DENND4A

This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]

Description

DENN domain containing 4A

Tissue specificity

Tissue enhanced (retina)

Subcell location

Nucleoplasm, Nucleoli rim, Mitotic chromosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (65658046 - 65792293)

Ensembl ID

ENSG00000174485  (ver. 103.38)

Orthologs

Mouse Dennd4a: ENSMUSG00000053641

UniProt

Q7Z401

neXtProt

NX_Q7Z401

Human splice variants
Mouse splice variants

Protein structure