Antibody data
- Antibody Data
- Antigen structure
- References [84]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
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- Product number
- 20507-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20507-1-AP, RRID:AB_10694284
- Product name
- DMT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DMT1 antibody (Cat. #20507-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats.
Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity.
Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation.
Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition.
Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes.
Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Excess iron accumulation mediated senescence in diabetic kidney injury.
Plasticity changes in iron homeostasis in hibernating Daurian ground squirrels (Spermophilus dauricus) may counteract chronically inactive skeletal muscle atrophy.
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity.
Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma.
Plasma non-transferrin-bound iron uptake by the small intestine leads to intestinal injury and intestinal flora dysbiosis in an iron overload mouse model and Caco-2 cells.
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.
Cis-monounsaturated fatty acids inhibit ferroptosis through downregulation of transferrin receptor 1.
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage.
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Ferroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Structural Characterization of Zinc-Sucrose Complex and Its Ability to Promote Zinc Absorption in Caco-2 Monolayer Cells and Mice.
Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.
IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism.
LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism.
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Artemether attenuates renal tubular injury by regulating iron metabolism in mice with streptozotocin-induced diabetes.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.
Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling.
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells.
SNAI2 promotes the development of ovarian cancer through regulating ferroptosis.
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.
Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier.
Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis.
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.
Verapamil downregulates iron uptake and upregulates divalent metal transporter 1 expression in H9C2 cardiomyocytes.
Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression.
Remarkable Plasticity of Bone Iron Homeostasis in Hibernating Daurian Ground Squirrels (Spermophilus dauricus) May Be Involved in Bone Maintenance.
Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation.
Exposure to low-dose cadmium induces testicular ferroptosis.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Tolerable upper intake level of iron damages the liver of weaned piglets.
Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition.
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Baicalein protects against MPP(+)/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro.
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
The Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug design, development and therapy 2024;18:1349-1368
Drug design, development and therapy 2024;18:1349-1368
Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats.
Qiu L, Hu M, Qin X, Song R, Sun Y, Wang X
Molecular nutrition & food research 2024 Mar;68(6):e2300617
Molecular nutrition & food research 2024 Mar;68(6):e2300617
Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity.
Zhao M, Qiao C, Yang S, Tang Y, Sun W, Sun S, Guo Q, Du F, Zhang N, Ning T, Wu J, Xu J, Li P
European journal of pharmacology 2024 Mar 5;966:176340
European journal of pharmacology 2024 Mar 5;966:176340
Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation.
Cao Y, Zhao W, Zhong Y, Jiang X, Mei H, Chang Y, Wu D, Dou J, Vasquez E, Shi X, Yang J, Jia Z, Tan X, Li Q, Dong Y, Xie R, Gao J, Wu Y, Liu Y
The Science of the total environment 2024 Mar 20;917:170317
The Science of the total environment 2024 Mar 20;917:170317
Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway.
Li P, Chen JM, Ge SH, Sun ML, Lu JD, Liu F, Wang LL, Zhang X, Wang XP
European journal of pharmacology 2024 Mar 15;967:176402
European journal of pharmacology 2024 Mar 15;967:176402
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Tang XH, Zhao TN, Guo L, Liu XY, Zhang WN, Zhang P
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.
Lu JS, Wang JH, Han K, Li N
Inflammation 2024 Jun;47(3):975-988
Inflammation 2024 Jun;47(3):975-988
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition.
Huang LY, Zhang YD, Liu YN, Liang ZY, Chen J, Wang B, Yin QL, Wang PP, Wang W, Qi SH
ACS chemical neuroscience 2024 Jun 5;15(11):2223-2232
ACS chemical neuroscience 2024 Jun 5;15(11):2223-2232
Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes.
Wang N, Zhao Y, Wu M, Li N, Yan C, Guo H, Li Q, Li Q, Wang Q
Molecular neurobiology 2024 Feb;61(2):1187-1201
Molecular neurobiology 2024 Feb;61(2):1187-1201
Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.
