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- References [138]
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- Product number
- 20507-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20507-1-AP, RRID:AB_10694284
- Product name
- DMT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DMT1 antibody (Cat. #20507-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aloperine Induces Ferroptosis of Colorectal Cancer Cells via the Nrf2 Pathway.
Dihuang Yinzi Ameliorates Cognitive Impairments and Inhibits Ferroptosis in APP/PS1 Mice.
Serotonin inhibits the influx of iron into cells by decreasing the expression of SLC11A2 in Caco-2 cells.
Steap4 Promotes Senile Osteoporosis via Fe(2+)-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs.
SLC38A1 Inhibits Ferroptosis of Alveolar Type II Epithelial Cells in Acute Lung Injury by Promoting Autophagic Degradation of Divalent Metal Transporter 1 (DMT1): an In Vivo and In Vitro Study.
Effect of saponins from gynostemma pentaphyllum on iron metabolism in apolipoprotein E deficient mice.
Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress-Induced Depression in Male Mice.
Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice.
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS).
CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis.
Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese.
BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states.
α-lipoic acid attenuates duodenal non-heme iron absorption via microRNA-mediated regulation of divalent metal transporter 1 in iron overloaded rats.
The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.
Downregulation of acetyl-CoA carboxylase induces ferroptosis and inhibits tumor growth in oral squamous cell carcinoma.
Hepatocyte growth factor alleviates alcoholic cardiomyopathy through the Nrf2 pathway-a focus on iron metabolism.
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.
Ferroptosis-driven neurobehavioral impairment in zebrafish embryos: Mechanistic links to developmental dibutyl phthalate exposure.
Effects of chitosan on restoring spermatogenesis in mice: Insights from gut microbiota and multi-omics analysis.
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS).
GDF15 attenuates Parkinson's disease progression via suppressing the activation of cGAS-STING pathway.
Heat shock protein B1-mediated ferroptosis regulates mitochondrial dysfunction in adipose tissue of ketotic dairy cows.
Metabolism and Mendelian randomization study on the mechanism of Buyang Huanwu Decoction in regulating iron metabolism and improving cerebral ischemia-reperfusion injury.
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation.
Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation.
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway.
Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis.
Inhibition of iron-induced cofilin activation and inflammation in microglia by a novel cofilin inhibitor.
Praeruptorin A screened by a ferrous ion probe inhibited DMT1 and ferroptosis to attenuate Doxorubicin-induced cardiomyopathy.
Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors modulating S100A8/A9-mediated iron metabolism pathway for managing intracerebral haemorrhage.
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
High intestinal iron absorption induced by decreased hepcidin leads to imbalance of iron metabolism in aging mice.
Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.
Fe(2+) Triggers Endocytosis of Carrier Proteins in Mammalian Cells.
COMM domain containing 4 inhibits hephaestin and ferroportin to enhance neuronal ferroptosis by disturbing the Cu-Fe balance in amyotrophic lateral sclerosis.
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet.
Tumor-derived miR-203a-3p potentiates muscle wasting by inducing muscle ferroptosis in pancreatic cancer.
Cell Cycle-Related Centromere Protein F Deficiency Suppresses Ovarian Cancer Cell Growth by Inducing Ferroptosis.
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Effect of ferric citrate on hippocampal iron accumulation and widespread molecular alterations associated with cognitive disorder in an ovariectomized mice model.
Golgi protein ACBD3 downregulation sensitizes cells to ferroptosis.
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress.
Glucose induced regulation of iron transporters implicates kidney iron accumulation.
Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats.
Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity.
Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation.
Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition.
Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers.
Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload.
Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption.
Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: An integrated multi-omics approach.
Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.
CCT3/ACTN4/TFRC axis protects hepatocellular carcinoma cells from ferroptosis by inhibiting iron endocytosis.
Magnetically attracting hydrogel reshapes iron metabolism for tissue repair.
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Excess iron accumulation mediated senescence in diabetic kidney injury.
Plasticity changes in iron homeostasis in hibernating Daurian ground squirrels (Spermophilus dauricus) may counteract chronically inactive skeletal muscle atrophy.
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity.
Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma.
Plasma non-transferrin-bound iron uptake by the small intestine leads to intestinal injury and intestinal flora dysbiosis in an iron overload mouse model and Caco-2 cells.
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.
Cis-monounsaturated fatty acids inhibit ferroptosis through downregulation of transferrin receptor 1.
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage.
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Ferroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Structural Characterization of Zinc-Sucrose Complex and Its Ability to Promote Zinc Absorption in Caco-2 Monolayer Cells and Mice.
Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.
IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism.
LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism.
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Artemether attenuates renal tubular injury by regulating iron metabolism in mice with streptozotocin-induced diabetes.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.
Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling.
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells.
SNAI2 promotes the development of ovarian cancer through regulating ferroptosis.
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.
Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier.
Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis.
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.
Verapamil downregulates iron uptake and upregulates divalent metal transporter 1 expression in H9C2 cardiomyocytes.
Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression.
