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- Antigen structure
- References [506]
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- Product number
- 11802-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11802-1-AP, RRID:AB_2207530
- Product name
- TOM20 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TOM20 antibody (Cat. #11802-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage.
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Identification of novel homozygous asthenoteratospermia-causing ARMC2 mutations associated with multiple morphological abnormalities of the sperm flagella.
Cadmium exposure activates mitophagy through downregulating thyroid hormone receptor/PGC1α signal in preeclampsia.
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis.
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart.
Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response.
Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons.
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate.
6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding.
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice.
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway.
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.
Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition.
Protocol for measuring mitochondrial size in mouse and human liver tissues.
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.
Solute carrier family 35 member A2 regulates mitophagy through the PI3K/AKT/mTOR axis, promoting the proliferation, migration, and invasion of osteosarcoma cells.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Neurotransmitter accumulation and Parkinson's disease-like phenotype caused by anion channelrhodopsin opto-controlled astrocytic mitochondrial depolarization in substantia nigra pars compacta.
Senecavirus A induces mitophagy to promote self-replication through direct interaction of 2C protein with K27-linked ubiquitinated TUFM catalyzed by RNF185.
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.
Lactate transported by MCT1 plays an active role in promoting mitochondrial biogenesis and enhancing TCA flux in skeletal muscle.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior.
The Role of Intestinal Cytochrome P450s in Vitamin D Metabolism.
Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis.
Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis.
Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport.
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway.
Drp1 regulated PINK1-dependent mitophagy protected duck follicular granulosa cells from acute heat stress injury.
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif.
Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2.
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.
NAD(+) dependent UPR(mt) activation underlies intestinal aging caused by mitochondrial DNA mutations.
Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.
Activation of mitophagy improves cognitive dysfunction in diabetic mice with recurrent non-severe hypoglycemia.
Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Stress response silencing by an E3 ligase mutated in neurodegeneration.
Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation.
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice.
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression.
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects.
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments.
Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis.
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks.
Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease.
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.
In Situ Analysis of Mitochondrial DNA Synthesis Using Metabolic Labeling Coupled to Fluorescence Microscopy.
Localization of Mitochondrial Nucleoids by Transmission Electron Microscopy Using the Transgenic Expression of the Mitochondrial Helicase Twinkle and APEX2.
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Novel FSIP2 Variants Induce Super-Length Mitochondrial Sheath and Asthenoteratozoospermia in Humans.
Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1.
Electroacupuncture Exerts Chondroprotective Effect in Knee Osteoarthritis of Rabbits Through the Mitophagy Pathway.
Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice.
IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells.
Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation.
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α.
Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.
SNAP25 ameliorates postoperative cognitive dysfunction by facilitating PINK1-dependent mitophagy and impeding caspase-3/GSDME-dependent pyroptosis.
Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction.
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture.
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
The actin binding protein profilin 1 is critical for mitochondria function.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membrane.
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function.
Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS.
Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia.
Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.
The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy.
Inhibition of TMEM16A improves cisplatin-induced acute kidney injury via preventing DRP1-mediated mitochondrial fission.
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells.
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
mtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible foci analysis.
WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity.
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Segregation of pathways leading to pexophagy.
Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission.
SAR-guided development of indole-matrine hybrids as potential anticancer agents via mitochondrial stress/cytochrome c/caspase 3 signaling pathway.
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV Replication via the TRIM28-Mediated Degradation of HBx.
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts.
Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
Necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitate Pseudomonas aeruginosa mediated lung injury.
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
RNA localization mechanisms transcend cell morphology.
Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations.
YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids.
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice.
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand.
MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells.
Microcystin-LR-Exposure-Induced Kidney Damage by Inhibiting MKK6-Mediated Mitophagy in Mice.
Expanding DdCBE-mediated targeting scope to aC motif preference in rat.
High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs.
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis.
Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury.
Spatial topology of organelle is a new breast cancer cell classifier.
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness.
Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif.
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization.
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.
SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2.
S-Doped carbonized polymer dots inhibit early myocardial fibrosis by regulating mitochondrial function.
Golgi damage caused by dysfunction of PiT-2 in primary familial brain calcification.
Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
Mice harboring a R133L heterozygous mutation in LMNA exhibited ectopic lipid accumulation, aging, and mitochondrial dysfunction in adipose tissue.
Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.
Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing.
Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.
Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation.
Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway.
Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
Urolithin A protects severe acute pancreatitis-associated acute cardiac injury by regulating mitochondrial fatty acid oxidative metabolism in cardiomyocytes.
Activation of moderate autophagy promotes survival of fat graft.
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors.
RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.
Mammalian autophagosomes form from finger-like phagophores.
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.
SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs.
The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication.
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.
Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects.
Plasma membrane lipid composition and metabolomics analysis of Yorkshire boar sperms with high and low resistance to cryopreservation.
Hypoxia causes pancreatic β-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40.
COPI-regulated mitochondria-ER contact site formation maintains axonal integrity.
RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Oxidative stress in human gingival fibroblasts from periodontitis versus healthy counterparts.
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia.
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction.
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro.
Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy.
Disruption of cellular iron homeostasis by IREB2 missense variants causes severe neurodevelopmental delay, dystonia and seizures.
Examining Mitochondrial Morphology in Mouse Brains.
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE.
Docosahexaenoic Acid Alleviates Brain Damage by Promoting Mitophagy in Mice with Ischaemic Stroke.
San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.
The Valuable Role of ARMC1 in Invasive Breast Cancer as a Novel Biomarker.
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation.
The inhibition of PGAM5 suppresses seizures in a kainate-induced epilepsy model via mitophagy reduction.
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer.
Inhibition of the PINK1-Parkin Pathway Enhances the Lethality of Sorafenib and Regorafenib in Hepatocellular Carcinoma.
Characterization and subcellular localization of Alongshan virus proteins.
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE.
Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.
Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy.
Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration.
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
Differential requirements for mitochondrial electron transport chain components in the adult murine liver.
In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors.
Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses.
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells.
PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway.
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.
Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response.
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.
Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway.
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Repeated social defeat stress inhibits development of hippocampus neurons through mitophagy and autophagy.
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation.
MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.
TGR5 Agonist INT-777 Alleviates Inflammatory Neurodegeneration in Parkinson's Disease Mouse Model by Modulating Mitochondrial Dynamics in Microglia.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Disruption of STIM1-mediated Ca(2+) sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass.
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Loss of legumain induces premature senescence and mediates aging-related renal fibrosis.
Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
Obstructive Sleep Apnea Affects Lacrimal Gland Function.
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.
Maternal exposure to CeO(2)NPs derails placental development through trophoblast dysfunction mediated by excessive autophagy activation.
Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons.
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.
Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations.
Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis.
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation.
Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy.
Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Massive Accumulation of Sphingomyelin Affects the Lysosomal and Mitochondria Compartments and Promotes Apoptosis in Niemann-Pick Disease Type A.
Deficient mitochondrial respiration in astrocytes impairs trace fear conditioning and increases naloxone-precipitated aversion in morphine-dependent mice.
SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
L-OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice.
Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy.
Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases.
Functionalized Allopurinols Targeting Amyloid-Binding Alcohol Dehydrogenase Rescue Aβ-Induced Mitochondrial Dysfunction.
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis.
Bombyx mori cypovirus (BmCPV) induces PINK1-Parkin mediated mitophagy via interaction of VP4 with host Tom40.
Drp1 knockdown represses apoptosis of rat retinal endothelial cells by inhibiting mitophagy.
Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles.
Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Heat Shock Protein 60 Restricts Release of Mitochondrial dsRNA to Suppress Hepatic Inflammation and Ameliorate Non-Alcoholic Fatty Liver Disease in Mice.
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Hyperglycemia Induces Meibomian Gland Dysfunction.
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.
Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy.
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.
Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1/Th17 immune responses.
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids.
The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy.
Gankyrin and TIGAR cooperatively accelerate glucose metabolism toward the PPP and TCA cycle in hepatocellular carcinoma.
The combination of nuclear receptor NR1D1 and ULK1 promotes mitophagy in adipocytes to ameliorate obesity.
Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy.
The Journey of SCAPs (Stem Cells from Apical Papilla), from Their Native Tissue to Grafting: Impact of Oxygen Concentration.
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles.
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma.
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease.
Systematic Functional Analysis of PINK1 and PRKN Coding Variants.
The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP().
GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth.
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Melatonin Attenuates Ropivacaine-Induced Apoptosis by Inhibiting Excessive Mitophagy Through the Parkin/PINK1 Pathway in PC12 and HT22 Cells.
Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage.
Baicalein suppresses high glucose-induced inflammation and apoptosis in trophoblasts by targeting the miRNA-17-5p-Mfn1/2-NF-κB pathway.
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8.
SIRT2 Is Critical for Sheep Oocyte Maturation through Regulating Function of Surrounding Granulosa Cells.
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver.
Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model.
OPA1 Modulates Mitochondrial Ca(2+) Uptake Through ER-Mitochondria Coupling.
Melatonin Attenuates Chromium (VI)-Induced Spermatogonial Stem Cell/Progenitor Mitophagy by Restoration of METTL3-Mediated RNA N(6)-Methyladenosine Modification.
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.
Receptor-Interacting Protein Kinase 3 Inhibition Prevents Cadmium-Mediated Macrophage Polarization and Subsequent Atherosclerosis via Maintaining Mitochondrial Homeostasis.
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma via ROS/Mitochondria Pathway.
Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.
Tongluo Yishen Decoction Ameliorates Renal Fibrosis via Regulating Mitochondrial Dysfunction Induced by Oxidative Stress in Unilateral Ureteral Obstruction Rats.
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore-forming toxins to Caenorhabditis elegans.
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency.
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells.
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis.
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation.
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1.
An in vitro system to silence mitochondrial gene expression.
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†.
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
Remote Ischemic Postconditioning Inhibited Mitophagy to Achieve Neuroprotective Effects in the Rat Model of Cardiac Arrest.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.
Machine learning-based classification of mitochondrial morphology in primary neurons and brain.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties.
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation.
Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons.
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.
Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.
Influence of Subcellular Localization and Functional State on Protein Turnover.
Tubular Mas receptor mediates lipid-induced kidney injury.
Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii.
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1.
Active RNA interference in mitochondria.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Lipidomics Reveals Dysregulated Glycerophospholipid Metabolism in the Corpus Striatum of Mice Treated with Cefepime.
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Facile Synthesis of Antibody-Coupled Polydopamine-Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria.
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation.
Monitoring mitochondrial translation in living cells.
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway.
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes.
Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission.
Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α.
HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury.
Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Methylene blue post-treatment improves hypoxia-ischemic recovery in a neonatal rat model.
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease.
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.
FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway.
Hyperlipidemia Affects Tight Junctions and Pump Function in the Corneal Endothelium.
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca(2+) efflux and Reactive Oxygen Species (ROS) homeostasis.
Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.
Mitophagy in the Hippocampus Is Excessive Activated After Cardiac Arrest and Cardiopulmonary Resuscitation.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin.
The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.
Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy.
Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway.
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice.
Mitochondria modulate programmed neuritic retraction.
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Rapid affinity purification of intracellular organelles using a twin strep tag.
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
IP(3) receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Parkin Modulates ERRα/eNOS Signaling Pathway in Endothelial Cells.
CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.
Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p.
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Generation and Characterization of SULT4A1 Mutant Mouse Models.
PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver.
Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions.
Photobiomodulation Therapy Attenuates Hypoxic-Ischemic Injury in a Neonatal Rat Model.
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.
Autophagy protects auditory hair cells against neomycin-induced damage.
Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.
A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis.
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.
Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Incorporation of VSV-G produces fusogenic plasma membrane vesicles capable of efficient transfer of bioactive macromolecules and mitochondria.
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development.
Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis.
Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.
MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection.
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.
Mitochondrial abnormalities in temporal lobe of autistic brain.
UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946
International journal of biological sciences 2024;20(5):1927-1946
NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage.
Wang G, Lin N
Journal of inflammation research 2024;17:1971-1981
Journal of inflammation research 2024;17:1971-1981
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC
Cell research 2024 Oct;34(10):683-706
Cell research 2024 Oct;34(10):683-706
Identification of novel homozygous asthenoteratospermia-causing ARMC2 mutations associated with multiple morphological abnormalities of the sperm flagella.
Zhao S, Liu Q, Su L, Meng L, Tan C, Wei C, Zhang H, Luo T, Zhang Q, Tan YQ, Tu C, Chen H, Gao X
Journal of assisted reproduction and genetics 2024 May;41(5):1297-1306
Journal of assisted reproduction and genetics 2024 May;41(5):1297-1306
Cadmium exposure activates mitophagy through downregulating thyroid hormone receptor/PGC1α signal in preeclampsia.
Yu Z, Yu T, Li X, Lin W, Li X, Zhai M, Yin J, Zhao L, Liu X, Zhao B, Duan C, Cheng H, Wang F, Wei Z, Yang Y
Ecotoxicology and environmental safety 2024 May;276:116259
Ecotoxicology and environmental safety 2024 May;276:116259
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Koma R, Shibaguchi T, Yamada T, Nonaka Y, Jue T, Yamazaki A, Masuda K
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis.
Zhong G, Qiao B, He Y, Liu H, Hong P, Rao G, Tang L, Tang Z, Hu L
Pesticide biochemistry and physiology 2024 May;201:105904
Pesticide biochemistry and physiology 2024 May;201:105904
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
López-Molina L, Sancho-Balsells A, Al-Massadi O, Montalban E, Alberch J, Arranz B, Girault JA, Giralt A
Neurobiology of disease 2024 May;194:106487
Neurobiology of disease 2024 May;194:106487
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart.
Ohanele C, Peoples JN, Karlstaedt A, Geiger JT, Gayle AD, Ghazal N, Sohani F, Brown ME, Davis ME, Porter GA, Faundez V, Kwong JQ
bioRxiv : the preprint server for biology 2024 May 13;
bioRxiv : the preprint server for biology 2024 May 13;
Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response.
Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G, Montes-Gómez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S, Tait SW
The EMBO journal 2024 Mar;43(6):904-930
The EMBO journal 2024 Mar;43(6):904-930
Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons.
Atarashi N, Morishita M, Matsuda S
The Journal of biological chemistry 2024 Mar;300(3):105744
The Journal of biological chemistry 2024 Mar;300(3):105744
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
Wei Y, Liu W, Wang R, Chen Y, Liu J, Guo X, Can C, Yang X, Wang D, Hu X, Ma D
Free radical biology & medicine 2024 Mar;213:36-51
Free radical biology & medicine 2024 Mar;213:36-51
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Xu CY, Xu C, Xu YN, Du SQ, Dai ZH, Jin SQ, Zheng G, Xie CL, Fang WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate.
Chen C, Li H, Zhang J, Cheng SC
Communications biology 2024 Mar 7;7(1):281
Communications biology 2024 Mar 7;7(1):281
6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding.
Fang J, Wang X, Cao G, Wang F, Ru Y, Wang B, Zhang Y, Zhang D, Yan J, Xu J, Ji J, Ji F, Zhou Y, Guo L, Li M, Liu W, Cai X, Cai Z
Journal of hazardous materials 2024 Mar 5;465:133312
Journal of hazardous materials 2024 Mar 5;465:133312
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice.
Wang R, Sun H, Cao Y, Zhang Z, Chen Y, Wang X, Liu L, Wu J, Xu H, Wu D, Mu C, Hao Z, Qin S, Ren H, Han J, Fang M, Wang G
Science signaling 2024 Mar 26;17(829):eadk8249
Science signaling 2024 Mar 26;17(829):eadk8249
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway.
Zhang Y, Deng Q, Hong H, Qian Z, Wan B, Xia M
Journal of translational medicine 2024 Mar 25;22(1):304
Journal of translational medicine 2024 Mar 25;22(1):304
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.
Huang W, Wang L, Huang Z, Sun Z, Zheng B
Respiratory research 2024 Mar 2;25(1):110
Respiratory research 2024 Mar 2;25(1):110
Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition.
Bond C, Hugelier S, Xing J, Sorokina EM, Lakadamyali M
bioRxiv : the preprint server for biology 2024 Mar 19;
bioRxiv : the preprint server for biology 2024 Mar 19;
Protocol for measuring mitochondrial size in mouse and human liver tissues.
Ramatchandirin B, Iijima M, Ikeda A, Pearah A, Radovick S, Wondisford FE, Sesaki H, He L
STAR protocols 2024 Mar 15;5(1):102842
STAR protocols 2024 Mar 15;5(1):102842
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L
iScience 2024 Mar 15;27(3):109246
iScience 2024 Mar 15;27(3):109246
Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.