Guan S, Zhang S, Liu M, Guo J, Chen Y, Shen X, Deng X, Lu J
Journal of dairy science 2024 Aug;107(8):5316-5329
Journal of dairy science 2024 Aug;107(8):5316-5329
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Kong L, Liu Y, Li J, Wang Y, Ji P, Shi Q, Han M, Xu H, Li W, Li W
Journal of ethnopharmacology 2024 Aug 10;330:118205
Journal of ethnopharmacology 2024 Aug 10;330:118205
Excess iron accumulation mediated senescence in diabetic kidney injury.
Cheng X, Li Y, Chen L, Jiang C, Peng S, Yao P, Tang Y
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Plasticity changes in iron homeostasis in hibernating Daurian ground squirrels (Spermophilus dauricus) may counteract chronically inactive skeletal muscle atrophy.
Kong Y, Yin R, He Y, Pan F, Yang H, Wang H, Zhang J, Gao Y
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2024 Apr;194(2):191-202
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2024 Apr;194(2):191-202
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Wang M, Liu Y, Gui H, Ma G, Li B, Zhang Z, Yu G, Wu A, Xu X, Zhang D
European journal of pharmacology 2024 Apr 15;969:176303
European journal of pharmacology 2024 Apr 15;969:176303
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
An JR, Liu JT, Gao XM, Wang QF, Sun GY, Su JN, Zhang C, Yu JX, Yang YF, Shi Y
Frontiers in cellular neuroscience 2023;17:1136070
Frontiers in cellular neuroscience 2023;17:1136070
Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity.
Chen J, Xiao F, Chen L, Zhou Z, Wei Y, Zhong Y, Li L, Xie Y
Frontiers in pharmacology 2023;14:1121280
Frontiers in pharmacology 2023;14:1121280
Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma.
Wang Z, He Y, Cun Y, Li Q, Zhao Y, Luo Z
Frontiers in cell and developmental biology 2023;11:1164544
Frontiers in cell and developmental biology 2023;11:1164544
Plasma non-transferrin-bound iron uptake by the small intestine leads to intestinal injury and intestinal flora dysbiosis in an iron overload mouse model and Caco-2 cells.
Zhang Q, Ding H, Yu X, Wang Q, Li X, Zhang R, Feng J
Science China. Life sciences 2023 Sep;66(9):2041-2055
Science China. Life sciences 2023 Sep;66(9):2041-2055
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.
Cheng HP, Feng DD, Li XH, Gao LH, Qiu YJ, Liang XY, Zhou Y, Huang P, Shao M, Zhang YN, Chang YF, Fu JF, Huang YH, Liu W, Tang SY, Li C, Luo ZQ
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535
Cis-monounsaturated fatty acids inhibit ferroptosis through downregulation of transferrin receptor 1.
Shan K, Fu G, Li J, Qi Y, Feng N, Li Y, Chen YQ
Nutrition research (New York, N.Y.) 2023 Oct;118:29-40
Nutrition research (New York, N.Y.) 2023 Oct;118:29-40
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage.
Ma SJ, Li C, Yan C, Liu N, Jiang GY, Yang HR, Yan HC, Li JY, Liu HL, Gao C
Free radical biology & medicine 2023 Nov 1;208:555-570
Free radical biology & medicine 2023 Nov 1;208:555-570
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.
Jin L, Yu B, Wang H, Shi L, Yang J, Wu L, Gao C, Pan H, Han F, Lin W, Lai EY, Wang YF, Yang Y
Free radical biology & medicine 2023 Nov 1;208:348-360
Free radical biology & medicine 2023 Nov 1;208:348-360
Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.
Ma M, Wang R, Xu M
Journal of hazardous materials 2023 Jun 15;452:131217
Journal of hazardous materials 2023 Jun 15;452:131217
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
Liu Y, Wang Y, Lin Z, Kang R, Tang D, Liu J
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Wu H, Liu Q, Shan X, Gao W, Chen Q
Autophagy 2023 Jul;19(7):2062-2077
Autophagy 2023 Jul;19(7):2062-2077
Ferroptosis Inducers Kill Mesenchymal Stem Cells Affected by Neuroblastoma.
Li X, Wang Q, Xu C, Zhang L, Zhou J, Lv J, Xu M, Jiang D
Cancers 2023 Feb 18;15(4)
Cancers 2023 Feb 18;15(4)
Structural Characterization of Zinc-Sucrose Complex and Its Ability to Promote Zinc Absorption in Caco-2 Monolayer Cells and Mice.