Remarkable Plasticity of Bone Iron Homeostasis in Hibernating Daurian Ground Squirrels (Spermophilus dauricus) May Be Involved in Bone Maintenance.
Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation.
Exposure to low-dose cadmium induces testicular ferroptosis.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Tolerable upper intake level of iron damages the liver of weaned piglets.
Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition.
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Baicalein protects against MPP(+)/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro.
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
The Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.
An J, Tian L, Wang R, Ma D, Song J, Yuan R, Wu J, Bu Y, Wang J
OncoTargets and therapy 2026;19:575500
OncoTargets and therapy 2026;19:575500
Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis
.
Guo Z, Wang J, Wang Y, Liu X, Xia Y, Liu P, Qi L, Liu J, Wang X
Molecular medicine reports 2026 Mar;33(3)
Molecular medicine reports 2026 Mar;33(3)
Dihuang Yinzi Ameliorates Cognitive Impairments and Inhibits Ferroptosis in APP/PS1 Mice.
Xie F, Zhou L, Yu M
Biochemical genetics 2026 Jun;64(3):4282-4297
Biochemical genetics 2026 Jun;64(3):4282-4297
Serotonin inhibits the influx of iron into cells by decreasing the expression of SLC11A2 in Caco-2 cells.
Sugino Y, Ameku M, Kawanishi N, Nonen S
Biomedical reports 2026 Jan;24(1):13
Biomedical reports 2026 Jan;24(1):13
Steap4 Promotes Senile Osteoporosis via Fe(2+)-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs.
Wang L, Yin G, Li W, Li M, Lu F, Xu C, Zhao G, Geng D, Bai J, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09926
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09926
SLC38A1 Inhibits Ferroptosis of Alveolar Type II Epithelial Cells in Acute Lung Injury by Promoting Autophagic Degradation of Divalent Metal Transporter 1 (DMT1): an In Vivo and In Vitro Study.
Su F, Yan X, Li X, Zeng B, Sun X, Huang C, Chen C, Li S, Chen Y
Inflammation 2026 Jan 3;49(1):25
Inflammation 2026 Jan 3;49(1):25
Effect of saponins from gynostemma pentaphyllum on iron metabolism in apolipoprotein E deficient mice.
Huang T, Xiao X, Ma J, Fang J, Bao Y
European journal of medical research 2026 Jan 12;31(1):260
European journal of medical research 2026 Jan 12;31(1):260
Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress-Induced Depression in Male Mice.
Zhang J, Zhao B, Jia M, Zhao Y, Lu Y, Xi W, Zhu Z, Gong X, Ma Q, Gao Y, Guo Y, Li P, Zhu F, Wei S, Ma X, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e13438
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e13438
Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice.
Zhang F, Zhang C, Luo Q, Li J, Qiu X, Qian Z
Redox report : communications in free radical research 2026 Dec;31(1):2602306
Redox report : communications in free radical research 2026 Dec;31(1):2602306
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS).
Secic D, Bischoff ME, Schmidt L, Panmanee W, Yang J, Meller J, Vest KE, Cunningham JT, Landero JA, Czyzyk-Krzeska MF
The Journal of biological chemistry 2026 Apr;302(4):111278
The Journal of biological chemistry 2026 Apr;302(4):111278
CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis.
Yan X, Niu Y, Wang Y, Wei S, Han L, Guo Z, Zhao L, Gao F
Open medicine (Warsaw, Poland) 2025;20(1):20241100
Open medicine (Warsaw, Poland) 2025;20(1):20241100
Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese.
Prajapati M, Zhang JZ, Chong GS, Chiu L, Mercadante CJ, Kowalski HL, Antipova O, Lai B, Ralle M, Jackson BP, Punshon T, Guo S, Aghajan M, Bartnikas TB
Cellular and molecular gastroenterology and hepatology 2025;19(7):101489
Cellular and molecular gastroenterology and hepatology 2025;19(7):101489
BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states.
Rizzollo F, Escamilla-Ayala A, Fattorelli N, Lysiak NB, More S, Hernández Varas P, Barazzuol L, Van den Haute C, Van Asselberghs J, Nittner D, Coene J, Venkataramani V, Michalke B, Gaillet C, Cañeque T, Davidson I, Verhelst SHL, Vangheluwe P, Calì T, Marine JC, Rodriguez R, Bonnereau J, Agostinis P
Nature metabolism 2025 Sep;7(9):1851-1870
Nature metabolism 2025 Sep;7(9):1851-1870
α-lipoic acid attenuates duodenal non-heme iron absorption via microRNA-mediated regulation of divalent metal transporter 1 in iron overloaded rats.
Jiang S, Shu Y, Guo S, Ni Y, Shan H, Ma W
Molecular biology reports 2025 Sep 24;52(1):946
Molecular biology reports 2025 Sep 24;52(1):946
The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.
Guo Y, Zhu S, Wu W, Cai Y, Sehgal SA, Huang F, Wu H
The Journal of biological chemistry 2025 Oct;301(10):110689
The Journal of biological chemistry 2025 Oct;301(10):110689
Downregulation of acetyl-CoA carboxylase induces ferroptosis and inhibits tumor growth in oral squamous cell carcinoma.
