19828-1-AP

antibody from Proteintech Group

Targeting: HADH HADH1, HADHSC, SCHAD

Provider product page for 19828-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

Submit

Product number: 19828-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19828-1-AP, RRID:AB_10667408
Product name: HADH antibody
Antibody type: Polyclonal
Description: HADH antibody (Cat. #19828-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HADH protein structure - 19828-1-AP shown in red.

Submitted references Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinoma.

Lin S, Luo Z, Li Y, Hu B, Qu M, Liu B, Cao C, Peng T, Xu M, Xu Y, Liu X, Wang X, Li L, Ding W, Xu Z, Li R, Zhao J, Zhang J, Wang L, Ren F, Wang C, Wu P
EBioMedicine 2026 May;127:106256

Integration of non-targeted metabolomics and transcriptomics reveals the mechanistic rationale of Coptidis Rhizoma's cold property via systemic energy homeostasis and adaptive thermogenesis in mice.

Xie R, Liu Y, Song Q, Song L, Li J, Zhang Y, Meng J, Dou B, Hu X, Gao L, Zhao Q, Huo H, Sui F
Journal of ethnopharmacology 2026 May 10;362:121344

OXCT1-induced succinylation at K81 shields HADH from HSPA8-Mediated degradation in alveolar epithelial cells to attenuate lung ischemia-reperfusion injury.

Li J, Guan H, Miao P, Han Z, Ding C, Jin Z, Wei L
Free radical biology & medicine 2026 Jun;249:43-59

A nuclear isoform of hydroxyacyl-COA dehydrogenase inhibits tumor progression in colorectal cancer.

Gao Y, Yu L, Hou J, Hong Y, Gao X, Chen Z
iScience 2026 Feb 20;29(2):114470

Comparative Assessment of Synthetic and Algal-Derived Astaxanthin Supplementation on Growth Traits, Lipid Homeostasis, and Liver Well-Being in High-Fat Diet-Fed Trachinotus ovatus.

Guo Y, Pu H, Lin S, Chen B, Chen A, Huai M, Zhao W, Niu J
Aquaculture nutrition 2025;2025:2756729

Liquid-liquid phase separation-driven molecular subtyping and prognostic modeling in colorectal cancer.

Guan H, Tian C, Lin J, Zhang L, Shi R, Wang W, Li S, Sui Y, Lu Y, Cui T, Chen D
Frontiers in immunology 2025;16:1741979

Inhibition of eIF5A hypusination enhances antioxidant defense to prevent kidney Ischemia/Reperfusion injury.

Cougnon M, Giraud S, Materozzi M, Allart E, Rubera I, Mackowiak C, Jarretou G, Boildieu N, Ameteau V, Lemarié E, Ouahmi H, Melis N, Poet M, Duranton C, Pellerin L, Counillon L, Shkreli M, Tauc M, Hauet T, Pisani DF
Redox biology 2025 Oct;86:103814

Sex-dependent adaptations in heart mitochondria from transgenic mice overexpressing cytochrome b(5) reductase-3.

Sánchez-Mendoza LM, González-Reyes JA, Rodríguez-López S, Calvo-Rubio M, Calero-Rodríguez P, de Cabo R, Burón MI, Villalba JM
Mitochondrion 2025 Mar;81:102004

Integrated proteogenomic characterization of ampullary adenocarcinoma.

Zhang Q, Xu X, Jiang D, Wang Y, Wang H, Zhu J, Tang S, Wang R, Zhao S, Li K, Feng J, Xiang H, Yao Z, Xu N, Fang R, Guo W, Liu Y, Hou Y, Ding C
Cell discovery 2025 Jan 7;11(1):2

Hydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.

Wu T, Li W, Hu Y, Zhang D, Tian L, Xu H, Zhang F, Xiao B, Shi Y, Chen Y, Liao X, Ma K, Chen L
Forensic science international 2025 Feb;367:112371

Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor.

Zhang Z, Wang R, Cai J, Li X, Feng X, Xu S, Jiang Z, Lin P, Huang Z, Xie Y
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108339

Identification of serum metabolites associated with aristolochic acid nephropathy severity and insights into the underlying mechanism.

Liu X, Peng Y, Wu S, Huang X, Gao L, Deng R, Lu J
Toxicology letters 2024 Oct;400:24-34

CYB5R3 overexpression exhibits sexual dimorphism: Mitochondrial and metabolic adaptations in transgenic female mice during calorie restriction.

Sánchez-Mendoza LM, Pérez-Sánchez C, García-Caballero C, Pérez-Rodríguez M, Calero-Rodríguez P, Vellón-García B, Moreno JA, Burón MI, de Cabo R, González-Reyes JA, Villalba JM
Free radical biology & medicine 2024 Oct;223:69-86

Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.