Triolo M, Baker N, Agarwal S, Larionov N, Podinić T, Khacho M
iScience 2024 Mar 15;27(3):109164
iScience 2024 Mar 15;27(3):109164
Solute carrier family 35 member A2 regulates mitophagy through the PI3K/AKT/mTOR axis, promoting the proliferation, migration, and invasion of osteosarcoma cells.
Luo X, Zhang J, Guo C, Jiang N, Zhang F, Jiao Q, Xu K, Yang J, Qu G, Lv XB, Zhang Z
Gene 2024 Mar 10;898:148110
Gene 2024 Mar 10;898:148110
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
Neurotransmitter accumulation and Parkinson's disease-like phenotype caused by anion channelrhodopsin opto-controlled astrocytic mitochondrial depolarization in substantia nigra pars compacta.
Li SM, Wang DD, Liu DH, Meng XY, Wang Z, Guo X, Liu Q, Liu PP, Li SA, Wang S, Yang RZ, Xu Y, Wang L, Kang JS
MedComm 2024 Jun;5(6):e568
MedComm 2024 Jun;5(6):e568
Senecavirus A induces mitophagy to promote self-replication through direct interaction of 2C protein with K27-linked ubiquitinated TUFM catalyzed by RNF185.
Chen M, Zhang X, Kong F, Gao P, Ge X, Zhou L, Han J, Guo X, Zhang Y, Yang H
Autophagy 2024 Jun;20(6):1286-1313
Autophagy 2024 Jun;20(6):1286-1313
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.
Liu J, Copland DA, Clare AJ, Gorski M, Richards BT, Scott L, Theodoropoulou S, Greferath U, Cox K, Shi G, Bell OH, Ou K, Powell JLB, Wu J, Robles LM, Li Y, Nicholson LB, Coffey PJ, Fletcher EL, Guymer R, Radeke MJ, Heid IM, Hageman GS, Chan YK, Dick AD
Science translational medicine 2024 Jun 5;16(750):eadi4125
Science translational medicine 2024 Jun 5;16(750):eadi4125
Lactate transported by MCT1 plays an active role in promoting mitochondrial biogenesis and enhancing TCA flux in skeletal muscle.
Zhang L, Xin C, Wang S, Zhuo S, Zhu J, Li Z, Liu Y, Yang L, Chen Y
Science advances 2024 Jun 28;10(26):eadn4508
Science advances 2024 Jun 28;10(26):eadn4508
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624
mSphere 2024 Jun 25;9(6):e0023624
Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior.
Ikeda A, Iijima M, Sesaki H
iScience 2024 Jun 21;27(6):109874
iScience 2024 Jun 21;27(6):109874
The Role of Intestinal Cytochrome P450s in Vitamin D Metabolism.
Uga M, Kaneko I, Shiozaki Y, Koike M, Tsugawa N, Jurutka PW, Miyamoto KI, Segawa H
Biomolecules 2024 Jun 17;14(6)
Biomolecules 2024 Jun 17;14(6)
Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis.
Nagarkoti S, Kim YM, Das A, Ash D, A Vitriol E, Read TA, Sudhahar V, Hossain MS, Yadav S, McMenamin M, Kelley S, Lucas R, Stepp D, Belin de Chantemele EJ, Caldwell RB, Fulton DJ, Fukai T, Ushio-Fukai M
bioRxiv : the preprint server for biology 2024 Jun 16;
bioRxiv : the preprint server for biology 2024 Jun 16;
Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
Al-Lamki RS, Tolkovsky AM, Alawwami M, Lu W, Field SF, Wang J, Pober JS, Bradley JR
The American journal of pathology 2024 Jul;194(7):1374-1387
The American journal of pathology 2024 Jul;194(7):1374-1387
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis.
Ren L, Charbord J, Chu L, Kemas AM, Bertuzzi M, Mi J, Xing C, Lauschke VM, Andersson O
Diabetologia 2024 Jan;67(1):137-155
Diabetologia 2024 Jan;67(1):137-155
Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
Chu C, Wang X, Chen F, Yang C, Shi L, Xu W, Wang K, Liu B, Wang C, Sun D, Li J, Ding W
Cell proliferation 2024 Jan;57(1):e13538
Cell proliferation 2024 Jan;57(1):e13538
A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport.
Mc Cluskey M, Dubouchaud H, Nicot AS, Saudou F
Traffic (Copenhagen, Denmark) 2024 Jan;25(1):e12926
Traffic (Copenhagen, Denmark) 2024 Jan;25(1):e12926
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
Su BQ, Yang GY, Wang J, Ming SL, Chu BB
PLoS pathogens 2024 Jan;20(1):e1011956
PLoS pathogens 2024 Jan;20(1):e1011956
β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway.
Ning Z, Zhong X, Wu Y, Wang Y, Hu D, Wang K, Deng M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155215
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155215
Drp1 regulated PINK1-dependent mitophagy protected duck follicular granulosa cells from acute heat stress injury.
Yang C, Luo P, Yang YT, Fu XL, Li BX, Shen X, Xu DN, Huang YM, Tian YB, Liu WJ
Poultry science 2024 Jan;103(1):103247
Poultry science 2024 Jan;103(1):103247
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Shi L, Tan Y, Zheng W, Cao G, Zhou H, Li P, Cui J, Song Y, Feng L, Li H, Shan W, Zhang B, Yi W
Cell death discovery 2024 Jan 26;10(1):53
Cell death discovery 2024 Jan 26;10(1):53
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif.
Pérez-Jover I, Rochon K, Hu D, Mahajan M, Madan Mohan P, Santos-Pérez I, Ormaetxea Gisasola J, Martinez Galvez JM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R
Nature communications 2024 Jan 2;15(1):52
Nature communications 2024 Jan 2;15(1):52
Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2.
Yan CY, Ye Y, Mu HL, Wu T, Huang WS, Wu YP, Sun WY, Liang L, Duan WJ, Ouyang SH, Huang RT, Wang R, Sun XX, Kurihara H, Li YF, He RR
iScience 2024 Jan 19;27(1):108690
iScience 2024 Jan 19;27(1):108690
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.
Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P
Molecular cell 2024 Jan 18;84(2):345-358.e5
Molecular cell 2024 Jan 18;84(2):345-358.e5
NAD(+) dependent UPR(mt) activation underlies intestinal aging caused by mitochondrial DNA mutations.
Yang L, Ruan Z, Lin X, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, Qin D, Lu G, Loomes KM, Chan WY, Liu X
Nature communications 2024 Jan 16;15(1):546
Nature communications 2024 Jan 16;15(1):546
Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.
Tian W, Shi D, Zhang Y, Wang H, Tang H, Han Z, Wong CCL, Cui L, Zheng J, Chen Y
Communications biology 2024 Jan 15;7(1):99
Communications biology 2024 Jan 15;7(1):99
Activation of mitophagy improves cognitive dysfunction in diabetic mice with recurrent non-severe hypoglycemia.
Wu K, Huang C, Zheng W, Wu Y, Huang Q, Lin M, Gao R, Qi L, He G, Liu X, Liu X, Wang L, Chen Z, Liu L
Molecular and cellular endocrinology 2024 Jan 15;580:112109
Molecular and cellular endocrinology 2024 Jan 15;580:112109
Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.
Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z
Redox biology 2024 Feb;69:103002
Redox biology 2024 Feb;69:103002
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X
Redox biology 2024 Feb;69:102990
Redox biology 2024 Feb;69:102990
Stress response silencing by an E3 ligase mutated in neurodegeneration.
Haakonsen DL, Heider M, Ingersoll AJ, Vodehnal K, Witus SR, Uenaka T, Wernig M, Rapé M
Nature 2024 Feb;626(8000):874-880
Nature 2024 Feb;626(8000):874-880
Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation.
Parmar G, Fong-McMaster C, Pileggi CA, Patten DA, Cuillerier A, Myers S, Wang Y, Hekimi S, Cuperlovic-Culf M, Harper ME
The Journal of biological chemistry 2024 Feb;300(2):105626
The Journal of biological chemistry 2024 Feb;300(2):105626
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Jiang HL, Yang HH, Liu YB, Duan JX, Guan XX, Zhang CY, Zhong WJ, Jin L, Li D, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2024 Feb;239(2):e31169
Journal of cellular physiology 2024 Feb;239(2):e31169
Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice.
Tang L, Zhang H, Liao Y, Zhou S, Yang Y, Zhang M, Guo Y, Xie T, Chen S, Ouyang W, Lin X, Wang S, Huang C, Zhang M, Zhuang J, Zhao J, Zhang R, Zhang C, Jin Z, Hu J, Liu Z
The American journal of pathology 2024 Feb;194(2):307-320
The American journal of pathology 2024 Feb;194(2):307-320
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Song Y, Geng W, Zhu D, Liang H, Du Z, Tong B, Wang K, Li S, Gao Y, Feng X, Liao Z, Mei R, Yang C
Free radical biology & medicine 2024 Feb 20;212:220-233
Free radical biology & medicine 2024 Feb 20;212:220-233
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
Ma W, Sun Y, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P, Zhang H
Molecular cell 2024 Feb 1;84(3):538-551.e7
Molecular cell 2024 Feb 1;84(3):538-551.e7
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
Yao H, Zhao H, Du Y, Zhang Y, Li Y, Zhu H
Translational research : the journal of laboratory and clinical medicine 2024 Aug;270:1-12
Translational research : the journal of laboratory and clinical medicine 2024 Aug;270:1-12
Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression.
Su Y, Bu F, Zhu Y, Yang L, Wu Q, Zheng Y, Zhao J, Yu L, Jiang N, Wang Y, Wu J, Xie Y, Zhang X, Gao Y, Lan K, Deng Q
Science bulletin 2024 Aug 30;69(16):2580-2595
Science bulletin 2024 Aug 30;69(16):2580-2595
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Yang M, Liu Y, Luo SL, Liu CB, Jiang N, Li CR, Zhao H, Han YC, Chen W, Li L, Sun L
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects.
Wang P, Yang Y, Guo J, Ma T, Hu Y, Huang L, He Y, Xi J
Biological trace element research 2024 Apr;202(4):1669-1682
Biological trace element research 2024 Apr;202(4):1669-1682
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Song Y, Liang H, Li G, Ma L, Zhu D, Zhang W, Tong B, Li S, Gao Y, Wu X, Zhang Y, Feng X, Wang K, Yang C
Autophagy 2024 Apr;20(4):809-829
Autophagy 2024 Apr;20(4):809-829
Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments.
Zhou S, Li X, Liang F, Ji G, Lv K, Yuan Y, Zhao Y, Yan N, Zhang C, Cai S, Zhang S, Liu X, Song B, Qu L
International journal of molecular sciences 2024 Apr 29;25(9)
International journal of molecular sciences 2024 Apr 29;25(9)
Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis.
Xu C, Mei Y, Yang R, Luo Q, Zhang J, Kou X, Hu J, Wang Y, Li Y, Chen R, Zhang Z, Yao Y, Sima J
Cell & bioscience 2024 Apr 27;14(1):55
Cell & bioscience 2024 Apr 27;14(1):55
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Guo P, Hu S, Liu X, He M, Li J, Ma T, Huang M, Fang Q, Wang Y
Journal of translational medicine 2024 Apr 26;22(1):390
Journal of translational medicine 2024 Apr 26;22(1):390
Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks.
Jin M, Iwamoto Y, Shirazinejad C, Drubin DG
bioRxiv : the preprint server for biology 2024 Apr 22;
bioRxiv : the preprint server for biology 2024 Apr 22;
Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease.
Ito R, Xie S, Tumenjargal M, Sugahara Y, Yang C, Takahashi H, Arai M, Inoue SI, Uchida A, Nakano K, Choi H, Yang G, Zhao Y, Yamaguchi R, Jin H, Sagae H, Wada Y, Tanaka T, Kimura H, Kodama T, Aburatani H, Takeda K, Inagaki T, Osborne TF, Yoneshiro T, Matsumura Y, Sakai J
iScience 2024 Apr 19;27(4):109398
iScience 2024 Apr 19;27(4):109398
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Wang L, Wang B, Zhang X, Yang Z, Zhang X, Gong H, Song Y, Zhang K, Sun M
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission.
Tang H, Yu Q, Chen X, Zhang J, Guo D, Guo W, Zhang S, Shi X
Scientific reports 2024 Apr 12;14(1):8535
Scientific reports 2024 Apr 12;14(1):8535
Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
Luo P, An Y, He J, Xing X, Zhang Q, Liu X, Chen Y, Yuan H, Chen J, Wong YK, Huang J, Gong Z, Du Q, Xiao W, Wang J
Cancer letters 2024 Apr 10;587:216621
Cancer letters 2024 Apr 10;587:216621
Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.
Fang XX, Wei P, Zhao K, Sheng ZC, Song BL, Yin L, Luo J
The Journal of cell biology 2024 Apr 1;223(4)
The Journal of cell biology 2024 Apr 1;223(4)
In Situ Analysis of Mitochondrial DNA Synthesis Using Metabolic Labeling Coupled to Fluorescence Microscopy.
Smolka JA, Lewis SC
Methods in molecular biology (Clifton, N.J.) 2023;2615:99-106
Methods in molecular biology (Clifton, N.J.) 2023;2615:99-106
Localization of Mitochondrial Nucleoids by Transmission Electron Microscopy Using the Transgenic Expression of the Mitochondrial Helicase Twinkle and APEX2.
Pla-Martín D, Babatz F, Schauss AC
Methods in molecular biology (Clifton, N.J.) 2023;2615:173-188
Methods in molecular biology (Clifton, N.J.) 2023;2615:173-188
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Xu WN, Liu C, Zheng HL, Xu HX, Yang RZ, Jiang SD, Zhu LX
International journal of biological sciences 2023;19(2):571-592
International journal of biological sciences 2023;19(2):571-592
Novel FSIP2 Variants Induce Super-Length Mitochondrial Sheath and Asthenoteratozoospermia in Humans.
Lv M, Tang D, Yu H, Geng H, Zhou Y, Shao Z, Li K, Gao Y, Guo S, Xu C, Tan Q, Liu C, Guo R, Wu H, Duan Z, Zhang J, Wang G, Hua R, Fu F, Wang K, Xu Y, Zhou P, Wei Z, Zhang F, Cao Y, He X
International journal of biological sciences 2023;19(2):393-411
International journal of biological sciences 2023;19(2):393-411
Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1.
You Y, Wang H, Wang Q, Yu Z, Zhao Z, Zhuang L, Zeng S, Zheng J, Wen W
Open medicine (Warsaw, Poland) 2023;18(1):20230798
Open medicine (Warsaw, Poland) 2023;18(1):20230798
Electroacupuncture Exerts Chondroprotective Effect in Knee Osteoarthritis of Rabbits Through the Mitophagy Pathway.
Xing L, Chen X, Guo C, Zhu W, Hu T, Ma W, Du M, Xu Y, Guo C
Journal of pain research 2023;16:2871-2882
Journal of pain research 2023;16:2871-2882
Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice.
Gorski K, Jackson CB, Nyman TA, Rezov V, Battersby BJ, Lehesjoki AE
Frontiers in molecular neuroscience 2023;16:1175851
Frontiers in molecular neuroscience 2023;16:1175851
IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells.
Terrén I, Sandá V, Amarilla-Irusta A, Lopez-Pardo A, Sevilla A, Astarloa-Pando G, Amo L, Zenarruzabeitia O, Scorrano L, Borrego F
Frontiers in immunology 2023;14:1211839
Frontiers in immunology 2023;14:1211839
Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation.
Liufu T, Yu H, Yu J, Yu M, Tian Y, Ou Y, Deng J, Xing G, Wang Z
Frontiers in physiology 2023;14:1164287
Frontiers in physiology 2023;14:1164287
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Yu B, Jin L, Yao X, Zhang Y, Zhang G, Wang F, Su X, Fang Q, Xiao L, Yang Y, Jiang LH, Chen J, Yang W, Lin W, Han F
Theranostics 2023;13(13):4356-4375
Theranostics 2023;13(13):4356-4375
F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α.
Guo L, Gu Z
Frontiers in oncology 2023;13:1207603
Frontiers in oncology 2023;13:1207603
Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.
Zhou H, Wan S, Luo Y, Liu H, Jiang J, Guo Y, Xiao J, Wu B
Gastroenterology report 2023;11:goad006
Gastroenterology report 2023;11:goad006
SNAP25 ameliorates postoperative cognitive dysfunction by facilitating PINK1-dependent mitophagy and impeding caspase-3/GSDME-dependent pyroptosis.
