11594-1-AP

antibody from Proteintech Group

Targeting: ACP5 HPAP, TRAP

Provider product page for 11594-1-AP

ELISA

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [38]
Comments [0]
Validations
Immunohistochemistry [2]

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Product number: 11594-1-AP - Provider product page
Provider: Proteintech Group
Product name: ACP5 antibody
Antibody type: Polyclonal
Description: ACP5 antibody (Cat. #11594-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACP5 protein structure - 11594-1-AP shown in red.

Submitted references TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation development in mice.

Khan S, Yan F, Li W, Guo J, Gu X, Tang Z, Bibi U, Dong X, Chen L, Yao Y, Xu J
Journal of translational medicine 2026 Mar 17;24(1)

Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice.

Wang N, Qian J, Wang M, Li L, Liao W, Chen R, Nie H, Ge R, Sun F, Yan F
International journal of oral science 2026 Jan 27;18(1):14

Bacteria-responsive DNAgel system for targeted delivery of photothermally enhanced MXene/MoS(2) in the treatment of pyogenic osteomyelitis.

Jiang Y, Siow L, Xing K, Lin M, Cao Z, Liu Y, Gong J, Zhou S, Gu T, Feng B, Lan R, Gao Y, Yang Y, Zhang C, Lin S, Zhu Z, Leong DT, Yu M
Bioactive materials 2026 Apr;58:123-138

Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.

Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086

Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling.

Ma Q, Lan Z, Yang Y, Sun R, Xue D, Lin X, Su Y, Ma L, Hu Z, Wu G, He X, Tian K, Jin Q
International immunopharmacology 2025 Oct 10;163:115277

Exercise increases bone mass by lactate/Gpr81 signaling pathway.

Guo Y, He L, Xue A, Sun Y, Liu R, Zhang M, Liu Y, Yu F, Guo P, Zhao Y, Tang L, Li X, Lu W, Li Y, Sun P
Communications biology 2025 Nov 10;8(1):1548

An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection.

Zheng Y, Wang S, Jin W, Li Z, Yang G, Li X, Li N, Wang Y, Sheng F, Song Z
Bioactive materials 2025 May;47:295-312

NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway.

Yang R, Yu W, Lin L, Cui Z, Tang J, Li G, Jin M, Gu Y, Lu E
Journal of advanced research 2025 Jun;72:303-317

METTL3 facilitates osteoblast differentiation and bone regeneration via m6A-dependent maturation of pri-miR-324-5p.

Xiao J, Xu Z, Deng Z, Xie J, Qiu Y
Cellular immunology 2025 Jul;413:104974

Human peripheral osteoclast-precursor-development patterns reveal the significance of RPS17-dependent ribosome synthesis to Ankylosing Spondylitis lesions.

Ke D, Dai H, Han J, Su Y, Zhu H, Zhang R, Gao T, Yang L, Yu Y, Bai X, Zhang C, Xu J
Bone research 2025 Dec 4;13(1):100

Ginsenoside Rb3 alleviates the formation of osteoclasts induced by periodontal ligament fibroblasts in the periodontitis microenvironment through the STAT3 pathway.

Zhang Y, Shi H
Cell biology international 2024 Sep;48(9):1343-1353

Metabolic Control During Macrophage Polarization by a Citrate-Functionalized Scaffold for Maintaining Bone Homeostasis.

Wu X, Xia Y, Dai H, Hong C, Zhao Y, Wei W, Zheng D
Advanced healthcare materials 2024 Sep;13(22):e2400770

StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway.

Zhou S, Li J, Ying T, Wang Y, Wang Q, Li X, Zhao F
iScience 2024 May 17;27(5):109682

Nel-like Molecule Type 1 Combined with Gold Nanoparticles Modulates Macrophage Polarization, Osteoclastogenesis, and Oral Microbiota in Periodontitis.

Liao W, Ni C, Ge R, Li Y, Jiang S, Yang W, Yan F
ACS applied materials & interfaces 2024 Feb 21;16(7):8442-8458

Toll-like receptor 4 deficiency affects the balance of osteoclastogenesis and osteoblastogenesis in periodontitis.