Xu Z, Jia G
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2025 Nov;100(8):451-459
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2025 Nov;100(8):451-459
Hepatocyte growth factor alleviates alcoholic cardiomyopathy through the Nrf2 pathway-a focus on iron metabolism.
Yu Y, Chen J, Cao K, Zhang J
Journal of thoracic disease 2025 Nov 30;17(11):10149-10162
Journal of thoracic disease 2025 Nov 30;17(11):10149-10162
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.
Teng LS, Ying ZD, Sun XH, Hou HC, Qiu SD, Liu P, Li KJ, Zhang L, Sheng XH
Chemico-biological interactions 2025 Nov 1;421:111724
Chemico-biological interactions 2025 Nov 1;421:111724
Ferroptosis-driven neurobehavioral impairment in zebrafish embryos: Mechanistic links to developmental dibutyl phthalate exposure.
Hou T, Guo Y, Tao L, Fan X
Environmental pollution (Barking, Essex : 1987) 2025 Nov 1;384:127009
Environmental pollution (Barking, Essex : 1987) 2025 Nov 1;384:127009
Effects of chitosan on restoring spermatogenesis in mice: Insights from gut microbiota and multi-omics analysis.
He G, Zhang B, Chen T, Shen C, Wang N, Yang J, Chang F, Sui Y, Yin X, Wang Y, Wang S, Li Y, Zong J, Luo Y, Meng Y, Li C, Zhou X
Food research international (Ottawa, Ont.) 2025 May;208:116218
Food research international (Ottawa, Ont.) 2025 May;208:116218
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS).
Secic D, Bischoff ME, Schmidt L, Vest KE, Cunningham JT, Landero JA, Czyzyk-Krzeska MF
bioRxiv : the preprint server for biology 2025 Jun 16;
bioRxiv : the preprint server for biology 2025 Jun 16;
GDF15 attenuates Parkinson's disease progression via suppressing the activation of cGAS-STING pathway.
Wang J, Geng T, Yao X, Liu Y
Molecular and cellular biochemistry 2025 Jul;480(7):4449-4466
Molecular and cellular biochemistry 2025 Jul;480(7):4449-4466
Heat shock protein B1-mediated ferroptosis regulates mitochondrial dysfunction in adipose tissue of ketotic dairy cows.
Fan Y, Ma L, Xu X, Fang X, Mauck J, Loor JJ, Sun X, Jia H, Xu C, Xu Q
Journal of dairy science 2025 Jul;108(7):7815-7836
Journal of dairy science 2025 Jul;108(7):7815-7836
Metabolism and Mendelian randomization study on the mechanism of Buyang Huanwu Decoction in regulating iron metabolism and improving cerebral ischemia-reperfusion injury.
Xiong T, Bai Y, Shi Y, Li Y, Hu Z, Duan J, Lan X, Ding H, Zhang W
Journal of ethnopharmacology 2025 Jul 24;351:120062
Journal of ethnopharmacology 2025 Jul 24;351:120062
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation.
Lin Z, Ying C, Si X, Xue N, Liu Y, Zheng R, Chen Y, Pu J, Zhang B
Neural regeneration research 2025 Jul 1;20(7):2038-2052
Neural regeneration research 2025 Jul 1;20(7):2038-2052
Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation.
Zhen C, Wang S, Yang J, Zhang G, Cai C, Wang J, Wang A, Xu Y, Fang Y, Wei M, Yin D, Luo X, Gong M, Zhang H, Shang P
Journal of orthopaedic translation 2025 Jan;50:144-157
Journal of orthopaedic translation 2025 Jan;50:144-157
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway.
Liu Y, Li T, Niu C, Yuan Z, Sun S, Liu D
Molecular medicine (Cambridge, Mass.) 2025 Jan 3;31(1):1
Molecular medicine (Cambridge, Mass.) 2025 Jan 3;31(1):1
Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis.
Ma C, Han L, Zhao W, Chen F, Huang R, Pang CH, Zhu Z, Pan G
Biochemical pharmacology 2025 Feb;232:116711
Biochemical pharmacology 2025 Feb;232:116711
Inhibition of iron-induced cofilin activation and inflammation in microglia by a novel cofilin inhibitor.
Shehjar F, James AW, Mahajan R, Shah ZA
Journal of neurochemistry 2025 Feb;169(2):e16260
Journal of neurochemistry 2025 Feb;169(2):e16260
Praeruptorin A screened by a ferrous ion probe inhibited DMT1 and ferroptosis to attenuate Doxorubicin-induced cardiomyopathy.
Li D, Chen Y, Zhang B, Heng X, Yin J, Zhao P, Sun N, Shao C
European journal of medicinal chemistry 2025 Feb 5;283:117108
European journal of medicinal chemistry 2025 Feb 5;283:117108
Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors modulating S100A8/A9-mediated iron metabolism pathway for managing intracerebral haemorrhage.
