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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [114]
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- Product number
- 66777-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- TOM20 antibody
- Antibody type
- Monoclonal
- Description
- TOM20 antibody (Cat. #66777-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1D6F5
- Vial size
- 20ul, 150ul
Submitted references Aagab-driven SHIP2 degradation rescues mitochondrial dysfunction in hypoxic-ischemic encephalopathy.
ACADVL upregulation is associated with placental ferroptosis in intrahepatic cholestasis of pregnancy.
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation.
Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury.
Cornuside alleviates microglia-mediated neuroinflammation to ameliorate chronic neuropathic pain-induced cognitive impairment via the Nrf2/Sirt3 signaling pathway.
Mitochondrial fission process 1 is required for bovine oocyte maturation through regulation of mitochondrial function and dynamics.
Secretome translation shaped by lysosomes and lunapark-marked ER junctions.
Inhibition of TRPV4 Regulates Mitophagy Through the Sirt1/FoxO1 Signaling Pathway To Alleviate Acute Lung Injury.
Islet regeneration protein Reg3g promotes macrophage clearance of β cell-derived dysfunctional mitochondria-rich vesicles to mitigate T2DM.
Mitochondrial Function Is Required to Preserve Viability of Stem Cells From the Apical Papilla Following Porphyromonas endodontalis Infection.
Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.
Pinellia pedatisecta Schott-Derived Exosome-Like Nanovesicles Promote Apoptosis in Colorectal Cancer by Regulating the Lysosome-Mediated Mitophagy Pathway.
Single-Molecule Localization Expansion Nanoscopy via Spontaneously Blinking Fluorophores.
GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer.
Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis.
18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy.
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Uric Acid Stimulates PINK1/Parkin-Mediated Mitophagy via Nrf2/HO-1 Pathway to Protect Against Neuronal Apoptosis in Alzheimer's Disease.
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics.
Physical exercise protects neurons from energy deficit and improves cognitive function by upregulating astrocytic Slc2a1 in Alzheimer's disease.
Stigmasterol improves diabetic retinopathy by inhibiting VAMP7-mediated autophagy/mitophagy.
Cathodal Transcranial Direct Current Stimulation Attenuates Cerebral Ischemia-Reperfusion Injury by Coordinating Mitophagy Inhibition and Nrf2 Activation Against Ferroptosis.
TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration.
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.
Integrated multiomics reveals host-virus coadaptation in persistent foot-and-mouth disease virus infection.
Ginsenoside Rh2 as a novel PIN1 inhibitor disrupting the cancer stem cell-like phenotype in non-small cell lung cancer.
The Role of HADHB in Mitochondrial Fatty Acid Metabolism During Initiation of Metastasis in ccRCC.
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes.
Gestational Exposure to Black Phosphorus Nanoparticles Induces Placental Trophoblast Dysfunction by Triggering Reactive Oxygen Species-Regulated Mitophagy.
TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway.
JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy.
Irisin promotes autophagy and attenuates NLRP3 inflammasome activation in Parkinson's disease.
TNF/TNFR1 Signaling Mediates DEHP-Induced Hepatocyte Pyroptosis via the GSDMD-mtROS Axis.
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
OPA1 deficiency induces mitophagy through PINK1/Parkin pathway during bovine oocytes maturation.
Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.
PPM1D ameliorates Alzheimer's disease by promoting mitophagy.
MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.
Targeting PTBP3-Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis.
BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy.
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy.
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3.
Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes.
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
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Melatonin alleviates glyphosate-induced testosterone synthesis inhibition via targeting mitochondrial function in roosters.
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Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy.
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Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
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Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Loss of NDUFS1 promotes gastric cancer progression by activating the mitochondrial ROS-HIF1α-FBLN5 signaling pathway.
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Recombinant measles virus vaccine rMV-Hu191 exerts an oncolytic effect on esophageal squamous cell carcinoma via caspase-3/GSDME-mediated pyroptosis.
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.
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Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells.
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ACADVL upregulation is associated with placental ferroptosis in intrahepatic cholestasis of pregnancy.
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Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury.
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Islet regeneration protein Reg3g promotes macrophage clearance of β cell-derived dysfunctional mitochondria-rich vesicles to mitigate T2DM.
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Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.
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GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer.
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18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy.
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GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
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Antioxidants & redox signaling 2025 Sep;43(7-9):381-399
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Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
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Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics.
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Experimental neurology 2025 Oct 6;395:115493
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Stigmasterol improves diabetic retinopathy by inhibiting VAMP7-mediated autophagy/mitophagy.
