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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11769-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11769-1-AP, RRID:AB_2185006
- Product name
- Septin 8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Septin 8 antibody (Cat. #11769-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice.
Pinch2 regulates myelination in the mouse central nervous system.
Abnormal Spinal Cord Myelination due to Oligodendrocyte Dysfunction in a Model of Huntington's Disease.
Impaired Platelet Function in Sept8-Deficient Mice In Vitro.
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.
Characterization of septin expression in normal and fibrotic kidneys.
Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.
A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling.
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.
Martens AK, Erwig M, Patzig J, Fledrich R, Füchtbauer EM, Werner HB
Cytoskeleton (Hoboken, N.J.) 2023 Jul-Aug;80(7-8):290-302
Cytoskeleton (Hoboken, N.J.) 2023 Jul-Aug;80(7-8):290-302
Pinch2 regulates myelination in the mouse central nervous system.
Paes de Faria J, Vale-Silva RS, Fässler R, Werner HB, Relvas JB
Development (Cambridge, England) 2022 Jul 1;149(13)
Development (Cambridge, England) 2022 Jul 1;149(13)
Abnormal Spinal Cord Myelination due to Oligodendrocyte Dysfunction in a Model of Huntington's Disease.
Ferrari Bardile C, Sidik H, Quek R, Yusof NABM, Garcia-Miralles M, Pouladi MA
Journal of Huntington's disease 2021;10(3):377-384
Journal of Huntington's disease 2021;10(3):377-384
Impaired Platelet Function in Sept8-Deficient Mice In Vitro.
Neubauer K, Jurk K, Petermann V, Kumm E, Zieger B
Thrombosis and haemostasis 2021 Apr;121(4):484-494
Thrombosis and haemostasis 2021 Apr;121(4):484-494
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.
Jarjour AA, Velichkova AN, Boyd A, Lord KM, Torsney C, Henderson DJ, Ffrench-Constant C
Glia 2020 Sep;68(9):1840-1858
Glia 2020 Sep;68(9):1840-1858
Characterization of septin expression in normal and fibrotic kidneys.
Neubauer K, Neubauer B, Seidl M, Zieger B
Cytoskeleton (Hoboken, N.J.) 2019 Jan;76(1):143-153
Cytoskeleton (Hoboken, N.J.) 2019 Jan;76(1):143-153
Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.
Erwig MS, Patzig J, Steyer AM, Dibaj P, Heilmann M, Heilmann I, Jung RB, Kusch K, Möbius W, Jahn O, Nave KA, Werner HB
eLife 2019 Jan 23;8
eLife 2019 Jan 23;8
A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling.
Sun L, Cao X, Lechuga S, Feygin A, Naydenov NG, Ivanov AI
Cells 2019 Dec 29;9(1)
Cells 2019 Dec 29;9(1)
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M
Journal of cell science 2016 Jun 1;129(11):2224-38
Journal of cell science 2016 Jun 1;129(11):2224-38
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.
Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB
eLife 2016 Aug 9;5
eLife 2016 Aug 9;5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11769-1-AP(SEPT8 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SEPT8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SEPT8. This antibody recognizes human,mouse,rat antigen. The SEPT8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
