Antibody data
- Antibody Data
- Antigen structure
- References [43]
- Comments [0]
- Validations [0]
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- Product number
- 18054-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- CYP7A1 antibody
- Antibody type
- Polyclonal
- Description
- CYP7A1 antibody (Cat. #18054-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Increased intestinal Lactobacillus abundance in post-pancreatectomy steatotic liver disease is associated with altered bile acid metabolism and FXR-FGF19 pathway suppression.
Prevention of Cholestatic Liver Disease Through BCL6-FXR Enterohepatic Crosstalk.
Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism.
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Buyanghuanwu decoction (BYHWD) attenuates hepatic fibrosis in CCl(4)-induced mice by regulating bile acid metabolism through activating PPARα.
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis.
Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis.
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Characterization of the Probiotic Properties and Cholesterol Metabolism Regulation Potential of Lactiplantibacillus plantarum QL-19.
Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage.
Dual improvement effects of ω-3 on bone loss and liver injury in rats with liver-bone axis damage.
Rabdosia rubescens Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.
Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization.
Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.
Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism.
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.
Combination Therapy of Half-Dose Resmetirom and Metformin Attenuates Metabolic Dysfunction-Associated Steatohepatitis Through Improving Cholesterol Metabolism and Inflammation.
Effects of co-exposure to heat and ozone on lipid metabolism in the liver and adipose tissue of C57BL/6J male mice.
Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway.
Sub-chronic realgar exposure causes liver inflammatory injury in mice by inducing bile acid-mediated NLRP3 inflammasome activation through down-regulation of ileal FXR.
Salvianolic acid B attenuates hypercholesterolemia via modulating the gut microbiota and bile acid metabolism.
Efficient Hydrolysis of Earthworm Protein and the Lipid-Lowering Mechanism of Peptides in the Hydrolysate.
Simiao Wan attenuates high-fat diet-induced hyperlipidemia in mice by modulating the gut microbiota-bile acid axis.
Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.
Epicatechin and β-glucan from whole highland barley grain ameliorates hyperlipidemia associated with attenuating intestinal barrier dysfunction and modulating gut microbiota in high-fat-diet-fed mice.
Triclosan exposure causes abnormal bile acid metabolism through IL-1β-NF-κB-Fxr signaling pathway.
Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.
Diammonium glycyrrhizinate alleviates iron overload-induced liver injury in mice via regulating the gut-liver axis.
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.
Multi-omics and chemical profiling approaches to understand the material foundation and pharmacological mechanism of sophorae tonkinensis radix et rhizome-induced liver injury in mice.
Integrated Transcriptome and Metabolomics to Reveal the Mechanism of Adipose Mesenchymal Stem Cells in Treating Liver Fibrosis.
Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.
Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
Iguchi K, Seki N, Sugiura Y, Maeda R, Nakano K, Kawai T, Okuda Y, Kamimura R, Uchida Y, Hamasaki A, Taura K, Terajima H
Gut microbes reports 2026;3(1):2607927
Gut microbes reports 2026;3(1):2607927
Prevention of Cholestatic Liver Disease Through BCL6-FXR Enterohepatic Crosstalk.
Fruzyna E, Sommars MA, Omura Y, Yarnoff KM, Wang JC, Futtner CR, Green RM, Barish GD
Cellular and molecular gastroenterology and hepatology 2026;20(4):101706
Cellular and molecular gastroenterology and hepatology 2026;20(4):101706
Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism.
He J, Xu WL, Chen F, Chen J, Xie P
Environmental science & technology 2026 Mar 31;60(12):8958-8970
Environmental science & technology 2026 Mar 31;60(12):8958-8970
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Zhang Y, Luo X, Wu S, Qin Y, Xue Q, Ye W, Hou S, Liu B, Huang D, Yuan W, Ao H, Tong G, Liao M
Journal of ethnopharmacology 2026 Jun 28;365:121585
Journal of ethnopharmacology 2026 Jun 28;365:121585
Buyanghuanwu decoction (BYHWD) attenuates hepatic fibrosis in CCl(4)-induced mice by regulating bile acid metabolism through activating PPARα.
Wei X, Wang Z, Wang J, Yang H, Zhou F, Qi S, Zhang J, Shi X, Xu G, Li Z, Xu Y, Zhang D
Journal of ethnopharmacology 2026 Jun 12;364:121476
Journal of ethnopharmacology 2026 Jun 12;364:121476
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis.
Xiong J, Guo T, Gao T, Aierken Y, Chong Q, Lv Z, Lu L
NPJ biofilms and microbiomes 2026 Jan 8;12(1):38
NPJ biofilms and microbiomes 2026 Jan 8;12(1):38
Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis.
