Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 641101 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#641101, RRID:AB_2157734
- Product name
- Purified anti-LAT
- Antibody type
- Monoclonal
- Antigen
- GST fusion protein corresponding to residues 31-233 of human LAT, cytoplasmic domain.
- Description
- LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcεRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store at 4° C
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Western blot analysis of extracts from Jurkat cells (lane 1) and mouse thymocytes (lane 2) using anti-LAT, clone 11B.12.
- Conjugate
- Unconjugated