BS4297

antibody from Bioworld Technology, Inc
Targeting: BID
Provider product page for BS4297
Western blot
Immunohistochemistry

Antibody data

Product number
BS4297 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BID (phospho S78) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human BID around the phosphorylation site of Serine 78.
Description
BID, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BID protein structure - BS4297 shown in red.