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Western blot
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- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11991-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11991-1-AP, RRID:AB_10641987
- Product name
- Galc antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Galc antibody (Cat. #11991-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia.
Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice.
Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model.
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Three-dimensional bio-printed constructs consisting of human umbilical-derived mesenchymal stem cells promote cell viability, proliferation, and differentiation in vitro.
Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.
Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats.
Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis.
Synergistic and Superimposed Effect of Bone Marrow-Derived Mesenchymal Stem Cells Combined with Fasudil in Experimental Autoimmune Encephalomyelitis.
GALC gene is downregulated by promoter hypermethylation in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Intravenous injection of AAVrh10-GALC after the neonatal period in twitcher mice results in significant expression in the central and peripheral nervous systems and improvement of clinical features.
Molecular cloning and knockdown of galactocerebrosidase in zebrafish: new insights into the pathogenesis of Krabbe's disease.
Multipotent stromal cells alleviate inflammation, neuropathology, and symptoms associated with globoid cell leukodystrophy in the twitcher mouse.
Conditional astroglial Rictor overexpression induces malignant glioma in mice.
Extended normal life after AAVrh10-mediated gene therapy in the mouse model of Krabbe disease.
AAV-mediated expression of galactocerebrosidase in brain results in attenuated symptoms and extended life span in murine models of globoid cell leukodystrophy.
Furuta Y, Osaki Y, Nakagawa Y, Han SI, Araki M, Shikama A, Ohuchi N, Yamazaki D, Matsuda E, Nohara S, Mizunoe Y, Kainoh K, Suehara Y, Ohno H, Takeuchi Y, Miyamoto T, Murayama Y, Sugano Y, Iwasaki H, Hirano KI, Koseki M, Nakano S, Tokiwa H, Sekiya M, Yahagi N, Matsuzaka T, Nakamagoe K, Tomidokoro Y, Mitsui J, Tsuji S, Suzuki H, Shimano H
Journal of atherosclerosis and thrombosis 2024 Sep 1;31(9):1304-1318
Journal of atherosclerosis and thrombosis 2024 Sep 1;31(9):1304-1318
Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors.
Feng Y, Gao C, Xie D, Liu L, Chen B, Liu S, Yang H, Gao Z, Wilson DA, Tu Y, Peng F
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2301736
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2301736
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924
Nature communications 2022 Oct 7;13(1):5924
The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice.
Li ZD, Li H, Kang S, Cui YG, Zheng H, Wang P, Han K, Yu P, Chang YZ
Cell death & disease 2022 Nov 28;13(11):1006
Cell death & disease 2022 Nov 28;13(11):1006
Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model.
Lai PL, Ng CH, Wu CH, Lai CY, Schuyler SC, Wang V, Lin H, Lee YC, Chuang MH, Yang CH, Chen WJ, Huang HC, Lu J
Cells 2022 Mar 24;11(7)
Cells 2022 Mar 24;11(7)
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R
Developmental cell 2021 Feb 8;56(3):260-276.e7
Developmental cell 2021 Feb 8;56(3):260-276.e7
Three-dimensional bio-printed constructs consisting of human umbilical-derived mesenchymal stem cells promote cell viability, proliferation, and differentiation in vitro.
Tao Q, Wu C, Li X, Chen W, Sun K, Zhang P, Yang Z, Liu N, Xu R, Xu T, Wang C
Cellular and molecular biology (Noisy-le-Grand, France) 2020 May 16;66(2):165-171
Cellular and molecular biology (Noisy-le-Grand, France) 2020 May 16;66(2):165-171
Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.
Wang Y, Nakajima T, Diao P, Yamada Y, Nakamura K, Nakayama J, Tanaka N, Aoyama T, Kamijo Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9594-9614
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9594-9614
Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
Yamada Y, Harada M, Hashimoto K, Guo R, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y
Glycoconjugate journal 2019 Feb;36(1):1-11
Glycoconjugate journal 2019 Feb;36(1):1-11
Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats.
Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Chang CD, Vit JP, Shelley B, Gowing G, Svendsen CN
Experimental neurology 2016 Jun;280:41-9
Experimental neurology 2016 Jun;280:41-9
Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis.
Casamassa A, La Rocca C, Sokolow S, Herchuelz A, Matarese G, Annunziato L, Boscia F
Glia 2016 Jul;64(7):1124-37
Glia 2016 Jul;64(7):1124-37
Synergistic and Superimposed Effect of Bone Marrow-Derived Mesenchymal Stem Cells Combined with Fasudil in Experimental Autoimmune Encephalomyelitis.
Yu JW, Li YH, Song GB, Yu JZ, Liu CY, Liu JC, Zhang HF, Yang WF, Wang Q, Yan YP, Xiao BG, Ma CG
Journal of molecular neuroscience : MN 2016 Dec;60(4):486-497
Journal of molecular neuroscience : MN 2016 Dec;60(4):486-497
GALC gene is downregulated by promoter hypermethylation in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Zhao Y, Guo Y, Wang Z, Xiao Z, Li R, Luo A, Wu C, Jing Z, Sun N, Chen X, Du H, Zeng Y
Oncology reports 2015 Sep;34(3):1369-78
Oncology reports 2015 Sep;34(3):1369-78
Intravenous injection of AAVrh10-GALC after the neonatal period in twitcher mice results in significant expression in the central and peripheral nervous systems and improvement of clinical features.
Rafi MA, Rao HZ, Luzi P, Luddi A, Curtis MT, Wenger DA
Molecular genetics and metabolism 2015 Mar;114(3):459-66
Molecular genetics and metabolism 2015 Mar;114(3):459-66
Molecular cloning and knockdown of galactocerebrosidase in zebrafish: new insights into the pathogenesis of Krabbe's disease.
Zizioli D, Guarienti M, Tobia C, Gariano G, Borsani G, Bresciani R, Ronca R, Giacopuzzi E, Preti A, Gaudenzi G, Belleri M, Di Salle E, Fabrias G, Casas J, Ribatti D, Monti E, Presta M
Biochimica et biophysica acta 2014 Apr;1842(4):665-75
Biochimica et biophysica acta 2014 Apr;1842(4):665-75
Multipotent stromal cells alleviate inflammation, neuropathology, and symptoms associated with globoid cell leukodystrophy in the twitcher mouse.
Scruggs BA, Zhang X, Bowles AC, Gold PA, Semon JA, Fisher-Perkins JM, Zhang S, Bonvillain RW, Myers L, Li SC, Kalueff AV, Bunnell BA
Stem cells (Dayton, Ohio) 2013 Aug;31(8):1523-34
Stem cells (Dayton, Ohio) 2013 Aug;31(8):1523-34
Conditional astroglial Rictor overexpression induces malignant glioma in mice.
Bashir T, Cloninger C, Artinian N, Anderson L, Bernath A, Holmes B, Benavides-Serrato A, Sabha N, Nishimura RN, Guha A, Gera J
PloS one 2012;7(10):e47741
PloS one 2012;7(10):e47741
Extended normal life after AAVrh10-mediated gene therapy in the mouse model of Krabbe disease.
Rafi MA, Rao HZ, Luzi P, Curtis MT, Wenger DA
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Nov;20(11):2031-42
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Nov;20(11):2031-42
AAV-mediated expression of galactocerebrosidase in brain results in attenuated symptoms and extended life span in murine models of globoid cell leukodystrophy.
Rafi MA, Zhi Rao H, Passini MA, Curtis M, Vanier MT, Zaka M, Luzi P, Wolfe JH, Wenger DA
Molecular therapy : the journal of the American Society of Gene Therapy 2005 May;11(5):734-44
Molecular therapy : the journal of the American Society of Gene Therapy 2005 May;11(5):734-44
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11991-1-AP(Galc antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Galc antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of mouse Galc. This antibody recognizes human, mouse, rat antigen. The Galc antibody has been validated for the following applications: ELISA, WB, IHC analysis.
