17938-1-AP

antibody from Proteintech Group

Targeting: LGALS9 LGALS9A

Provider product page for 17938-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [31]
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Validations
Western blot [1]

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Product number: 17938-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17938-1-AP, RRID:AB_2137233
Product name: Galectin-9 antibody
Antibody type: Polyclonal
Description: KD/KO validated Galectin-9 antibody (Cat. #17938-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LGALS9 protein structure - 17938-1-AP shown in red.

Submitted references Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.

Du L, Zhang X, Gong Y, Liu M, Sun J, Hu X, Peng J, Liu Z, Zhang T, Xu J, Gao F, Cheng W
Materials today. Bio 2026 Feb;36:102702

C5aR1(+) microglia exacerbate neuroinflammation and cerebral edema in acute brain injury.

Zhou J, Ma S, Feng D, Tian Y, Li L, Guo H, Shi Y, Cui W, Dong J, Hao S, Guo C, Xu M, Han L, Bai H, He D, Cui X, Chen L, Wu X, Gao F, Hu Q, Zhang Z, Wang K, Zhou G, Feng T, Xue D, Lin Q, Wang L, Gao L, Heng L, Zhao T, Luo T, Tian B, Zhang X, Guo W, Li Z, Liu H, Ge S, Liu Q, Qu Y
Neuron 2026 Feb 4;114(3):444-462.e9

Interaction between HIV-1 Tat and EBV Zta favours immune escape of B cells by downregulating HLA-ABC expression.

Shmakova A, Schwager A, Tsimailo I, Clerf E, Kozhevnikova Y, Feng J, Gérard L, Boutboul D, Oksenhendler E, Habib M, Drouet E, Germini D, Vassetzky Y
Cellular and molecular life sciences : CMLS 2026 Feb 2;83(1):88

Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction.

Chen Y, Fan B, Zeng J, Zou Y, Tao C, Chen C, Zhang P, Liang J, Qi F, Tang H, Lu L
Research (Washington, D.C.) 2025;8:0741

Integrated Single-Cell Analysis Reveals the Heterogeneity of Tumor-Associated Macrophages and Their Implications for Immunotherapy in Colorectal Cancer.

Xu G, Fang B, Tang X, Wei Q, Li J
Journal of inflammation research 2025;18:13381-13396

GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.

Chong S, Liu Y, Bian Z, Hu D, Guo S, Dong C, Zeng J, Fan S, Chen X
Cellular signalling 2025 Oct;134:111942

Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.

Zhang J, Xu Y, Han X, Gao Y, Wei Z, Sun X
Cancer genetics 2025 Nov;298-299:141-150

T-cell differentiation stage block bias confers hypermethylation and mediastinal preference in T-cell lymphoblastic lymphoma.

Wang J, Qian B, Yu X, Zhang Y, Zhou C, Yang T, Xia L, Zhang G, Zhang YX, Wang Y, Fang Y
Clinical and translational medicine 2025 Jul;15(7):e70380

Expression and clinical significance of CD155, FGL1, Galectin-9, and PD‑L1 in breast cancer with neoadjuvant chemotherapy.

Zeng Y, Zhao B, Yan M, Chen W, Liu R, Pan M, Xie Z, Zhou S, Liu M, Fan H, Wang W, Shao N, Kuang X, Bi J
Medical oncology (Northwood, London, England) 2025 Jul 25;42(9):375

Targeting the CD47-HCK-LGALS9 axis disrupts proliferation-immunosuppression coupling in early-stage endometrial cancer.

Ye J, Yan Y, Sun X, Wu Q, Shi Y, Zhang M, Lin X, Ren Y, Mao X, Lin M, Sun P
Molecular cancer 2025 Dec 23;25(1)

Galectin-9 activates microglial asparagine endopeptidase and promotes α-synuclein pathology in Parkinson's disease.

Peng Q, Zhang G, Guo X, Xu X, Li Y, Pan L, Meng L, Xiong J, Li S, Zhang Z
Cell death and differentiation 2025 Dec 14;

Comprehensive multi-omics approach reveals critical genes and immunometabolic networks in glioblastoma.

Yi Z, Song M, Liang L, Ren J, Tian J, Mao G, Mao G, Chen M
International journal of surgery (London, England) 2025 Aug 1;111(8):5137-5149

Sulfur dioxide inhibits mast cell degranulation by sulphenylation of galectin-9 at cysteine 74.