Wang W, Gao W, Zhang L, Xia Z, Zhao B
Experimental neurology 2023 Sep;367:114463
Experimental neurology 2023 Sep;367:114463
Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction.
Pellegrini H, Sharpe EH, Liu G, Nishiuchi E, Doerr N, Kipp KR, Chin T, Schimmel MF, Weimbs T
The Journal of biological chemistry 2023 Sep;299(9):105158
The Journal of biological chemistry 2023 Sep;299(9):105158
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture.
Ma Q, Xin J, Peng Q, Li N, Sun S, Hou H, Ma G, Wang N, Zhang L, Tam KY, Dussmann H, Prehn JH, Wang H, Ying Z
EMBO reports 2023 Sep 6;24(9):e55859
EMBO reports 2023 Sep 6;24(9):e55859
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.
Shelton SD, House S, Ramesh V, Chen Z, Wei T, Wang X, Llamas CB, Venigalla SSK, Menezes CJ, Zhao Z, Gill JG, DeBerardinis RJ, Morrison SJ, Tasdogan A, Mishra P
bioRxiv : the preprint server for biology 2023 Sep 5;
bioRxiv : the preprint server for biology 2023 Sep 5;
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L, Liu X
Cell death & disease 2023 Sep 30;14(9):645
Cell death & disease 2023 Sep 30;14(9):645
The actin binding protein profilin 1 is critical for mitochondria function.
Read TA, Cisterna BA, Skruber K, Ahmadieh S, Lindamood HL, Vitriol JA, Shi Y, Lefebvre AEYT, Black JB, Butler MT, Bear JE, Cherezova A, Ilatovskaya DV, Weintraub NL, Vitriol EA
bioRxiv : the preprint server for biology 2023 Sep 19;
bioRxiv : the preprint server for biology 2023 Sep 19;
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membrane.
Zhang S, Guo Y, Fidelito G, Robinson DRL, Liang C, Lim R, Bichler Z, Guo R, Wu G, Xu H, Zhou QD, Singh BK, Yen P, Kappei D, Stroud DA, Ho L
iScience 2023 Sep 15;26(9):107558
iScience 2023 Sep 15;26(9):107558
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Zhu SY, Zhou WQ, Niu YY, Zheng C, Liu X, Zhang YY, Yu C
Acta pharmacologica Sinica 2023 Oct;44(10):2091-2102
Acta pharmacologica Sinica 2023 Oct;44(10):2091-2102
Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function.
Wu Q, Hu Z, Wang Z, Che Y, Zhang M, Zheng S, Xing K, Zhong X, Chen Y, Shi F, Yuan S
Translational research : the journal of laboratory and clinical medicine 2023 Oct;260:1-16
Translational research : the journal of laboratory and clinical medicine 2023 Oct;260:1-16
Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS.
Ruan Y, Cheng J, Dai J, Ma Z, Luo S, Yan R, Wang L, Zhou J, Yu B, Tong X, Shen H, Zhou L, Yuan TF, Han Q
Science advances 2023 Oct 6;9(40):eadh0183
Science advances 2023 Oct 6;9(40):eadh0183
Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia.
Henning Y, Willbrand K, Larafa S, Weißenberg G, Matschke V, Theiss C, Görtz GE, Matschke J
Cell death discovery 2023 Oct 25;9(1):398
Cell death discovery 2023 Oct 25;9(1):398
Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.
Sun Y, Zheng H, Qian L, Liu Y, Zhu D, Xu Z, Chang W, Xu J, Wang L, Sun B, Gu L, Yuan H, Lou H
JACS Au 2023 Oct 23;3(10):2749-2762
JACS Au 2023 Oct 23;3(10):2749-2762
The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.
Lee H, Lee TJ, Galloway CA, Zhi W, Xiao W, de Mesy Bentley KL, Sharma A, Teng Y, Sesaki H, Yoon Y
Nature communications 2023 Oct 23;14(1):6721
Nature communications 2023 Oct 23;14(1):6721
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Ye H, Li D, Wei X, Yu L, Jia L
iScience 2023 Oct 20;26(10):107772
iScience 2023 Oct 20;26(10):107772
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
Lee Q, Chan WC, Qu X, Sun Y, Abdelkarim H, Le J, Saqib U, Sun MY, Kruse K, Banerjee A, Hitchinson B, Geyer M, Huang F, Guaiquil V, Mutso AA, Sanders M, Rosenblatt MI, Maienschein-Cline M, Lawrence MS, Gaponenko V, Malik AB, Komarova YA
Cell reports. Medicine 2023 Oct 17;4(10):101223
Cell reports. Medicine 2023 Oct 17;4(10):101223
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J
The EMBO journal 2023 Oct 16;42(20):e113743
The EMBO journal 2023 Oct 16;42(20):e113743
Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy.
Chu C, Wang X, Yang C, Chen F, Shi L, Xu W, Wang K, Liu B, Wang C, Sun D, Ding W
Redox biology 2023 Nov;67:102906
Redox biology 2023 Nov;67:102906
Inhibition of TMEM16A improves cisplatin-induced acute kidney injury via preventing DRP1-mediated mitochondrial fission.
Li XL, Liu XW, Liu WL, Lin YQ, Liu J, Peng YS, Cheng LM, Du YH
Acta pharmacologica Sinica 2023 Nov;44(11):2230-2242
Acta pharmacologica Sinica 2023 Nov;44(11):2230-2242
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells.
Xu W, Ma X, Wang Q, Ye J, Wang N, Ye Z, Chen T
Cellular & molecular biology letters 2023 Nov 7;28(1):90
Cellular & molecular biology letters 2023 Nov 7;28(1):90
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Zhou Q, Yang Y, Xu Z, Deng K, Zhang Z, Hao J, Li N, Wang Y, Wang Z, Chen H, Yang Y, Xiao F, Zhang X, Gao S, Li YP
EMBO reports 2023 Nov 6;24(11):e56614
EMBO reports 2023 Nov 6;24(11):e56614
mtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible foci analysis.
Rey T, Tábara LC, Prudent J, Minczuk M
Nucleic acids research 2023 Nov 27;51(21):e107
Nucleic acids research 2023 Nov 27;51(21):e107
WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis.
Tai P, Chen X, Jia G, Chen G, Gong L, Cheng Y, Li Z, Wang H, Chen A, Zhang G, Zhu Y, Xiao M, Wang Z, Liu Y, Shan D, He D, Li M, Zhan T, Khan A, Li X, Zeng X, Li C, Ouyang D, Ai K, Chen X, Liu D, Liu Z, Wei D, Cao K
Journal of translational medicine 2023 Nov 17;21(1):823
Journal of translational medicine 2023 Nov 17;21(1):823
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.
Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L
Neuron 2023 Nov 15;111(22):3634-3649.e7
Neuron 2023 Nov 15;111(22):3634-3649.e7
SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity.
Cho Y, Hwang JW, Park NJ, Moon J, Ali KH, Seo YH, Kim IS, Kim SN, Kim YK
Free radical biology & medicine 2023 Nov 1;208:73-87
Free radical biology & medicine 2023 Nov 1;208:73-87
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Xu B, Zhou Z, Fang J, Wang J, Tao K, Liu J, Liu S
Free radical biology & medicine 2023 Nov 1;208:319-333
Free radical biology & medicine 2023 Nov 1;208:319-333
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Zhu Z, Li X, Wang X, Zuo X, Ma Y, Gao X, Liang Z, Zhang Z, Song Z, Ding T, Ju C, Li P, Li K, Zhang J, Quan H, Wang Z, Hu X
Bioengineering & translational medicine 2023 May;8(3):e10473
Bioengineering & translational medicine 2023 May;8(3):e10473
Segregation of pathways leading to pexophagy.
Barone FG, Urbé S, Clague MJ
Life science alliance 2023 May;6(5)
Life science alliance 2023 May;6(5)
Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission.
Inoue T, Miura K, Han R, Seto-Tetsuo F, Arioka M, Igawa K, Tomooka K, Sasaguri T
Journal of pharmacological sciences 2023 May;152(1):39-49
Journal of pharmacological sciences 2023 May;152(1):39-49
SAR-guided development of indole-matrine hybrids as potential anticancer agents via mitochondrial stress/cytochrome c/caspase 3 signaling pathway.
Li L, Li J, Ma L, Shang H, Zou Z
Bioorganic chemistry 2023 May;134:106341
Bioorganic chemistry 2023 May;134:106341
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
Dong Y, Han F, Su Y, Sun B, Zhao W, Pan C
International immunopharmacology 2023 May;118:110056
International immunopharmacology 2023 May;118:110056
Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV Replication via the TRIM28-Mediated Degradation of HBx.
Liu C, Zhao K, Chen Y, Yao Y, Tang J, Wang J, Xu C, Yang Q, Zheng Y, Yuan Y, Sun H, Zhang Y, Zhou Y, Chen J, Wang Y, Wu C, Pei R, Chen X
Journal of virology 2023 May 31;97(5):e0058023
Journal of virology 2023 May 31;97(5):e0058023
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts.
Huang T, Wang Y, Yu Z, Miao X, Jiang Z, Yu K, Fu M, Lai K, Wang Y, Yang G
iScience 2023 May 19;26(5):106682
iScience 2023 May 19;26(5):106682
Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
Pusec CM, Ilievski V, De Jesus A, Farooq Z, Zapater JL, Sweis N, Ismail H, Khan MW, Ardehali H, Cordoba-Chacon J, Layden BT
Scientific reports 2023 May 17;13(1):8034
Scientific reports 2023 May 17;13(1):8034
β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
Hua F, Zhu H, Yu W, Zheng Q, Zhang L, Liang W, Lin Y, Xiao F, Yi P, Xiong Y, Dong Y, Li H, Fang L, Liu H, Ying J, Wang X
Journal of neuroinflammation 2023 May 11;20(1):113
Journal of neuroinflammation 2023 May 11;20(1):113
Necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitate Pseudomonas aeruginosa mediated lung injury.
Li H, Guan J, Chen J, Sun W, Chen H, Wen Y, Chen Q, Xie S, Zhang X, Tao A, Yan J
Biochimica et biophysica acta. Molecular basis of disease 2023 Mar;1869(3):166613
Biochimica et biophysica acta. Molecular basis of disease 2023 Mar;1869(3):166613
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
Jiang Y, Li Y, Zhang Y, Hu D, Zhang S, Wang C, Huang S, Zhang A, Jia Z, You R
International immunopharmacology 2023 Mar;116:109847
International immunopharmacology 2023 Mar;116:109847
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Zhong WJ, Zhang J, Duan JX, Zhang CY, Ma SC, Li YS, Yang NS, Yang HH, Xiong JB, Guan CX, Jiang ZX, You ZJ, Zhou Y
Journal of translational medicine 2023 Mar 6;21(1):179
Journal of translational medicine 2023 Mar 6;21(1):179
RNA localization mechanisms transcend cell morphology.
Goering R, Arora A, Pockalny MC, Taliaferro JM
eLife 2023 Mar 3;12
eLife 2023 Mar 3;12
Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations.
Triolo M, Wade S, Baker N, Khacho M
STAR protocols 2023 Mar 17;4(1):102107
STAR protocols 2023 Mar 17;4(1):102107
YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
Li T, Zheng Y, Wu Z, Guo M, Liu R, Zeng W, Lv Y
Toxicology letters 2023 Mar 15;377:38-50
Toxicology letters 2023 Mar 15;377:38-50
STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
Qin C, Wang Y, Zhao B, Li Z, Li T, Yang X, Zhao Y, Wang W
Cell death & disease 2023 Mar 11;14(3):191
Cell death & disease 2023 Mar 11;14(3):191
Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids.
Bai J, Koos DS, Stepanian K, Fouladian Z, Shayler DWH, Aparicio JG, Fraser SE, Moats RA, Cobrinik D
bioRxiv : the preprint server for biology 2023 Mar 1;
bioRxiv : the preprint server for biology 2023 Mar 1;
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Hong JR, Jin L, Zhang CY, Zhong WJ, Yang HH, Wang GM, Ma SC, Guan CX, Li Q, Zhou Y
Heliyon 2023 Jun;9(6):e17361
Heliyon 2023 Jun;9(6):e17361
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
Lai X, Zhang Y, Wu J, Shen M, Yin S, Yan J
Neurotoxicity research 2023 Jun;41(3):242-255
Neurotoxicity research 2023 Jun;41(3):242-255
Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice.
Wang X, Wang L, Luo M, Bu Q, Liu C, Jiang L, Xu R, Wang S, Zhang H, Zhang J, Wan X, Li H, Wang Y, Liu B, Zhao Y, Chen Y, Dai Y, Li M, Wang H, Tian J, Zhao Y, Cen X
Cell biology and toxicology 2023 Jun;39(3):771-793
Cell biology and toxicology 2023 Jun;39(3):771-793
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Wang F, Fan X, Kong J, Wang C, Ma B, Sun W, Ye Z, Liu P, Wen J
Vascular 2023 Jun;31(3):533-543
Vascular 2023 Jun;31(3):533-543
Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC
The Journal of biological chemistry 2023 Jun;299(6):104774
The Journal of biological chemistry 2023 Jun;299(6):104774
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, Fiorino G, Watzlawik JO, Hou X, McCarty AM, Lewis-Tuffin LJ, Zhong J, Madden BJ, Ordureau A, An H, Puschmann A, Wszolek ZK, Ross OA, Harper JW, Caulfield TR, Springer W
Autophagy 2023 Jun;19(6):1711-1732
Autophagy 2023 Jun;19(6):1711-1732
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
Chen R, Yang T, Jin B, Xu W, Yan Y, Wood N, Lehmann HI, Wang S, Zhu X, Yuan W, Chen H, Liu Z, Li G, Bowen TS, Li J, Xiao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2206732
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2206732
LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
Meng K, Lu S, Li YY, Hu LL, Zhang J, Cao Y, Wang Y, Zhang CZ, He QY
EMBO reports 2023 Jun 5;24(6):e56282
EMBO reports 2023 Jun 5;24(6):e56282
Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand.
Greiser M, Karbowski M, Kaplan AD, Coleman AK, Verhoeven N, Mannella CA, Lederer WJ, Boyman L
eLife 2023 Jun 5;12
eLife 2023 Jun 5;12
MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells.
Cao Y, Xia Y, Wang Y, Shi H, Wu Y, Lu Y
Journal of clinical and translational hepatology 2023 Jun 28;11(3):584-594
Journal of clinical and translational hepatology 2023 Jun 28;11(3):584-594
Microcystin-LR-Exposure-Induced Kidney Damage by Inhibiting MKK6-Mediated Mitophagy in Mice.
Yao X, Liu Y, Yang Y, Li Y, Hu N, Song F, Yang F
Toxins 2023 Jun 19;15(6)
Toxins 2023 Jun 19;15(6)
Expanding DdCBE-mediated targeting scope to aC motif preference in rat.
Qi X, Tan L, Zhang X, Jin J, Kong W, Chen W, Wang J, Dong W, Gao L, Luo L, Lu D, Gong J, Guan F, Shu W, Huang X, Zhang L, Wang S, Shen B, Ma Y
Molecular therapy. Nucleic acids 2023 Jun 13;32:1-12
Molecular therapy. Nucleic acids 2023 Jun 13;32:1-12
High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs.
Zheng P, Ma W, Gu Y, Wu H, Bian Z, Liu N, Yang D, Chen X
Journal of clinical biochemistry and nutrition 2023 Jul;73(1):61-76
Journal of clinical biochemistry and nutrition 2023 Jul;73(1):61-76
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3-mediated mitophagy.
Wei Y, Xiao G, Xu H, Sun X, Shi Y, Wang F, Kang J, Peng J, Zhou F
The FEBS journal 2023 Jul;290(14):3629-3645
The FEBS journal 2023 Jul;290(14):3629-3645
Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis.
Zhou YX, Wei J, Deng G, Hu A, Sun PY, Zhao X, Song BL, Luo J
Nature cell biology 2023 Jul;25(7):937-949
Nature cell biology 2023 Jul;25(7):937-949
Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis.
Radaelli E, Assenmacher CA, Verrelle J, Banerjee E, Manero F, Khiati S, Girona A, Lopez-Lluch G, Navas P, Spinazzi M
eLife 2023 Jul 28;12
eLife 2023 Jul 28;12
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury.
Wu C, Wang L, Chen S, Shi L, Liu M, Tu P, Sun J, Zhao R, Zhang Y, Wang J, Pan Y, Ma Y, Guo Y
Journal of neuroinflammation 2023 Jul 22;20(1):171
Journal of neuroinflammation 2023 Jul 22;20(1):171
Spatial topology of organelle is a new breast cancer cell classifier.