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Gestational Exposure to Black Phosphorus Nanoparticles Induces Placental Trophoblast Dysfunction by Triggering Reactive Oxygen Species-Regulated Mitophagy.
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TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway.
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Molecular neurobiology 2025 Mar;62(3):3125-3142
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Journal of orthopaedic translation 2025 Mar;51:132-144
Irisin promotes autophagy and attenuates NLRP3 inflammasome activation in Parkinson's disease.
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International immunopharmacology 2025 Mar 6;149:114201
TNF/TNFR1 Signaling Mediates DEHP-Induced Hepatocyte Pyroptosis via the GSDMD-mtROS Axis.
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OPA1 deficiency induces mitophagy through PINK1/Parkin pathway during bovine oocytes maturation.
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Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.
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Molecular neurobiology 2025 Jun;62(6):6636-6654
PPM1D ameliorates Alzheimer's disease by promoting mitophagy.
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Experimental neurology 2025 Jun;388:115218
MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.
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BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy.
Wang J, Yin Z, Yang J, Sun S, Tang X, Zhang S, Wang YP, Wang H
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Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
Xiang W, Zhang T, Li B, Li S, Zhang B, Fang S, Chen L, Gong Y, Huang B, Feng D, Wu J, Yuan J, Wu Y, Yan X, Jin R, Zhang X, Fang X, Lian J, Chen L, Zhou S, Ni Z
Nature aging 2025 Jul;5(7):1295-1316
Nature aging 2025 Jul;5(7):1295-1316
m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy.
Cai D, Chen X, Xu H, Zhao Q, Zhou X, Wu J, Yuan S, Gao Y, Li D, Zhang R, Peng W, Li G, Nan A
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Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
Sun J, Ding J, Yue H, Xu B, Sodhi A, Xue K, Ren H, Qian J
Autophagy 2025 Jan;21(1):191-209
Autophagy 2025 Jan;21(1):191-209
Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3.
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156260
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156260
Ubiquitin ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes.
Zheng J, Chen J, Cao Z, Wu K, Wang J, Guo Y, Zhuang M
Developmental cell 2025 Jan 6;60(1):30-39.e3
Developmental cell 2025 Jan 6;60(1):30-39.e3
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
Zhao B, Tan WL, Yu BB, Fan J, Liu C, Liu J, Liu Z
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Tubular CD44 plays a key role in aggravating AKI through NF-κB p65-mediated mitochondrial dysfunction.
Huang J, Meng P, Liang Y, Li X, Zhou S, Li J, Wang X, Miao J, Shen W, Zhou L
Cell death & disease 2025 Feb 20;16(1):119
Cell death & disease 2025 Feb 20;16(1):119
Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury.
Chen K, Ying J, Zhu J, Chen L, Liu R, Jing M, Wang Y, Zhou K, Wu L, Wu C, Xiao J, Ni W
International immunopharmacology 2025 Feb 20;148:114057
International immunopharmacology 2025 Feb 20;148:114057
Dual activation of PPARα/γ by bezafibrate triggers PINK1/Parkin-Mediated mitophagy to enhance lenvatinib sensitivity in hepatocellular carcinoma.
Wang J, Chen L, Jiang L, Wang Y, Xue W, Cai X, Li H, Wang T
Biochemical pharmacology 2025 Dec;242(Pt 3):117367
Biochemical pharmacology 2025 Dec;242(Pt 3):117367
HSPA12B Protects Against Age-Related Endothelial Cell Senescence by Regulating STING Degradation.
Li T, Zhu P, Adams J, Tu F, Wang J, Garbe C, Dalal S, Singh K, Zhang X, Liu L, Williams DL, Li C, Wang X
Aging cell 2025 Dec;24(12):e70260
Aging cell 2025 Dec;24(12):e70260
Small peptide P110 mitigates axonal degeneration of SPG15 patient iPSC-derived neurons by targeting mitochondrial dysfunction.
Tamilselvam B, Thakur G, Mathew R, Chai E, Lopez J, Chen Z, Zhan W, Blackstone C, Li XJ
Neurobiology of disease 2025 Dec;217:107174
Neurobiology of disease 2025 Dec;217:107174
Photocatalytic labelling-enabled subcellular-resolved RNA profiling and synchronous multi-omics investigation.
