PPP1R17

The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Description

Protein phosphatase 1 regulatory subunit 17

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

7 (31687215 - 31708455)

Ensembl ID

ENSG00000106341  (ver. 103.38)

Orthologs

Mouse Ppp1r17: ENSMUSG00000002930

UniProt

O96001

neXtProt

NX_O96001

Human splice variants
Mouse splice variants

Protein structure