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- References [32]
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- Product number
- 13997-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13997-1-AP, RRID:AB_10860100
- Product name
- Cryptochrome 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cryptochrome 2 antibody (Cat. #13997-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Epigenetic Activation of Circadian Clock Genes Elicits Inflammation in Experimental Murine Dry Eye.
Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.
Decreased Memory and Learning Ability Mediated by Bmal1/M1 Macrophages/Angptl2/Inflammatory Cytokine Pathway in Mice Exposed to Long-Term Blue Light Irradiation.
Cryptochrome 2 Suppresses Epithelial-Mesenchymal Transition by Promoting Trophoblastic Ferroptosis in Unexplained Recurrent Spontaneous Abortion.
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet.
Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm".
Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice.
Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis.
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium.
7,8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1/Akt pathway.
Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms.
Cryptochrome 2 acetylation attenuates its antiproliferative effect in breast cancer.
Meta-Analysis of Mechanism of Influence of CRY2 on the Differentiation of Mouse Osteoblast through the Regulation of Wnt/Β-Catenin Signaling Pathway.
The association between disruption of the circadian rhythm and aggravation of colitis in mice.
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Melatonin pretreatment prevents propofol-induced sleep disturbance by modulating circadian rhythm in rats.
Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise.
Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression.
Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.
Inhibition of CRY2 by STAT3/miRNA-7-5p Promotes Osteoblast Differentiation through Upregulation of CLOCK/BMAL1/P300 Expression.
Cryptochromes-Mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.
Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.
The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation.
G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.
Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats.
Effect of Jiaotai Pill () on intestinal damage in partially sleep deprived rats.
KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
Wei R, Chen Q, Zheng Q, Reinach PS, Tan X, Pan C, Xu W, Tong L, Chen W
Ocular immunology and inflammation 2024 Sep;32(7):1180-1188
Ocular immunology and inflammation 2024 Sep;32(7):1180-1188
Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.
Xia TJ, Jin SW, Liu YG, Zhang SS, Wang Z, Liu XM, Pan RL, Jiang N, Liao YH, Yan MZ, Chang Q
Journal of ethnopharmacology 2024 May 23;326:117992
Journal of ethnopharmacology 2024 May 23;326:117992
Decreased Memory and Learning Ability Mediated by Bmal1/M1 Macrophages/Angptl2/Inflammatory Cytokine Pathway in Mice Exposed to Long-Term Blue Light Irradiation.
Hiramoto K, Kubo S, Tsuji K, Sugiyama D, Hamano H
Current issues in molecular biology 2024 May 18;46(5):4924-4934
Current issues in molecular biology 2024 May 18;46(5):4924-4934
Cryptochrome 2 Suppresses Epithelial-Mesenchymal Transition by Promoting Trophoblastic Ferroptosis in Unexplained Recurrent Spontaneous Abortion.
Li F, Guo L, Zhou M, Han L, Wu S, Wu L, Yang J
The American journal of pathology 2024 Jul;194(7):1197-1217
The American journal of pathology 2024 Jul;194(7):1197-1217
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet.
Li R, Wang G, Liu R, Luo L, Zhang Y, Wan Z
Journal of physiology and biochemistry 2024 Feb;80(1):137-147
Journal of physiology and biochemistry 2024 Feb;80(1):137-147
Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm".
Xu DD, Hou ZQ, Xu YY, Liang J, Gao YJ, Zhang C, Guo F, Huang DD, Ge JF, Xia QR
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 Feb 2;19(1):4
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2024 Feb 2;19(1):4
Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice.
Xia TJ, Wang Z, Jin SW, Liu XM, Liu YG, Zhang SS, Pan RL, Jiang N, Liao YH, Yan MZ, Du LD, Chang Q
Frontiers in pharmacology 2023;14:1210393
Frontiers in pharmacology 2023;14:1210393
Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis.
Chen Y, Li J, Li S, Cheng Y, Fu X, Li J, Zhu L
International journal of molecular sciences 2023 Sep 18;24(18)
International journal of molecular sciences 2023 Sep 18;24(18)
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
Yao D, Li R, Hao J, Huang H, Wang X, Ran L, Fang Y, He Y, Wang W, Liu X, Wang M
Translational psychiatry 2023 Oct 6;13(1):310
Translational psychiatry 2023 Oct 6;13(1):310
CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Lin L, Huang Y, Wang J, Guo X, Yu F, He D, Wu C, Guo L, Wu B
Biochemical pharmacology 2023 Nov;217:115843
Biochemical pharmacology 2023 Nov;217:115843
Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium.
Dulko E, Jedrusiak M, Osuru HP, Atluri N, Illendula M, Davis EM, Beenhakker MP, Lunardi N
Anesthesia and analgesia 2023 Jul 1;137(1):209-220
Anesthesia and analgesia 2023 Jul 1;137(1):209-220
7,8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1/Akt pathway.
Hang PZ, Liu J, Wang JP, Li FF, Li PF, Kong QN, Shi J, Ji HY, Du ZM, Zhao J
European journal of pharmacology 2023 Jan 5;938:175420
European journal of pharmacology 2023 Jan 5;938:175420
Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms.