Wang L, Goldwag J, Bouyea M, Barra J, Matteson K, Maharjan N, Eladdadi A, Embrechts MJ, Intes X, Kruger U, Barroso M
iScience 2023 Jul 21;26(7):107229
iScience 2023 Jul 21;26(7):107229
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Mozzi A, Oldani M, Forcella ME, Vantaggiato C, Cappelletti G, Pontremoli C, Valenti F, Forni D, Saresella M, Biasin M, Sironi M, Fusi P, Cagliani R
iScience 2023 Jul 21;26(7):107118
iScience 2023 Jul 21;26(7):107118
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness.
He B, Gao R, Lv S, Chen A, Huang J, Wang L, Feng Y, Feng J, Liu B, Lei J, Deng B, He B, Cui B, Peng F, Yan M, Wang Z, Lam EW, Jin B, Shao Z, Li Y, Jiao J, Wang X, Liu Q
Signal transduction and targeted therapy 2023 Jul 19;8(1):275
Signal transduction and targeted therapy 2023 Jul 19;8(1):275
Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif.
Pérez-Jover I, Rochon K, Hu D, Mohan PM, Santos-Perez I, Gisasola JO, Galvez JMM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R
Research square 2023 Jul 18;
Research square 2023 Jul 18;
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization.
Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P
Nature 2023 Jan;613(7942):160-168
Nature 2023 Jan;613(7942):160-168
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C, Wang H, Wang H, Du M, Peng P, Jia H, Xu X, Wang J, Yang L, Luo Z
Experimental & molecular medicine 2023 Jan;55(1):253-268
Experimental & molecular medicine 2023 Jan;55(1):253-268
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.
Guo Y, Wen J, He A, Qu C, Peng Y, Luo S, Wang X
Journal of advanced research 2023 Jan;43:175-186
Journal of advanced research 2023 Jan;43:175-186
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.
Zhang Y, Fang Q, Wang H, Qi J, Sun S, Liao M, Wu Y, Hu Y, Jiang P, Cheng C, Qian X, Tang M, Cao W, Xiang S, Zhang C, Yang J, Gao X, Ying Z, Chai R
Autophagy 2023 Jan;19(1):75-91
Autophagy 2023 Jan;19(1):75-91
SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2.
Jiang X, Liu K, Jiang H, Yin H, Wang ED, Cheng H, Yuan F, Xiao F, Wang F, Lu W, Peng B, Shu Y, Li X, Chen S, Guo F
Cell reports 2023 Jan 31;42(1):111984
Cell reports 2023 Jan 31;42(1):111984
S-Doped carbonized polymer dots inhibit early myocardial fibrosis by regulating mitochondrial function.
Wang Y, Yang M, Zhang J, Ren J, Liu N, Liu B, Lu L, Yang B
Biomaterials science 2023 Jan 31;11(3):894-907
Biomaterials science 2023 Jan 31;11(3):894-907
Golgi damage caused by dysfunction of PiT-2 in primary familial brain calcification.
Sun H, Wang Z, Zhang Q, Chen N, Tang M, Yang Z, Xu Y, Kang J, Wang Y
Biochemical and biophysical research communications 2023 Jan 29;642:167-174
Biochemical and biophysical research communications 2023 Jan 29;642:167-174
Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
Hu T, Meng L, Tan C, Luo C, He WB, Tu C, Zhang H, Du J, Nie H, Lu GX, Lin G, Tan YQ
Journal of medical genetics 2023 Feb;60(2):144-153
Journal of medical genetics 2023 Feb;60(2):144-153
Mice harboring a R133L heterozygous mutation in LMNA exhibited ectopic lipid accumulation, aging, and mitochondrial dysfunction in adipose tissue.
Qiu R, Wang S, Lin D, He Y, Huang S, Wu B, Li H, Wang M, Zheng F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22730
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22730
Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.
Whittle EF, Chilian M, Karimiani EG, Progri H, Buhas D, Kose M, Ganetzky RD, Toosi MB, Torbati PN, Badv RS, Shelihan I, Yang H, Elloumi HZ, Lee S, Jamshidi Y, Pittman AM, Houlden H, Ignatius E, Rahman S, Maroofian R, Yoon WH, Carroll CJ
Genetics in medicine : official journal of the American College of Medical Genetics 2023 Feb;25(2):100332
Genetics in medicine : official journal of the American College of Medical Genetics 2023 Feb;25(2):100332
Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
Pan Z, Wu X, Zhang X, Hu K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114095
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114095
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing.
Nabavizadeh N, Bressin A, Shboul M, Moreno Traspas R, Chia PH, Bonnard C, Szenker-Ravi E, Sarıbaş B, Beillard E, Altunoglu U, Hojati Z, Drutman S, Freier S, El-Khateeb M, Fathallah R, Casanova JL, Soror W, Arafat A, Escande-Beillard N, Mayer A, Reversade B
EMBO molecular medicine 2023 Feb 8;15(2):e16478
EMBO molecular medicine 2023 Feb 8;15(2):e16478
Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.
Reynolds MB, Hong HS, Michmerhuizen BC, Lawrence AE, Zhang L, Knight JS, Lyssiotis CA, Abuaita BH, O'Riordan MX
Science advances 2023 Feb 3;9(5):eade8701
Science advances 2023 Feb 3;9(5):eade8701
Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
Liu Y, Liu K, Thorne RF, Shi R, Zhang Q, Wu M, Liu L
Cell reports 2023 Feb 28;42(2):112041
Cell reports 2023 Feb 28;42(2):112041
Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation.
He Y, Ji Z, Gong Y, Fan L, Xu P, Chen X, Miao J, Zhang K, Zhang W, Ma P, Zhao H, Cheng C, Wang D, Wang J, Jing N, Liu K, Zhang P, Dong B, Zhuang G, Fu Y, Xue W, Gao WQ, Zhu HH
Cell reports 2023 Feb 28;42(2):112033
Cell reports 2023 Feb 28;42(2):112033
Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway.
Han X, Wang J, Li R, Huang M, Yue G, Guan L, Deng Y, Cai W, Xu J
International journal of molecular sciences 2023 Feb 28;24(5)
International journal of molecular sciences 2023 Feb 28;24(5)
Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle.
Ouyang Q, Chen Q, Ke S, Ding L, Yang X, Rong P, Feng W, Cao Y, Wang Q, Li M, Su S, Wei W, Liu M, Liu J, Zhang X, Li JZ, Wang HY, Chen S
Developmental cell 2023 Feb 27;58(4):289-305.e6
Developmental cell 2023 Feb 27;58(4):289-305.e6
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
Zhao N, Deng G, Yuan PX, Zhang YF, Jiang LY, Zhao X, Song BL
Journal of lipid research 2023 Dec;64(12):100465
Journal of lipid research 2023 Dec;64(12):100465
Urolithin A protects severe acute pancreatitis-associated acute cardiac injury by regulating mitochondrial fatty acid oxidative metabolism in cardiomyocytes.
Yang Y, Hu Q, Kang H, Li J, Zhao X, Zhu L, Tang W, Wan M
MedComm 2023 Dec;4(6):e459
MedComm 2023 Dec;4(6):e459
Activation of moderate autophagy promotes survival of fat graft.
Pei SJ, Zhu YZ, Yang JM, Zhang MC, Shi CL, Ding Y, Yi YY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23289
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23289
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.
Guo B, Song H, Fan J, Wang B, Chen L, Hu Q, Yin Y
Experimental brain research 2023 Dec;241(11-12):2735-2750
Experimental brain research 2023 Dec;241(11-12):2735-2750
Zinc Overload Induces Damage to H9c2 Cardiomyocyte Through Mitochondrial Dysfunction and ROS-Mediated Mitophagy.
Yang Y, Wang P, Guo J, Ma T, Hu Y, Huang L, Xing B, He Y, Xi J
Cardiovascular toxicology 2023 Dec;23(11-12):388-405
Cardiovascular toxicology 2023 Dec;23(11-12):388-405
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors.
Chowdhury S, Latham KA, Tran AC, Carroll CJ, Stanton RJ, Weekes MP, Neil SJD, Swanson CM, Strang BL
The Journal of general virology 2023 Dec;104(12)
The Journal of general virology 2023 Dec;104(12)
RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.
Susanto TT, Hung V, Levine AG, Kerr CH, Yoo Y, Chen Y, Oses-Prieto JA, Fromm L, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M
bioRxiv : the preprint server for biology 2023 Dec 7;
bioRxiv : the preprint server for biology 2023 Dec 7;
Mammalian autophagosomes form from finger-like phagophores.
Puri C, Gratian MJ, Rubinsztein DC
Developmental cell 2023 Dec 4;58(23):2746-2760.e5
Developmental cell 2023 Dec 4;58(23):2746-2760.e5
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.
Hong JR, Zhang CY, Zhong WJ, Yang HH, Xiong JB, Deng P, Yang NS, Chen H, Jin L, Guan CX, Duan JX, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937
SIRT3 Regulates Levels of Deacetylated SOD2 to Prevent Oxidative Stress and Mitochondrial Dysfunction During Oocyte Maturation in Pigs.
Jiao L, Hu CX, Zhang Y, Zhang YX, Cai WW, Pan WL, Sun SC, Zhang Y
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2149-2160
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2149-2160
The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication.
Zhang S, Zeng L, Su B-Q, Yang G-Y, Wang J, Ming S-L, Chu B-B
mBio 2023 Dec 19;14(6):e0265123
mBio 2023 Dec 19;14(6):e0265123
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.
Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, Zhang Y, Liu B, Wang J, Zhao W, Li M, Wei L
mBio 2023 Dec 19;14(6):e0148023
mBio 2023 Dec 19;14(6):e0148023
Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects.
Tan S, Wang D, Fu Y, Zheng H, Liu Y, Lu B
Science bulletin 2023 Dec 15;68(23):3013-3026
Science bulletin 2023 Dec 15;68(23):3013-3026
Plasma membrane lipid composition and metabolomics analysis of Yorkshire boar sperms with high and low resistance to cryopreservation.
Zhang Y, Yuan W, Liu Y, Liu Y, Liang H, Xu Q, Liu Z, Weng X
Theriogenology 2023 Aug;206:28-39
Theriogenology 2023 Aug;206:28-39
Hypoxia causes pancreatic β-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40.
Tsuyama T, Sato Y, Yoshizawa T, Matsuoka T, Yamagata K
EMBO reports 2023 Aug 3;24(8):e56227
EMBO reports 2023 Aug 3;24(8):e56227
COPI-regulated mitochondria-ER contact site formation maintains axonal integrity.
Maddison DC, Malik B, Amadio L, Bis-Brewer DM, Züchner S, Peters OM, Smith GA
Cell reports 2023 Aug 29;42(8):112883
Cell reports 2023 Aug 29;42(8):112883
RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.
Liu C, Wang L, Li Y, Guo M, Hu J, Wang T, Li M, Yang Z, Lin R, Xu W, Chen Y, Luo M, Gao F, Chen JY, Sun Q, Liu H, Sun B, Li W
Nucleic acids research 2023 Aug 11;51(14):7357-7375
Nucleic acids research 2023 Aug 11;51(14):7357-7375
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, Guo Y, Zhao Q, Xie X, He Y, Du G, Pang X
Journal of ethnopharmacology 2023 Aug 10;312:116455
Journal of ethnopharmacology 2023 Aug 10;312:116455
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Jiang C, Shen J, Wang C, Huang Y, Wang L, Yang Y, Hu W, Li P, Wu H
Toxicology letters 2023 Aug 1;384:86-95
Toxicology letters 2023 Aug 1;384:86-95
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J
Nature metabolism 2023 Apr;5(4):642-659
Nature metabolism 2023 Apr;5(4):642-659
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy.
Li L, Song JJ, Zhang MX, Zhang HW, Zhu HY, Guo W, Pan CL, Liu X, Xu L, Zhang ZY
Acta pharmacologica Sinica 2023 Apr;44(4):726-740
Acta pharmacologica Sinica 2023 Apr;44(4):726-740
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
Oxidative stress in human gingival fibroblasts from periodontitis versus healthy counterparts.
Liu J, Wang X, Zheng M, Luan Q
Oral diseases 2023 Apr;29(3):1214-1225
Oral diseases 2023 Apr;29(3):1214-1225
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia.
Gohel D, Shukla S, Rajan WD, Wojtas B, Kaminska B, Singh R
Free radical biology & medicine 2023 Apr;199:26-33
Free radical biology & medicine 2023 Apr;199:26-33
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction.
Guo Y, Zhang H, Yan C, Shen B, Zhang Y, Guo X, Sun S, Yu F, Yan J, Liu R, Zhang Q, Zhang D, Liu H, Liu Y, Zhang Y, Li W, Qin J, Lv H, Wang Z, Yuan Y, Yang JF, Zhong YT, Gao S, Zhou B, Liu L, Kong D, Hao X, Hu J, Chen Q
Nature chemical biology 2023 Apr;19(4):468-477
Nature chemical biology 2023 Apr;19(4):468-477
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Cai W, Hu M, Li C, Wu R, Lu D, Xie C, Zhang W, Li T, Shen S, Huang H, Qiu W, Liu Q, Lu Y, Lu Z
Autophagy 2023 Apr;19(4):1144-1163
Autophagy 2023 Apr;19(4):1144-1163
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.
Yang D, He L, Ma S, Li S, Zhang Y, Hu C, Huang J, Xu Z, Tang D, Chen Z
International journal of molecular sciences 2023 Apr 3;24(7)
International journal of molecular sciences 2023 Apr 3;24(7)
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.
Cai S, Zhang C, Zhuang Z, Zhang S, Ma L, Yang S, Zhou T, Wang Z, Xie W, Jin S, Zhao J, Guan X, Wu J, Cui J, Wu Y
Signal transduction and targeted therapy 2023 Apr 26;8(1):170
Signal transduction and targeted therapy 2023 Apr 26;8(1):170
Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis.
Chen Z, Ho IL, Soeung M, Yen EY, Liu J, Yan L, Rose JL, Srinivasan S, Jiang S, Edward Chang Q, Feng N, Gay JP, Wang Q, Wang J, Lorenzi PL, Veillon LJ, Wei B, Weinstein JN, Deem AK, Gao S, Genovese G, Viale A, Yao W, Lyssiotis CA, Marszalek JR, Draetta GF, Ying H
Nature communications 2023 Apr 17;14(1):2194
Nature communications 2023 Apr 17;14(1):2194
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
Morris S, Molina-Riquelme I, Barrientos G, Bravo F, Aedo G, Gómez W, Lagos D, Verdejo H, Peischard S, Seebohm G, Psathaki OE, Eisner V, Busch KB
Biochimica et biophysica acta. Bioenergetics 2023 Apr 1;1864(2):148949
Biochimica et biophysica acta. Bioenergetics 2023 Apr 1;1864(2):148949
Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro.
Heuschkel MA, Babler A, Heyn J, van der Vorst EPC, Steenman M, Gesper M, Kappel BA, Magne D, Gouëffic Y, Kramann R, Jahnen-Dechent W, Marx N, Quillard T, Goettsch C
Frontiers in cardiovascular medicine 2022;9:959457
Frontiers in cardiovascular medicine 2022;9:959457
Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy.
Wei X, Chang ACH, Chang H, Xu S, Xue Y, Zhang Y, Lei M, Chang ACY, Zhang Q
Frontiers in cardiovascular medicine 2022;9:800185
Frontiers in cardiovascular medicine 2022;9:800185
Disruption of cellular iron homeostasis by IREB2 missense variants causes severe neurodevelopmental delay, dystonia and seizures.
Maio N, Saneto RP, Steet R, Sotero de Menezes MA, Skinner C, Rouault TA
Brain communications 2022;4(3):fcac102
Brain communications 2022;4(3):fcac102
Examining Mitochondrial Morphology in Mouse Brains.
Royea J, Khacho M
Methods in molecular biology (Clifton, N.J.) 2022;2515:17-28
Methods in molecular biology (Clifton, N.J.) 2022;2515:17-28
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE.
Ren C, Hu C, Wu Y, Li T, Zou A, Yu D, Shen T, Cai W, Yu J
Oxidative medicine and cellular longevity 2022;2022:5961123
Oxidative medicine and cellular longevity 2022;2022:5961123
Docosahexaenoic Acid Alleviates Brain Damage by Promoting Mitophagy in Mice with Ischaemic Stroke.
Sun E, Zhang J, Deng Y, Wang J, Wu Q, Chen W, Ma X, Chen S, Xiang X, Chen Y, Wu T, Yang Y, Chen B
Oxidative medicine and cellular longevity 2022;2022:3119649
Oxidative medicine and cellular longevity 2022;2022:3119649
San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.
