10348-1-AP

antibody from Proteintech Group

Targeting: STOML2 HSPC108, SLP-2

Provider product page for 10348-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [49]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 10348-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10348-1-AP, RRID:AB_2286822
Product name: STOML2 antibody
Antibody type: Polyclonal
Description: KD/KO validated STOML2 antibody (Cat. #10348-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

STOML2 protein structure - 10348-1-AP shown in red.

Submitted references Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.

Attia AS, Hussein S, Sameh H, Khalil A, Waley AB, Matar I, Sameh R
Cancer biomarkers : section A of Disease markers 2024;39(3):211-221

CHCHD10(S59L/+) mouse model: Behavioral and neuropathological features of frontotemporal dementia.

Genin EC, di Borgo PP, Lorivel T, Hugues S, Farinelli M, Mauri-Crouzet A, Lespinasse F, Godin L, Paquis-Flucklinger V, Petit-Paitel A
Neurobiology of disease 2024 Jun 1;195:106498

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P
Molecular cell 2024 Jan 18;84(2):345-358.e5

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space.

Adriaenssens E, Asselbergh B, Rivera-Mejías P, Bervoets S, Vendredy L, De Winter V, Spaas K, de Rycke R, van Isterdael G, Impens F, Langer T, Timmerman V
Nature cell biology 2023 Mar;25(3):467-480

STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.

Qin C, Wang Y, Zhao B, Li Z, Li T, Yang X, Zhao Y, Wang W
Cell death & disease 2023 Mar 11;14(3):191

Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.

Kumari S, Sankhwar P, Tripathi R, Kawale AK, Gupta S, Jha RK
Reproductive sciences (Thousand Oaks, Calif.) 2023 Jun;30(6):1854-1866

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Sayles NM, Southwell N, McAvoy K, Kim K, Pesini A, Anderson CJ, Quinzii C, Cloonan S, Kawamata H, Manfredi G
Cell reports 2022 Mar 8;38(10):110475

Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells.

Yang S, Huang Y, Zhang H, Wang F, Shao L, Wang X
Oncology letters 2021 Oct;22(4):707

STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation.

Ma W, Chen Y, Xiong W, Li W, Xu Z, Wang Y, Wei Z, Mou T, Wu Z, Cheng M, Zou Y, Zhu Y, Zhou W, Liu F, Geng Y
Journal of experimental & clinical cancer research : CR 2021 Nov 15;40(1):359

Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.

Chao D, Ariake K, Sato S, Ohtsuka H, Takadate T, Ishida M, Masuda K, Maeda S, Miura T, Mitachi K, Yu XJ, Fujishima F, Mizuma M, Nakagawa K, Morikawa T, Kamei T, Unno M
Oncology reports 2021 Jun;45(6)

Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels.

Fatiga FF, Wang LJ, Hsu T, Capuno JI, Fu CY
Journal of cellular biochemistry 2021 Dec;122(12):1848-1862

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.

Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P
eLife 2021 Dec 31;10

Coexisting overexpression of STOML1 and STOML2 proteins may be associated with pathology of oral squamous cell carcinoma.

Wang D, Qi H, Li A, Deng F, Xu Y, Hu Z, Liu Q, Wang Y
Oral surgery, oral medicine, oral pathology and oral radiology 2020 Jun;129(6):591-599.e3

Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC.

Liu Q, Li A, Wang L, He W, Zhao L, Wu C, Lu S, Ye X, Zhao H, Shen X, Xiao X, Liu Z
Molecular therapy oncolytics 2020 Jun 26;17:169-179

Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signalling.

Wang M, Li C, Shi W
Journal of drug targeting 2020 Jul;28(6):600-608

STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma.

Qu H, Jiang W, Wang Y, Chen P
American journal of translational research 2019;11(2):683-695

Mitochondrial stress response triggered by defects in protein synthesis quality control.

Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ
Life science alliance 2019 Feb;2(1)

A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression.

Ma W, Xu Z, Wang Y, Li W, Wei Z, Chen T, Mou T, Cheng M, Luo J, Luo T, Chen Y, Yu J, Zhou W, Li G
Theranostics 2018;8(20):5744-5757

The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma.

Yang X, Hu Y, Shi H, Zhang C, Wang Z, Liu X, Chen H, Zhang L, Cui D
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2018 Aug;275(8):2127-2134

Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress.

Anderson CJ, Kahl A, Qian L, Stepanova A, Starkov A, Manfredi G, Iadecola C, Zhou P
Journal of neurochemistry 2018 Aug;146(3):235-250

Stomatin-like protein 2 deficiency results in impaired mitochondrial translation.

Mitsopoulos P, Lapohos O, Weraarpachai W, Antonicka H, Chang YH, Madrenas J
PloS one 2017;12(6):e0179967

Clinical significance of SLP-2 in hepatocellular carcinoma tissues and its regulation in cancer cell proliferation, migration, and EMT.

Huang Y, Chen Y, Lin X, Lin Q, Han M, Guo G
OncoTargets and therapy 2017;10:4665-4673

Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans.

Feng Q, Hu ZY, Liu XQ, Zhang X, Lan X, Geng YQ, Chen XM, He JL, Wang YX, Ding YB
Reproductive biomedicine online 2017 Feb;34(2):191-202

Stomatin-like protein 2 is overexpressed in cervical cancer and involved in tumor cell apoptosis.

Deng H, Deng Y, Liu F, Chen J, Li Z, Zhao K, Guan X, Liang W
Oncology letters 2017 Dec;14(6):6355-6364

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T
EMBO reports 2016 Dec;17(12):1844-1856

Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation.

