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- Antigen structure
- References [22]
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- Product number
- 18177-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18177-1-AP, RRID:AB_2279680
- Product name
- HEPACAM antibody
- Antibody type
- Polyclonal
- Description
- HEPACAM antibody (Cat. #18177-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma.
Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity.
Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.
Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.
HepaCAM‑PIK3CA axis regulates the reprogramming of glutamine metabolism to inhibit prostate cancer cell proliferation.
STAT3 phosphorylation is required for the HepaCAM-mediated inhibition of castration-resistant prostate cancer cell viability and metastasis.
Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM.
Megalencephalic Leukoencephalopathy with Subcortical Cysts Disease-Linked MLC1 Protein Favors Gap-Junction Intercellular Communication by Regulating Connexin 43 Trafficking in Astrocytes.
HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain.
Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties.
HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro.
Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
5-azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene.
The SMAD2/3 pathway is involved in hepaCAM-induced apoptosis by inhibiting the nuclear translocation of SMAD2/3 in bladder cancer cells.
Expression of hepaCAM inhibits bladder cancer cell proliferation via a Wnt/β-catenin-dependent pathway in vitro and in vivo.
HepaCAM inhibits clear cell renal carcinoma 786-0 cell proliferation via blocking PKCε translocation from cytoplasm to plasma membrane.
Identification of hypermethylation in hepatocyte cell adhesion molecule gene promoter region in bladder carcinoma.
The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule.
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations.
De A, Lattier JM, Morales JE, Kelly JR, Zheng X, Chen Z, Sebastian S, Nassiri Toosi Z, Huse JT, Lang FF, McCarty JH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Nov 22;43(47):8043-8057
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Nov 22;43(47):8043-8057
Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity.
Stefanowicz AJ, Recio L, Black MB, Beames T, Andersen ME, Stern RA, Clewell RA, McMullen PD, Hartman JK, Ranade A
International journal of toxicology 2023 Jan-Feb;42(1):19-36
International journal of toxicology 2023 Jan-Feb;42(1):19-36
Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.
Jin S, Chen X, Tian Y, Jarvis R, Promes V, Yang Y
bioRxiv : the preprint server for biology 2023 Feb 14;
bioRxiv : the preprint server for biology 2023 Feb 14;
Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.
Jin S, Chen X, Tian Y, Jarvis R, Promes V, Yang Y
Nature communications 2023 Aug 24;14(1):5150
Nature communications 2023 Aug 24;14(1):5150
HepaCAM‑PIK3CA axis regulates the reprogramming of glutamine metabolism to inhibit prostate cancer cell proliferation.
He Z, Gao Y, Li T, Yu C, Ou L, Luo C
International journal of oncology 2022 Apr;60(4)
International journal of oncology 2022 Apr;60(4)
STAT3 phosphorylation is required for the HepaCAM-mediated inhibition of castration-resistant prostate cancer cell viability and metastasis.
Tan B, Chen X, Fan Y, Yang Y, Yang J, Tan L
The Prostate 2021 Jun;81(9):603-611
The Prostate 2021 Jun;81(9):603-611
Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM.
Li T, Liu N, Gao Y, Quan Z, Hao Y, Yu C, Li L, Yuan M, Niu L, Luo C, Wu X
British journal of cancer 2021 Jan;124(1):247-258
British journal of cancer 2021 Jan;124(1):247-258
Megalencephalic Leukoencephalopathy with Subcortical Cysts Disease-Linked MLC1 Protein Favors Gap-Junction Intercellular Communication by Regulating Connexin 43 Trafficking in Astrocytes.
Lanciotti A, Brignone MS, Belfiore M, Columba-Cabezas S, Mallozzi C, Vincentini O, Molinari P, Petrucci TC, Visentin S, Ambrosini E
Cells 2020 Jun 8;9(6)
Cells 2020 Jun 8;9(6)
HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
Fan Y, Ou L, Fan J, Li L, Wu X, Luo C, Gao Y, Niu L
Urology 2019 May;127:61-67
Urology 2019 May;127:61-67
HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain.
