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- Antibody Data
- Antigen structure
- References [40]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11051-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11051-1-AP, RRID:AB_593422
- Product name
- GSNOR,ADH5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GSNOR,ADH5 antibody (Cat. #11051-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease.
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells.
Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model.
S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia.
Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis.
A postpartum enriched environment rescues impaired cognition and oxidative markers in aged mice with gestational inflammation.
S-nitrosoglutathione reductase (GSNOR) deficiency accelerates cardiomyocyte differentiation of induced pluripotent stem cells.
S-nitrosoglutathione reductase maintains mitochondrial homeostasis by promoting clearance of damaged mitochondria in porcine preimplantation embryos.
Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5.
Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
AKR1A1 is a novel mammalian S-nitroso-glutathione reductase.
Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity.
S-nitrosylation of endothelial nitric oxide synthase impacts erectile function.
Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium.
GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.
Balance between S-nitrosylation and denitrosylation modulates myoblast proliferation independently of soluble guanylyl cyclase activation.
GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.
Copper disrupts S-nitrosothiol signaling in activated BV2 microglia.
S-Nitrosoglutathione Attenuates Airway Hyperresponsiveness in Murine Bronchopulmonary Dysplasia.
De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility.
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Augmentation of CFTR maturation by S-nitrosoglutathione reductase.
Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis.
Hypoxia-induced changes in protein s-nitrosylation in female mouse brainstem.
Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.
S-nitrosoglutathione inhibits inducible nitric oxide synthase upregulation by redox posttranslational modification in experimental diabetic retinopathy.
A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
The role of regulatory proteins and S-nitrosylation of endothelial nitric oxide synthase in the human clitoris: implications for female sexual function.
An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells.
Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats.
Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo.
Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.
ADH IB expression, but not ADH III, is decreased in human lung cancer.
Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.
S-nitrosoglutathione reductase in human lung cancer.
Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.
Increased nitrosoglutathione reductase activity in hypoxic pulmonary hypertension in mice.
Rarick KR, Li K, Teng RJ, Jing X, Martin DP, Xu H, Jones DW, Hogg N, Hillery CA, Garcia G, Day BW, Naylor S, Pritchard KA Jr
Free radical biology & medicine 2024 Mar;215:112-126
Free radical biology & medicine 2024 Mar;215:112-126
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553
European journal of pharmacology 2024 Jun 5;972:176553
Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells.
Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, Ogi T, Nakada S
Nature communications 2023 Sep 15;14(1):5607
Nature communications 2023 Sep 15;14(1):5607
Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model.
Mu A, Cao Z, Huang D, Hosokawa H, Maegawa S, Takata M
Molecular biology reports 2023 Oct;50(10):8385-8395
Molecular biology reports 2023 Oct;50(10):8385-8395
S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia.
Kulandavelu S, Dulce RA, Murray CI, Bellio MA, Fritsch J, Kanashiro-Takeuchi R, Arora H, Paulino E, Soetkamp D, Balkan W, Van Eyk JE, Hare JM
Journal of the American Heart Association 2022 Mar;11(5):e024008
Journal of the American Heart Association 2022 Mar;11(5):e024008
Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis.
Ding Q, Cao F, Lai S, Zhuge H, Chang K, Valencak TG, Liu J, Li S, Ren D
Food research international (Ottawa, Ont.) 2022 Jul;157:111259
Food research international (Ottawa, Ont.) 2022 Jul;157:111259
A postpartum enriched environment rescues impaired cognition and oxidative markers in aged mice with gestational inflammation.
Zhang YX, Wei QY, Wang YT, Zeng LP, Sun SY, Wu YF, Ren CY, Wang F, Chen GH, Cao L
Brain and behavior 2022 Dec;12(12):e2817
Brain and behavior 2022 Dec;12(12):e2817
S-nitrosoglutathione reductase (GSNOR) deficiency accelerates cardiomyocyte differentiation of induced pluripotent stem cells.
Salerno AG, Wanschel ACBA, Dulce RA, Hatzistergos KE, Balkan W, Hare JM
The journal of cardiovascular aging 2021;1
The journal of cardiovascular aging 2021;1
S-nitrosoglutathione reductase maintains mitochondrial homeostasis by promoting clearance of damaged mitochondria in porcine preimplantation embryos.
Niu YJ, Zhou D, Cui XS
Cell proliferation 2021 Mar;54(3):e12990
Cell proliferation 2021 Mar;54(3):e12990
Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5.
Raffay TM, Bonilla-Fernandez K, Jafri A, Sopi RB, Smith LA, Cui F, O'Reilly M, Zhang R, Hodges CA, MacFarlane PM, Deutsch G, Martin RJ, Gaston B
American journal of respiratory cell and molecular biology 2021 Jul;65(1):70-80
American journal of respiratory cell and molecular biology 2021 Jul;65(1):70-80
Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.
