RA0467

antibody from Oursmab

Targeting: LINGO1 FLJ14594, LERN1, LRRN6A

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0467

Provider

Oursmab

Product name

Opicinumab (Biosimilar Reference Antibody) (LINGO1)

Antibody type

Monoclonal

Description

Opicinumab (also known as BIIB-033 or anti-LINGO-1) is a fully human monoclonal antibody that targets leucine-rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO-1), a transmembrane glycoprotein expressed primarily in the central nervous system (CNS) on neurons and oligodendrocytes. LINGO-1 is a negative regulator of oligodendrocyte differentiation, myelination, and axonal regeneration. By binding to and inhibiting LINGO-1, opicinumab aims to promote remyelination and axonal repair in demyelinating diseases. It has been clinically evaluated as a remyelination and neuroprotective therapy for multiple sclerosis (MS), including relapsing and progressive forms, but has not yet demonstrated conclusive efficacy in Phase II trials.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.