abx016049

antibody from Abbexa

Targeting: PROZ PZ

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

abx016049

Provider

Abbexa

Product name

Vitamin K-Dependent Protein Z (PROZ) Antibody

Antibody type

Monoclonal

Description

PROZ protein Z, vitamin K-dependent plasma glycoprotein.It is 62 kDa large and 396 amino acids long.It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain.It lacks the serine residue that would make it catalytically active as a serine protease.It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots.It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.It is a glycoprotein.Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C.The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces.The main role of protein Z appears to be the degradation of factor Xa.This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z.Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z.In some studies, deficiency states have been associated with a propensity to thrombosis.Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.