Li N, Wang R, Deng Z, Zhou J, Li W, Du Q, Zheng L
Journal of agricultural and food chemistry 2023 Aug 9;71(31):12094-12104
Journal of agricultural and food chemistry 2023 Aug 9;71(31):12094-12104
Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.
Liu J, Chen H, Lin H, Peng S, Chen L, Cheng X, Yao P, Tang Y
The Journal of nutritional biochemistry 2023 Apr;114:109258
The Journal of nutritional biochemistry 2023 Apr;114:109258
IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism.
Liu TY, Hu CC, Han CY, Mao SY, Zhang WX, Xu YM, Sun YJ, Jiang DB, Zhang XY, Zhang JX, Wang J, Qiao XP, Pan JY, Yang SY, Yang K
Biology direct 2023 Apr 23;18(1):19
Biology direct 2023 Apr 23;18(1):19
LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism.
He XY, Fan X, Qu L, Wang X, Jiang L, Sang LJ, Shi CY, Lin S, Yang JC, Yang ZZ, Lei K, Li JH, Ju HQ, Yan Q, Liu J, Wang F, Shao J, Xiong Y, Wang W, Lin A
Nature communications 2023 Apr 20;14(1):2253
Nature communications 2023 Apr 20;14(1):2253
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Han S, Lin F, Qi Y, Liu C, Zhou L, Xia Y, Chen K, Xing J, Liu Z, Yu W, Zhang Y, Zhou X, Rao T, Cheng F
Oxidative medicine and cellular longevity 2022;2022:3846217
Oxidative medicine and cellular longevity 2022;2022:3846217
Artemether attenuates renal tubular injury by regulating iron metabolism in mice with streptozotocin-induced diabetes.
Rong G, Cai Y, Weng W, Chen Y, Yu X, Shao M, Han P, Sun H
American journal of translational research 2022;14(9):6095-6106
American journal of translational research 2022;14(9):6095-6106
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Wang H, Jiang C, Yang Y, Li J, Wang Y, Wang C, Gao Y
PeerJ 2022;10:e13592
PeerJ 2022;10:e13592
Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development.
Niu J, Wan X, Yu GY, Jiang S, Yi RN, Wu YP, Ouyang SH, Liang L, Kurihara H, Sun WY, Zhu XF, Zhang RH, Cao YF, He JB, Duan WJ, Li YF, He RR
Redox biology 2022 Oct;56:102437
Redox biology 2022 Oct;56:102437
Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling.
Huang Q, Tian L, Zhao X, Lei S, Zhao B, Qiu Z, Xia ZY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113595
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113595
Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.
Han P, Wang X, Zhou T, Cheng J, Wang C, Sun F, Zhao X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells.
Song Q, Peng S, Che F, Zhu X
Journal of pharmacological sciences 2022 Mar;148(3):300-306
Journal of pharmacological sciences 2022 Mar;148(3):300-306
SNAI2 promotes the development of ovarian cancer through regulating ferroptosis.
Jin Y, Chen L, Li L, Huang G, Huang H, Tang C
Bioengineered 2022 Mar;13(3):6451-6463
Bioengineered 2022 Mar;13(3):6451-6463
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.
Henning Y, Blind US, Larafa S, Matschke J, Fandrey J
Cell death & disease 2022 Jul 29;13(7):662
Cell death & disease 2022 Jul 29;13(7):662
Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier.
Liu LL, Du D, Zheng W, Zhang Y
Neurotoxicology 2022 Jan;88:44-56
Neurotoxicology 2022 Jan;88:44-56
Resistance to disuse-induced iron overload in Daurian ground squirrels (Spermophilus dauricus) during extended hibernation inactivity.
Yin R, Zhang J, Xu S, Kong Y, Wang H, Gao Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2022 Jan;257:110650
Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis.
Cheng Z, Akatsuka S, Li GH, Mori K, Takahashi T, Toyokuni S
Cancer science 2022 Jan;113(1):65-78
Cancer science 2022 Jan;113(1):65-78
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.
