BS7984

antibody from Bioworld Technology, Inc

Targeting: ALKBH1 ABH, alkB, ALKBH, hABH

Immunohistochemistry

Antibody data

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Validation data

Product number: BS7984 - Provider product page
Provider: Bioworld Technology, Inc
Product name: ALKBH1 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human ALKBH1.
Description: ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.
Reactivity: Human
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

ALKBH1 protein structure - BS7984 shown in red.