ABIN371640

antibody from antibodies-online

Targeting: BID

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

ABIN371640

Provider

antibodies-online

Product name

anti-BH3 Interacting Domain Death Agonist (BID) antibody

Antibody type

Monoclonal

Description

Purified

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

SB50a

Vial size

0.1 mg

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.Shelf life: one year from despatch.

References

Submitted references

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.

Cirman T, Oresić K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B
The Journal of biological chemistry 2004 Jan 30;279(5):3578-87

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Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.

Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS
The Journal of biological chemistry 2001 Feb 2;276(5):3149-57

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Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion.

Chen M, He H, Zhan S, Krajewski S, Reed JC, Gottlieb RA
The Journal of biological chemistry 2001 Aug 17;276(33):30724-8

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

Barry M, Heibein JA, Pinkoski MJ, Lee SF, Moyer RW, Green DR, Bleackley RC
Molecular and cellular biology 2000 Jun;20(11):3781-94

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The destabilization of lipid membranes induced by the C-terminal fragment of caspase 8-cleaved bid is inhibited by the N-terminal fragment.

Kudla G, Montessuit S, Eskes R, Berrier C, Martinou JC, Ghazi A, Antonsson B
The Journal of biological chemistry 2000 Jul 28;275(30):22713-8

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane.

Eskes R, Desagher S, Antonsson B, Martinou JC
Molecular and cellular biology 2000 Feb;20(3):929-35

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death.

Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, Erdjument-Bromage H, Tempst P, Korsmeyer SJ
The Journal of biological chemistry 1999 Jan 8;274(2):1156-63

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

Li H, Zhu H, Xu CJ, Yuan J
Cell 1998 Aug 21;94(4):491-501

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

Luo X, Budihardjo I, Zou H, Slaughter C, Wang X
Cell 1998 Aug 21;94(4):481-90

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BID: a novel BH3 domain-only death agonist.

Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ
Genes & development 1996 Nov 15;10(22):2859-69