Bi Y, Yu L, Deng Q, Kong L, Guo F, Zhang Y, Wang R, Chen PR, Liu J, Fan X
Nature chemistry 2025 Dec;17(12):1871-1882
Nature chemistry 2025 Dec;17(12):1871-1882
ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer.
Li H, Liu Y, Cai Z, Li K, Gao S, Lan A, Shu D, He K, Liu X, Peng Y, Guo S, Yu H, Jin A, Shen M, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e09769
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e09769
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Zhang X, Su Y, Yang W, Song Z, Sun Z, Wu X, Chen J, Gao B, Wang Z, Wang L, Jiang Q, Bu L, Li J, Lin Y, Xie W, Li J, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
A Common Mutation in the Homeostatic Iron Regulatory Gene Alters Astrocyte Migration and Redox Profile.
Nolt M, Neely E, Kheirabadi S, Jaberi A, Sheikhi A, Connor J
FASEB bioAdvances 2025 Aug;7(8):e70042
FASEB bioAdvances 2025 Aug;7(8):e70042
Atrazine exposure induces TDP-43 protein translocation: A potential mechanism for prefrontal cortical neurodegeneration induced by environmental pollutants.
Ma Y, Wang K, Jiao Y, Li Y, Hu R, Li Y, Shi G, Huang M
Toxicology 2025 Aug;515:154128
Toxicology 2025 Aug;515:154128
Gastrodin Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitochondrial Fusion and Activating the AMPK-OPA1 Signaling Pathway.
Liu Z, Han Z, Bao W, Guo Y, Yuan Y, Cheng J, Zhang J, Hu Y
CNS neuroscience & therapeutics 2025 Aug;31(8):e70559
CNS neuroscience & therapeutics 2025 Aug;31(8):e70559
Deficiency of FUN14 domain-containing 1 enhances the migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis through mitochondrial dysregulation.
Lu Y, Fang YX, Ou-Yang ZM, Wu T, Zhang Q, Zou YW, Zheng HW, Jing J, Lin LH, Ma JD, Liang Z, Dai L
Cellular signalling 2025 Aug;132:111829
Cellular signalling 2025 Aug;132:111829
An Olsalazine-Loaded Hollow Mesoporous Prussian Blue/Polydopamine Nanozyme Alleviates Anxiety/Depression-like Behavior and Enhances Brain Neural Activity in Colitis Mice.
Luo Q, Liu D, Yang J, Li T, Sheng H, Liu S, Zhou X, Zhou C, Wang H, Wang Z, Ho CSH
ACS applied materials & interfaces 2025 Aug 6;17(31):44300-44318
ACS applied materials & interfaces 2025 Aug 6;17(31):44300-44318
2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway.
Bao H, Chen X, Hu X, Cao Z, Zhou W, Chen B, Liao F, Wei F, Huang R, Li W, Chen Z
Scientific reports 2025 Aug 12;15(1):29469
Scientific reports 2025 Aug 12;15(1):29469
Oxidative stress-induced release of mitochondrial DNA (mtDNA) promotes the progression of vitiligo by activating the cGAS-STING signaling pathway in monocytes.
Wu T, Chen X, Fan J, Ye P, Zhang J, Wang Z, Zhou Y, Wang B, Jin X, Xiong S, Gao S, Chang Y, Li C, Jian Z
Free radical biology & medicine 2025 Aug 1;235:43-55
Free radical biology & medicine 2025 Aug 1;235:43-55
Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration.
Ling Z, Ge X, Jin C, Song Z, Zhang H, Fu Y, Zheng K, Xu R, Jiang H
Bioactive materials 2025 Apr;46:195-212
Bioactive materials 2025 Apr;46:195-212
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
Xu H, Zhao Q, Cai D, Chen X, Zhou X, Gao Y, Wu J, Yuan S, Li D, Zhang R, Peng W, Li G, Nan A
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.
Yan Y, Ran X, Zhou Z, Gu Y, Wang R, Qiu C, Sun Y, Wang J, Xiao J, Lu Y, Wang J
Frontiers in pharmacology 2024;15:1358646
Frontiers in pharmacology 2024;15:1358646
Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway.
Gao Y, Sun W, Wang J, Zhao D, Tian H, Qiu Y, Ji S, Wang S, Fu Q, Zhang F, Zhang Z, Wang F, Shao J, Zheng S, Meng J
International immunopharmacology 2024 Sep 10;138:112652
International immunopharmacology 2024 Sep 10;138:112652
Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson's disease.
