15712-1-AP

antibody from Proteintech Group

Targeting: GSS

Provider product page for 15712-1-AP

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Antigen structure
References [33]
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Product number: 15712-1-AP - Provider product page
Provider: Proteintech Group
Product name: GSS antibody
Antibody type: Polyclonal
Description: GSS antibody (Cat. #15712-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig, hamster, canine and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat, Canine, Hamster, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GSS protein structure - 15712-1-AP shown in red.

Submitted references Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine-Glutathione Axis in Mice.

Kim MJ, Park YR, Jang G, Han YK, Ishii I, Jang SY, Park KM
Antioxidants & redox signaling 2026 Jan;44(1-3):11-23

Fuxin decoction regulates the Nrf2/SLC7A11/GPX4 pathway to ameliorate doxorubicin-induced ferroptosis in cardiomyocytes.

Han Q, Guo Y, Yu Y, Shi J, Yuan H, Yu H, Liu X, Xue Y, Li Y
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120037

Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.

Huang X, Zhang Y, Jiang Y, Li T, Yang S, Wang Y, Yu B, Zhou M, Zhang G, Zhao X, Sun J, Sun X
Neural regeneration research 2026 Jan 1;21(1):406-416

Rictor orchestrates β-catenin/FOXO balance by maintaining redox homeostasis during development of ovarian cancer.

Zhao X, Lai H, Li G, Qin Y, Chen R, Labrie M, Stommel JM, Mills GB, Ma D, Gao Q, Fang Y
Oncogene 2025 Jun;44(23):1820-1832

The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.

Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X
Cell death & disease 2025 Jul 26;16(1):564

Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.

Zhao B, Liu R, Guo S, Li S, Huang Z, Wang Y, Yu C, Hou Z, Zhang Y, Zhang Y, Liu X
Scientific reports 2025 Jul 22;15(1):26616

Exogenous H(2)S reduces oxidative stress induced by lipid mixture in HepG2 cells through USP22/SIRT1 axis.

Cui X, Li C, He S, Li Y
Scientific reports 2025 Jul 2;15(1):23129

Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.

Liu S, Wu J, Huang H, Hu B, Xie D, Cao F, Li J, Guo C, Peng W, Jin Y, Dai W
Chinese medicine 2025 Jul 11;20(1):110

Salvia miltiorrhiza extract ameliorated ovarian damage induced by cyclophosphamide in mice by multidimensional mechanisms.

Zhou L, Bai HL, Wang LJ, Xiao J, Liu Y, Ai JH, Li KZ, Ma D, Han Y
Journal of ovarian research 2025 Jul 11;18(1):149

The role of SLC7A11 in arsenite-induced oncogenic phenotypes of human bronchial epithelial cells: A metabolic perspective.

Fang X, Ruan Y, Yin X, Wang J, Chen C, Hu Y, Wang H, Pi J, Xu Y
Environmental pollution (Barking, Essex : 1987) 2025 Jul 1;376:126381

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer.

Xie J, Liu W, Deng X, Wang H, Ou X, An X, Situ MY, Yang A, Peng C, He R, Xie Y, Tang H, Chen Y, Liang JY, Shao R, Xiao W, Zheng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e00722

Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism.

Zhao Q, Zhang H, Wu HM, Yang QY, Zhao H, Kang L, Lv XY
World journal of gastroenterology 2025 Aug 28;31(32):108654

Calycosin alleviates ferroptosis and attenuates doxorubicin-induced myocardial injury via the Nrf2/SLC7A11/GPX4 signaling pathway.

Han Q, Shi J, Yu Y, Yuan H, Guo Y, Liu X, Xue Y, Li Y
Frontiers in pharmacology 2024;15:1497733

Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential.

Sun LJ, Qu HL, He XT, Tian BM, Wu RX, Yin Y, Zou JK, Sun HH, Li X, Chen FM
Cell proliferation 2024 Oct;57(10):e13663

HADH suppresses clear cell renal cell carcinoma progression through reduced NRF2-dependent glutathione synthesis.

Chu C, Liu S, He Z, Wu M, Xia J, Zeng H, Xie W, Cheng R, Zhao X, Li X
Translational oncology 2024 Nov;49:102112

Pathological and Biological Significance of the Specific Glycan, TRA-1-60, on Aggressive Gastric Adenocarcinoma.

Mitsui A, Iioka H, Ling Y, Okuda S, Kurose A, Schopperle M, Kondo T, Sakaguchi M, Saito K, Kondo E
Laboratory investigation; a journal of technical methods and pathology 2024 Jul;104(7):102073

Glutamate rescues heat stress-induced apoptosis of Sertoli cells by enhancing the activity of antioxidant enzymes and activating the Trx1-Akt pathway in vitro.

Cai XQ, Yang H, Liang BQ, Deng CC, Xue HY, Zhang JJ, Wang XZ
Theriogenology 2024 Jul 15;223:1-10

NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins.

Furuya-Ikude C, Kitta A, Tomonobu N, Kawasaki Y, Sakaguchi M, Kondo E
In vitro cellular & developmental biology. Animal 2024 Dec;60(10):1151-1159

Overexpression of glutathione synthetase gene improving redox homeostasis and chicken infectious bursal disease virus propagation in chicken embryo fibroblast DF-1.

Lin J, Min R, Yi X, Zhuang Y
Bioresources and bioprocessing 2023 Sep 9;10(1):60

Engineered Extracellular Vesicle-Delivered CRISPR/Cas9 for Radiotherapy Sensitization of Glioblastoma.

Liu X, Cao Z, Wang W, Zou C, Wang Y, Pan L, Jia B, Zhang K, Zhang W, Li W, Hao Q, Zhang Y, Zhang W, Xue X, Lin W, Li M, Gu J
ACS nano 2023 Sep 12;17(17):16432-16447

Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.

Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394

Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.

Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis.

Zhang P, Wang Y, Yang W, Yin Y, Li C, Ma X, Shi L, Li R, Tao K
International journal of biological sciences 2022;18(16):6189-6209

Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.

Chang MT, Tsai LC, Nakagawa-Goto K, Lee KH, Shyur LF
Pharmacological research 2022 Apr;178:106148

IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer.

Zhang L, Liu W, Liu F, Wang Q, Song M, Yu Q, Tang K, Teng T, Wu D, Wang X, Han W, Li Y
Oxidative medicine and cellular longevity 2020;2020:1675613

Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.

Squirewell EJ, Mareus R, Horne LP, Stacpoole PW, James MO
Drug metabolism and disposition: the biological fate of chemicals 2020 Nov;48(11):1224-1230

γ-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level.

Yang Y, Li L, Hang Q, Fang Y, Dong X, Cao P, Yin Z, Luo L
Redox biology 2019 Jan;20:157-166

Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.

Peng L, Zhao Y, Li Y, Zhou Y, Li L, Lei S, Yu S, Zhao Y
Journal of molecular medicine (Berlin, Germany) 2019 Feb;97(2):189-199

l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.

Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862

Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.

Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1265-1280

Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.

Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830

Effect of Type I Diabetes on the Proteome of Mouse Oocytes.

Jiang G, Zhang G, An T, He Z, Kang L, Yang X, Gu Y, Zhang D, Wang Y, Gao S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2320-2330

Potent effects of dioscin against obesity in mice.

Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973

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