BS8474

antibody from Bioworld Technology, Inc
Targeting: EEF2K CaMKIII, eEF-2K
Provider product page for BS8474
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8474 - Provider product page
Provider
Bioworld Technology, Inc
Product name
eEF2K polyclonal antibody
Antibody type
Polyclonal
Antigen
Elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; EEF2K
Description
eEF2K is 105 kDa protein that is detected in skeletal muscle extracts and is phosphorylated rapidly by SAPK4, but poorly by p38, p38ÎÛ, JNK or ERK 2. SAPK4 phosphorylates eEF2K at Ser 359 and Ser 396 in vitro, causing its inactivation. The phosphorylation of eEF2K at Ser 359 is also induced by insulin-like growth factor-1. Ser 359 is in close proximity to Ser 366 and the Ser 366 residue also becomes phosphorylated in response to growth factors. eEF2K is phosphorylated by p70 S6 kinase at Ser 366 and this results in the inactivation of eEF2K, especially at low (micromolar) calcium concentrations.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
EEF2K protein structure - BS8474 shown in red.