Han Z, Wang B, Wen YQ, Li YN, Feng CX, Ding XS, Shen Y, Yang Q, Gao L
Free radical biology & medicine 2024 Oct;223:493-505
Free radical biology & medicine 2024 Oct;223:493-505
An accelerated Parkinson's disease monkey model using AAV-α-synuclein plus poly(ADP-ribose).
Liu S, Yang N, Yan Y, Wang S, Chen J, Wang Y, Gan X, Zhou J, Xie G, Wang H, Huang T, Ji W, Wang Z, Si W
Cell reports methods 2024 Oct 21;4(10):100876
Cell reports methods 2024 Oct 21;4(10):100876
Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress.
Cui Y, Yang G, Li H, Sun J, Liu X, Xia X
Biochemical and biophysical research communications 2024 Oct 20;730:150365
Biochemical and biophysical research communications 2024 Oct 20;730:150365
Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease.
Zhang Z, Li M, Li X, Feng Z, Luo G, Wang Y, Gao X
Journal of neuroinflammation 2024 Oct 15;21(1):261
Journal of neuroinflammation 2024 Oct 15;21(1):261
NLRX1 and STING alleviate renal ischemia-reperfusion injury by regulating LC3 lipidation during mitophagy.
Liao Y, Li P, Hang Q, Chong Y, Long W, Wei X, Sun D, Liu Y
Experimental cell research 2024 Nov 1;443(1):114323
Experimental cell research 2024 Nov 1;443(1):114323
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
Li Y, Zhao K, Hu Y, Yang F, Li P, Liu Y
iScience 2024 May 17;27(5):109764
iScience 2024 May 17;27(5):109764
Melatonin alleviates glyphosate-induced testosterone synthesis inhibition via targeting mitochondrial function in roosters.
Ren YL, Liang Q, Lian CY, Zhang W, Wang L
Environmental pollution (Barking, Essex : 1987) 2024 May 1;348:123828
Environmental pollution (Barking, Essex : 1987) 2024 May 1;348:123828
Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.
Quirion L, Robert A, Boulais J, Huang S, Bernal Astrain G, Strakhova R, Jo CH, Kherdjemil Y, Faubert D, Thibault MP, Kmita M, Baskin JM, Gingras AC, Smith MJ, Côté JF
Journal of cell science 2024 May 1;137(9)
Journal of cell science 2024 May 1;137(9)
Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy.
Liu J, Gao Y, Zhang H, Hao Z, Zhou G, Wen H, Su Q, Tong C, Yang X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155358
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155358
Design and Synthesis of 3-(2H-Chromen-3-yl)-5-aryl-1,2,4-oxadiazole Derivatives as Novel Toll-like Receptor 2/1 Agonists That Inhibit Lung Cancer In Vitro and In Vivo.
Wang Y, Cheng X, Liu X, Xu J, Wang L, Zhang S, Liu S, Peng T
Journal of medicinal chemistry 2024 Mar 28;67(6):4583-4602
Journal of medicinal chemistry 2024 Mar 28;67(6):4583-4602
Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.
Quirion L, Robert A, Boulais J, Huang S, Bernal Astrain G, Strakhova R, Jo CH, Kherdjemil Y, Thibault MP, Faubert D, Kmita M, Baskin JM, Gingras AC, Smith MJ, Cote JF
bioRxiv : the preprint server for biology 2024 Mar 25;
bioRxiv : the preprint server for biology 2024 Mar 25;
Kynurenine in IDO1(high) cancer cell-derived extracellular vesicles promotes angiogenesis by inducing endothelial mitophagy in ovarian cancer.
Ying X, Zheng X, Zhang X, Yin Y, Wang X
Journal of translational medicine 2024 Mar 11;22(1):267
Journal of translational medicine 2024 Mar 11;22(1):267
Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora.
Li Y, He P, Chen Y, Hu J, Deng B, Liu C, Yu B, Dong W
Scientific reports 2024 Jun 6;14(1):13063
Scientific reports 2024 Jun 6;14(1):13063
Hypoxia-inducible factor prolyl hydroxylase inhibitor alleviates heatstroke-induced acute kidney injury by activating BNIP3-mediated mitophagy.
Wang L, Song Y, Zhang P, Chen W, Xiao F, Zhou P, Yang X, Dai H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23723
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23723
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
Xiong Y, Luo J, Hong ZY, Zhu WZ, Hu A, Song BL
Journal of lipid research 2024 Jul;65(7):100579
Journal of lipid research 2024 Jul;65(7):100579
Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.
