641102

antibody from BioLegend

Targeting: LAT LAT1

Immunoprecipitation

Antibody data

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Validation data

Product number: 641102 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#641102, RRID:AB_2157732
Product name: Purified anti-LAT
Antibody type: Monoclonal
Antigen: GST fusion protein corresponding to residues 31-233 of human LAT, cytoplasmic domain.
Description: LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcεRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Upon receipt, store at 4° C

LAT protein structure - 641102 shown in red.