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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
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- Product number
- HPA011101 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA011101, RRID:AB_1079039
- Product name
- Anti-SPINT2
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human SPINT2, Gene description: serine peptidase inhibitor, Kunitz type, 2, Alternative Gene Names: HAI-2, Kop, Validated applications: IHC, Uniprot ID: O43291, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.3 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Posttranslational modifications induce autoantibodies with risk prediction capability in patients with small cell lung cancer
The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity
Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins
STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
SPINT2 Deregulation in Prostate Carcinoma
The Protease Inhibitor HAI-2, but Not HAI-1, Regulates Matriptase Activation and Shedding through Prostasin
Lastwika K, Kunihiro A, Solan J, Zhang Y, Taverne L, Shelley D, Rho J, Randolph T, Li C, Grogan E, Massion P, Fitzpatrick A, MacPherson D, Houghton A, Lampe P
Science Translational Medicine 2023;15(678)
Science Translational Medicine 2023;15(678)
The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity
Lee B, Ramirez Alvarez C, Kee C, Sharma A, Thomas L, Schmidt F, Stanifer M, Boulant S, Herrmann C
PLOS Pathogens 2021;17(6):e1009687
PLOS Pathogens 2021;17(6):e1009687
Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins
Wu C, Lu M, Feng X, Nakato G, Udey M
Cells 2020;9(4):1027
Cells 2020;9(4):1027
STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer
Ma Z, Liu D, Li W, Di S, Zhang Z, Zhang J, Xu L, Guo K, Zhu Y, Han J, Li X, Yan X
Cell Death & Disease 2019;10(6)
Cell Death & Disease 2019;10(6)
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
Wu C, Feng X, Lu M, Morimura S, Udey M
Journal of Clinical Investigation 2017;127(2):623-634
Journal of Clinical Investigation 2017;127(2):623-634
SPINT2 Deregulation in Prostate Carcinoma
Pereira M, de Almeida G, Pinto F, Viana-Pereira M, Reis R
Journal of Histochemistry & Cytochemistry 2015;64(1):32-41
Journal of Histochemistry & Cytochemistry 2015;64(1):32-41
The Protease Inhibitor HAI-2, but Not HAI-1, Regulates Matriptase Activation and Shedding through Prostasin
Friis S, Sales K, Schafer J, Vogel L, Kataoka H, Bugge T
Journal of Biological Chemistry 2014;289(32):22319-22332
Journal of Biological Chemistry 2014;289(32):22319-22332
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