Li L, Sun W, Tan T, Xu J, Chen Y, Chen Y, Gao G, Ai X, Zhou J, Li Y, Zhang D, Lei S
Journal of translational medicine 2026 Feb 18;24(1)
Journal of translational medicine 2026 Feb 18;24(1)
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Wang Z, Wei J, Huang Z, Liu X, Li S, Fang Z, Hu L, Li R, Tao L, Li C, Chen H
Nutrients 2026 Feb 17;18(4)
Nutrients 2026 Feb 17;18(4)
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W
Islets 2026 Dec 31;18(1):2633793
Islets 2026 Dec 31;18(1):2633793
Characterization of the Probiotic Properties and Cholesterol Metabolism Regulation Potential of Lactiplantibacillus plantarum QL-19.
Liu M, Han Y, Wang S, Wang Y, Xu H
Probiotics and antimicrobial proteins 2026 Apr;18(3):3975-3990
Probiotics and antimicrobial proteins 2026 Apr;18(3):3975-3990
Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage.
Shi C, Feng S, Liu T, Meng Z, Zheng Y, Huang Z, Wang T, Zhang B, Xue D, Ma B, Meng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(24):e19500
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(24):e19500
Dual improvement effects of ω-3 on bone loss and liver injury in rats with liver-bone axis damage.
Huang J, Chen L, Yu H, Zhou S, Guan J, Xu C
Food & function 2026 Apr 14;17(7):3229-3247
Food & function 2026 Apr 14;17(7):3229-3247
Rabdosia rubescens Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.
Zou X, Chen W, Shao Y, Shi T, Ke Y
Canadian journal of gastroenterology & hepatology 2025;2025:9507266
Canadian journal of gastroenterology & hepatology 2025;2025:9507266
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.
Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z
Drug design, development and therapy 2025;19:3611-3630
Drug design, development and therapy 2025;19:3611-3630
Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization.
Chen Y, Zhou Z, Che H, Li D
Frontiers in physiology 2025;16:1642153
Frontiers in physiology 2025;16:1642153
Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.
Sun Y, Qu Y, Yang Z, Lv B, Wang G, Fan K, Wang Y, Pan J, Du Z, Yu Y
Frontiers in pharmacology 2025;16:1569856
Frontiers in pharmacology 2025;16:1569856
Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism.
Li M, Deng K, Zheng R, Li Y, Xiang L, Cheng J, Wang Y, Kuang S, Huang S, Lv Z
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120488
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120488
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
Huang L, Li H, Yang W, Huang L, Chen Q, Li S, Zou Z, Zhao L, Zeng Z
Journal of microbiology and biotechnology 2025 Sep 22;35:e2504017
Journal of microbiology and biotechnology 2025 Sep 22;35:e2504017
3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.
Wang Y, Li Z, Xiao W, Yongbo X, Li Y, Li Z, Chen D, Feng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157273
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157273
Combination Therapy of Half-Dose Resmetirom and Metformin Attenuates Metabolic Dysfunction-Associated Steatohepatitis Through Improving Cholesterol Metabolism and Inflammation.
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Biomedicines 2025 May 27;13(6)
Biomedicines 2025 May 27;13(6)
Effects of co-exposure to heat and ozone on lipid metabolism in the liver and adipose tissue of C57BL/6J male mice.
Jiang X, Li M, Li W, Guo Y, Zhang J, Ye L, Guo Z, Yang Y, Liu W, Chen L, Wang Q, Wu W, Dong G, Gui Z, Li D, Chen W, Chen S
Journal of hazardous materials 2025 Jun 5;489:137577
Journal of hazardous materials 2025 Jun 5;489:137577
Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway.
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Pharmaceuticals (Basel, Switzerland) 2025 Jun 20;18(7)
Sub-chronic realgar exposure causes liver inflammatory injury in mice by inducing bile acid-mediated NLRP3 inflammasome activation through down-regulation of ileal FXR.
Li G, Wang T, Xie Y, He L, Liu H, Chen H, Jiang H, Huo T
Journal of ethnopharmacology 2025 Jul 24;351:120174
Journal of ethnopharmacology 2025 Jul 24;351:120174
Salvianolic acid B attenuates hypercholesterolemia via modulating the gut microbiota and bile acid metabolism.
Meng X, Chen Y, Zhao B, Liu Q, Zhao L, Zheng X, Feng W
European journal of pharmacology 2025 Jul 15;999:177701
European journal of pharmacology 2025 Jul 15;999:177701
Efficient Hydrolysis of Earthworm Protein and the Lipid-Lowering Mechanism of Peptides in the Hydrolysate.