Li H, Wang Y, Su X, Wang Q, Zhang S, Sun W, Zhang T, Dong M, Zhang Z, Lv S
Journal of diabetes research 2022;2022:2640209
Journal of diabetes research 2022;2022:2640209
The Valuable Role of ARMC1 in Invasive Breast Cancer as a Novel Biomarker.
Gan Y, Zhong F, Wang H, Li L
BioMed research international 2022;2022:1740295
BioMed research international 2022;2022:1740295
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
Wang X, Shelton SD, Bordieanu B, Frank AR, Yi Y, Venigalla SSK, Gu Z, Lenser NP, Glogauer M, Chandel NS, Zhao H, Zhao Z, McFadden DG, Mishra P
Nature aging 2022;2(2):155-169
Nature aging 2022;2(2):155-169
Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation.
Ni Y, Wu GH, Cai JJ, Zhang R, Zheng Y, Liu JQ, Yang XH, Yang X, Shen Y, Lai JM, Ye XM, Mo SJ
International journal of biological sciences 2022;18(13):5168-5184
International journal of biological sciences 2022;18(13):5168-5184
The inhibition of PGAM5 suppresses seizures in a kainate-induced epilepsy model via mitophagy reduction.
Zhong F, Gan Y, Song J, Zhang W, Yuan S, Qin Z, Wu J, Lü Y, Yu W
Frontiers in molecular neuroscience 2022;15:1047801
Frontiers in molecular neuroscience 2022;15:1047801
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Cao X, Chen Y, Sang X, Xu S, Xie Z, Zhu Z, Wang P, Bi J, Xu L
Frontiers in aging neuroscience 2022;14:1013943
Frontiers in aging neuroscience 2022;14:1013943
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Zhu Z, Wang X, Song Z, Zuo X, Ma Y, Zhang Z, Ju C, Liang Z, Li K, Hu X, Wang Z
Frontiers in pharmacology 2022;13:991421
Frontiers in pharmacology 2022;13:991421
MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer.
Hamada K, Kurashige T, Shimamura M, Arakawa H, Nakamura Y, Nagayama Y
Frontiers in endocrinology 2022;13:932754
Frontiers in endocrinology 2022;13:932754
Inhibition of the PINK1-Parkin Pathway Enhances the Lethality of Sorafenib and Regorafenib in Hepatocellular Carcinoma.
Zhang S, Wang Y, Cao Y, Wu J, Zhang Z, Ren H, Xu X, Kaznacheyeva E, Li Q, Wang G
Frontiers in pharmacology 2022;13:851832
Frontiers in pharmacology 2022;13:851832
Characterization and subcellular localization of Alongshan virus proteins.
Zhao Y, Wu P, Liu L, Ma B, Pan M, Huang Y, Du N, Yu H, Sui L, Wang ZD, Hou Z, Liu Q
Frontiers in microbiology 2022;13:1000322
Frontiers in microbiology 2022;13:1000322
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Yang L, Wu C, Parker E, Li Y, Dong Y, Tucker L, Brann DW, Lin HW, Zhang Q
Theranostics 2022;12(5):2205-2231
Theranostics 2022;12(5):2205-2231
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.
Li C, Pan Y, Tan Y, Wang Y, Sun X
Frontiers in cell and developmental biology 2022;10:896014
Frontiers in cell and developmental biology 2022;10:896014
Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE.
Li W, Luo LX, Zhou QQ, Gong HB, Fu YY, Yan CY, Li E, Sun J, Luo Z, Ding ZJ, Zhang QY, Mu HL, Cao YF, Ouyang SH, Kurihara H, Li YF, Sun WY, Li M, He RR
Redox biology 2022 Sep;55:102421
Redox biology 2022 Sep;55:102421
Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.
Lv WH, Zhao T, Pantopoulos K, Chen GH, Wei XL, Zhang DG, Luo Z
Antioxidants & redox signaling 2022 Sep;37(7-9):417-436
Antioxidants & redox signaling 2022 Sep;37(7-9):417-436
Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy.
Ta N, Qu C, Wu H, Zhang D, Sun T, Li Y, Wang J, Wang X, Tang T, Chen Q, Liu L
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2117396119
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2117396119
Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration.
Dahlke E, Engmann T, Anan Y, Häsler R, Solinas G, Theilig F
International journal of molecular sciences 2022 Sep 5;23(17)
International journal of molecular sciences 2022 Sep 5;23(17)
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.
Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J, Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y, Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y, Matsumura Y, Sakai J
Nature communications 2022 Sep 29;13(1):5715
Nature communications 2022 Sep 29;13(1):5715
Differential requirements for mitochondrial electron transport chain components in the adult murine liver.
Lesner NP, Wang X, Chen Z, Frank A, Menezes CJ, House S, Shelton SD, Lemoff A, McFadden DG, Wansapura J, DeBerardinis RJ, Mishra P
eLife 2022 Sep 26;11
eLife 2022 Sep 26;11
In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors.
Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, Solmonson A, Rao AD, Kaushik AK, Rogers TJ, Ubellacker JM, LaVigne CA, Yang C, Ko B, Ramesh V, Sudderth J, Zacharias LG, Martin-Sandoval MS, Do D, Mathews TP, Zhao Z, Mishra P, Morrison SJ, DeBerardinis RJ
Science advances 2022 Sep 2;8(35):eabn9550
Science advances 2022 Sep 2;8(35):eabn9550
Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses.
Li J, Tan X, Sun Q, Li X, Chen R, Luo L
Investigative ophthalmology & visual science 2022 Sep 1;63(10):1
Investigative ophthalmology & visual science 2022 Sep 1;63(10):1
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells.
Baker N, Wade S, Triolo M, Girgis J, Chwastek D, Larrigan S, Feige P, Fujita R, Crist C, Rudnicki MA, Burelle Y, Khacho M
Cell stem cell 2022 Sep 1;29(9):1315-1332.e9
Cell stem cell 2022 Sep 1;29(9):1315-1332.e9
PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway.
Wang Y, Yan S, Liu X, Deng F, Wang P, Yang L, Hu L, Huang K, He J
Cell death and differentiation 2022 Oct;29(10):1982-1995
Cell death and differentiation 2022 Oct;29(10):1982-1995
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Wang R, Shang Y, Chen B, Xu F, Zhang J, Zhang Z, Zhao X, Wan X, Xu A, Wu L, Zhao G
Cell death & disease 2022 Oct 6;13(10):851
Cell death & disease 2022 Oct 6;13(10):851
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, Liao X, Yang C, Qi M, Cheng J, Chen G, Huang L
Cell death & disease 2022 Oct 26;13(10):899
Cell death & disease 2022 Oct 26;13(10):899
CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.
Yu J, Liufu T, Zheng Y, Xu J, Meng L, Zhang W, Yuan Y, Hong D, Charlet-Berguerand N, Wang Z, Deng J
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 11;119(41):e2208649119
Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response.
Tang J, Liu Z, Han J, Xue J, Liu L, Lin J, Wu C, Zhang Q, Wu S, Liu C, Huang H, Fu Y, Li M, Zhuo Y, Li Y
Antioxidants (Basel, Switzerland) 2022 Oct 10;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 10;11(10)
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X
Acta neuropathologica 2022 Nov;144(5):911-938
Acta neuropathologica 2022 Nov;144(5):911-938
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D
Nature communications 2022 Nov 7;13(1):6704
Nature communications 2022 Nov 7;13(1):6704
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway.
Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G, Sima J
Cell & bioscience 2022 Nov 4;12(1):180
Cell & bioscience 2022 Nov 4;12(1):180
Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway.
Li MY, Qin YQ, Tian YG, Li KC, Oliver BG, Liu XF, Zhao P, Li JS
BMC pulmonary medicine 2022 Nov 22;22(1):434
BMC pulmonary medicine 2022 Nov 22;22(1):434
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J
Circulation 2022 Nov 22;146(21):1591-1609
Circulation 2022 Nov 22;146(21):1591-1609
Repeated social defeat stress inhibits development of hippocampus neurons through mitophagy and autophagy.
Guo L, Jiang ZM, Sun RX, Pang W, Zhou X, Du ML, Chen MX, Lv X, Wang JT
Brain research bulletin 2022 May;182:111-117
Brain research bulletin 2022 May;182:111-117
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Lurette O, Guedouari H, Morris JL, Martín-Jiménez R, Robichaud JP, Hamel-Côté G, Khan M, Dauphinee N, Pichaud N, Prudent J, Hebert-Chatelain E
Cellular and molecular life sciences : CMLS 2022 May 30;79(6):327
Cellular and molecular life sciences : CMLS 2022 May 30;79(6):327
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage.
Cao K, Riley JS, Heilig R, Montes-Gómez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP, Tait SWG
Developmental cell 2022 May 23;57(10):1211-1225.e6
Developmental cell 2022 May 23;57(10):1211-1225.e6
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation.
Yang S, Du Y, Zhao X, Tang Q, Su W, Hu Y, Yu P
International journal of molecular sciences 2022 May 11;23(10)
International journal of molecular sciences 2022 May 11;23(10)
MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.
Ito N, Takahashi T, Shiiba I, Nagashima S, Inatome R, Yanagi S
Journal of biochemistry 2022 May 11;171(5):529-541
Journal of biochemistry 2022 May 11;171(5):529-541
TGR5 Agonist INT-777 Alleviates Inflammatory Neurodegeneration in Parkinson's Disease Mouse Model by Modulating Mitochondrial Dynamics in Microglia.
Huang R, Gao Y, Chen J, Duan Q, He P, Zhang J, Huang H, Zhang Q, Ma G, Zhang Y, Nie K, Wang L
Neuroscience 2022 May 10;490:100-119
Neuroscience 2022 May 10;490:100-119
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050
Diabetes 2022 May 1;71(5):1034-1050
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC
Nature 2022 Mar;603(7899):159-165
Nature 2022 Mar;603(7899):159-165
Disruption of STIM1-mediated Ca(2+) sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass.
Wilson RJ, Lyons SP, Koves TR, Bryson VG, Zhang H, Li T, Crown SB, Ding JD, Grimsrud PA, Rosenberg PB, Muoio DM
Molecular metabolism 2022 Mar;57:101429
Molecular metabolism 2022 Mar;57:101429
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Veterinary microbiology 2022 Mar;266:109367
Veterinary microbiology 2022 Mar;266:109367
Loss of legumain induces premature senescence and mediates aging-related renal fibrosis.
Wang D, Kang L, Chen C, Guo J, Du L, Zhou D, Li G, Zhang Y, Mi X, Zhang M, Liu S, Tan X
Aging cell 2022 Mar;21(3):e13574
Aging cell 2022 Mar;21(3):e13574
Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
Tian H, Yan H, Zhang Y, Fu Q, Li C, He J, Li H, Zhou Y, Huang Y, Li R
Bioengineered 2022 Mar;13(3):5190-5204
Bioengineered 2022 Mar;13(3):5190-5204
Obstructive Sleep Apnea Affects Lacrimal Gland Function.
Wang S, He X, Li Q, Zhang Y, Hu J, Zong R, Zhuang J, Quantock AJ, Gao Y, Li W, Liu Z
Investigative ophthalmology & visual science 2022 Mar 2;63(3):3
Investigative ophthalmology & visual science 2022 Mar 2;63(3):3
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.
Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z
Journal of nanobiotechnology 2022 Mar 19;20(1):149
Journal of nanobiotechnology 2022 Mar 19;20(1):149
Maternal exposure to CeO(2)NPs derails placental development through trophoblast dysfunction mediated by excessive autophagy activation.
Chen Z, Geng Y, Gao R, Zhong H, Chen J, Mu X, Chen X, Zhang Y, Li F, He J
Journal of nanobiotechnology 2022 Mar 15;20(1):131
Journal of nanobiotechnology 2022 Mar 15;20(1):131
Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons.
López-Molina L, Fernández-Irigoyen J, Cifuentes-Díaz C, Alberch J, Girault JA, Santamaría E, Ginés S, Giralt A
Cells 2022 Mar 1;11(5)
Cells 2022 Mar 1;11(5)
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
Ghait M, Husain RA, Duduskar SN, Haack TB, Rooney M, Göhrig B, Bauer M, Rubio I, Deshmukh SD
European journal of immunology 2022 Jun;52(6):907-923
European journal of immunology 2022 Jun;52(6):907-923
Long-term exercise pre-training attenuates Alzheimer's disease-related pathology in a transgenic rat model of Alzheimer's disease.
Yang L, Wu C, Li Y, Dong Y, Wu CY, Lee RH, Brann DW, Lin HW, Zhang Q
GeroScience 2022 Jun;44(3):1457-1477
GeroScience 2022 Jun;44(3):1457-1477
Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations.
Zhang Y, Wu J, Fu Y, Yu R, Su H, Zheng Q, Wu H, Zhou S, Wang K, Zhao J, Shen S, Xu G, Wang L, Yan C, Zou X, Lv Y, Zhang S
Oncogene 2022 Jun;41(25):3394-3408
Oncogene 2022 Jun;41(25):3394-3408
Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis.
Jin L, Yu B, Liu G, Nie W, Wang J, Chen J, Xiao L, Xia H, Han F, Yang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jun;36(6):e22342
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jun;36(6):e22342
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Song Y, Ge X, Chen Y, Hussain T, Liang Z, Dong Y, Wang Y, Tang C, Zhou X
Autophagy 2022 Jun;18(6):1401-1415
Autophagy 2022 Jun;18(6):1401-1415
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya J, Saito M, Kuwano K
Journal of cachexia, sarcopenia and muscle 2022 Jun;13(3):1864-1882
Journal of cachexia, sarcopenia and muscle 2022 Jun;13(3):1864-1882
SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation.
Gao A, Zou J, Mao Z, Zhou H, Zeng G
European journal of pharmacology 2022 Jun 5;924:174980
European journal of pharmacology 2022 Jun 5;924:174980
Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy.
Chen R, Yuan W, Zheng Y, Zhu X, Jin B, Yang T, Yan Y, Xu W, Chen H, Gao J, Li G, Gokulnath P, Vulugundam G, Li J, Xiao J
Journal of nanobiotechnology 2022 Jun 27;20(1):304
Journal of nanobiotechnology 2022 Jun 27;20(1):304
Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Xue J, Li Y, Qi Y, Zhang Z, Tang X
Neurotoxicology 2022 Jul;91:211-217
Neurotoxicology 2022 Jul;91:211-217
Massive Accumulation of Sphingomyelin Affects the Lysosomal and Mitochondria Compartments and Promotes Apoptosis in Niemann-Pick Disease Type A.
Carsana EV, Lunghi G, Prioni S, Mauri L, Loberto N, Prinetti A, Zucca FA, Bassi R, Sonnino S, Chiricozzi E, Duga S, Straniero L, Asselta R, Soldà G, Samarani M, Aureli M
Journal of molecular neuroscience : MN 2022 Jul;72(7):1482-1499
Journal of molecular neuroscience : MN 2022 Jul;72(7):1482-1499
Deficient mitochondrial respiration in astrocytes impairs trace fear conditioning and increases naloxone-precipitated aversion in morphine-dependent mice.
Murlanova K, Jouroukhin Y, Huseynov S, Pletnikova O, Morales MJ, Guan Y, Baraban JM, Bergles DE, Pletnikov MV
Glia 2022 Jul;70(7):1289-1300
Glia 2022 Jul;70(7):1289-1300
SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, Gentile D, Siddig S, Stork M, Hopkins CE, Händler K, Weis J, Roos A, Schultze JL, Nicotera P, Ehninger D, Bano D
Molecular metabolism 2022 Jul;61:101503
Molecular metabolism 2022 Jul;61:101503
Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death.
Sun Y, Yang YM, Hu YY, Ouyang L, Sun ZH, Yin XF, Li N, He QY, Wang Y
Redox biology 2022 Jul;53:102334
Redox biology 2022 Jul;53:102334
L-OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice.
Jiang HL, Yang HH, Liu YB, Zhang CY, Zhong WJ, Guan XX, Jin L, Hong JR, Yang JT, Tan XH, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2022 Jul;237(7):3030-3043
Journal of cellular physiology 2022 Jul;237(7):3030-3043
Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy.
Jin Z, Chang B, Wei Y, Yang Y, Zhang H, Liu J, Piao L, Bai L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113092
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113092
Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases.
Watanabe S, Nihongaki Y, Itoh K, Uyama T, Toda S, Watanabe S, Inoue T
Nature communications 2022 Jul 29;13(1):4413
Nature communications 2022 Jul 29;13(1):4413
Functionalized Allopurinols Targeting Amyloid-Binding Alcohol Dehydrogenase Rescue Aβ-Induced Mitochondrial Dysfunction.