Yang Y, Lv M, Liu R, Yu P, Shen Z, Bai D, Zhao P, Yang J, Tang X, Yang H, Yong Y, Jiang G
Journal of nanobiotechnology 2025 Feb 19;23(1):122
Journal of nanobiotechnology 2025 Feb 19;23(1):122
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Wu H, Zhu G, Zhu Q, Ma J, Mao S, Ding M, Zhu J, Tang X, Bian Z, Shan Y, Gu S, Sun F, Jiang C, Pan Q
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
High intestinal iron absorption induced by decreased hepcidin leads to imbalance of iron metabolism in aging mice.
Qiu L, Xiong W, Qin X, Zhou J, Zhu Y, Wang X
Biogerontology 2025 Dec 21;27(1):26
Biogerontology 2025 Dec 21;27(1):26
Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.
Yang X, Wu Y, Zhang Q, Zhou Y, Chang S, Zhang C, Liu D
BMC cancer 2025 Dec 13;26(1):81
BMC cancer 2025 Dec 13;26(1):81
Fe(2+) Triggers Endocytosis of Carrier Proteins in Mammalian Cells.
Zhang W, Chen C, Wang R, Li Y, Zhu Y, Sun J, Luo Y, Luo J, Zhao L, Sun Y, Guo H, Zhang H, Fang B, Hu Y, Liu R, Wang X, Guo J, Liu P, An P, Wang P, Chen J, Ren F
Advanced healthcare materials 2025 Aug;14(20):e2502090
Advanced healthcare materials 2025 Aug;14(20):e2502090
COMM domain containing 4 inhibits hephaestin and ferroportin to enhance neuronal ferroptosis by disturbing the Cu-Fe balance in amyotrophic lateral sclerosis.
Tan X, Su X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Wang S, Wang J, Feng H
Brain research 2025 Aug 15;1861:149707
Brain research 2025 Aug 15;1861:149707
Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.
Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557
Redox biology 2025 Apr;81:103557
Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet.
Zhang H, Shi H, Zhou S, Meng M, Ma N, Chang G, Shen X
Journal of dairy science 2025 Apr;108(4):4365-4380
Journal of dairy science 2025 Apr;108(4):4365-4380
Tumor-derived miR-203a-3p potentiates muscle wasting by inducing muscle ferroptosis in pancreatic cancer.
Hu Y, Hu Y, Zhang S, Guo Y, Wang F, Du Y, Wang L, Li P, Xu Y, Zhang H, Yang Z, Liu Z, Xu J, Liu M
Cancer letters 2025 Apr 1;614:217523
Cancer letters 2025 Apr 1;614:217523
Cell Cycle-Related Centromere Protein F Deficiency Suppresses Ovarian Cancer Cell Growth by Inducing Ferroptosis.
Liu X, Guo L, Suo Y, Tang X, Zhu T, Zhao T, Zhang W, Zhang P
Gynecologic and obstetric investigation 2024;89(5):424-436
Gynecologic and obstetric investigation 2024;89(5):424-436
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug design, development and therapy 2024;18:1349-1368
Drug design, development and therapy 2024;18:1349-1368
Effect of ferric citrate on hippocampal iron accumulation and widespread molecular alterations associated with cognitive disorder in an ovariectomized mice model.
Cui L, Zhou H, Hao Y, Yang X, Li Z, Gao Y, Zhang Z, Ren L, Ji L, Sun R, Wang Y, Wang X
CNS neuroscience & therapeutics 2024 Sep;30(9):e70018
CNS neuroscience & therapeutics 2024 Sep;30(9):e70018
Golgi protein ACBD3 downregulation sensitizes cells to ferroptosis.
Qian Y, Ma S, Qiu R, Sun Z, Liu W, Wu F, Lam SM, Xia Z, Wang K, Fang L, Shui G, Cao X
Cell biology international 2024 Oct;48(10):1559-1572
Cell biology international 2024 Oct;48(10):1559-1572
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress.
Li Z, Cui C, Xu L, Ding M, Wang Y
Free radical research 2024 Nov;58(11):686-701
Free radical research 2024 Nov;58(11):686-701
Glucose induced regulation of iron transporters implicates kidney iron accumulation.
Kumar R, Kulshreshtha D, Aggarwal A, Asthana S, Dinda A, Mukhopadhyay CK
Biochimica et biophysica acta. General subjects 2024 Nov;1868(11):130713
Biochimica et biophysica acta. General subjects 2024 Nov;1868(11):130713
Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats.
Qiu L, Hu M, Qin X, Song R, Sun Y, Wang X
Molecular nutrition & food research 2024 Mar;68(6):e2300617
Molecular nutrition & food research 2024 Mar;68(6):e2300617
Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity.
Zhao M, Qiao C, Yang S, Tang Y, Sun W, Sun S, Guo Q, Du F, Zhang N, Ning T, Wu J, Xu J, Li P
European journal of pharmacology 2024 Mar 5;966:176340
European journal of pharmacology 2024 Mar 5;966:176340
Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation.