Sterling JK, Kam TI, Guttha S, Park H, Baumann B, Mehrabani-Tabari AA, Schultz H, Anderson B, Alnemri A, Chou SC, Troncoso JC, Dawson VL, Dawson TM, Dunaief JL
Cell reports 2022 Feb 15;38(7):110358
Cell reports 2022 Feb 15;38(7):110358
Verapamil downregulates iron uptake and upregulates divalent metal transporter 1 expression in H9C2 cardiomyocytes.
Jiang LR, Shen MQ, Bao YX, Qian ZM
Fundamental & clinical pharmacology 2022 Dec;36(6):985-991
Fundamental & clinical pharmacology 2022 Dec;36(6):985-991
Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression.
Pinto AT, Machado AB, Osório H, Pinto ML, Vitorino R, Justino G, Santa C, Castro F, Cruz T, Rodrigues C, Lima J, Sousa JLR, Cardoso AP, Figueira R, Monteiro A, Marques M, Manadas B, Pauwels J, Gevaert K, Mareel M, Rocha S, Duarte T, Oliveira MJ
Cancers 2022 Dec 30;15(1)
Cancers 2022 Dec 30;15(1)
Remarkable Plasticity of Bone Iron Homeostasis in Hibernating Daurian Ground Squirrels (Spermophilus dauricus) May Be Involved in Bone Maintenance.
He Y, Kong Y, Yin R, Yang H, Zhang J, Wang H, Gao Y
International journal of molecular sciences 2022 Dec 13;23(24)
International journal of molecular sciences 2022 Dec 13;23(24)
Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation.
Shi Q, Liu R, Chen L
Molecular medicine reports 2022 Apr;25(4)
Molecular medicine reports 2022 Apr;25(4)
Exposure to low-dose cadmium induces testicular ferroptosis.
Xiong L, Bin Zhou, Young JL, Wintergerst K, Cai L
Ecotoxicology and environmental safety 2022 Apr 1;234:113373
Ecotoxicology and environmental safety 2022 Apr 1;234:113373
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Song Q, Peng S, Sun Z, Heng X, Zhu X
Yonsei medical journal 2021 Sep;62(9):843-849
Yonsei medical journal 2021 Sep;62(9):843-849
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
Zimmer TS, David B, Broekaart DWM, Schidlowski M, Ruffolo G, Korotkov A, van der Wel NN, van Rijen PC, Mühlebner A, van Hecke W, Baayen JC, Idema S, François L, van Eyll J, Dedeurwaerdere S, Kessels HW, Surges R, Rüber T, Gorter JA, Mills JD, van Vliet EA, Aronica E
Acta neuropathologica 2021 Oct;142(4):729-759
Acta neuropathologica 2021 Oct;142(4):729-759
GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis.
Wang L, Ouyang S, Li B, Wu H, Wang F
Cell death discovery 2021 Nov 3;7(1):334
Cell death discovery 2021 Nov 3;7(1):334
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats.
Yang G, Qian C, Zhang C, Bao Y, Liu MY, Jiang F, Li W, Liu Y, Ke Y, Qian ZM
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Translational research : the journal of laboratory and clinical medicine 2021 Mar;229:53-68
Tolerable upper intake level of iron damages the liver of weaned piglets.
Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition.
Li X, Jiang XW, Chu HX, Zhao QC, Ding HW, Cai CH
Chinese herbal medicines 2021 Jan;13(1):105-115
Chinese herbal medicines 2021 Jan;13(1):105-115
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Song Q, Zhao Y, Yang Y, Han X, Duan J
Toxicology and applied pharmacology 2021 Jan 1;410:115361
Toxicology and applied pharmacology 2021 Jan 1;410:115361
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z
Experimental and molecular pathology 2021 Feb;118:104570
Experimental and molecular pathology 2021 Feb;118:104570
Baicalein protects against MPP(+)/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Song Q, Peng S, Zhu X
Neurotoxicology 2021 Dec;87:188-194
Neurotoxicology 2021 Dec;87:188-194
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Xiang T, Luo X, Zeng C, Li S, Ma M, Wu Y
Brain research 2021 Dec 1;1772:147668
Brain research 2021 Dec 1;1772:147668
Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro.