Morsy A, Maddeboina K, Gao J, Wang H, Valdez J, Dow LF, Wang X, Trippier PC
ACS chemical neuroscience 2022 Jul 20;13(14):2176-2190
ACS chemical neuroscience 2022 Jul 20;13(14):2176-2190
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis.
Liu J, Wang X, Xue F, Zheng M, Luan Q
Journal of periodontal research 2022 Jan;57(1):94-103
Journal of periodontal research 2022 Jan;57(1):94-103
Bombyx mori cypovirus (BmCPV) induces PINK1-Parkin mediated mitophagy via interaction of VP4 with host Tom40.
Zhu M, Pan J, Zhang M, Tong X, Zhang Y, Zhang Z, Liang Z, Zhang X, Hu X, Xue R, Cao G, Gong C
Developmental and comparative immunology 2022 Jan;126:104244
Developmental and comparative immunology 2022 Jan;126:104244
Drp1 knockdown represses apoptosis of rat retinal endothelial cells by inhibiting mitophagy.
Wu H, Li G, Chen W, Luo W, Yang Z, You Z, Zou Y
Acta histochemica 2022 Jan;124(1):151837
Acta histochemica 2022 Jan;124(1):151837
Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles.
Ramirez A, Old W, Selwood DL, Liu X
European journal of cell biology 2022 Jan;101(1):151185
European journal of cell biology 2022 Jan;101(1):151185
Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
American journal of human genetics 2022 Jan 6;109(1):157-171
American journal of human genetics 2022 Jan 6;109(1):157-171
Heat Shock Protein 60 Restricts Release of Mitochondrial dsRNA to Suppress Hepatic Inflammation and Ameliorate Non-Alcoholic Fatty Liver Disease in Mice.
Huang YH, Wang FS, Wang PW, Lin HY, Luo SD, Yang YL
International journal of molecular sciences 2022 Jan 5;23(1)
International journal of molecular sciences 2022 Jan 5;23(1)
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Liu J, Jiang J, Qiu J, Wang L, Zhuo J, Wang B, Sun D, Yu S, Lou H
Food & function 2022 Jan 4;13(1):375-385
Food & function 2022 Jan 4;13(1):375-385
Hyperglycemia Induces Meibomian Gland Dysfunction.
Guo Y, Zhang H, Zhao Z, Luo X, Zhang M, Bu J, Liang M, Wu H, Yu J, He H, Zong R, Chen Y, Liu Z, Li W
Investigative ophthalmology & visual science 2022 Jan 3;63(1):30
Investigative ophthalmology & visual science 2022 Jan 3;63(1):30
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.
Fu J, Zhou M, Gritsenko MA, Nakayasu ES, Song L, Luo ZQ
eLife 2022 Jan 27;11
eLife 2022 Jan 27;11
Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy.
Han X, Hu S, Yang Q, Sang X, Tang D, Cao G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153835
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153835
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.
Yao D, Li Y, Zeng S, Li Z, Shah Z, Song B, Liu J, Wu Y, Yang L, Long Q, Wang W, Hu Z, Tang H, Liu X
Science China. Life sciences 2022 Feb;65(2):227-235
Science China. Life sciences 2022 Feb;65(2):227-235
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.
Rusilowicz-Jones EV, Barone FG, Lopes FM, Stephen E, Mortiboys H, Urbé S, Clague MJ
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1/Th17 immune responses.
Zhu Q, Muyayalo KP, Xu QH, Wang J, Wang H, Liao AH
Journal of reproductive immunology 2022 Feb;149:103469
Journal of reproductive immunology 2022 Feb;149:103469
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Ryan DG, Knatko EV, Casey AM, Hukelmann JL, Dayalan Naidu S, Brenes AJ, Ekkunagul T, Baker C, Higgins M, Tronci L, Nikitopolou E, Honda T, Hartley RC, O'Neill LAJ, Frezza C, Lamond AI, Abramov AY, Arthur JSC, Cantrell DA, Murphy MP, Dinkova-Kostova AT
iScience 2022 Feb 18;25(2):103827
iScience 2022 Feb 18;25(2):103827
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Wang Q, Zhou L, Wang J, Su D, Li D, Du Y, Yang G, Zhang G, Chu B
Viruses 2022 Feb 15;14(2)
Viruses 2022 Feb 15;14(2)
Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids.
Lee JH, Hussain M, Kim EW, Cheng SJ, Leung AKL, Fakouri NB, Croteau DL, Bohr VA
Experimental & molecular medicine 2022 Dec;54(12):2135-2147
Experimental & molecular medicine 2022 Dec;54(12):2135-2147
The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy.
Sun S, Hou H, Ma G, Ma Q, Li N, Zhang L, Dong C, Cao M, Tam KY, Ying Z, Wang H
The Journal of biological chemistry 2022 Dec;298(12):102704
The Journal of biological chemistry 2022 Dec;298(12):102704
Gankyrin and TIGAR cooperatively accelerate glucose metabolism toward the PPP and TCA cycle in hepatocellular carcinoma.
Yang C, Cui XW, Ding ZW, Jiang TY, Feng XF, Pan YF, Lin YK, Shang TY, Wang Q, Pan J, Wang J, Wang HY, Dong LW
Cancer science 2022 Dec;113(12):4151-4164
Cancer science 2022 Dec;113(12):4151-4164
The combination of nuclear receptor NR1D1 and ULK1 promotes mitophagy in adipocytes to ameliorate obesity.
Yu B, Pan JB, Yu FY
Adipocyte 2022 Dec;11(1):202-212
Adipocyte 2022 Dec;11(1):202-212
Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy.
Meng Y, Qiu L, Zeng X, Hu X, Zhang Y, Wan X, Mao X, Wu J, Xu Y, Xiong Q, Chen Z, Zhang B, Han J
Signal transduction and targeted therapy 2022 Dec 9;7(1):388
Signal transduction and targeted therapy 2022 Dec 9;7(1):388
The Journey of SCAPs (Stem Cells from Apical Papilla), from Their Native Tissue to Grafting: Impact of Oxygen Concentration.
Mavinga M, Palmier M, Rémy M, Jeannière C, Lenoir S, Rey S, Saint-Marc M, Alonso F, Génot E, Thébaud N, Chevret E, Mournetas V, Rousseau B, Boiziau C, Boeuf H
Cells 2022 Dec 16;11(24)
Cells 2022 Dec 16;11(24)
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.
Liu H, Fan H, He P, Zhuang H, Liu X, Chen M, Zhong W, Zhang Y, Zhen C, Li Y, Jiang H, Meng T, Xu Y, Zhao G, Feng D
The EMBO journal 2022 Dec 15;41(24):e111173
The EMBO journal 2022 Dec 15;41(24):e111173
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
Wischhof L, Lee HM, Tutas J, Overkott C, Tedt E, Stork M, Peitz M, Brüstle O, Ulas T, Händler K, Schultze JL, Ehninger D, Nicotera P, Salomoni P, Bano D
The EMBO journal 2022 Dec 1;41(23):e110595
The EMBO journal 2022 Dec 1;41(23):e110595
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles.
Li YJ, Liu RP, Ding MN, Zheng Q, Wu JZ, Xue XY, Gu YQ, Ma BN, Cai YJ, Li S, Lin S, Zhang LY, Li X
Acta pharmacologica Sinica 2022 Aug;43(8):2026-2041
Acta pharmacologica Sinica 2022 Aug;43(8):2026-2041
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma.
Yao J, Wang J, Xu Y, Guo Q, Sun Y, Liu J, Li S, Guo Y, Wei L
Autophagy 2022 Aug;18(8):1879-1897
Autophagy 2022 Aug;18(8):1879-1897
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease.
Lampinen R, Belaya I, Saveleva L, Liddell JR, Rait D, Huuskonen MT, Giniatullina R, Sorvari A, Soppela L, Mikhailov N, Boccuni I, Giniatullin R, Cruz-Haces M, Konovalova J, Koskuvi M, Domanskyi A, Hämäläinen RH, Goldsteins G, Koistinaho J, Malm T, Chew S, Rilla K, White AR, Marsh-Armstrong N, Kanninen KM
Neurobiology of disease 2022 Aug;170:105753
Neurobiology of disease 2022 Aug;170:105753
Systematic Functional Analysis of PINK1 and PRKN Coding Variants.
Broadway BJ, Boneski PK, Bredenberg JM, Kolicheski A, Hou X, Soto-Beasley AI, Ross OA, Springer W, Fiesel FC
Cells 2022 Aug 5;11(15)
Cells 2022 Aug 5;11(15)
The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP().
Liao Z, Gong Z, Wang Z, Yang W, Liu W, Hou L, Liu X, Hua J, Wang B, Li N
Cells 2022 Aug 30;11(17)
Cells 2022 Aug 30;11(17)
GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth.
Zhang B, Chen Y, Bao L, Luo W
Cells 2022 Aug 20;11(16)
Cells 2022 Aug 20;11(16)
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Liang C, Zhang S, Robinson D, Ploeg MV, Wilson R, Nah J, Taylor D, Beh S, Lim R, Sun L, Muoio DM, Stroud DA, Ho L
Cell reports 2022 Aug 16;40(7):111204
Cell reports 2022 Aug 16;40(7):111204
Melatonin Attenuates Ropivacaine-Induced Apoptosis by Inhibiting Excessive Mitophagy Through the Parkin/PINK1 Pathway in PC12 and HT22 Cells.
Zeng L, He J, Liu C, Zhang F, Zhang Z, Chen H, Wang Q, Ding X, Luo H
Inflammation 2022 Apr;45(2):725-738
Inflammation 2022 Apr;45(2):725-738
Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage.
Yan XL, Xu FY, Ji JJ, Song P, Pei YQ, He MJ, Wang ZC, You SJ, Hua ZC, Cheng J, Jia J
Acta pharmacologica Sinica 2022 Apr;43(4):811-828
Acta pharmacologica Sinica 2022 Apr;43(4):811-828
Baicalein suppresses high glucose-induced inflammation and apoptosis in trophoblasts by targeting the miRNA-17-5p-Mfn1/2-NF-κB pathway.
Li J, Wang Y, Wu T, Li S, Sun YN, Liu ZH
Placenta 2022 Apr;121:126-136
Placenta 2022 Apr;121:126-136
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8.
Hojo Y, Kishi S, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Nishiguchi Y, Nakashima C, Luo Y, Shinohara H, Kuniyasu H
International journal of molecular sciences 2022 Apr 4;23(7)
International journal of molecular sciences 2022 Apr 4;23(7)
SIRT2 Is Critical for Sheep Oocyte Maturation through Regulating Function of Surrounding Granulosa Cells.
Fang X, Xia W, Li S, Qi Y, Liu M, Yu Y, Li H, Li M, Tao C, Wang Z, Li J
International journal of molecular sciences 2022 Apr 30;23(9)
International journal of molecular sciences 2022 Apr 30;23(9)
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J, Zou Y
International journal of molecular sciences 2022 Apr 28;23(9)
International journal of molecular sciences 2022 Apr 28;23(9)
Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver.
Yamada T, Murata D, Kleiner DE, Anders R, Rosenberg AZ, Kaplan J, Hamilton JP, Aghajan M, Levi M, Wang NY, Dawson TM, Yanagawa T, Powers AF, Iijima M, Sesaki H
iScience 2022 Apr 15;25(4):103996
iScience 2022 Apr 15;25(4):103996
Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model.
Qiu J, Chen Y, Zhuo J, Zhang L, Liu J, Wang B, Sun D, Yu S, Lou H
Neuropharmacology 2022 Apr 1;207:108963
Neuropharmacology 2022 Apr 1;207:108963
OPA1 Modulates Mitochondrial Ca(2+) Uptake Through ER-Mitochondria Coupling.
Cartes-Saavedra B, Macuada J, Lagos D, Arancibia D, Andrés ME, Yu-Wai-Man P, Hajnóczky G, Eisner V
Frontiers in cell and developmental biology 2021;9:774108
Frontiers in cell and developmental biology 2021;9:774108
Melatonin Attenuates Chromium (VI)-Induced Spermatogonial Stem Cell/Progenitor Mitophagy by Restoration of METTL3-Mediated RNA N(6)-Methyladenosine Modification.
Lv Y, Li T, Yang M, Su L, Zhu Z, Zhao S, Zeng W, Zheng Y
Frontiers in cell and developmental biology 2021;9:684398
Frontiers in cell and developmental biology 2021;9:684398
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.
Yang L, Wu C, Tucker L, Dong Y, Li Y, Xu P, Zhang Q
Journal of Alzheimer's disease : JAD 2021;83(4):1415-1429
Journal of Alzheimer's disease : JAD 2021;83(4):1415-1429
Receptor-Interacting Protein Kinase 3 Inhibition Prevents Cadmium-Mediated Macrophage Polarization and Subsequent Atherosclerosis via Maintaining Mitochondrial Homeostasis.
Zhang J, Feng W, Li M, Chen P, Ning X, Ou C, Chen M
Frontiers in cardiovascular medicine 2021;8:737652
Frontiers in cardiovascular medicine 2021;8:737652
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma via ROS/Mitochondria Pathway.
Ren Y, Lin Y, Chen J, Jin Y
Biological & pharmaceutical bulletin 2021;44(10):1557-1564
Biological & pharmaceutical bulletin 2021;44(10):1557-1564
Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.
Zhao R, Wang B, Wang D, Wu B, Ji P, Tan D
Oxidative medicine and cellular longevity 2021;2021:6675264
Oxidative medicine and cellular longevity 2021;2021:6675264
Tongluo Yishen Decoction Ameliorates Renal Fibrosis via Regulating Mitochondrial Dysfunction Induced by Oxidative Stress in Unilateral Ureteral Obstruction Rats.
Jia Q, Han L, Zhang X, Yang W, Gao Y, Shen Y, Li B, Wang S, Qin M, Lowe S, Qin J, Hao G
Frontiers in pharmacology 2021;12:762756
Frontiers in pharmacology 2021;12:762756
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Frontiers in immunology 2021;12:715098
Frontiers in immunology 2021;12:715098
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation.
Liu C, Wang L, Liu X, Tan Y, Tao L, Xiao Y, Deng P, Wang H, Deng Q, Lin Y, Jie H, Zhang H, Zhang J, Peng Y, Zhang H, Zhou Z, Sun Q, Cen X, Zhao Y
Theranostics 2021;11(6):2966-2986
Theranostics 2021;11(6):2966-2986
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring.
Yang L, Dong Y, Wu C, Youngblood H, Li Y, Zong X, Li L, Xu T, Zhang Q
Theranostics 2021;11(3):1269-1294
Theranostics 2021;11(3):1269-1294
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore-forming toxins to Caenorhabditis elegans.
Shi J, Zhang F, Chen L, Bravo A, Soberón M, Sun M
Environmental microbiology 2021 Sep;23(9):4896-4907
Environmental microbiology 2021 Sep;23(9):4896-4907
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X
Nature communications 2021 Sep 6;12(1):5305
Nature communications 2021 Sep 6;12(1):5305
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Wang M, Wan C, He T, Han C, Zhu K, Waddington JL, Zhen X
Neuropharmacology 2021 Sep 15;196:108360
Neuropharmacology 2021 Sep 15;196:108360
Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency.
Ji C, Guo Y, Liu Y, Xu S, Zhao S, Luo X, Qiu F, Huang R, Xu Q, Zheng R, Xia M, Zhao Y, Ren J, Qiu Y
The ocular surface 2021 Oct;22:230-241
The ocular surface 2021 Oct;22:230-241
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells.
Kim ES, Jeon MT, Kim KS, Lee S, Kim S, Kim DG
Viruses 2021 Oct 8;13(10)
Viruses 2021 Oct 8;13(10)
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M
Molecular cell 2021 Oct 21;81(20):4191-4208.e8
Molecular cell 2021 Oct 21;81(20):4191-4208.e8
TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis.
Chen H, He A, Li H, Chen H, Xie H, Luo L, Huang Y, Chen J, Guan J, He Q, Ma J, Ou C, Tao A, Yan J
Cell death & disease 2021 Oct 13;12(10):938
Cell death & disease 2021 Oct 13;12(10):938
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells.
Bhagawati M, Arroum T, Webeling N, Montoro AG, Mootz HD, Busch KB
Molecular biology of the cell 2021 Oct 1;32(20):br1
Molecular biology of the cell 2021 Oct 1;32(20):br1
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation.