Cao Y, Zhao W, Zhong Y, Jiang X, Mei H, Chang Y, Wu D, Dou J, Vasquez E, Shi X, Yang J, Jia Z, Tan X, Li Q, Dong Y, Xie R, Gao J, Wu Y, Liu Y
The Science of the total environment 2024 Mar 20;917:170317
The Science of the total environment 2024 Mar 20;917:170317
Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.
Li P, Chen JM, Ge SH, Sun ML, Lu JD, Liu F, Wang LL, Zhang X, Wang XP
European journal of pharmacology 2024 Mar 15;967:176402
European journal of pharmacology 2024 Mar 15;967:176402
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Tang XH, Zhao TN, Guo L, Liu XY, Zhang WN, Zhang P
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.
Lu JS, Wang JH, Han K, Li N
Inflammation 2024 Jun;47(3):975-988
Inflammation 2024 Jun;47(3):975-988
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition.
Huang LY, Zhang YD, Liu YN, Liang ZY, Chen J, Wang B, Yin QL, Wang PP, Wang W, Qi SH
ACS chemical neuroscience 2024 Jun 5;15(11):2223-2232
ACS chemical neuroscience 2024 Jun 5;15(11):2223-2232
Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers.
Krieg S, Rohde T, Rausch T, Butthof L, Wendler-Link L, Eckert C, Breuhahn K, Galy B, Korbel J, Billmann M, Breinig M, Tschaharganeh DF
Genome medicine 2024 Jun 17;16(1):83
Genome medicine 2024 Jun 17;16(1):83
Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload.
Wang C, Zhao H, Liu Y, Qu M, Lv S, He G, Liang H, Chen K, Yang L, He Y, Ou C
Ecotoxicology and environmental safety 2024 Jun 15;278:116404
Ecotoxicology and environmental safety 2024 Jun 15;278:116404
Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption.
Prajapati M, Zhang JZ, Chong GS, Chiu L, Mercadante CJ, Kowalski HL, Antipova O, Lai B, Ralle M, Jackson BP, Punshon T, Guo S, Aghajan M, Bartnikas TB
bioRxiv : the preprint server for biology 2024 Jul 20;
bioRxiv : the preprint server for biology 2024 Jul 20;
Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes.
Wang N, Zhao Y, Wu M, Li N, Yan C, Guo H, Li Q, Li Q, Wang Q
Molecular neurobiology 2024 Feb;61(2):1187-1201
Molecular neurobiology 2024 Feb;61(2):1187-1201
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
Wang J, Zhen C, Zhang G, Yang Z, Shang P
International journal of molecular sciences 2024 Dec 6;25(23)
International journal of molecular sciences 2024 Dec 6;25(23)
Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: An integrated multi-omics approach.
Chang Y, Jiang X, Dou J, Xie R, Zhao W, Cao Y, Gao J, Yao F, Wu D, Mei H, Zhong Y, Ge Y, Xu H, Jiang W, Xiao X, Jiang Y, Hu S, Wu Y, Liu Y
Journal of hazardous materials 2024 Dec 5;480:135814
Journal of hazardous materials 2024 Dec 5;480:135814
Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.
Guan S, Zhang S, Liu M, Guo J, Chen Y, Shen X, Deng X, Lu J
Journal of dairy science 2024 Aug;107(8):5316-5329
Journal of dairy science 2024 Aug;107(8):5316-5329
CCT3/ACTN4/TFRC axis protects hepatocellular carcinoma cells from ferroptosis by inhibiting iron endocytosis.
Zhu H, Liu Q, Meng Q, Zhang L, Ju S, Lang J, Zhu D, Chen Y, Aishan N, Ouyang X, Zhang S, Jin L, Xiao L, Wang L, Li L, Ji F
Journal of experimental & clinical cancer research : CR 2024 Aug 29;43(1):245
Journal of experimental & clinical cancer research : CR 2024 Aug 29;43(1):245
Magnetically attracting hydrogel reshapes iron metabolism for tissue repair.
Xu Y, Cai F, Zhou Y, Tang J, Mao J, Wang W, Li Z, Zhou L, Feng Y, Xi K, Gu Y, Chen L
Science advances 2024 Aug 16;10(33):eado7249
Science advances 2024 Aug 16;10(33):eado7249
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Kong L, Liu Y, Li J, Wang Y, Ji P, Shi Q, Han M, Xu H, Li W, Li W
Journal of ethnopharmacology 2024 Aug 10;330:118205
Journal of ethnopharmacology 2024 Aug 10;330:118205
Excess iron accumulation mediated senescence in diabetic kidney injury.
Cheng X, Li Y, Chen L, Jiang C, Peng S, Yao P, Tang Y
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Plasticity changes in iron homeostasis in hibernating Daurian ground squirrels (Spermophilus dauricus) may counteract chronically inactive skeletal muscle atrophy.
Kong Y, Yin R, He Y, Pan F, Yang H, Wang H, Zhang J, Gao Y
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2024 Apr;194(2):191-202
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2024 Apr;194(2):191-202
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Wang M, Liu Y, Gui H, Ma G, Li B, Zhang Z, Yu G, Wu A, Xu X, Zhang D
European journal of pharmacology 2024 Apr 15;969:176303
European journal of pharmacology 2024 Apr 15;969:176303
Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.
