orb386071

antibody from Biorbyt
Targeting: GP2 ZAP75
Provider product page for orb386071
Western blot
ELISA
Immunohistochemistry

Antibody data

Product number
orb386071 - Provider product page
Provider
Biorbyt
Product name
Glycoprotein 2 Antibody / GP2 / ZAP75
Antibody type
Monoclonal
Description
GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
GP2/1712
Vial size
20 ug
Storage
Store the GP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
GP2 protein structure - orb386071 shown in red.