BS7127

antibody from Bioworld Technology, Inc
Targeting: GRK1 GPRK1, RHOK, RK
Provider product page for BS7127
Western blot
Immunohistochemistry

Antibody data

Product number
BS7127 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GRK1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GRK1.
Description
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1Ï« and ÉÇ); two forms of ÉÇ-adrenergic receptor kinase: GRK 2 (ÉÇARK, ÉÇARK1) and GRK 3 (ÉÇARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GRK1 protein structure - BS7127 shown in red.