Bartolome A, Boskovic S, Paunovic I, Bozic V, Cvejic D
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2016 Apr;124(4):271-7

Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival.

Sun F, Ding W, He JH, Wang XJ, Ma ZB, Li YF
BMC cancer 2015 Oct 20;15:746

miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.

Yang X, Zang W, Xuan X, Wang Z, Liu Z, Wang J, Cui J, Zhao G
International journal of oncology 2015 May;46(5):2163-71

Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.

Mitsopoulos P, Chang YH, Wai T, König T, Dunn SD, Langer T, Madrenas J
Molecular and cellular biology 2015 May;35(10):1838-47

Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.

Shin DI, Oh YJ
Experimental neurobiology 2014 Mar;23(1):65-76

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T
Cell metabolism 2014 Jul 1;20(1):158-71

Increased expression of stomatin-like protein 2 (STOML2) predicts decreased survival in gastric adenocarcinoma: a retrospective study.

Li XH, He F, Yan SM, Li Y, Cao Y, Huang CY, Zhou ZW
Medical oncology (Northwood, London, England) 2014 Jan;31(1):763

Stomatin-like protein 2 is associated with the clinicopathological features of human papillary thyroid cancer and is regulated by TGF-β in thyroid cancer cells.

Liu Z, Yang Y, Zhang Y, Ye X, Wang L, Xu G
Oncology reports 2014 Jan;31(1):153-60

Expression of SLP-2 was associated with invasion of esophageal squamous cell carcinoma.

Cao W, Zhang B, Ding F, Zhang W, Sun B, Liu Z
PloS one 2013;8(5):e63890

Increased levels of SLP-2 correlate with poor prognosis in gastric cancer.

Liu D, Zhang L, Shen Z, Tan F, Hu Y, Yu J, Li G
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2013 Oct;16(4):498-504

Loss of Yme1L perturbates mitochondrial dynamics.

Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z
Cell death & disease 2013 Oct 31;4(10):e896

Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation.

Christie DA, Kirchhof MG, Vardhana S, Dustin ML, Madrenas J
PloS one 2012;7(5):e37144

Stomatin-like protein 2 deficiency in T cells is associated with altered mitochondrial respiration and defective CD4+ T cell responses.

Christie DA, Mitsopoulos P, Blagih J, Dunn SD, St-Pierre J, Jones RG, Hatch GM, Madrenas J
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 1;189(9):4349-60

Knockdown of stomatin-like protein 2 (STOML2) reduces the invasive ability of glioma cells through inhibition of the NF-κB/MMP-9 pathway.

Song L, Liu L, Wu Z, Lin C, Dai T, Yu C, Wang X, Wu J, Li M, Li J
The Journal of pathology 2012 Feb;226(3):534-43

Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function.

Christie DA, Lemke CD, Elias IM, Chau LA, Kirchhof MG, Li B, Ball EH, Dunn SD, Hatch GM, Madrenas J
Molecular and cellular biology 2011 Sep;31(18):3845-56

SLP-2 overexpression could serve as a prognostic factor in node positive and HER2 negative breast cancer.

Cao W, Zhang B, Li J, Liu Y, Liu Z, Sun B
Pathology 2011 Dec;43(7):713-8

An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer.

Han CL, Chen JS, Chan EC, Wu CP, Yu KH, Chen KT, Tsou CC, Tsai CF, Chien CW, Kuo YB, Lin PY, Yu JS, Hsueh C, Chen MC, Chan CC, Chang YS, Chen YJ
Molecular & cellular proteomics : MCP 2011 Apr;10(4):M110.003087

[Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion].

Cao WF, Zhang LY, Zhang B, Wang YQ, Liu ZH, Sun BC
Zhonghua zhong liu za zhi [Chinese journal of oncology] 2010 Nov;32(11):830-3

SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma.

Chang D, Ma K, Gong M, Cui Y, Liu ZH, Zhou XG, Zhou CN, Wang TY
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010 Mar;15(2):104-10

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation.

McCray BA, Skordalakes E, Taylor JP
Human molecular genetics 2010 Mar 15;19(6):1033-47

Profiling protein markers associated with lymph node metastasis in prostate cancer by DIGE-based proteomics analysis.

Pang J, Liu WP, Liu XP, Li LY, Fang YQ, Sun QP, Liu SJ, Li MT, Su ZL, Gao X
Journal of proteome research 2010 Jan;9(1):216-26

Downregulation of a mitochondria associated protein SLP-2 inhibits tumor cell motility, proliferation and enhances cell sensitivity to chemotherapeutic reagents.

Wang Y, Cao W, Yu Z, Liu Z
Cancer biology & therapy 2009 Sep;8(17):1651-8

Modulation of T cell activation by stomatin-like protein 2.

Kirchhof MG, Chau LA, Lemke CD, Vardhana S, Darlington PJ, Márquez ME, Taylor R, Rizkalla K, Blanca I, Dustin ML, Madrenas J
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):1927-36

Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma.

Zhang L, Ding F, Cao W, Liu Z, Liu W, Yu Z, Wu Y, Li W, Li Y, Liu Z
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Mar 1;12(5):1639-46

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: C6 cells were subjected to SDS PAGE followed by western blot with 10348-1-AP( STOML2 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using STOML2 antibody 10348-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-STOML2 (IP:10348-1-AP, 3ug; Detection:10348-1-AP 1:1000) with mouse brain tissue lysate 1000ug.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human endometrial cancer using 10348-1-AP(STOML2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human endometrial cancer using 10348-1-AP(STOML2 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue