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- Antigen structure
- References [9]
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- ELISA [1]
- Immunohistochemistry [1]
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- Product number
- H00004891-M01 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00004891-M01, RRID:AB_548152
- Product name
- Mouse Monoclonal NRAMP2/SLC11A2/DMT1 Antibody
- Antibody type
- Monoclonal
- Description
- IgG purified. SLC11A2 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
- Reactivity
- Human, Mouse, Bovine, Porcine
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCĪ±-dependent manner.
Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease.
Maternal protein restriction depresses the duodenal expression of iron transporters and serum iron level in male weaning piglets.
Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2.
Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra.
Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone.
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
Zhao L, Bartnikas T, Chu X, Klein J, Yun C, Srinivasan S, He P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):3549-3561
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):3549-3561
Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease.
van Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel MC, Pertijs J, Patel D, Bass P, van Goor H, Unwin R, Srai SK, Swinkels D
Scientific reports 2018 Jun 19;8(1):9353
Scientific reports 2018 Jun 19;8(1):9353
Maternal protein restriction depresses the duodenal expression of iron transporters and serum iron level in male weaning piglets.
Ma W, Lu J, Jiang S, Cai D, Pan S, Jia Y, Zhao R
The British journal of nutrition 2017 Apr;117(7):923-929
The British journal of nutrition 2017 Apr;117(7):923-929
Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2.
Montalbetti N, Simonin A, Simonin C, Awale M, Reymond JL, Hediger MA
Biochemical pharmacology 2015 Aug 1;96(3):216-24
Biochemical pharmacology 2015 Aug 1;96(3):216-24
Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra.
Montalbetti N, Simonin A, Dalghi MG, Kovacs G, Hediger MA
Journal of biomolecular screening 2014 Jul;19(6):900-8
Journal of biomolecular screening 2014 Jul;19(6):900-8
Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone.
Hansen SL, Trakooljul N, Liu HC, Hicks JA, Ashwell MS, Spears JW
Journal of animal science 2010 Jan;88(1):275-83
Journal of animal science 2010 Jan;88(1):275-83
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 8;106(36):15489-94
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 8;106(36):15489-94
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.
Barth S, Edlich F, Berchner-Pfannschmidt U, Gneuss S, Jahreis G, Hasgall PA, Fandrey J, Wenger RH, Camenisch G
The Journal of biological chemistry 2009 Aug 21;284(34):23046-58
The Journal of biological chemistry 2009 Aug 21;284(34):23046-58
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S
Blood 2008 Nov 15;112(10):4268-75
Blood 2008 Nov 15;112(10):4268-75
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ELISA: NRAMP2/SLC11A2/DMT1 Antibody (4C6) [H00004891-M01] - Detection limit for recombinant GST tagged SLC11A2 is 0.03 ng/ml as a capture antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NRAMP2/SLC11A2/DMT1 Antibody (4C6) [H00004891-M01] - Analysis of monoclonal antibody to SLC11A2 on formalin-fixed paraffin-embedded human endometrium cancer. Antibody concentration 3 ug/ml.