Zhang M, Mai X, Yang S, Huang Y, Zhang L, Ren W, Bai W, Xin X, Zhao W, Hao L
Foods (Basel, Switzerland) 2025 Jul 1;14(13)
Foods (Basel, Switzerland) 2025 Jul 1;14(13)
Simiao Wan attenuates high-fat diet-induced hyperlipidemia in mice by modulating the gut microbiota-bile acid axis.
Wang K, Xu W, He W, Ding M, Xia T, Tan X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118868
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118868
Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.
Wei M, LYu P, Li P, Hu J, Wu R, Ouyang Q, Guo K
Drug design, development and therapy 2024;18:6427-6446
Drug design, development and therapy 2024;18:6427-6446
Epicatechin and β-glucan from whole highland barley grain ameliorates hyperlipidemia associated with attenuating intestinal barrier dysfunction and modulating gut microbiota in high-fat-diet-fed mice.
Liu Z, Tang R, Liu J, Zhang Z, Li Y, Zhao R
International journal of biological macromolecules 2024 Oct;278(Pt 3):134917
International journal of biological macromolecules 2024 Oct;278(Pt 3):134917
Triclosan exposure causes abnormal bile acid metabolism through IL-1β-NF-κB-Fxr signaling pathway.
Liu J, Xu F, Guo M, Song Y
Ecotoxicology and environmental safety 2024 Oct 1;284:116989
Ecotoxicology and environmental safety 2024 Oct 1;284:116989
Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.
Liu Z, Liu J, Tang R, Zhang Z, Tian S
Foods (Basel, Switzerland) 2024 Jun 12;13(12)
Foods (Basel, Switzerland) 2024 Jun 12;13(12)
Diammonium glycyrrhizinate alleviates iron overload-induced liver injury in mice via regulating the gut-liver axis.
Liu Y, Li X, Guo Z, Li G, He L, Liu H, Cai S, Huo T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156216
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.
Zhang L, Zou W, Zhang S, Wu H, Gao Y, Zhang J, Zheng J
Cellular & molecular biology letters 2024 Dec 18;29(1):154
Cellular & molecular biology letters 2024 Dec 18;29(1):154
Multi-omics and chemical profiling approaches to understand the material foundation and pharmacological mechanism of sophorae tonkinensis radix et rhizome-induced liver injury in mice.
Rao SW, Liu CJ, Liang D, Duan YY, Chen ZH, Li JJ, Pang HQ, Zhang FX, Shi W
Journal of ethnopharmacology 2024 Aug 10;330:118224
Journal of ethnopharmacology 2024 Aug 10;330:118224
Integrated Transcriptome and Metabolomics to Reveal the Mechanism of Adipose Mesenchymal Stem Cells in Treating Liver Fibrosis.
Liu H, Wang X, Deng H, Huang H, Liu Y, Zhong Z, Shen L, Cao S, Ma X, Zhou Z, Chen D, Peng G
International journal of molecular sciences 2023 Nov 8;24(22)
International journal of molecular sciences 2023 Nov 8;24(22)
Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.
Kosaka S, Miyashita M, McNamala K, Nomura M, Shima H, Kawai M, Sato I, Harada-Shoji N, Ishida T, Choi MH, Sasano H
The Journal of steroid biochemistry and molecular biology 2022 Jul;221:106103
The Journal of steroid biochemistry and molecular biology 2022 Jul;221:106103
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Jiang Y, Fu C, Liu G, Guo J, Su Z
Food & nutrition research 2018;62
Food & nutrition research 2018;62
Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.
Bai D, Li Q, Xiong Y, Wang C, Shen P, Bai L, Yuan L, Wu P
Toxicological sciences : an official journal of the Society of Toxicology 2018 Aug 1;164(2):501-511
Toxicological sciences : an official journal of the Society of Toxicology 2018 Aug 1;164(2):501-511
Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
Liu X, Henkel AS, LeCuyer BE, Hubchak SC, Schipma MJ, Zhang E, Green RM
Journal of lipid research 2017 Mar;58(3):504-511
Journal of lipid research 2017 Mar;58(3):504-511
Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice.
Henkel AS, LeCuyer B, Olivares S, Green RM
Cellular and molecular gastroenterology and hepatology 2017 Mar;3(2):261-271
Cellular and molecular gastroenterology and hepatology 2017 Mar;3(2):261-271
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15
Food & function 2016 Aug 10;7(8):3505-15
The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
He K, Ye X, Wu H, Wang Y, Zou Z, Ning N, Hu Y, Chen B, Fang X, Li X
Lipids 2015 Feb;50(2):185-94
Lipids 2015 Feb;50(2):185-94
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