25712-1-AP

antibody from Proteintech Group

Targeting: VIRMA DKFZP434I116, fSAP121, KIAA1429

Provider product page for 25712-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [42]
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Validations
Western blot [1]

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Product number: 25712-1-AP - Provider product page
Provider: Proteintech Group
Product name: VIRMA/KIAA1429 antibody
Antibody type: Polyclonal
Description: KD/KO validated VIRMA/KIAA1429 antibody (Cat. #25712-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

VIRMA protein structure - 25712-1-AP shown in red.

Submitted references Elevated m(6)A RNA modifications associate with immune dysregulation and cancer in people with HIV-1.

Mishra T, Tripathi S, Stapleton JT, Wu L
BMC cancer 2026 Mar 21;26(1)

DUX4-induced HSATII RNA accumulation drives protein aggregation, impacting RNA processing pathways.

Arends T, Bennett SR, Tapscott SJ
The Journal of cell biology 2026 Feb 2;225(2)

The bladder cancer m(6)A landscape is defined by global methylation dilution and focal 3'-UTR hypermethylation.

Koch J, Xu J, Bormann F, Coutinho Carneiro V, Neuberger M, Nitschke K, Nientiedt M, Erben P, Michel MS, Rodriguez-Paredes M, Lyko F
EMBO reports 2026 Apr;27(8):2118-2143

KIAA1429 promotes clear cell renal cell carcinoma progression by regulating MYC mRNA stability.

Zhu X, Shen C, Zhang Y, Chen X, Zhang W, Zheng B, Chen Z
iScience 2026 Apr 17;29(4):115198

RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.

Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141

IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3.

Shen X, Shu W, Zhang J, Zhou T, Dong K, Zhang J, Yao Y, Li H, Cheng S, Zhang T, Chen G, Yu S, Zhang Q, Wang H, Liu Y
Cellular signalling 2025 Oct;134:111906

KIAA1429-mediated M(6)A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis.

Liu J, Fu Q, Li M, Chen J, Xu M, Zhai X, Li S, Li L, Wu X, Xu W, Wang K, Si H
Cellular & molecular biology letters 2025 Oct 27;30(1):123

Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.

Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Kanthasamy AG
Cell reports 2025 May 27;44(5):115618

VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.

Wu M, Wu X, Sun H, Wang W, Zhang L, Liu X, Zhang Y, Zhang X, Liu J, Shen B, Zhou T
Science advances 2025 Jun 27;11(26):eadq9643

IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.

Luo X, Wei Q, Xie L, Chen N, Gu B, Xu J, Jiang X, Zuo X, Zhao H, Liu X, Yang Y, Liu T, Zhu Y, Yi P, Xu J
Clinical and translational medicine 2025 Jul;15(7):e70388

Phosphorylation of KIAA1429 promotes oxaliplatin resistance through activating the FZD7-Wnt signaling in BRAF(V600E)-mutated colorectal cancer.

Wan T, He M, Liu Z, Zhou Y, Zhou Y, Xiao W, Xie H, Luo S, Zheng H, Kang L, Shi Y, Huang L
Journal of experimental & clinical cancer research : CR 2025 Jul 3;44(1):187

Total m6A RNA levels and VIRMA expression as potential diagnostic and prognostic markers in oral squamous cell carcinoma.

Shima K, Shimojukkoku Y, Oku Y, Higashimoto K, Tsuchiyama T, Kajiya Y, Kurihara-Shimomura M, Sasahira T
Diagnostic pathology 2025 Jul 3;20(1):81

De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.

Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826

DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways.

Arends T, Bennett SR, Tapscott SJ
bioRxiv : the preprint server for biology 2025 Jan 22;

Armadillo domain of ARID1A directly interacts with DNA-PKcs to couple chromatin remodeling with nonhomologous end joining (NHEJ) pathway.

Kanno SI, Kobayashi T, Watanabe R, Kurimasa A, Tanaka K, Yasui A, Ui A
Nucleic acids research 2025 Feb 27;53(5)

KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8(+) T cells in colorectal cancer.