Zhong X, Chen R
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
An JR, Liu JT, Gao XM, Wang QF, Sun GY, Su JN, Zhang C, Yu JX, Yang YF, Shi Y
Frontiers in cellular neuroscience 2023;17:1136070
Frontiers in cellular neuroscience 2023;17:1136070
Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity.
Chen J, Xiao F, Chen L, Zhou Z, Wei Y, Zhong Y, Li L, Xie Y
Frontiers in pharmacology 2023;14:1121280
Frontiers in pharmacology 2023;14:1121280
Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma.
Wang Z, He Y, Cun Y, Li Q, Zhao Y, Luo Z
Frontiers in cell and developmental biology 2023;11:1164544
Frontiers in cell and developmental biology 2023;11:1164544
Plasma non-transferrin-bound iron uptake by the small intestine leads to intestinal injury and intestinal flora dysbiosis in an iron overload mouse model and Caco-2 cells.
Zhang Q, Ding H, Yu X, Wang Q, Li X, Zhang R, Feng J
Science China. Life sciences 2023 Sep;66(9):2041-2055
Science China. Life sciences 2023 Sep;66(9):2041-2055
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.
Cheng HP, Feng DD, Li XH, Gao LH, Qiu YJ, Liang XY, Zhou Y, Huang P, Shao M, Zhang YN, Chang YF, Fu JF, Huang YH, Liu W, Tang SY, Li C, Luo ZQ
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535
Cis-monounsaturated fatty acids inhibit ferroptosis through downregulation of transferrin receptor 1.
Shan K, Fu G, Li J, Qi Y, Feng N, Li Y, Chen YQ
Nutrition research (New York, N.Y.) 2023 Oct;118:29-40
Nutrition research (New York, N.Y.) 2023 Oct;118:29-40
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage.
Ma SJ, Li C, Yan C, Liu N, Jiang GY, Yang HR, Yan HC, Li JY, Liu HL, Gao C
Free radical biology & medicine 2023 Nov 1;208:555-570
Free radical biology & medicine 2023 Nov 1;208:555-570
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
Jin L, Yu B, Wang H, Shi L, Yang J, Wu L, Gao C, Pan H, Han F, Lin W, Lai EY, Wang YF, Yang Y
Free radical biology & medicine 2023 Nov 1;208:348-360
Free radical biology & medicine 2023 Nov 1;208:348-360
Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.
Ma M, Wang R, Xu M
Journal of hazardous materials 2023 Jun 15;452:131217
Journal of hazardous materials 2023 Jun 15;452:131217
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
Liu Y, Wang Y, Lin Z, Kang R, Tang D, Liu J
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Wu H, Liu Q, Shan X, Gao W, Chen Q
Autophagy 2023 Jul;19(7):2062-2077
Autophagy 2023 Jul;19(7):2062-2077
Ferroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Li X, Wang Q, Xu C, Zhang L, Zhou J, Lv J, Xu M, Jiang D
Cancers 2023 Feb 18;15(4)
Cancers 2023 Feb 18;15(4)
Structural Characterization of Zinc-Sucrose Complex and Its Ability to Promote Zinc Absorption in Caco-2 Monolayer Cells and Mice.
Li N, Wang R, Deng Z, Zhou J, Li W, Du Q, Zheng L
Journal of agricultural and food chemistry 2023 Aug 9;71(31):12094-12104
Journal of agricultural and food chemistry 2023 Aug 9;71(31):12094-12104
Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.
Liu J, Chen H, Lin H, Peng S, Chen L, Cheng X, Yao P, Tang Y
The Journal of nutritional biochemistry 2023 Apr;114:109258
The Journal of nutritional biochemistry 2023 Apr;114:109258
IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism.
Liu TY, Hu CC, Han CY, Mao SY, Zhang WX, Xu YM, Sun YJ, Jiang DB, Zhang XY, Zhang JX, Wang J, Qiao XP, Pan JY, Yang SY, Yang K
Biology direct 2023 Apr 23;18(1):19
Biology direct 2023 Apr 23;18(1):19
LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism.
He XY, Fan X, Qu L, Wang X, Jiang L, Sang LJ, Shi CY, Lin S, Yang JC, Yang ZZ, Lei K, Li JH, Ju HQ, Yan Q, Liu J, Wang F, Shao J, Xiong Y, Wang W, Lin A
Nature communications 2023 Apr 20;14(1):2253
Nature communications 2023 Apr 20;14(1):2253
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Han S, Lin F, Qi Y, Liu C, Zhou L, Xia Y, Chen K, Xing J, Liu Z, Yu W, Zhang Y, Zhou X, Rao T, Cheng F
Oxidative medicine and cellular longevity 2022;2022:3846217
Oxidative medicine and cellular longevity 2022;2022:3846217
Artemether attenuates renal tubular injury by regulating iron metabolism in mice with streptozotocin-induced diabetes.