Sun L, Hong X, Wang D, Li Y
The European journal of neuroscience 2024 Jan;59(2):208-219
The European journal of neuroscience 2024 Jan;59(2):208-219
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H
Nature communications 2024 Jan 2;15(1):168
Nature communications 2024 Jan 2;15(1):168
Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis.
Gao Y, Mi N, Wu W, Zhao Y, Fan F, Liao W, Ming Y, Guan W, Bai C
Journal of extracellular vesicles 2024 Feb;13(2):e12410
Journal of extracellular vesicles 2024 Feb;13(2):e12410
HDAC10 switches NLRP3 modification from acetylation to ubiquitination and attenuates acute inflammatory diseases.
Yang M, Qin Z, Lin Y, Ma D, Sun C, Xuan H, Cui X, Ma W, Zhu X, Han L
Cell communication and signaling : CCS 2024 Dec 20;22(1):615
Cell communication and signaling : CCS 2024 Dec 20;22(1):615
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
Liu Y, Xu Y, Hao Q, Shi L, Chen Y, Liu Y, Li M, Zhang Y, Li T, Li Y, Jiang Z, Liu Y, Wang C, Bian Z, Yang L, Wang S
Cell death & disease 2024 Dec 20;15(12):921
Cell death & disease 2024 Dec 20;15(12):921
EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis.
Jin M, Wu X, Hu J, Chen Y, Yang B, Cheng C, Yang M, Zhang X
PLoS pathogens 2024 Aug;20(8):e1012437
PLoS pathogens 2024 Aug;20(8):e1012437
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Liang JH, Yu H, Xia CP, Zheng YH, Zhang Z, Chen Y, Raza MA, Wu L, Yan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy.
Ahola S, Pazurek LA, Mayer F, Lampe P, Hermans S, Becker L, Amarie OV, Fuchs H, Gailus-Durner V, de Angelis MH, Riedel D, Nolte H, Langer T
Science advances 2024 Aug 2;10(31):eadp0443
Science advances 2024 Aug 2;10(31):eadp0443
SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy.
Wang J, Dai L, Deng M, Xiao T, Zhang Z, Zhang Z
Molecular neurobiology 2024 Apr;61(4):2446-2458
Molecular neurobiology 2024 Apr;61(4):2446-2458
Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1/Parkin pathway in caerulein‑treated pancreatic ductal epithelial cells in vitro.
Lei Y, Yang HY, Meng N, Qin YY, Xu MT, Xiang XL, Liu L, Tang GD
Experimental and therapeutic medicine 2024 Apr;27(4):147
Experimental and therapeutic medicine 2024 Apr;27(4):147
Induction of therapeutic immunity and cancer eradication through biofunctionalized liposome-like nanovesicles derived from irradiated-cancer cells.
Deng S, Wang J, Hu Y, Sun Y, Yang X, Zhang B, Deng Y, Wei W, Zhang Z, Wen L, Qin Y, Huang F, Sheng Y, Wan C, Yang K
Journal of nanobiotechnology 2024 Apr 8;22(1):156
Journal of nanobiotechnology 2024 Apr 8;22(1):156
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y
Cancer letters 2024 Apr 28;588:216802
Cancer letters 2024 Apr 28;588:216802
Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion.
Knippler CM, Arnst JL, Robinson IE, Matsuk V, Khatib TO, Harvey RD, Shanmugam M, Mouw JK, Fu H, Ganesh T, Marcus AI
iScience 2024 Apr 19;27(4):109591
iScience 2024 Apr 19;27(4):109591
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
Zhang Q, Shen X, Yuan X, Huang J, Zhu Y, Zhu T, Zhang T, Wu H, Wu Q, Fan Y, Ni J, Meng L, He A, Shi C, Li H, Hu Q, Wang J, Chang C, Huang F, Li F, Chen M, Liu A, Ye S, Zheng M, Fang H
Nature communications 2024 Apr 13;15(1):3213
Nature communications 2024 Apr 13;15(1):3213
Novel FSIP2 Variants Induce Super-Length Mitochondrial Sheath and Asthenoteratozoospermia in Humans.