Pan L, She H, Hu Y, Liu L, Wang H, Zhu L
International immunopharmacology 2024 Aug 20;137:112500

Photocurable 3D-Printed PMBG/TCP Scaffold Coordinated with PTH (1-34) Bidirectionally Regulates Bone Homeostasis to Accelerate Bone Regeneration.

Ren Y, Kong W, Liu Y, Yang X, Xu X, Qiang L, Mi X, Zhang C, Niu H, Wang C, Wang J
Advanced healthcare materials 2023 Oct;12(25):e2300292

GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.

Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S
Redox biology 2023 May;61:102635

Improvement of Osteoporosis in Rats With Hind-Limb Unloading Treated With Pulsed Electromagnetic Field and Whole-Body Vibration.

Liu X, Gao X, Tong J, Yu L, Xu M, Zhang J
Physical therapy 2022 Oct 6;102(10)

Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.

Yu Y, Jiang L, Li J, Lei L, Li H
Journal of periodontology 2022 Jul;93(7):1036-1047

Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration.

Li Z, Wang H, Zhang K, Yang B, Xie X, Yang Z, Kong L, Shi P, Zhang Y, Ho YP, Zhang ZY, Li G, Bian L
Bioactive materials 2022 Jul;13:9-22

Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.

Saito T, Terajima M, Taga Y, Hayashi F, Oshima S, Kasamatsu A, Okubo Y, Ito C, Toshimori K, Sunohara M, Tanzawa H, Uzawa K, Yamauchi M
Bone 2022 Jan;154:116242

Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.

Hu Y, Wang Q, Yu J, Zhou Q, Deng Y, Liu J, Zhang L, Xu Y, Xiong W, Wang Y
Nature communications 2022 Jan 10;13(1):114

Deer Antler Reserve Mesenchyme Cell-Conditioned Medium Reduces the Destruction of Periodontitis in Mice.

Lin H, Chen Z, Guo Q, Zhang P, Tian Y, Chen H, Zhao H, Shen Y
Stem cells and development 2022 Dec;31(23-24):766-776

Prognostic Significance of ACP5 in Human Gastric Cancer.

An T, Liang Q, Hao T, Deng L, Lu X, Wang Y, Cheng L, Wu W, Zhang C
Digestive diseases (Basel, Switzerland) 2021;39(4):310-317

Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone.

Feng W, He M, Jiang X, Liu H, Xie T, Qin Z, Huang Q, Liao S, Lin C, He J, Xu J, Ma J, Liu Y, Wei Q
Frontiers in oncology 2021;11:715552

The function of the calcium channel Orai1 in osteoclast development.

Robinson LJ, Soboloff J, Tourkova IL, Larrouture QC, Witt MR, Gross S, Hooper R, Samakai E, Worley PF, Barnett JB, Blair HC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jun;35(6):e21653

4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.

Yi W, Liu T, Gao X, Xie Y, Liu M
Experimental and therapeutic medicine 2021 Apr;21(4):354

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.

Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110

Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.

Qian Z, Zhong Z, Ni S, Li D, Zhang F, Zhou Y, Kang Z, Qian J, Yu B
Journal of cellular and molecular medicine 2020 Sep;24(17):10112-10127

Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.

Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769

Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.

Hu Y, Yu J, Wang Q, Zhang L, Chen X, Cao Y, Zhao J, Xu Y, Jiang D, Wang Y, Xiong W
Molecular therapy oncolytics 2020 Mar 27;16:272-288

Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.

Ma C, Geng B, Zhang X, Li R, Yang X, Xia Y
Medical science monitor : international medical journal of experimental and clinical research 2020 Jan 8;26:e918370

Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.

Zhong Z, Qian Z, Zhang X, Chen F, Ni S, Kang Z, Zhang F, Li D, Yu B
Frontiers in pharmacology 2019;10:1530

miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.

Lou Z, Peng Z, Wang B, Li X, Li X, Zhang X
Journal of bone and mineral metabolism 2019 Sep;37(5):815-824

Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.

Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022

Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.

Cai C, Liu C, Zhao L, Liu H, Li W, Guan H, Zhao L, Xiao J
Frontiers in pharmacology 2018;9:1286

(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.

Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1.

Chen J, Fan J, Wang S, Sun Z
Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):877-885

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11594-1-AP(ACP5 antibody) at dilution of 1:25 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ACP5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACP5. This antibody recognizes human,mouse,rat antigen. The ACP5 antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 11594-1-AP.pdf

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