Song Q, Zhang F, Han X, Yang Y, Zhao Y, Duan J
Experimental eye research 2021 Aug;209:108642
Experimental eye research 2021 Aug;209:108642
Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.
Ma J, Qian C, Bao Y, Liu MY, Ma HM, Shen MQ, Li W, Wang JJ, Bao YX, Liu Y, Ke Y, Qian ZM
Redox biology 2021 Apr;40:101865
Redox biology 2021 Apr;40:101865
Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Petit F, Drecourt A, Dussiot M, Zangarelli C, Hermine O, Munnich A, Rötig A
Blood 2021 Apr 15;137(15):2090-2102
Blood 2021 Apr 15;137(15):2090-2102
Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.
Ding H, Yu X, Chen L, Han J, Zhao Y, Feng J
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration.
Yamaguchi H, Honda S, Torii S, Shimizu K, Katoh K, Miyake K, Miyake N, Fujikake N, Sakurai HT, Arakawa S, Shimizu S
Nature communications 2020 Oct 20;11(1):5311
Nature communications 2020 Oct 20;11(1):5311
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Li Y, Jin C, Shen M, Wang Z, Tan S, Chen A, Wang S, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Nov 20;160:845-859
Free radical biology & medicine 2020 Nov 20;160:845-859
Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins.
Song Q, Zhao Y, Li Q, Han X, Duan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109690
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109690
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7
Molecular cell 2020 Feb 6;77(3):645-655.e7
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Morgan SE, Schroten H, Ishikawa H, Zhao N
Brain sciences 2020 Aug 8;10(8)
Brain sciences 2020 Aug 8;10(8)
Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.
Guo C, Xue H, Guo T, Zhang W, Xuan WQ, Ren YT, Wang D, Chen YH, Meng YH, Gao HL, Zhao P
Food & function 2020 Aug 1;11(8):7183-7196
Food & function 2020 Aug 1;11(8):7183-7196
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Li S, Qian ZM, Xu G, Zheng J, Wu Y
Bioscience reports 2020 Apr 30;40(4)
Bioscience reports 2020 Apr 30;40(4)
Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter.
Zhao P, Qian C, Chen YJ, Sheng Y, Ke Y, Qian ZM
Cell death & disease 2019 Sep 24;10(10):708
Cell death & disease 2019 Sep 24;10(10):708
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Scheiber IF, Wu Y, Morgan SE, Zhao N
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
Hu P, Zhao D, Zhao F, Wang J, Zhu W
Animals : an open access journal from MDPI 2019 Jul 11;9(7)
Animals : an open access journal from MDPI 2019 Jul 11;9(7)
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
Liu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, Chua JJE, Chung MCM, Khanna S, Lim KL, Soong TW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Sep 26;38(39):8364-8377
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Sep 26;38(39):8364-8377
The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Yang L, Wang D, Wang XT, Lu YP, Zhu L
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):128-135
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):128-135
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Zhang MW, Zhao P, Yung WH, Sheng Y, Ke Y, Qian ZM
Aging 2018 Dec 16;10(12):3834-3850
Aging 2018 Dec 16;10(12):3834-3850
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Zhou YF, Zhang C, Yang G, Qian ZM, Zhang MW, Ma J, Zhang FL, Ke Y
Frontiers in physiology 2017;8:332
Frontiers in physiology 2017;8:332
Effects of alpha-lipoic acid on expression of iron transport and storage proteins in BV-2 microglia cells.
Chen P, Li FM, Zhou YF, Qian C, Li J, Jiang LR, Qian ZM
Pharmacological reports : PR 2017 Feb;69(1):1-5
Pharmacological reports : PR 2017 Feb;69(1):1-5
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
Zhao N, Zhang AS, Wortham AM, Jue S, Knutson MD, Enns CA
Nutrients 2017 Dec 8;9(12)
Nutrients 2017 Dec 8;9(12)
A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.
Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, Gao J
Molecular medicine reports 2016 Sep;14(3):1970-8
Molecular medicine reports 2016 Sep;14(3):1970-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC11A2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SLC11A2. This antibody recognizes human, mouse, rat antigen. The SLC11A2 antibody has been validated for the following applications: ELISA, WB analysis.