Antibody data

Product number
Ab088680 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant AMPK gamma 1 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human AMPK gamma 1 Antibody, Recombinant, could be used for WB, IF, ICC and so on.Application:WB: 1/500-1/1000ICC/IF: 1/50-1/200Protein Function:AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-19
Vial size
100_l,10_l,1ml,50_l
Concentration
0,5 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
PRKAG1 protein structure - Ab088680 shown in red.