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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations [0]
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- Product number
- HPA035977 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA035977, RRID:AB_10670673
- Product name
- Anti-KMT2D
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human KMT2D, Gene description: lysine (K)-specific methyltransferase 2D, Alternative Gene Names: ALR, CAGL114, MLL2, MLL4, TNRC21, Validated applications: IHC, Uniprot ID: O14686, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Deficiency of TET2-mediated KMT2D self-transcription confers a targetable vulnerability in hepatocellular carcinoma
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells
Forkhead box protein D2 suppresses colorectal cancer by reprogramming enhancer interactions.
Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer
Genomic Analyses of Metaplastic or Sarcomatoid Carcinomas From Different Organs Revealed Frequent Mutations in KMT2D
MLL4 mediates differentiation and tumor suppression through ferroptosis
Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth
The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression.
Low MLL2 Protein Expression Is Associated With Fibrosis in Early Stage Gastric Cancer.
PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
Jin Y, Rao K, Zheng J, Zhang X, Luo Y, He J, Brenner D
PNAS Nexus 2024;3(11)
PNAS Nexus 2024;3(11)
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells
Vlasevska S, Garcia-Ibanez L, Duval R, Holmes A, Jahan R, Cai B, Kim A, Mo T, Basso K, Soni R, Bhagat G, Dalla-Favera R, Pasqualucci L
Proceedings of the National Academy of Sciences 2023;120(11)
Proceedings of the National Academy of Sciences 2023;120(11)
Forkhead box protein D2 suppresses colorectal cancer by reprogramming enhancer interactions.
Kim HM, Kang B, Park S, Park H, Kim CJ, Lee H, Yoo M, Kweon MN, Im SH, Kim TI, Roh TY
Nucleic acids research 2023 Jul 7;51(12):6143-6155
Nucleic acids research 2023 Jul 7;51(12):6143-6155
Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer
Zhai Q, Luo M, Zhang Y, Zhang W, Wu C, Lv S, Wei Q
Translational Cancer Research 2022;11(8):2607-2621
Translational Cancer Research 2022;11(8):2607-2621
Genomic Analyses of Metaplastic or Sarcomatoid Carcinomas From Different Organs Revealed Frequent Mutations in KMT2D
Zheng B, Song Z, Chen Y, Yan W
Frontiers in Molecular Biosciences 2021;8
Frontiers in Molecular Biosciences 2021;8
MLL4 mediates differentiation and tumor suppression through ferroptosis
Egolf S, Zou J, Anderson A, Simpson C, Aubert Y, Prouty S, Ge K, Seykora J, Capell B
Science Advances 2021;7(50)
Science Advances 2021;7(50)
Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth
Castro‐Piedras I, Sharma M, Brelsfoard J, Vartak D, Martinez E, Rivera C, Molehin D, Bright R, Fokar M, Guindon J, Pruitt K
EMBO reports 2021;22(6)
EMBO reports 2021;22(6)
The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression.
Li W, Wu L, Jia H, Lin Z, Zhong R, Li Y, Jiang C, Liu S, Zhou X, Zhang E
Cellular & molecular biology letters 2021 Nov 10;26(1):45
Cellular & molecular biology letters 2021 Nov 10;26(1):45
Low MLL2 Protein Expression Is Associated With Fibrosis in Early Stage Gastric Cancer.
Numakura S, Uozaki H
In vivo (Athens, Greece) 2021 Jan-Feb;35(1):603-609
In vivo (Athens, Greece) 2021 Jan-Feb;35(1):603-609
PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
Toska E, Castel P, Chhangawala S, Arruabarrena-Aristorena A, Chan C, Hristidis V, Cocco E, Sallaku M, Xu G, Park J, Minuesa G, Shifman S, Socci N, Koche R, Leslie C, Scaltriti M, Baselga J
Cell Reports 2019;27(1):294-306.e5
Cell Reports 2019;27(1):294-306.e5
KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
Hillman R, Celestino J, Terranova C, Beird H, Gumbs C, Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu K, Gershenson D, Rai K, Broaddus R, Futreal P
Nature Communications 2018;9(1)
Nature Communications 2018;9(1)
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
Lin-Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson C, Sen P, Saffie R, Busino L, Garcia B, Berger S, Capell B
Genes & Development 2018;32(2):181-193
Genes & Development 2018;32(2):181-193
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
Zhang J, Dominguez-Sola D, Hussein S, Lee J, Holmes A, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L
Nature Medicine 2015;21(10):1190-1198
Nature Medicine 2015;21(10):1190-1198
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
Dubuc A, Remke M, Korshunov A, Northcott P, Zhan S, Mendez-Lago M, Kool M, Jones D, Unterberger A, Morrissy A, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, Witt H, Hielscher T, Hawkins C, Vibhakar R, Croul S, Rutka J, Weiss W, Jones S, Eberhart C, Marra M, Pfister S, Taylor M
Acta Neuropathologica 2012;125(3):373-384
Acta Neuropathologica 2012;125(3):373-384
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