Lv M, Tang D, Yu H, Geng H, Zhou Y, Shao Z, Li K, Gao Y, Guo S, Xu C, Tan Q, Liu C, Guo R, Wu H, Duan Z, Zhang J, Wang G, Hua R, Fu F, Wang K, Xu Y, Zhou P, Wei Z, Zhang F, Cao Y, He X
International journal of biological sciences 2023;19(2):393-411
International journal of biological sciences 2023;19(2):393-411
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L, Liu X
Cell death & disease 2023 Sep 30;14(9):645
Cell death & disease 2023 Sep 30;14(9):645
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Baringer SL, Lukacher AS, Palsa K, Kim H, Lippmann ES, Spiegelman VS, Simpson IA, Connor JR
Journal of neurochemistry 2023 Oct;167(2):248-261
Journal of neurochemistry 2023 Oct;167(2):248-261
Loss of NDUFS1 promotes gastric cancer progression by activating the mitochondrial ROS-HIF1α-FBLN5 signaling pathway.
Chen T, Li D, Wang Y, Shen X, Dong A, Dong C, Duan K, Ren J, Li W, Shu G, Yang J, Xie Y, Qian F, Zhou J
British journal of cancer 2023 Oct;129(8):1261-1273
British journal of cancer 2023 Oct;129(8):1261-1273
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J
The EMBO journal 2023 Oct 16;42(20):e113743
The EMBO journal 2023 Oct 16;42(20):e113743
Recombinant measles virus vaccine rMV-Hu191 exerts an oncolytic effect on esophageal squamous cell carcinoma via caspase-3/GSDME-mediated pyroptosis.
Wu A, Li Z, Wang Y, Chen Y, Peng J, Zhu M, Li Y, Song H, Zhou D, Zhang C, Lv Y, Zhao Z
Cell death discovery 2023 May 19;9(1):171
Cell death discovery 2023 May 19;9(1):171
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Baringer SL, Lukacher AS, Palsa K, Kim H, Lippmann ES, Spiegelman VS, Simpson IA, Connor JR
bioRxiv : the preprint server for biology 2023 May 17;
bioRxiv : the preprint server for biology 2023 May 17;
Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.
Zhong S, Chen W, Wang B, Gao C, Liu X, Song Y, Qi H, Liu H, Wu T, Wang R, Chen B
Redox biology 2023 Jul;63:102760
Redox biology 2023 Jul;63:102760
Tunneling nanotubes-based intercellular mitochondrial trafficking as a novel therapeutic target in dry eye.
Jiang D, Xu W, Peng F, Sun Y, Pan C, Yu J, Zheng Q, Chen W
Experimental eye research 2023 Jul;232:109497
Experimental eye research 2023 Jul;232:109497
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, Xi Y, Sun L, He L, Tang C, Sun L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons.
Chen Z, Chai E, Mou Y, Roda RH, Blackstone C, Li XJ
Brain : a journal of neurology 2022 Nov 21;145(11):4016-4031
Brain : a journal of neurology 2022 Nov 21;145(11):4016-4031
AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.
Peng F, Jiang D, Xu W, Sun Y, Zha Z, Tan X, Yu J, Pan C, Zheng Q, Chen W
Investigative ophthalmology & visual science 2022 Nov 1;63(12):18
Investigative ophthalmology & visual science 2022 Nov 1;63(12):18
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.
Shin YY, Seo Y, Oh SJ, Ahn JS, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Sung ES, Kim HS
Journal of pineal research 2022 Jan;72(1):e12779
Journal of pineal research 2022 Jan;72(1):e12779
WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.
Liao HQ, Guo ZY, Huang LH, Liu G, Lu JF, Zhang YF, Xing XW
Molecular human reproduction 2022 Dec 28;29(1)
Molecular human reproduction 2022 Dec 28;29(1)
Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells.
Lu L, Liu JB, Wang JQ, Lian CY, Wang ZY, Wang L
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120314
Environmental pollution (Barking, Essex : 1987) 2022 Dec 1;314:120314
Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Wang Q, Guan Z, Qi L, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P
Science (New York, N.Y.) 2021 Sep 17;373(6561):1377-1381
Science (New York, N.Y.) 2021 Sep 17;373(6561):1377-1381
Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation.
Mollo N, Esposito M, Aurilia M, Scognamiglio R, Accarino R, Bonfiglio F, Cicatiello R, Charalambous M, Procaccini C, Micillo T, Genesio R, Calì G, Secondo A, Paladino S, Matarese G, De Vita G, Conti A, Nitsch L, Izzo A
Biology 2021 Jun 30;10(7)
Biology 2021 Jun 30;10(7)
Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.
Ou W, Liang Y, Qin Y, Wu W, Xie M, Zhang Y, Zhang Y, Ji L, Yu H, Li T
Redox biology 2021 Jul;43:101994
Redox biology 2021 Jul;43:101994
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