Mu A, Hira A, Niwa A, Osawa M, Yoshida K, Mori M, Okamoto Y, Inoue K, Kondo K, Kanemaki MT, Matsuda T, Ito E, Kojima S, Nakahata T, Ogawa S, Tanaka K, Matsuo K, Saito MK, Takata M
Blood 2021 Apr 15;137(15):2021-2032
Blood 2021 Apr 15;137(15):2021-2032
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA, Wang M, Mu A, Millington CL, Oberbeck N, Watcham S, Pontel LB, Kamimae-Lanning AN, Langevin F, Nadler C, Cordell RL, Monks PS, Yu R, Wilson NK, Hira A, Yoshida K, Mori M, Okamoto Y, Okuno Y, Muramatsu H, Shiraishi Y, Kobayashi M, Moriguchi T, Osumi T, Kato M, Miyano S, Ito E, Kojima S, Yabe H, Yabe M, Matsuo K, Ogawa S, Göttgens B, Hodskinson MRG, Takata M, Patel KJ
Molecular cell 2020 Dec 17;80(6):996-1012.e9
Molecular cell 2020 Dec 17;80(6):996-1012.e9
AKR1A1 is a novel mammalian S-nitroso-glutathione reductase.
Stomberski CT, Anand P, Venetos NM, Hausladen A, Zhou HL, Premont RT, Stamler JS
The Journal of biological chemistry 2019 Nov 29;294(48):18285-18293
The Journal of biological chemistry 2019 Nov 29;294(48):18285-18293
Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity.
Brandhorst TT, Kean IRL, Lawry SM, Wiesner DL, Klein BS
Scientific reports 2019 Mar 25;9(1):5047
Scientific reports 2019 Mar 25;9(1):5047
S-nitrosylation of endothelial nitric oxide synthase impacts erectile function.
Kavoussi PK, Smith RP, Oliver JL, Costabile RA, Steers WD, Brown-Steinke K, de Ronde K, Lysiak JJ, Palmer LA
International journal of impotence research 2019 Jan;31(1):31-38
International journal of impotence research 2019 Jan;31(1):31-38
Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium.
Marozkina N, Bosch J, Cotton C, Smith L, Seckler J, Zaman K, Rehman S, Periasamy A, Gaston H, Altawallbeh G, Davis M, Jones DR, Schilz R, Randell SH, Gaston B
American journal of physiology. Lung cellular and molecular physiology 2019 Aug 1;317(2):L247-L258
American journal of physiology. Lung cellular and molecular physiology 2019 Aug 1;317(2):L247-L258
GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.
Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X, Han L, Deng J, Fan F, Liu B, Huo Y, Xu Q, Chen C, Wang X, Feng J
Redox biology 2018 Jul;17:386-399
Redox biology 2018 Jul;17:386-399
Balance between S-nitrosylation and denitrosylation modulates myoblast proliferation independently of soluble guanylyl cyclase activation.
Yamashita AMS, Ancillotti MTC, Rangel LP, Fontenele M, Figueiredo-Freitas C, Possidonio AC, Soares CP, Sorenson MM, Mermelstein C, Nogueira L
American journal of physiology. Cell physiology 2017 Jul 1;313(1):C11-C26
American journal of physiology. Cell physiology 2017 Jul 1;313(1):C11-C26
GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.
Moon Y, Cao Y, Zhu J, Xu Y, Balkan W, Buys ES, Diaz F, Kerrick WG, Hare JM, Percival JM
Antioxidants & redox signaling 2017 Feb 1;26(4):165-181
Antioxidants & redox signaling 2017 Feb 1;26(4):165-181
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.
Bae S, Chon J, Field MS, Stover PJ
The Journal of nutrition 2017 Apr;147(4):499-505
The Journal of nutrition 2017 Apr;147(4):499-505
Copper disrupts S-nitrosothiol signaling in activated BV2 microglia.
Rossi-George A, Guo CJ
Neurochemistry international 2016 Oct;99:1-8
Neurochemistry international 2016 Oct;99:1-8
S-Nitrosoglutathione Attenuates Airway Hyperresponsiveness in Murine Bronchopulmonary Dysplasia.
Raffay TM, Dylag AM, Di Fiore JM, Smith LA, Einisman HJ, Li Y, Lakner MM, Khalil AM, MacFarlane PM, Martin RJ, Gaston B
Molecular pharmacology 2016 Oct;90(4):418-26
Molecular pharmacology 2016 Oct;90(4):418-26
De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility.
Kawai T, Yanaka N, Richards JS, Shimada M
Endocrinology 2016 May;157(5):2160-72
Endocrinology 2016 May;157(5):2160-72
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Rizza S, Montagna C, Cardaci S, Maiani E, Di Giacomo G, Sanchez-Quiles V, Blagoev B, Rasola A, De Zio D, Stamler JS, Cecconi F, Filomeni G
Cancer research 2016 Jul 15;76(14):4170-82
Cancer research 2016 Jul 15;76(14):4170-82
Augmentation of CFTR maturation by S-nitrosoglutathione reductase.