Deng Q, Luo L, Quan Z, Liu N, Du Z, Sun W, Luo C, Wu X
Molecular medicine reports 2019 Mar;19(3):2115-2124
Molecular medicine reports 2019 Mar;19(3):2115-2124
Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties.
Bradley RA, Shireman J, McFalls C, Choi J, Canfield SG, Dong Y, Liu K, Lisota B, Jones JR, Petersen A, Bhattacharyya A, Palecek SP, Shusta EV, Kendziorski C, Zhang SC
Development (Cambridge, England) 2019 Jul 8;146(13)
Development (Cambridge, England) 2019 Jul 8;146(13)
HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro.
Du Z, Li L, Sun W, Wang X, Zhang Y, Chen Z, Yuan M, Quan Z, Liu N, Hao Y, Li T, Wang J, Luo C, Wu X
International journal of oncology 2018 Jul;53(1):99-112
International journal of oncology 2018 Jul;53(1):99-112
Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
Tang M, Zhao Y, Liu N, Chen E, Quan Z, Wu X, Luo C
Journal of cancer research and clinical oncology 2017 May;143(5):793-805
Journal of cancer research and clinical oncology 2017 May;143(5):793-805
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Quan Z, He Y, Luo C, Xia Y, Zhao Y, Liu N, Wu X
Cellular signalling 2017 Apr;32:48-58
Cellular signalling 2017 Apr;32:48-58
5-azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene.
Wang X, Chen E, Yang X, Wang Y, Quan Z, Wu X, Luo C
Oncology reports 2016 Mar;35(3):1375-84
Oncology reports 2016 Mar;35(3):1375-84
The SMAD2/3 pathway is involved in hepaCAM-induced apoptosis by inhibiting the nuclear translocation of SMAD2/3 in bladder cancer cells.
Wang X, Chen E, Tang M, Yang X, Wang Y, Quan Z, Wu X, Luo C
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10731-43
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10731-43
Expression of hepaCAM inhibits bladder cancer cell proliferation via a Wnt/β-catenin-dependent pathway in vitro and in vivo.
Du HF, Ou LP, Lv CK, Yang X, Song XD, Fan YR, Wu XH, Luo CL
Cancer biology & therapy 2015;16(10):1502-13
Cancer biology & therapy 2015;16(10):1502-13
HepaCAM inhibits clear cell renal carcinoma 786-0 cell proliferation via blocking PKCε translocation from cytoplasm to plasma membrane.
Tan B, Tan J, Du H, Quan Z, Xu X, Jiang X, Luo C, Wu X
Molecular and cellular biochemistry 2014 Jun;391(1-2):95-102
Molecular and cellular biochemistry 2014 Jun;391(1-2):95-102
Identification of hypermethylation in hepatocyte cell adhesion molecule gene promoter region in bladder carcinoma.
Tao J, Liu Q, Wu X, Xu X, Zhang Y, Wang Q, Luo C
International journal of medical sciences 2013;10(13):1860-7
International journal of medical sciences 2013;10(13):1860-7
The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule.
Zhang L, Wu X, Luo C, Chen X, Yang L, Tao J, Shi J
Molecular medicine reports 2013 Jul;8(1):272-6
Molecular medicine reports 2013 Jul;8(1):272-6
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
Xu B, He Y, Wu X, Luo C, Liu A, Zhang J
The Journal of urology 2012 Oct;188(4):1346-53
The Journal of urology 2012 Oct;188(4):1346-53
Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations.
Lanciotti A, Brignone MS, Molinari P, Visentin S, De Nuccio C, Macchia G, Aiello C, Bertini E, Aloisi F, Petrucci TC, Ambrosini E
Human molecular genetics 2012 May 15;21(10):2166-80
Human molecular genetics 2012 May 15;21(10):2166-80
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 18177-1-AP(HEPACAM antibody) at dilution of 1:500
- Sample type
- tissue