Song N, Fang Y, Zhu H, Liu J, Jiang S, Sun S, Xu R, Ding J, Hu G, Lu M
Redox biology 2021 Nov;47:102168
Redox biology 2021 Nov;47:102168
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
Xu K, Lu C, Ren X, Wang J, Xu P, Zhang Y
Environmental toxicology 2021 Nov;36(11):2123-2137
Environmental toxicology 2021 Nov;36(11):2123-2137
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
Tu C, Li H, Liu X, Wang Y, Li W, Meng L, Wang W, Li Y, Li D, Du J, Lu G, Lin G, Tan YQ
Autophagy 2021 Nov;17(11):3848-3864
Autophagy 2021 Nov;17(11):3848-3864
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606
Autophagy 2021 Nov;17(11):3592-3606
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Hao K, Chen Y, Yan X, Zhu X
Nature communications 2021 Nov 30;12(1):6971
Nature communications 2021 Nov 30;12(1):6971
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1.
Queliconi BB, Kojima W, Kimura M, Imai K, Udagawa C, Motono C, Hirokawa T, Tashiro S, Caaveiro JMM, Tsumoto K, Yamano K, Tanaka K, Matsuda N
Journal of cell science 2021 Nov 15;134(22)
Journal of cell science 2021 Nov 15;134(22)
An in vitro system to silence mitochondrial gene expression.
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
Cell 2021 Nov 11;184(23):5824-5837.e15
Cell 2021 Nov 11;184(23):5824-5837.e15
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723
Toxicology and applied pharmacology 2021 Nov 1;430:115723
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Labbé K, Mookerjee S, Le Vasseur M, Gibbs E, Lerner C, Nunnari J
The Journal of cell biology 2021 Nov 1;220(11)
The Journal of cell biology 2021 Nov 1;220(11)
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Zhang Q, He X, Yao S, Lin T, Zhang L, Chen D, Chen C, Yang Q, Li F, Zhu YM, Guan MX
Nucleic acids research 2021 May 7;49(8):4689-4704
Nucleic acids research 2021 May 7;49(8):4689-4704
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†.
Zhang C, Tao L, Yue Y, Ren L, Zhang Z, Wang X, Tian J, An L
Biology of reproduction 2021 May 7;104(5):1114-1125
Biology of reproduction 2021 May 7;104(5):1114-1125
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis.
Navinés-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Proaño-Pérez E, Muñoz-Cano R, Gastaminza G, Olivera A, Martin M
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2277-2289
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2277-2289
Remote Ischemic Postconditioning Inhibited Mitophagy to Achieve Neuroprotective Effects in the Rat Model of Cardiac Arrest.
Huang Y, Gao X, Zhou X, Zhang Y, Tan Z, Zhu S
Neurochemical research 2021 Mar;46(3):573-583
Neurochemical research 2021 Mar;46(3):573-583
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans.
Li Y, Wang WL, Tu CF, Meng LL, Hu TY, Du J, Lin G, Nie HC, Tan YQ
Asian journal of andrology 2021 Mar-Apr;23(2):197-204
Asian journal of andrology 2021 Mar-Apr;23(2):197-204
Machine learning-based classification of mitochondrial morphology in primary neurons and brain.
Fogo GM, Anzell AR, Maheras KJ, Raghunayakula S, Wider JM, Emaus KJ, Bryson TD, Bukowski MJ, Neumar RW, Przyklenk K, Sanderson TH
Scientific reports 2021 Mar 4;11(1):5133
Scientific reports 2021 Mar 4;11(1):5133
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties.
Huntington TE, Srinivasan R
Cell calcium 2021 Jun;96:102383
Cell calcium 2021 Jun;96:102383
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)
The Journal of cell biology 2021 Jun 7;220(6)
Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation.
Mollo N, Esposito M, Aurilia M, Scognamiglio R, Accarino R, Bonfiglio F, Cicatiello R, Charalambous M, Procaccini C, Micillo T, Genesio R, Calì G, Secondo A, Paladino S, Matarese G, De Vita G, Conti A, Nitsch L, Izzo A
Biology 2021 Jun 30;10(7)
Biology 2021 Jun 30;10(7)
Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons.
Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, West AP, Geoffroy CG
Cells 2021 Jun 29;10(7)
Cells 2021 Jun 29;10(7)
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.
McGuirk S, Audet-Delage Y, Annis MG, Xue Y, Vernier M, Zhao K, St-Louis C, Minarrieta L, Patten DA, Morin G, Greenwood CM, Giguère V, Huang S, Siegel PM, St-Pierre J
eLife 2021 Jun 28;10
eLife 2021 Jun 28;10
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
Zheng S, Jian D, Gan H, Wang L, Zhao J, Zhai X
Neuroscience letters 2021 Jun 21;756:135967
Neuroscience letters 2021 Jun 21;756:135967
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.
Della-Flora Nunes G, Wilson ER, Marziali LN, Hurley E, Silvestri N, He B, O'Malley BW, Beirowski B, Poitelon Y, Wrabetz L, Feltri ML
Nature communications 2021 Jun 2;12(1):3285
Nature communications 2021 Jun 2;12(1):3285
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Cao Q, Luo J, Xiong Y, Liu Z, Ye Q
International immunopharmacology 2021 Jul;96:107643
International immunopharmacology 2021 Jul;96:107643
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
Song Y, Dong Y, Liao Y, Liang Z, Yao J, Zhou X
The Journal of infection 2021 Jul;83(1):61-68
The Journal of infection 2021 Jul;83(1):61-68
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy.
Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Wang J, Xing HR
FEBS open bio 2021 Jul;11(7):1997-2007
FEBS open bio 2021 Jul;11(7):1997-2007
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
Wang F, Chen X, Cheng H, Song L, Liu J, Caplan S, Zhu L, Wu JY
EMBO reports 2021 Jul 5;22(7):e52006
EMBO reports 2021 Jul 5;22(7):e52006
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.
Haschler TN, Horsley H, Balys M, Anderson G, Taanman JW, Unwin RJ, Norman JT
Scientific reports 2021 Jul 30;11(1):15510
Scientific reports 2021 Jul 30;11(1):15510
Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.
Li A, Li X, Yi J, Ma J, Zhou J
International journal of molecular sciences 2021 Jul 10;22(14)
International journal of molecular sciences 2021 Jul 10;22(14)
Influence of Subcellular Localization and Functional State on Protein Turnover.
Yousefi R, Jevdokimenko K, Kluever V, Pacheu-Grau D, Fornasiero EF
Cells 2021 Jul 10;10(7)
Cells 2021 Jul 10;10(7)
Tubular Mas receptor mediates lipid-induced kidney injury.
Kong Y, Zhao X, Qiu M, Lin Y, Feng P, Li S, Liang B, Zhu Q, Huang H, Li C, Wang W
Cell death & disease 2021 Jan 21;12(1):110
Cell death & disease 2021 Jan 21;12(1):110
Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii.
Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I, Tan MW
Scientific reports 2021 Jan 12;11(1):618
Scientific reports 2021 Jan 12;11(1):618
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1.
Qin S, Ye L, Zheng Y, Gao J
FEBS letters 2021 Feb;595(4):507-520
FEBS letters 2021 Feb;595(4):507-520
Active RNA interference in mitochondria.
Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X
Cell research 2021 Feb;31(2):219-228
Cell research 2021 Feb;31(2):219-228
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H
Autophagy 2021 Feb;17(2):496-511
Autophagy 2021 Feb;17(2):496-511
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.
Meng Q, Zaharieva EK, Sasatani M, Kobayashi J
Redox report : communications in free radical research 2021 Dec;26(1):160-169
Redox report : communications in free radical research 2021 Dec;26(1):160-169
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Liu W, Xu L, Wang X, Zhang D, Sun G, Wang M, Wang M, Han Y, Chai R, Wang H
Autophagy 2021 Dec;17(12):4159-4181
Autophagy 2021 Dec;17(12):4159-4181
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Khodayari N, Wang RL, Oshins R, Lu Y, Millett M, Aranyos AM, Mostofizadeh S, Scindia Y, Flagg TO, Brantly M
International journal of molecular sciences 2021 Dec 9;22(24)
International journal of molecular sciences 2021 Dec 9;22(24)
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.
Zhang XJ, She ZG, Wang J, Sun D, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H
Science translational medicine 2021 Dec 15;13(624):eabg8117
Science translational medicine 2021 Dec 15;13(624):eabg8117
Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.
Peng G, Zheng H, Wu C, Wu C, Ma X, Xiong J, Hou J, Zhang L, Yang L, Pan H
Brain research 2021 Dec 1;1772:147665
Brain research 2021 Dec 1;1772:147665
Lipidomics Reveals Dysregulated Glycerophospholipid Metabolism in the Corpus Striatum of Mice Treated with Cefepime.
Liu X, Wei Q, Yang X, Wang X, Zhang J, Xu R, Zhang H, Wang S, Wan X, Jiang L, He Y, Li S, Chen R, Wang Y, Chen Y, Qin F, Chen Y, Dai Y, Li H, Zhao Y, Zhang H, Bu Q, Wang H, Tian J, Zhao Y, Cen X
ACS chemical neuroscience 2021 Dec 1;12(23):4449-4464
ACS chemical neuroscience 2021 Dec 1;12(23):4449-4464
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Zhang X, Zhang Y, Pan J, Zhu M, Liang Z, Shen Z, Dai K, Yan B, Dai Y, Xue R, Cao G, Hu X, Gong C
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.
Han X, Xu T, Fang Q, Zhang H, Yue L, Hu G, Sun L
Redox biology 2021 Aug;44:102010
Redox biology 2021 Aug;44:102010
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Sun H, Ou T, Hu J, Yang Z, Lei Q, Li Y, Wang G, Li Y, Wu K, Wang S, Wu S
Biochemical pharmacology 2021 Aug;190:114588
Biochemical pharmacology 2021 Aug;190:114588
Facile Synthesis of Antibody-Coupled Polydopamine-Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria.
Chang M, Wang Q, Liu X, Shi X, Xu G
Analytical chemistry 2021 Aug 17;93(32):11099-11107
Analytical chemistry 2021 Aug 17;93(32):11099-11107
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
Haasler L, Kondadi AK, Tsigaras T, von Montfort C, Graf P, Stahl W, Brenneisen P
Archives of toxicology 2021 Apr;95(4):1349-1365
Archives of toxicology 2021 Apr;95(4):1349-1365
Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation.
Zhang C, Li X, Hu X, Xu Q, Zhang Y, Liu H, Diao Y, Zhang X, Li L, Yu J, Yin H, Peng J
International immunopharmacology 2021 Apr;93:107412
International immunopharmacology 2021 Apr;93:107412
Monitoring mitochondrial translation in living cells.
Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D
EMBO reports 2021 Apr 7;22(4):e51635
EMBO reports 2021 Apr 7;22(4):e51635
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283
The EMBO journal 2021 Apr 15;40(8):e106283
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Cieśla M, Ngoc PCT, Cordero E, Martinez ÁS, Morsing M, Muthukumar S, Beneventi G, Madej M, Munita R, Jönsson T, Lövgren K, Ebbesson A, Nodin B, Hedenfalk I, Jirström K, Vallon-Christersson J, Honeth G, Staaf J, Incarnato D, Pietras K, Bosch A, Bellodi C
Molecular cell 2021 Apr 1;81(7):1453-1468.e12
Molecular cell 2021 Apr 1;81(7):1453-1468.e12
Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway.
Zhao F, Feng LX, Liu Q, Wang HS, Tang CY, Cheng W, Deng YH, Wu X, Yan P, Duan XJ, Peng JC, Duan SB
Oxidative medicine and cellular longevity 2020;2020:1898213
Oxidative medicine and cellular longevity 2020;2020:1898213
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes.
Contino S, Suelves N, Vrancx C, Vadukul DM, Payen VL, Stanga S, Bertrand L, Kienlen-Campard P
Frontiers in neuroscience 2020;14:586108
Frontiers in neuroscience 2020;14:586108
Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission.
Song N, Zhu H, Xu R, Liu J, Fang Y, Zhang J, Ding J, Hu G, Lu M
Frontiers in pharmacology 2020;11:618992
Frontiers in pharmacology 2020;11:618992
Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma JS, Yamamoto M
Frontiers in immunology 2020;11:561948
Frontiers in immunology 2020;11:561948
The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α.
Gao F, Reynolds MB, Passalacqua KD, Sexton JZ, Abuaita BH, O'Riordan MXD
Frontiers in cellular and infection microbiology 2020;10:593805
Frontiers in cellular and infection microbiology 2020;10:593805
HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury.
Fu ZJ, Wang ZY, Xu L, Chen XH, Li XX, Liao WT, Ma HK, Jiang MD, Xu TT, Xu J, Shen Y, Song B, Gao PJ, Han WQ, Zhang W
Redox biology 2020 Sep;36:101671
Redox biology 2020 Sep;36:101671
Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Wang YY, Ke CC, Chen YL, Lin YH, Yu IS, Ku WC, O'Bryan MK, Lin YH
PLoS genetics 2020 Sep;16(9):e1009020
PLoS genetics 2020 Sep;16(9):e1009020
Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice.
He X, Liu C, Yang X, Lv M, Ni X, Li Q, Cheng H, Liu W, Tian S, Wu H, Gao Y, Yang C, Tan Q, Cong J, Tang D, Zhang J, Song B, Zhong Y, Li H, Zhi W, Mao X, Fu F, Ge L, Shen Q, Zhang M, Saiyin H, Jin L, Xu Y, Zhou P, Wei Z, Zhang F, Cao Y
American journal of human genetics 2020 Sep 3;107(3):514-526
American journal of human genetics 2020 Sep 3;107(3):514-526
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.
Xu X, Ng B, Sim B, Radulescu CI, Yusof NABM, Goh WI, Lin S, Lim JSY, Cha Y, Kusko R, Kay C, Ratovitski T, Ross C, Hayden MR, Wright G, Pouladi MA
Cell death & disease 2020 Sep 25;11(9):809
Cell death & disease 2020 Sep 25;11(9):809
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.
Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G
Science China. Life sciences 2020 Oct;63(10):1429-1449
Science China. Life sciences 2020 Oct;63(10):1429-1449
Methylene blue post-treatment improves hypoxia-ischemic recovery in a neonatal rat model.
Zhang G, Lu Y, Yang L, Dong Y, Wen J, Xu J, Zhang Q
Neurochemistry international 2020 Oct;139:104782
Neurochemistry international 2020 Oct;139:104782
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.
Thevarajan I, Zolkiewski M, Zolkiewska A
The international journal of biochemistry & cell biology 2020 Oct;127:105841
The international journal of biochemistry & cell biology 2020 Oct;127:105841
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940
Cell death & disease 2020 Oct 31;11(10):940
Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease.
Xiong X, Li S, Han TL, Zhou F, Zhang X, Tian M, Tang L, Li Y
Experimental cell research 2020 Nov 1;396(1):112266
Experimental cell research 2020 Nov 1;396(1):112266
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
Lee H, Smith SB, Sheu SS, Yoon Y
The Journal of biological chemistry 2020 May 8;295(19):6543-6560
The Journal of biological chemistry 2020 May 8;295(19):6543-6560
FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.
Qi F, Meng Q, Hayashi I, Kobayashi J
Journal of radiation research 2020 May 22;61(3):368-375
Journal of radiation research 2020 May 22;61(3):368-375
FSH prevents porcine granulosa cells from hypoxia-induced apoptosis via activating mitophagy through the HIF-1α-PINK1-Parkin pathway.
Li C, Zhou J, Liu Z, Zhou J, Yao W, Tao J, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3631-3645
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3631-3645
Hyperlipidemia Affects Tight Junctions and Pump Function in the Corneal Endothelium.
Bu J, Yu J, Wu Y, Cai X, Li K, Tang L, Jiang N, Jeyalatha MV, Zhang M, Sun H, He H, Quantock AJ, Chen Y, Liu Z, Li W
The American journal of pathology 2020 Mar;190(3):563-576
The American journal of pathology 2020 Mar;190(3):563-576
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z
Autophagy 2020 Mar;16(3):419-434
Autophagy 2020 Mar;16(3):419-434
Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca(2+) efflux and Reactive Oxygen Species (ROS) homeostasis.
Cherubini M, Lopez-Molina L, Gines S
Neurobiology of disease 2020 Mar;136:104741
Neurobiology of disease 2020 Mar;136:104741
Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.