Zaman K, Sawczak V, Zaidi A, Butler M, Bennett D, Getsy P, Zeinomar M, Greenberg Z, Forbes M, Rehman S, Jyothikumar V, DeRonde K, Sattar A, Smith L, Corey D, Straub A, Sun F, Palmer L, Periasamy A, Randell S, Kelley TJ, Lewis SJ, Gaston B
American journal of physiology. Lung cellular and molecular physiology 2016 Feb 1;310(3):L263-70
American journal of physiology. Lung cellular and molecular physiology 2016 Feb 1;310(3):L263-70
Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis.
Luzina IG, Lockatell V, Todd NW, Kopach P, Pentikis HS, Atamas SP
The Journal of pharmacology and experimental therapeutics 2015 Oct;355(1):13-22
The Journal of pharmacology and experimental therapeutics 2015 Oct;355(1):13-22
Hypoxia-induced changes in protein s-nitrosylation in female mouse brainstem.
Palmer LA, Kimberly deRonde, Brown-Steinke K, Gunter S, Jyothikumar V, Forbes MS, Lewis SJ
American journal of respiratory cell and molecular biology 2015 Jan;52(1):37-45
American journal of respiratory cell and molecular biology 2015 Jan;52(1):37-45
Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.
Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B
The European respiratory journal 2015 Jan;45(1):87-97
The European respiratory journal 2015 Jan;45(1):87-97
S-nitrosoglutathione inhibits inducible nitric oxide synthase upregulation by redox posttranslational modification in experimental diabetic retinopathy.
Rosales MA, Silva KC, Duarte DA, de Oliveira MG, de Souza GF, Catharino RR, Ferreira MS, Lopes de Faria JB, Lopes de Faria JM
Investigative ophthalmology & visual science 2014 May 2;55(5):2921-32
Investigative ophthalmology & visual science 2014 May 2;55(5):2921-32
A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
Wu K, Ren R, Su W, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte JC, Liu GH, Chen C
The Journal of biological chemistry 2014 Jul 18;289(29):20193-9
The Journal of biological chemistry 2014 Jul 18;289(29):20193-9
The role of regulatory proteins and S-nitrosylation of endothelial nitric oxide synthase in the human clitoris: implications for female sexual function.
Oliver JL, Kavoussi PK, Smith RP, Woodson RI, Corbett ST, Costabile RA, Palmer LA, Lysiak JJ
The journal of sexual medicine 2014 Aug;11(8):1927-35
The journal of sexual medicine 2014 Aug;11(8):1927-35
An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells.
Karim S, Liaskou E, Hadley S, Youster J, Faint J, Adams DH, Lalor PF
Toxicological sciences : an official journal of the Society of Toxicology 2013 Mar;132(1):131-41
Toxicological sciences : an official journal of the Society of Toxicology 2013 Mar;132(1):131-41
Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats.
Hu T, Beattie WS, Mazer CD, Leong-Poi H, Fujii H, Wilson DF, Tsui AK, Liu E, Muhammad M, Baker AJ, Hare GM
Anesthesia and analgesia 2013 Mar;116(3):649-62
Anesthesia and analgesia 2013 Mar;116(3):649-62
Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo.
Chen Q, Sievers RE, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML
Journal of applied physiology (Bethesda, Md. : 1985) 2013 Mar 15;114(6):752-60
Journal of applied physiology (Bethesda, Md. : 1985) 2013 Mar 15;114(6):752-60
Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.
Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F
American journal of physiology. Heart and circulatory physiology 2013 Apr 15;304(8):H1134-46
American journal of physiology. Heart and circulatory physiology 2013 Apr 15;304(8):H1134-46
ADH IB expression, but not ADH III, is decreased in human lung cancer.
Mutka SC, Green LH, Verderber EL, Richards JP, Looker DL, Chlipala EA, Rosenthal GJ
PloS one 2012;7(12):e52995
PloS one 2012;7(12):e52995
Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.
Chakravarti R, Stuehr DJ
The Journal of biological chemistry 2012 May 11;287(20):16179-86
The Journal of biological chemistry 2012 May 11;287(20):16179-86
S-nitrosoglutathione reductase in human lung cancer.
Marozkina NV, Wei C, Yemen S, Wallrabe H, Nagji AS, Liu L, Morozkina T, Jones DR, Gaston B
American journal of respiratory cell and molecular biology 2012 Jan;46(1):63-70
American journal of respiratory cell and molecular biology 2012 Jan;46(1):63-70
Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.
Straub AC, Billaud M, Johnstone SR, Best AK, Yemen S, Dwyer ST, Looft-Wilson R, Lysiak JJ, Gaston B, Palmer L, Isakson BE
Arteriosclerosis, thrombosis, and vascular biology 2011 Feb;31(2):399-407
Arteriosclerosis, thrombosis, and vascular biology 2011 Feb;31(2):399-407
Increased nitrosoglutathione reductase activity in hypoxic pulmonary hypertension in mice.
Wu X, Du L, Xu X, Tan L, Li R
Journal of pharmacological sciences 2010;113(1):32-40
Journal of pharmacological sciences 2010;113(1):32-40
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 11051-1-AP(GSNOR,ADH5 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GSNOR,ADH5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GSNOR,ADH5. This antibody recognizes human, mouse, rat antigen. The GSNOR,ADH5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