Du Y, Liu Y, Wang M, Wang Y, Lin M
Scientific reports 2025 Dec 4;15(1):43619

Acetylated KIAA1429 by TIP60 facilitates metastasis and immune evasion of hepatocellular carcinoma via N6-methyladenosine-KDM5B-mediated regulation of FoxO1.

Quan H, Zhou H, Chen F, Chen J, He Y, Xiao H, Liu J, Shi L, Xie W, Chen P, Luo J
Cell death discovery 2025 Apr 29;11(1):210

H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3.

Hou X, Yang Y, Wang C, Huang Z, Zhang M, Yang J, Li N, Yang H, Yang L, Wu K
Journal of cellular physiology 2024 Sep;239(9):e31402

Inhibition of KIAA1429/HK1 axis enhances the sensitivity of liver cancer cells to sorafenib by regulating the Warburg effect.

Liu D, Shan M, Zeng R, He M, Dai X, Lu L, Yang M, He H, Zhang Y, Xiang L, Chen A, Sun L, He F, Lian J
Biochemical pharmacology 2024 Sep;227:116419

VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.

Zhu C, Cheng Y, Yu Y, Zhang Y, Ren G
Biomolecules & biomedicine 2024 Sep 6;24(5):1244-1257

Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.

George JW, Cancino RA, Griffin Miller JL, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
Endocrinology 2024 Jul 1;165(8)

BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.

Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811

High expression of RBM15 is associated with better prognosis in esophageal squamous cell carcinoma.

Liu Y, Pu Y, Kuang X, Jiang Y, Liu J, Dai N, Li M, Li K, Xu M
Journal of gastrointestinal oncology 2024 Dec 31;15(6):2400-2412

Comprehensive analysis of a novel RNA modifications-related model in the prognostic characterization, immune landscape and drug therapy of bladder cancer.

Zhang Z, Chen P, Yun J
Frontiers in genetics 2023;14:1156095

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71

CRISPR-Cas9 knockout screening identifies KIAA1429 as an essential gene in Ewing sarcoma.

Tan K, Lu W, Chen F, Shi H, Ma Y, Chen Z, Wu W, Lv Z, Mo J
Journal of experimental & clinical cancer research : CR 2023 Sep 28;42(1):250

The predictive significance of a 5-m6A RNA methylation regulator signature in colorectal cancer.

Zhang D, Wu G, Yang L, Wu Q, Yuan L
Heliyon 2023 Oct;9(10):e20172

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822

ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Chen W, Wang H, Mi S, Shao L, Xu Z, Xue M
Molecular oncology 2023 Feb;17(2):344-364

EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.

Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7

Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.

George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;

A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.

Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7

KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway.

Chen X, Lu T, Cai Y, Han Y, Ding M, Chu Y, Zhou X, Wang X
Cellular & molecular biology letters 2023 Apr 19;28(1):32

Effect of the m6ARNA gene on the prognosis of thyroid cancer, immune infiltration, and promising immunotherapy.

Xia M, Wang S, Ye Y, Tu Y, Huang T, Gao L
Frontiers in immunology 2022;13:995645

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.

Li Z, Zheng C, Huang L, Yin X, Wang Z, Liu C, Li B
Annals of translational medicine 2022 Dec;10(24):1347

Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.

Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)

m(6)A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer.

Zhang C, Ou S, Zhou Y, Liu P, Zhang P, Li Z, Xu R, Li Y
Frontiers in oncology 2021;11:696371

WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m(6)A modification of ATF4 mRNA.

Wang J, Zhang J, Ma Y, Zeng Y, Lu C, Yang F, Jiang N, Zhang X, Wang Y, Xu Y, Hou H, Jiang S, Zhuang S
Aging 2021 Mar 26;13(8):11135-11149

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

The m(6)A-methylase complex recruits TREX and regulates mRNA export.

Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I, Wilson SA
Scientific reports 2018 Sep 14;8(1):13827

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: SKOV-3 cells were subjected to SDS PAGE followed by western blot with 25712-1-AP( KIAA1429 Antibody) at dilution of 1:600
Other comments: WB
Appendix: 25712-1-AP.pdf

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