Meng K, Lu S, Yan X, Sun Y, Gao J, Wang Y, Yin X, Sun Z, He QY
Journal of proteome research 2020 Mar 6;19(3):1275-1284
Journal of proteome research 2020 Mar 6;19(3):1275-1284
Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Tokuyama T, Hirai A, Shiiba I, Ito N, Matsuno K, Takeda K, Saito K, Mii K, Matsushita N, Fukuda T, Inatome R, Yanagi S
Biomolecules 2020 Mar 13;10(3)
Biomolecules 2020 Mar 13;10(3)
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
Zhang S, Reljić B, Liang C, Kerouanton B, Francisco JC, Peh JH, Mary C, Jagannathan NS, Olexiouk V, Tang C, Fidelito G, Nama S, Cheng RK, Wee CL, Wang LC, Duek Roggli P, Sampath P, Lane L, Petretto E, Sobota RM, Jesuthasan S, Tucker-Kellogg L, Reversade B, Menschaert G, Sun L, Stroud DA, Ho L
Nature communications 2020 Mar 11;11(1):1312
Nature communications 2020 Mar 11;11(1):1312
The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells.
Fazzari M, Audano M, Lunghi G, Di Biase E, Loberto N, Mauri L, Mitro N, Sonnino S, Chiricozzi E
Glycoconjugate journal 2020 Jun;37(3):293-306
Glycoconjugate journal 2020 Jun;37(3):293-306
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L
Biochemical pharmacology 2020 Jul;177:113997
Biochemical pharmacology 2020 Jul;177:113997
Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.
Zhang ZL, Wang NN, Ma QL, Chen Y, Yao L, Zhang L, Li QS, Shi MH, Wang HF, Ying Z
Acta pharmacologica Sinica 2020 Jan;41(1):93-100
Acta pharmacologica Sinica 2020 Jan;41(1):93-100
Mitophagy in the Hippocampus Is Excessive Activated After Cardiac Arrest and Cardiopulmonary Resuscitation.
Huang Y, Gao X, Zhou X, Xie B, Zhang Y, Zhu J, Zhu S
Neurochemical research 2020 Feb;45(2):322-330
Neurochemical research 2020 Feb;45(2):322-330
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J
Cell reports 2020 Dec 8;33(10):108475
Cell reports 2020 Dec 8;33(10):108475
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ
Science (New York, N.Y.) 2020 Dec 4;370(6521)
Science (New York, N.Y.) 2020 Dec 4;370(6521)
A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.
Chen JL, Wang XX, Chen L, Tang J, Xia YF, Qian K, Qin ZH, Waeber C, Sheng R
Neuropharmacology 2020 Dec 15;181:108326
Neuropharmacology 2020 Dec 15;181:108326
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin.
García-Puga M, Saenz-Antoñanzas A, Fernández-Torrón R, Munain AL, Matheu A
Aging 2020 Apr 8;12(7):6260-6275
Aging 2020 Apr 8;12(7):6260-6275
The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H
Frontiers in immunology 2019;10:68
Frontiers in immunology 2019;10:68
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, Chen H, Song Y, Sabir N, Hussain M, Zhao D, Zhou X
Frontiers in immunology 2019;10:268
Frontiers in immunology 2019;10:268
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Liu T, Li X, Wu M, Qin L, Chen H, Qian P
Frontiers in microbiology 2019;10:1202
Frontiers in microbiology 2019;10:1202
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL
Science China. Life sciences 2019 Sep;62(9):1117-1135
Science China. Life sciences 2019 Sep;62(9):1117-1135
SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.
Hossain MI, Marcus JM, Lee JH, Garcia PL, Gagné JP, Poirier GG, Falany CN, Andrabi SA
Drug metabolism and disposition: the biological fate of chemicals 2019 Sep;47(9):949-953
Drug metabolism and disposition: the biological fate of chemicals 2019 Sep;47(9):949-953
Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.
Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106
Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy.
Doki T, Yamashita S, Wei FY, Hara K, Yamamoto T, Zhang Z, Zhang X, Tawara N, Hino H, Uyama E, Kurashige T, Maruyama H, Tomizawa K, Ando Y
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1728-1740
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1728-1740
Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.
Módis K, Ramanujam VS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C
Biochemical pharmacology 2019 Nov;169:113604
Biochemical pharmacology 2019 Nov;169:113604
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway.
Saccà CD, Gorini F, Ambrosio S, Amente S, Faicchia D, Matarese G, Lania L, Majello B
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 May;1862(5):535-546
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 May;1862(5):535-546
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY
PLoS genetics 2019 May;15(5):e1007947
PLoS genetics 2019 May;15(5):e1007947
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Sabir N, Hussain T, Liao Y, Wang J, Song Y, Shahid M, Cheng G, Mangi MH, Yao J, Yang L, Zhao D, Zhou X
Cells 2019 May 5;8(5)
Cells 2019 May 5;8(5)
The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20.
Zhang C, Wang R, Liu Z, Bunker E, Lee S, Giuntini M, Chapnick D, Liu X
The Journal of biological chemistry 2019 May 3;294(18):7472-7487
The Journal of biological chemistry 2019 May 3;294(18):7472-7487
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions.
Wang R, Dong Y, Lu Y, Zhang W, Brann DW, Zhang Q
Molecular neurobiology 2019 Mar;56(3):1852-1869
Molecular neurobiology 2019 Mar;56(3):1852-1869
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Yang L, Dong Y, Wu C, Li Y, Guo Y, Yang B, Zong X, Hamblin MR, Liu TC, Zhang Q
Journal of biophotonics 2019 Jun;12(6):e201800359
Journal of biophotonics 2019 Jun;12(6):e201800359
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Wang R, Zhu Y, Lin X, Ren C, Zhao J, Wang F, Gao X, Xiao R, Zhao L, Chen H, Jin M, Ma W, Zhou H
Autophagy 2019 Jul;15(7):1163-1181
Autophagy 2019 Jul;15(7):1163-1181
Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.
Smith GA, Lin TH, Sheehan AE, Van der Goes van Naters W, Neukomm LJ, Graves HK, Bis-Brewer DM, Züchner S, Freeman MR
Neuron 2019 Jul 3;103(1):52-65.e6
Neuron 2019 Jul 3;103(1):52-65.e6
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Li SZ, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W, Zhong B, Zhang XD
Nature communications 2019 Jul 19;10(1):3233
Nature communications 2019 Jul 19;10(1):3233
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254
EBioMedicine 2019 Jan;39:239-254
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G
Autophagy 2019 Jan;15(1):113-130
Autophagy 2019 Jan;15(1):113-130
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Mitochondria modulate programmed neuritic retraction.
Baranov SV, Baranova OV, Yablonska S, Suofu Y, Vazquez AL, Kozai TDY, Cui XT, Ferrando LM, Larkin TM, Tyurina YY, Kagan VE, Carlisle DL, Kristal BS, Friedlander RM
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):650-659
Proceedings of the National Academy of Sciences of the United States of America 2019 Jan 8;116(2):650-659
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P
The Journal of cell biology 2019 Feb 4;218(2):598-614
The Journal of cell biology 2019 Feb 4;218(2):598-614
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Zhou Q, Li H, Li Y, Tan M, Fan S, Cao C, Meng F, Zhu L, Zhao L, Guan MX, Jin H, Sun Y
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N
eLife 2019 Dec 3;8
eLife 2019 Dec 3;8
Rapid affinity purification of intracellular organelles using a twin strep tag.
Xiong J, He J, Xie WP, Hinojosa E, Ambati CSR, Putluri N, Kim HE, Zhu MX, Du G
Journal of cell science 2019 Dec 13;132(24)
Journal of cell science 2019 Dec 13;132(24)
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S
Nature 2019 Aug;572(7771):614-619
Nature 2019 Aug;572(7771):614-619
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
Nagashima S, Takeda K, Ohno N, Ishido S, Aoki M, Saitoh Y, Takada T, Tokuyama T, Sugiura A, Fukuda T, Matsushita N, Inatome R, Yanagi S
Life science alliance 2019 Aug;2(4)
Life science alliance 2019 Aug;2(4)
Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
Martinez-Arroyo O, Gruevska A, Victor VM, González-Polo RA, Yakhine-Diop SMS, Fuentes JM, Esplugues JV, Blas-Garcia A, Apostolova N
Antiviral research 2019 Aug;168:36-50
Antiviral research 2019 Aug;168:36-50
Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon E, Lyssiotis CA, Weerapana E, Banerjee R
The Journal of biological chemistry 2019 Aug 9;294(32):12077-12090
The Journal of biological chemistry 2019 Aug 9;294(32):12077-12090
IP(3) receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.
Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky G
Nature communications 2019 Aug 19;10(1):3726
Nature communications 2019 Aug 19;10(1):3726
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
He Q, Li Z, Meng C, Wu J, Zhao Y, Zhao J
Cells 2019 Aug 14;8(8)
Cells 2019 Aug 14;8(8)
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S
The EMBO journal 2019 Aug 1;38(15):e100999
The EMBO journal 2019 Aug 1;38(15):e100999
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Parkin Modulates ERRα/eNOS Signaling Pathway in Endothelial Cells.
Xia W, Yin J, Zhang S, Guo C, Li Y, Zhang Y, Zhang A, Jia Z, Chen H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):2022-2034
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):2022-2034
CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.
Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, Roizen JD, Kushner JA, Orange JS, Hakonarson H
PloS one 2018;13(9):e0203952
PloS one 2018;13(9):e0203952
Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p.
Zhang J, Liu L, Xue Y, Ma Y, Liu X, Li Z, Li Z, Liu Y
Frontiers in molecular neuroscience 2018;11:92
Frontiers in molecular neuroscience 2018;11:92
PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Gao X, Chen D, Hu X, Zhou Y, Wang Y, Wu C, Chen J, Wang Y, Pei R, Chen X
Journal of innate immunity 2018;10(4):315-327
Journal of innate immunity 2018;10(4):315-327
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC
Scientific reports 2018 Sep 18;8(1):14013
Scientific reports 2018 Sep 18;8(1):14013
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, Zhao M, He H, Zhang Y, Rao Q, Zhao D, Wang Y, Fan L, Li P, Liu Y, Liu F, Zhang F, Ye J, Yan Q, Guo S, Wang Z
Scientific reports 2018 Jul 2;8(1):9972
Scientific reports 2018 Jul 2;8(1):9972
Generation and Characterization of SULT4A1 Mutant Mouse Models.
Garcia PL, Hossain MI, Andrabi SA, Falany CN
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):41-45
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):41-45
PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver.
Xiao Y, Zhou Y, Lu Y, Zhou K, Cai W
Cell death & disease 2018 Feb 7;9(2):160
Cell death & disease 2018 Feb 7;9(2):160
Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions.
Song Y, Du Y, Zou W, Luo Y, Zhang X, Fu J
Scientific reports 2018 Feb 19;8(1):3301
Scientific reports 2018 Feb 19;8(1):3301
Photobiomodulation Therapy Attenuates Hypoxic-Ischemic Injury in a Neonatal Rat Model.
Tucker LD, Lu Y, Dong Y, Yang L, Li Y, Zhao N, Zhang Q
Journal of molecular neuroscience : MN 2018 Aug;65(4):514-526
Journal of molecular neuroscience : MN 2018 Aug;65(4):514-526
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cai WF, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS, Lin SC
Cell research 2018 Aug;28(8):865-867
Cell research 2018 Aug;28(8):865-867
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.
Contino S, Porporato PE, Bird M, Marinangeli C, Opsomer R, Sonveaux P, Bontemps F, Dewachter I, Octave JN, Bertrand L, Stanga S, Kienlen-Campard P
Frontiers in physiology 2017;8:796
Frontiers in physiology 2017;8:796
Autophagy protects auditory hair cells against neomycin-induced damage.
He Z, Guo L, Shu Y, Fang Q, Zhou H, Liu Y, Liu D, Lu L, Zhang X, Ding X, Liu D, Tang M, Kong W, Sha S, Li H, Gao X, Chai R
Autophagy 2017;13(11):1884-1904
Autophagy 2017;13(11):1884-1904
Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.
Zeng HL, Yang Q, Du H, Li H, Shen Y, Liu T, Chen X, Kamal GM, Guan Q, Cheng L, Wang J, Xu F
Oncotarget 2017 Nov 24;8(60):102020-102032
Oncotarget 2017 Nov 24;8(60):102020-102032
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.
Sun S, Liu J, Zhao M, Han Y, Chen P, Mo Q, Wang B, Chen G, Fang Y, Tian Y, Zhou J, Ma D, Gao Q, Wu P
Cell death & disease 2017 Jun 8;8(6):e2870
Cell death & disease 2017 Jun 8;8(6):e2870
A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis.
Zhang J, Liu X, Liang X, Lu Y, Zhu L, Fu R, Ji Y, Fan W, Chen J, Lin B, Yuan Y, Jiang P, Zhou X, Guan MX
Scientific reports 2017 Jul 18;7(1):5704
Scientific reports 2017 Jul 18;7(1):5704
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q
Neurobiology of aging 2017 Jan;49:165-182
Neurobiology of aging 2017 Jan;49:165-182
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Polo M, Alegre F, Moragrega AB, Gibellini L, Marti-Rodrigo A, Blas-Garcia A, Esplugues JV, Apostolova N
British journal of pharmacology 2017 Dec;174(23):4409-4429
British journal of pharmacology 2017 Dec;174(23):4409-4429
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M
Nature immunology 2017 Aug;18(8):899-910
Nature immunology 2017 Aug;18(8):899-910
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W
Molecular neurodegeneration 2017 Apr 24;12(1):32
Molecular neurodegeneration 2017 Apr 24;12(1):32
Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.
Gao J, Li M, Qin S, Zhang T, Jiang S, Hu Y, Deng Y, Zhang C, You D, Li H, Mu D, Zhang Z, Jiang C
Autophagy 2016;12(4):632-47
Autophagy 2016;12(4):632-47
Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells.
Anand R, Strecker V, Urbach J, Wittig I, Reichert AS
PloS one 2016;11(8):e0160258
PloS one 2016;11(8):e0160258
Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.
Mot AI, Liddell JR, White AR, Crouch PJ
The international journal of biochemistry & cell biology 2016 Oct;79:128-138
The international journal of biochemistry & cell biology 2016 Oct;79:128-138
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
Incorporation of VSV-G produces fusogenic plasma membrane vesicles capable of efficient transfer of bioactive macromolecules and mitochondria.
Lin HP, Zheng DJ, Li YP, Wang N, Chen SJ, Fu YC, Xu WC, Wei CJ
Biomedical microdevices 2016 Jun;18(3):41
Biomedical microdevices 2016 Jun;18(3):41
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J
Molecular neurodegeneration 2016 Jul 26;11(1):55
Molecular neurodegeneration 2016 Jul 26;11(1):55
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Chen Y, Deng J, Wang P, Yang M, Chen X, Zhu L, Liu J, Lu B, Shen Y, Fushimi K, Xu Q, Wu JY
Human molecular genetics 2016 Dec 1;25(23):5059-5068
Human molecular genetics 2016 Dec 1;25(23):5059-5068
Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development.
Deng Q, Guo T, Zhou X, Xi Y, Yang X, Ge W
Genetics 2016 Aug;203(4):1777-88
Genetics 2016 Aug;203(4):1777-88
Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis.
Li S, Wang J, Zhou A, Khan FA, Hu L, Zhang S
Oncotarget 2016 Aug 30;7(35):56002-56012
Oncotarget 2016 Aug 30;7(35):56002-56012
Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.
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Scientific reports 2016 Apr 26;6:25153
Scientific reports 2016 Apr 26;6:25153
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PLoS genetics 2015 Sep;11(9):e1005357
PLoS genetics 2015 Sep;11(9):e1005357
Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization.
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Acta biochimica et biophysica Sinica 2015 Jul;47(7):522-9
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Nature communications 2015 Jul 6;6:7527
Nature communications 2015 Jul 6;6:7527
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Journal of virology 2015 Apr;89(7):3804-18
Journal of virology 2015 Apr;89(7):3804-18
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.
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PLoS computational biology 2014 Nov;10(11):e1003935
PLoS computational biology 2014 Nov;10(11):e1003935
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PLoS pathogens 2014 Mar;10(3):e1004020
PLoS pathogens 2014 Mar;10(3):e1004020
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Cell 2014 Jul 31;158(3):607-19
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Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
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PloS one 2013;8(9):e75625
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Neurobiology of disease 2013 Jun;54:349-61
Neurobiology of disease 2013 Jun;54:349-61
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Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 1;188(1):358-66
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 1;188(1):358-66
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Cell research 2010 Sep;20(9):994-1011
Cell research 2010 Sep;20(9):994-1011
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11802-1-AP( TOM20 Antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TOM20 (IP:11802-1-AP, 3ug; Detection:11802-1-AP 1:2000) with HEK-293 cells lysate 2400ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TOM20 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TOM20. This antibody recognizes human, mouse antigen. The TOM20 antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.
