19;24(11):103274

His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation.

Parkinson G, Roboti P, Zhang L, Taylor S, Woodman P
Journal of cell science 2021 Nov 1;134(21)

Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.

Iannantuono NVG, Emery G
Journal of cell science 2021 Jun 15;134(12)

A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation.

Zhang W, Yang X, Chen L, Liu YY, Venkatarangan V, Reist L, Hanson P, Xu H, Wang Y, Li M
PLoS biology 2021 Jul;19(7):e3001361

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, Aguirre AJ
Cell reports 2021 Jul 13;36(2):109367

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.

Merigliano C, Burla R, La Torre M, Del Giudice S, Teo H, Liew CW, Chojnowski A, Goh WI, Olmos Y, Maccaroni K, Giubettini M, Chiolo I, Carlton JG, Raimondo D, Vernì F, Stewart CL, Rhodes D, Wright GD, Burke BE, Saggio I
PLoS genetics 2021 Aug;17(8):e1009757

LRRK2 activation controls the repair of damaged endomembranes in macrophages.

Herbst S, Campbell P, Harvey J, Bernard EM, Papayannopoulos V, Wood NW, Morris HR, Gutierrez MG
The EMBO journal 2020 Sep 15;39(18):e104494

Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis.

Rasheed A, Robichaud S, Nguyen MA, Geoffrion M, Wyatt H, Cottee ML, Dennison T, Pietrangelo A, Lee R, Lagace TA, Ouimet M, Rayner KJ
Arteriosclerosis, thrombosis, and vascular biology 2020 May;40(5):1155-1167

Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins.

Eriksson I, Wäster P, Öllinger K
Cell death & disease 2020 May 14;11(5):370

Human Cytomegalovirus Utilizes Extracellular Vesicles To Enhance Virus Spread.

Streck NT, Zhao Y, Sundstrom JM, Buchkovich NJ
Journal of virology 2020 Jul 30;94(16)

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.

Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, Roux A
Nature cell biology 2020 Aug;22(8):947-959

Studying the Spatial Organization of ESCRTs in Cytokinetic Abscission Using the High-Resolution Imaging Techniques SIM and Cryo-SXT.

Adar-Levor S, Goliand I, Elbaum M, Elia N
Methods in molecular biology (Clifton, N.J.) 2019;1998:129-148

A charged multivesicular body protein (CHMP4B) is required for lens growth and differentiation.

Zhou Y, Bennett TM, Shiels A
Differentiation; research in biological diversity 2019 Sep-Oct;109:16-27

Non-muscle Myosin-II Is Required for the Generation of a Constriction Site for Subsequent Abscission.

Wang K, Wloka C, Bi E
iScience 2019 Mar 29;13:69-81

A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission.

Karasmanis EP, Hwang D, Nakos K, Bowen JR, Angelis D, Spiliotis ET
Current biology : CB 2019 Jul 8;29(13):2174-2182.e7

Vps4A mediates the localization and exosome release of β-catenin to inhibit epithelial-mesenchymal transition in hepatocellular carcinoma.

Han Q, Lv L, Wei J, Lei X, Lin H, Li G, Cao J, Xie J, Yang W, Wu S, You J, Lu J, Liu P, Min J
Cancer letters 2019 Aug 10;457:47-59

Nuclear envelope assembly defects link mitotic errors to chromothripsis.

Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D
Nature 2018 Sep;561(7724):551-555

iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.

Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P, Wang C
Cell death & disease 2018 May 1;9(5):528

Nonenvelopment Role for the ESCRT-III Complex during Human Cytomegalovirus Infection.

Streck NT, Carmichael J, Buchkovich NJ
Journal of virology 2018 Jun 15;92(12)

Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.

Goliand I, Adar-Levor S, Segal I, Nachmias D, Dadosh T, Kozlov MM, Elia N
Cell reports 2018 Aug 14;24(7):1756-1764

Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.

Kim SB, Kim HR, Park MC, Cho S, Goughnour PC, Han D, Yoon I, Kim Y, Kang T, Song E, Kim P, Choi H, Mun JY, Song C, Lee S, Jung HS, Kim S
The Journal of cell biology 2017 Jul 3;216(7):2201-2216

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.

Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M
Science signaling 2016 Jan 19;9(411):ra8

ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome.

Flores-Rodriguez N, Kenwright DA, Chung PH, Harrison AW, Stefani F, Waigh TA, Allan VJ, Woodman PG
Journal of cell science 2015 Feb 15;128(4):755-67

Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.

Ali N, Zhang L, Taylor S, Mironov A, Urbé S, Woodman P
Current biology : CB 2013 Mar 18;23(6):453-61

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 13683-1-AP(CHMP4B antibody) at dilution of 1:200
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human oesophagus cancer using 13683-1-AP(CHMP4B antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CHMP4B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CHMP4B. This antibody recognizes human, mouse, rat antigen. The CHMP4B antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13683-1-AP.pdf

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