27235-1-AP

antibody from Proteintech Group

Targeting: ASIC1 ACCN2, BNaC2, hBNaC2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

27235-1-AP

Provider

Proteintech Group

Product name

ASIC1 antibody

Antibody type

Polyclonal

Description

ASIC1 antibody (Cat. #27235-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ASIC1a promotes alveolar epithelial apoptosis and acute lung injury through repression of the LncRNA00178/miR-466b-3p/Gucy1b1 ceRNA network.

Zhang A, Zhu Y, Chen H, Lv X, Zhang T, Ren R, Wang Y, Xu H, Xu Z, Li Z, Qian S, Zhang J, Li M, Hu X, Cao C, Abou-Elnour A, Ding Z, Wang J, Huang Y
International immunopharmacology 2026 May 1;176:116484

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The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic paraventricular nucleus in male mice.

Yue J, Zhang Q, Wang M, Yao X, Wang M, Liu L, Huang Z, Xing Y, Yan J, Yan Z, Song XL, Wang W
Translational psychiatry 2026 Mar 19;16(1)

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The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1b.

Golder M, Butcher NJ, Naughton JD, Liu J, Crawford T, Rash LD, Mobli M, Cristofori-Armstrong B
European journal of pharmacology 2026 Apr 28;1022:178850

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PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer.

Wu X, Wang B, Hou Y, Fang Y, Jiang Y, Song Y, Liu Y, Jin C
Biomolecules 2025 Mar 1;15(3)

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Mechanism of glycolysis-pyrolysis crosstalk driving vicious circle of intervertebral disc degeneration.

Gao S, Liu T, Hou X, Song C, Luo Y, Cai W, Zhou D, Lv J, Mei Y, Shi H, Wang S, Li Y, Liu Z
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3129-3148

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Acid-sensing ion channel 1a promotes alcohol-associated liver disease in mice via regulating endoplasmic reticulum autophagy.

Zhu YQ, Wang LL, Li ZH, Qian SS, Xu Z, Zhang J, Song YH, Pan XS, Du N, Abou-Elnour A, Tay LJ, Zhang JR, Li MX, Shen YX, Huang Y
Acta pharmacologica Sinica 2025 Apr;46(4):989-1001

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ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.

Wang YM, Tang H, Tang YJ, Liu J, Yin YF, Tang YL, Feng YG, Gu HF
Journal of advanced research 2024 Sep;63:195-206

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Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth.

Balboni A, D'Angelo C, Collura N, Brusco S, Di Berardino C, Targa A, Massoti B, Mastrangelo E, Milani M, Seneci P, Broccoli V, Muzio L, Galli R, Menegon A
Scientific reports 2024 Sep 3;14(1):20421

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Mesenchymal stromal cell response to intervertebral disc-like pH is tissue source dependent.

Cannon K, Gill S, Mercuri J
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Jun;42(6):1303-1313

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ASIC1a regulates airway epithelial cell pyroptosis in acute lung injury by NLRP3-Caspase1-GSDMD pathway.

Tan YY, Zhang DW, Yang C, Huang Y, Kang JY, Xu ZH, Wei YY, Ding ZX, Fei GH
International immunopharmacology 2024 Dec 25;143(Pt 3):113623

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Targeting ASIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic Stroke.

Ge H, Zhou T, Zhang C, Cun Y, Chen W, Yang Y, Zhang Q, Li H, Zhong J, Zhang X, Feng H, Hu R
Research (Washington, D.C.) 2023;6:0105

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Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.

Wang W, Xu M, Yue J, Zhang Q, Nie X, Jin Y, Zhang Z
Endocrinology 2022 Oct 1;163(10)

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ASIC1a induces mitochondrial apoptotic responses in acute lung injury.

Li Y, Zhang A, Li K, Zhao D, Li F, Liao S, Zhang Y, Huang Y
European journal of pharmacology 2022 Nov 5;934:175296

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N-phenethyl-5-phenylpicolinamide alleviates inflammation in acute lung injury by inhibiting HIF-1α/glycolysis/ASIC1a pathway.

Du N, Lin H, Zhang A, Cao C, Hu X, Zhang J, Wang L, Pan X, Zhu Y, Qian F, Wang Y, Zhao D, Liu M, Huang Y
Life sciences 2022 Nov 15;309:120987

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Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.

Dai WY, Luo ZP
Cellular signalling 2022 Mar;91:110243

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ASIC1a promotes the proliferation of synovial fibroblasts via the ERK/MAPK pathway.

Tao J, Lu Z, Su J, Qian X, Zhang Y, Xu Y, Song S, Hang X, Peng X, Chen F
Laboratory investigation; a journal of technical methods and pathology 2021 Oct;101(10):1353-1362

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Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a.

Qian X, Zhang Y, Tao J, Niu R, Song S, Wang C, Peng X, Chen F
Laboratory investigation; a journal of technical methods and pathology 2021 Mar;101(3):280-291

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The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency.

Pan X, Zhu Y, Wu X, Liu L, Ying R, Wang L, Du N, Zhang J, Jin J, Meng X, Dai F, Huang Y
European journal of pharmacology 2021 Feb 15;893:173816