Gao X, Wei Y, Sun H, Hao S, Ma M, Sun H, Zang D, Qi C, Ge J
Molecular neurobiology 2023 Aug;60(8):4595-4617
Molecular neurobiology 2023 Aug;60(8):4595-4617
Cryptochrome 2 acetylation attenuates its antiproliferative effect in breast cancer.
Xia K, Li S, Yang Y, Shi X, Zhao B, Lv L, Xin Z, Kang J, Ren P, Wu H
Cell death & disease 2023 Apr 6;14(4):250
Cell death & disease 2023 Apr 6;14(4):250
Meta-Analysis of Mechanism of Influence of CRY2 on the Differentiation of Mouse Osteoblast through the Regulation of Wnt/Β-Catenin Signaling Pathway.
Ma C, Yang C, Xie T, Dai W, Ma J
BioMed research international 2022;2022:3727165
BioMed research international 2022;2022:3727165
The association between disruption of the circadian rhythm and aggravation of colitis in mice.
Chen YD, Zhao RF, Zheng G, Ling FM, Li JR, Xu MY, Guo D, Zhang QL, Li S, Zhu LR
Gastroenterology report 2022;10:goac028
Gastroenterology report 2022;10:goac028
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
Barajas JM, Lin CH, Sun HL, Alencastro F, Zhu AC, Aljuhani M, Navari L, Yilmaz SA, Yu L, Corps K, He C, Duncan AW, Ghoshal K
The American journal of pathology 2022 Jan;192(1):56-71
The American journal of pathology 2022 Jan;192(1):56-71
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Melatonin pretreatment prevents propofol-induced sleep disturbance by modulating circadian rhythm in rats.
Yin XL, Li JC, Xue R, Li S, Zhang Y, Dong HJ, Li Y, Wang HL, Zhang YZ
Experimental neurology 2022 Aug;354:114086
Experimental neurology 2022 Aug;354:114086
Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise.
Luo L, Li R, Wang G, Chen J, Chen L, Qin LQ, Yu Z, Wan Z
Food & function 2022 Apr 20;13(8):4445-4458
Food & function 2022 Apr 20;13(8):4445-4458
Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.
Tan X, Cao F, Tang F, Lu C, Yu Q, Feng S, Yang Z, Chen S, He X, He J, Weng L, Sun L
Journal of immunology research 2021;2021:9995869
Journal of immunology research 2021;2021:9995869
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301
Cell death & disease 2021 Mar 19;12(4):301
CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression.
Zhang D, Ni N, Wang Y, Tang Z, Gao H, Ju Y, Sun N, He X, Gu P, Fan X
Cell death and differentiation 2021 Jan;28(1):283-302
Cell death and differentiation 2021 Jan;28(1):283-302
Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.
Lee Y, Fong SY, Shon J, Zhang SL, Brooks R, Lahens NF, Chen D, Dang CV, Field JM, Sehgal A
Science advances 2021 Feb;7(7)
Science advances 2021 Feb;7(7)
Inhibition of CRY2 by STAT3/miRNA-7-5p Promotes Osteoblast Differentiation through Upregulation of CLOCK/BMAL1/P300 Expression.
Tang Z, Xu T, Li Y, Fei W, Yang G, Hong Y
Molecular therapy. Nucleic acids 2020 Mar 6;19:865-876
Molecular therapy. Nucleic acids 2020 Mar 6;19:865-876
Cryptochromes-Mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.
Rizzini L, Levine DC, Perelis M, Bass J, Peek CB, Pagano M
Current biology : CB 2019 Jun 17;29(12):1954-1962.e4
Current biology : CB 2019 Jun 17;29(12):1954-1962.e4
Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.
Ji G, Lv K, Chen H, Wang Y, Zhang Y, Li Y, Qu L
Free radical biology & medicine 2019 Dec;145:312-320
Free radical biology & medicine 2019 Dec;145:312-320
The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation.
Lee Y, Shen Y, Francey LJ, Ramanathan C, Sehgal A, Liu AC, Hogenesch JB
Scientific reports 2019 Aug 15;9(1):11883
Scientific reports 2019 Aug 15;9(1):11883
G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.
Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A
PLoS biology 2019 Apr;17(4):e3000228
PLoS biology 2019 Apr;17(4):e3000228
Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats.
Huang WY, Zou X, Lu FE, Su H, Zhang C, Ren YL, Fang K, Xu LJ, Wang KF, Chen QJ, Dong H
Current medical science 2018 Aug;38(4):704-713
Current medical science 2018 Aug;38(4):704-713
Effect of Jiaotai Pill () on intestinal damage in partially sleep deprived rats.
Huang WY, Zou X, Lu FE, Zhang C, Ren YL, Xu LJ, Wang KF, Dong H
Chinese journal of integrative medicine 2017 Dec;23(12):901-907
Chinese journal of integrative medicine 2017 Dec;23(12):901-907
KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
Lee Y, Jang AR, Francey LJ, Sehgal A, Hogenesch JB
eLife 2015 Aug 29;4
eLife 2015 Aug 29;4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Cryptochrome 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cryptochrome 2. This antibody recognizes human,mouse,rat antigen. The Cryptochrome 2 antibody has been validated for the following applications: ELISA, WB analysis.