Yin Y, Wang Z, Yang Y, Shen M, Hu H, Chen C, Zhou H, Li Z, Wu S
iScience 2024 Jul 19;27(7):110331

Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.

Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611

HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.

Mao H, Wang R, Shao F, Zhao M, Tian D, Xia H, Zhao Y
Scientific reports 2023 Sep 5;13(1):14629

Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice.

Elmansi AM, Miller RA
GeroScience 2023 Oct;45(5):2967-2981

A very high-carbohydrate diet differentially affects whole-body glucose tolerance and hepatic insulin resistance in rats.

Karasawa T, Koike A, Terada S
Nutrition (Burbank, Los Angeles County, Calif.) 2023 Oct;114:112113

Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.

Koves TR, Zhang GF, Davidson MT, Chaves AB, Crown SB, Johnson JM, Slentz DH, Grimsrud PA, Muoio DM
Cell metabolism 2023 Jun 6;35(6):1038-1056.e8

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.

Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951

Investigation of seasonal changes in lipid synthesis and metabolism-related genes in the oviduct of Chinese brown frog (Rana dybowskii).

Wang Y, Liu Y, Wang Y, Zhang A, Xie W, Zhang H, Weng Q, Xu M
European journal of histochemistry : EJH 2023 Dec 20;67(4)

Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia.

Shen X, Li G, Wang L, Yu H, Zhou L, Deng H, Wang N, Lai C, Zhou W, Gao Y
Molecules (Basel, Switzerland) 2022 Sep 28;27(19)

Luo T, Peng J, Li Q, Zhang Y, Huang Y, Xu L, Yang G, Tan D, Zhang Q, Tan Y
International journal of molecular sciences 2022 Nov 8;23(22)

A novel isoform of hydroxyacyl-CoA dehydrogenase inhibits cell proliferation.

Xia G, Gao Y, Wu C, Pan H, Hou J, Su J, Wei S, Gao X
Biochemical and biophysical research communications 2022 May 28;606:75-79

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Lu J, Zhang Y, Sun M, Ding C, Zhang L, Kong Y, Cai M, Miccoli P, Ma C, Yue X
Frontiers in oncology 2021;11:737127

SCF(JFK) is functionally linked to obesity and metabolic syndrome.

He L, Yan R, Yang Z, Zhang Y, Liu X, Yang J, Liu X, Liu X, Xia L, Wang Y, Wu J, Wu X, Shan L, Yang X, Liang J, Shang Y, Sun L
EMBO reports 2021 Jul 5;22(7):e52036

Proteomic Analysis Reveals the Effect of Trichostatin A and Bone Marrow-Derived Dendritic Cells on the Fatty Acid Metabolism of NIH3T3 Cells under Oxygen-Glucose Deprivation Conditions.

Wang X, Song T, Sun Y, Men L, Gu Y, Zhang S, Chen X
Journal of proteome research 2021 Jan 1;20(1):960-971

Insulin resistance is improved in high-fat fed mice by photobiomodulation therapy at 630 nm.

Silva G, Ferraresi C, de Almeida RT, Motta ML, Paixão T, Ottone VO, Fonseca IA, Oliveira MX, Rocha-Vieira E, Dias-Peixoto MF, Esteves EA, Coimbra CC, Amorim FT, Magalhães FC
Journal of biophotonics 2020 Mar;13(3):e201960140

Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.

Fukazawa A, Koike A, Karasawa T, Tsutsui M, Kondo S, Terada S
Nutrients 2020 Apr 30;12(5)

High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance.

de Matos MA, Vieira DV, Pinhal KC, Lopes JF, Dias-Peixoto MF, Pauli JR, de Castro Magalhães F, Little JP, Rocha-Vieira E, Amorim FT
Frontiers in physiology 2018;9:1451

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q
EBioMedicine 2018 Dec;38:178-190

Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.

Wu L, Guo X, Lyu Y, Clarke SL, Lucas EA, Smith BJ, Hildebrand D, Wang W, Medeiros DM, Shen X, Lin D
Scientific reports 2017 Nov 7;7(1):14624

Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Wu L, Guo X, Hartson SD, Davis MA, He H, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, von Lintig J, Lin D
Molecular nutrition & food research 2017 May;61(5)

Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.

Martin J, Maurhofer O, Bellance N, Benard G, Graber F, Hahn D, Galinier A, Hora C, Gupta A, Ferrand G, Hoppeler H, Rossignol R, Dufour JF, St-Pierre MV
Hepatology (Baltimore, Md.) 2013 May;57(5):2037-48

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 19828-1-AP(HADH antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-HADH (IP:19828-1-AP, 3ug; Detection:19828-1-AP 1:700) with HepG2 cells lysate 400ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human kidney using 19828-1-AP(HADH antibody) at dilution of 1:400 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HADH antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HADH. This antibody recognizes human,mouse,rat antigen. The HADH antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Appendix: 19828-1-AP.pdf

: Show more