Rong G, Cai Y, Weng W, Chen Y, Yu X, Shao M, Han P, Sun H
American journal of translational research 2022;14(9):6095-6106
American journal of translational research 2022;14(9):6095-6106
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Wang H, Jiang C, Yang Y, Li J, Wang Y, Wang C, Gao Y
PeerJ 2022;10:e13592
PeerJ 2022;10:e13592
Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.
Niu J, Wan X, Yu GY, Jiang S, Yi RN, Wu YP, Ouyang SH, Liang L, Kurihara H, Sun WY, Zhu XF, Zhang RH, Cao YF, He JB, Duan WJ, Li YF, He RR
Redox biology 2022 Oct;56:102437
Redox biology 2022 Oct;56:102437
Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling.
Huang Q, Tian L, Zhao X, Lei S, Zhao B, Qiu Z, Xia ZY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113595
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113595
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
Han P, Wang X, Zhou T, Cheng J, Wang C, Sun F, Zhao X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells.
Song Q, Peng S, Che F, Zhu X
Journal of pharmacological sciences 2022 Mar;148(3):300-306
Journal of pharmacological sciences 2022 Mar;148(3):300-306
SNAI2 promotes the development of ovarian cancer through regulating ferroptosis.
Jin Y, Chen L, Li L, Huang G, Huang H, Tang C
Bioengineered 2022 Mar;13(3):6451-6463
Bioengineered 2022 Mar;13(3):6451-6463
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.
Henning Y, Blind US, Larafa S, Matschke J, Fandrey J
Cell death & disease 2022 Jul 29;13(7):662
Cell death & disease 2022 Jul 29;13(7):662
Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier.
Liu LL, Du D, Zheng W, Zhang Y
Neurotoxicology 2022 Jan;88:44-56
Neurotoxicology 2022 Jan;88:44-56
Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Yin R, Zhang J, Xu S, Kong Y, Wang H, Gao Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis.
Cheng Z, Akatsuka S, Li GH, Mori K, Takahashi T, Toyokuni S
Cancer science 2022 Jan;113(1):65-78
Cancer science 2022 Jan;113(1):65-78
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.
Sterling JK, Kam TI, Guttha S, Park H, Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A, Chou SC, Troncoso JC, Dawson VL, Dawson TM, Dunaief JL
Cell reports 2022 Feb 15;38(7):110358
Cell reports 2022 Feb 15;38(7):110358
Verapamil downregulates iron uptake and upregulates divalent metal transporter 1 expression in H9C2 cardiomyocytes.
Jiang LR, Shen MQ, Bao YX, Qian ZM
Fundamental & clinical pharmacology 2022 Dec;36(6):985-991
Fundamental & clinical pharmacology 2022 Dec;36(6):985-991
Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression.
Pinto AT, Machado AB, Osório H, Pinto ML, Vitorino R, Justino G, Santa C, Castro F, Cruz T, Rodrigues C, Lima J, Sousa JLR, Cardoso AP, Figueira R, Monteiro A, Marques M, Manadas B, Pauwels J, Gevaert K, Mareel M, Rocha S, Duarte T, Oliveira MJ
Cancers 2022 Dec 30;15(1)
Cancers 2022 Dec 30;15(1)
Remarkable Plasticity of Bone Iron Homeostasis in Hibernating Daurian Ground Squirrels (Spermophilus dauricus) May Be Involved in Bone Maintenance.
He Y, Kong Y, Yin R, Yang H, Zhang J, Wang H, Gao Y
International journal of molecular sciences 2022 Dec 13;23(24)
International journal of molecular sciences 2022 Dec 13;23(24)
Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation.
Shi Q, Liu R, Chen L
Molecular medicine reports 2022 Apr;25(4)
Molecular medicine reports 2022 Apr;25(4)
Exposure to low-dose cadmium induces testicular ferroptosis.
Xiong L, Bin Zhou, Young JL, Wintergerst K, Cai L
Ecotoxicology and environmental safety 2022 Apr 1;234:113373
Ecotoxicology and environmental safety 2022 Apr 1;234:113373
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Song Q, Peng S, Sun Z, Heng X, Zhu X
Yonsei medical journal 2021 Sep;62(9):843-849
Yonsei medical journal 2021 Sep;62(9):843-849
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
Zimmer TS, David B, Broekaart DWM, Schidlowski M, Ruffolo G, Korotkov A, van der Wel NN, van Rijen PC, Mühlebner A, van Hecke W, Baayen JC, Idema S, François L, van Eyll J, Dedeurwaerdere S, Kessels HW, Surges R, Rüber T, Gorter JA, Mills JD, van Vliet EA, Aronica E
Acta neuropathologica 2021 Oct;142(4):729-759
Acta neuropathologica 2021 Oct;142(4):729-759
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Wang L, Ouyang S, Li B, Wu H, Wang F
Cell death discovery 2021 Nov 3;7(1):334
Cell death discovery 2021 Nov 3;7(1):334
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Yang G, Qian C, Zhang C, Bao Y, Liu MY, Jiang F, Li W, Liu Y, Ke Y, Qian ZM
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Tolerable upper intake level of iron damages the liver of weaned piglets.
Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition.
Li X, Jiang XW, Chu HX, Zhao QC, Ding HW, Cai CH
Chinese herbal medicines 2021 Jan;13(1):105-115
Chinese herbal medicines 2021 Jan;13(1):105-115
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Song Q, Zhao Y, Yang Y, Han X, Duan J
Toxicology and applied pharmacology 2021 Jan 1;410:115361
Toxicology and applied pharmacology 2021 Jan 1;410:115361
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z
Experimental and molecular pathology 2021 Feb;118:104570
Experimental and molecular pathology 2021 Feb;118:104570
Baicalein protects against MPP(+)/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Song Q, Peng S, Zhu X
Neurotoxicology 2021 Dec;87:188-194
Neurotoxicology 2021 Dec;87:188-194
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Xiang T, Luo X, Zeng C, Li S, Ma M, Wu Y
Brain research 2021 Dec 1;1772:147668
Brain research 2021 Dec 1;1772:147668
Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro.
Song Q, Zhang F, Han X, Yang Y, Zhao Y, Duan J
Experimental eye research 2021 Aug;209:108642
Experimental eye research 2021 Aug;209:108642
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Ma J, Qian C, Bao Y, Liu MY, Ma HM, Shen MQ, Li W, Wang JJ, Bao YX, Liu Y, Ke Y, Qian ZM
Redox biology 2021 Apr;40:101865
Redox biology 2021 Apr;40:101865
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Petit F, Drecourt A, Dussiot M, Zangarelli C, Hermine O, Munnich A, Rötig A
Blood 2021 Apr 15;137(15):2090-2102
Blood 2021 Apr 15;137(15):2090-2102
Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.
Ding H, Yu X, Chen L, Han J, Zhao Y, Feng J
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Yamaguchi H, Honda S, Torii S, Shimizu K, Katoh K, Miyake K, Miyake N, Fujikake N, Sakurai HT, Arakawa S, Shimizu S
Nature communications 2020 Oct 20;11(1):5311
Nature communications 2020 Oct 20;11(1):5311
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Li Y, Jin C, Shen M, Wang Z, Tan S, Chen A, Wang S, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Nov 20;160:845-859
Free radical biology & medicine 2020 Nov 20;160:845-859
Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.
Song Q, Zhao Y, Li Q, Han X, Duan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109690
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109690
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7
Molecular cell 2020 Feb 6;77(3):645-655.e7
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Morgan SE, Schroten H, Ishikawa H, Zhao N
Brain sciences 2020 Aug 8;10(8)
Brain sciences 2020 Aug 8;10(8)
Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.
Guo C, Xue H, Guo T, Zhang W, Xuan WQ, Ren YT, Wang D, Chen YH, Meng YH, Gao HL, Zhao P
Food & function 2020 Aug 1;11(8):7183-7196
Food & function 2020 Aug 1;11(8):7183-7196
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Li S, Qian ZM, Xu G, Zheng J, Wu Y
Bioscience reports 2020 Apr 30;40(4)
Bioscience reports 2020 Apr 30;40(4)
Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.
Zhao P, Qian C, Chen YJ, Sheng Y, Ke Y, Qian ZM
Cell death & disease 2019 Sep 24;10(10):708
Cell death & disease 2019 Sep 24;10(10):708
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Scheiber IF, Wu Y, Morgan SE, Zhao N
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
Hu P, Zhao D, Zhao F, Wang J, Zhu W
Animals : an open access journal from MDPI 2019 Jul 11;9(7)
Animals : an open access journal from MDPI 2019 Jul 11;9(7)
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
Liu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, Chua JJE, Chung MCM, Khanna S, Lim KL, Soong TW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Sep 26;38(39):8364-8377
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Sep 26;38(39):8364-8377
The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Yang L, Wang D, Wang XT, Lu YP, Zhu L
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):128-135
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):128-135
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Zhang MW, Zhao P, Yung WH, Sheng Y, Ke Y, Qian ZM
Aging 2018 Dec 16;10(12):3834-3850
Aging 2018 Dec 16;10(12):3834-3850
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Zhou YF, Zhang C, Yang G, Qian ZM, Zhang MW, Ma J, Zhang FL, Ke Y
Frontiers in physiology 2017;8:332
Frontiers in physiology 2017;8:332
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
Chen P, Li FM, Zhou YF, Qian C, Li J, Jiang LR, Qian ZM
Pharmacological reports : PR 2017 Feb;69(1):1-5
Pharmacological reports : PR 2017 Feb;69(1):1-5
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
Zhao N, Zhang AS, Wortham AM, Jue S, Knutson MD, Enns CA
Nutrients 2017 Dec 8;9(12)
Nutrients 2017 Dec 8;9(12)
A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.
Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, Gao J
Molecular medicine reports 2016 Sep;14(3):1970-8
Molecular medicine reports 2016 Sep;14(3):1970-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC11A2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SLC11A2. This antibody recognizes human, mouse, rat antigen. The SLC11A2 antibody has been validated for the following applications: ELISA, WB analysis.