Song J, Zheng J, Li Z, Fu L, Yang J, Li K, Yu X, Lv B, Du J, Huang Y, Jin H
Frontiers in immunology 2024;15:1369326

Bevacizumab induces ferroptosis and enhances CD8(+) T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9.

Hou CY, Lv P, Yuan HF, Zhao LN, Wang YF, Zhang HH, Yang G, Zhang XD
Acta pharmacologica Sinica 2024 Sep;45(9):1951-1963

PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability.

Yu J, Xiang Y, Gao Y, Chang S, Kong R, Lv X, Yu J, Jin Y, Li C, Ma Y, Wang Z, Zhou J, Yuan H, Shang S, Hua F, Zhang X, Cui B, Li P
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4378-4395

Lnc-H19-derived protein shapes the immunosuppressive microenvironment of glioblastoma.

Chen J, Gao Y, Zhong J, Wu X, Leng Z, Liu M, Wang Y, Wang Y, Yang X, Huang N, Xiao F, Zhang M, Liu X, Zhang N
Cell reports. Medicine 2024 Nov 19;5(11):101806

Integrated bioinformatics analysis and in vivo validation of potential immune-related genes linked to diabetic nephropathy.

Deng J, Wu P
Heliyon 2024 Nov 15;10(21):e40151

Galectin-receptor interaction: a key player in liver fibrosis induced by Schistosoma japonicum infection.

Huang Z, Liu X, Huang S, Lu F
Parasites & vectors 2024 May 20;17(1):232

ATXN3 functions as a tumor suppressor through potentiating galectin-9-mediated apoptosis in human colon adenocarcinoma.

Cheng Y, Wang S, Gao Q, Fang D
The Journal of biological chemistry 2024 Jul;300(7):107415

Attenuated Salmonella typhimurium L forms suppress tumor growth and promote apoptosis in murine ovarian tumors.

Zhang Y, Tang Z, Shao Y, Yue X, Chu Y, Chen D
Scientific reports 2024 Jul 11;14(1):16045

The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.

Wang X, Wang S, Xu X, Jiang Y, Ren L, Zhang H, Li Z, Liu X, Hu X, Ren Y
Parasites & vectors 2024 Jul 10;17(1):299

A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma.

Huang Y, Xu J, Xie C, Liao Y, Lin R, Zeng Y, Yu F
Journal of hepatocellular carcinoma 2023;10:1639-1657

Galectin-9 and PD-L1 antibody blockade combination therapy inhibits tumour progression in pancreatic cancer.

Li E, Xu J, Chen Q, Zhang X, Xu X, Liang T
Immunotherapy 2023 Feb;15(3):135-147

Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression.

Zhang Q, Cao W, Yang C, Hong L, Geng S, Han H, Zhong C
The Journal of nutritional biochemistry 2023 Feb;112:109226

Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes.

Wang H, Peng W, Wang J, Zhang C, Zhao W, Ran Y, Yang X, Chen J, Li H
Viruses 2023 Apr 20;15(4)

Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.

Peng Q, Zhang G, Guo X, Dai L, Xiong M, Zhang Z, Chen L, Zhang Z
Frontiers in molecular neuroscience 2022;15:1046992

Prognostic Value and Biological Function of Galectins in Malignant Glioma.

Zhu H, Liu D, Cheng L, Liu J, Wang G, Li H, Zhang Y, Mi H, Zhang S, Shu K, Yu X
Frontiers in oncology 2022;12:834307

Galectin-9/TIM-3 as a Key Regulator of Immune Response in Gliomas With Chromosome 1p/19q Codeletion.

Li G, Huang R, Fan W, Wang D, Wu F, Zeng F, Yu M, Zhai Y, Chang Y, Pan C, Jiang T, Yan W, Wang H, Zhang W
Frontiers in immunology 2021;12:800928

Critical role of Tim-3 mediated autophagy in chronic stress induced immunosuppression.

Qin A, Zhong T, Zou H, Wan X, Yao B, Zheng X, Yin D
Cell & bioscience 2019;9:13

Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9.

Fan J, Tang X, Wang Q, Zhang Z, Wu S, Li W, Liu S, Yao G, Chen H, Sun L
Stem cell research & therapy 2018 Sep 17;9(1):237

Role of downregulation of galectin-9 in the tumorigenesis of gastric cancer.

Yang J, Zhu L, Cai Y, Suo J, Jin J
International journal of oncology 2014 Sep;45(3):1313-20

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Galectin 9 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Galectin 9. This antibody recognizes human,mouse,rat antigen. The Galectin 9 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 17938-1-AP.pdf

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