11038-1-AP

antibody from Proteintech Group

Targeting: TPM2 AMCD1, DA1, NEM4

Provider product page for 11038-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [13]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 11038-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11038-1-AP, RRID:AB_2205660
Product name: TPM2 antibody
Antibody type: Polyclonal
Description: TPM2 antibody (Cat. #11038-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TPM2 protein structure - 11038-1-AP shown in red.

Submitted references Integrated transcriptomics and proteomics analysis reveal potential target in pediatric primary restrictive cardiomyopathy.

Fu X, Liu J, Guo Q, Wang L, Wu J, Wu Z, Xing Y, Zhu P, Dong N, Shi J, Peng H
Pediatric research 2026 Mar 24;

USP13 ameliorates myocardial infarction injury by inhibiting ferroptosis via stabilizing ALDOA.

Li P, Chen D, Zhang C, Gong Q, Yidilisi A, Fang J, Zhang Y, Jin J, Huang J, Jiang J
Redox biology 2026 Feb;89:103995

Vascular smooth muscle RbFox2 regulates the cytoskeleton and arterial stiffness by a RhoBTB1-Cullin-3 mechanism.

Kumar G, Chaihongsa N, Brozoski DT, Golosova D, Vazirabad I, Lu KT, Wackman KK, Singh RK, Sigmund CD
JCI insight 2026 Apr 2;

Myopathy-linked mutations in TPM2 and their impact on troponin-mediated regulation of actomyosin contractility.

Küçükdogru R, Robaszkiewicz K, Siatkowska M, Franz P, Tsiavaliaris G, Moraczewska J
The FEBS journal 2025 Nov;292(21):5789-5801

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction-Regulating Proteins in a Rat Model of HFpEF.

Vahle B, Schauer A, Augstein A, Jarabo MP, Friedrich J, Barthel P, Männel A, Mangner N, Labeit S, Bowen TS, Linke A, Adams V
Journal of cachexia, sarcopenia and muscle 2025 Jun;16(3):e13843

Skeletal Muscle Alterations in Different Phenotypes of Heart Failure with Preserved Ejection Fraction.

Vahle B, Klädtke R, Schauer A, Bowen TS, Wisløff U, Linke A, Adams V
International journal of molecular sciences 2025 Jun 27;26(13)

Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance.

Corinaldesi C, Holmes AB, Martire G, Tosato A, Rizzato D, Lovisa F, Gallingani I, Shen Q, Ferrone L, Harris M, Davies K, Molinaro L, Mortara U, Dei Tos AP, Ofori K, D'Amore ESG, Chiarle R, Ngan B, Carraro E, Pillon M, Hussein S, Bhagat G, Pizzi M, Mussolin L, Basso K
Leukemia 2025 Jan;39(1):189-198

Tropomyosin isoforms encoded by TPM2 control the actin-bundling activity of fascin-1.

Siatkowska M, Robaszkiewicz K, Rousová A, Navrátil J, Knopfová L, Talián G, Beneš P, Moraczewska J
Biological research 2025 Aug 31;58(1):60

Proteomic changes in the hippocampus of large mammals after total-body low dose radiation.

Iacono D, Hatch K, Murphy EK, Post J, Cole RN, Perl DP, Day RM
PloS one 2024;19(3):e0296903

Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle.

Vahle B, Heilmann L, Schauer A, Augstein A, Jarabo MP, Barthel P, Mangner N, Labeit S, Bowen TS, Linke A, Adams V
International journal of molecular sciences 2024 Jun 16;25(12)

Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer.

Ho CC, Gilbert MB, Urtecho G, Lee H, Drew DA, Klempner SJ, Cho JS, Ryan TJ, Rustgi N, Lee H, Lee J, Caraballo A, Magicheva-Gupta MV, Rios C, Shin AE, Tseng YY, Davis JL, Chung DC, Chan AT, Wang HH, Ryeom S
Cancer prevention research (Philadelphia, Pa.) 2024 Aug 1;17(8):361-376

Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma.

Luo M, Huang M, Yang N, Zhu Y, Huang P, Xu Z, Wang W, Cai L
Bone research 2023 May 29;11(1):28

TPM2 attenuates progression of prostate cancer by blocking PDLIM7-mediated nuclear translocation of YAP1.

Wu Z, Ge L, Ma L, Lu M, Song Y, Deng S, Duan P, Du T, Wu Y, Zhang Z, Zhang S
Cell & bioscience 2023 Feb 23;13(1):39

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11038-1-AP(TPM2 antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using TPM2 antibody 11038-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11038-1-AP(TPM2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11038-1-AP(TPM2 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue