BMP15

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]

Description

Bone morphogenetic protein 15

Tissue specificity

Not detected

Predicted location

Secreted in other tissues

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

X (50910735 - 50916641)

Ensembl ID

ENSG00000130385  (ver. 103.38)

Orthologs

Mouse Bmp15: ENSMUSG00000023279

UniProt

O95972

neXtProt

NX_O95972

Human splice variants
Mouse splice variants

Protein structure