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- References [173]
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- Immunohistochemistry [1]
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- Product number
- 24390-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- PERK/EIF2AK3 antibody
- Antibody type
- Polyclonal
- Description
- PERK/EIF2AK3 antibody (Cat. #24390-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes.
Subchronic exposure to decabromodiphenyl ethane impairs cognitive function and induces neuronal ferroptosis via disruption of mitochondria-associated endoplasmic reticulum membranes.
Inhibition of α-1,3-mannosyltransferase sensitizes head and neck squamous cell carcinomas to cetuximab via endoplasmic reticulum stress.
ASCC3 promotes chemosensitivity in colorectal cancer cells.
Lycopene ameliorates swainsonine-induced autophagy in rat renal tubular epithelial cells via the endoplasmic reticulum stress UPR pathway.
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells.
5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.
Ageing promotes metastasis via activation of the integrated stress response.
METTL18 ensures pancreatic function by maintaining proper translation and proteostasis.
Advanced oxidation protein products exacerbate osteoarthritis progression by disrupting stress granules assembly via endoplasmic reticulum stress.
Vitamin D receptor (ApaI/BsmI) polymorphisms, human leukocyte antigen-DQB2/DRB3 sub-alleles, and endoplasmic reticulum stress: unravelling their interplay in the pathogenesis of Graves' disease in a tertiary care centre.
Neuroimaging and molecular mechanism of action of Cang-ai volatile oil in the treatment of vascular cognitive impairment.
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes.
Shockwave-driven activation of endoplasmic reticulum stress in osteoblasts to enhance bone formation under osteoporotic conditions.
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.
Unveiling the HSP90 inhibitor mediated effects on endoplasmic reticulum stress and redox signaling:from a cancer inhibitor to retinal degeneration catalyst.
RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs.
Mechanistic insights into fluoride-induced reproductive toxicity in female ovine animals: Mitochondrial dysfunction and ER stress-driven apoptosis in ovine granulosa cells.
PDZD8 Dysregulation Mediates RVLM Neuronal Hyperexcitation Via Activation of Ca(2+)-Calpain-2 Signaling in Stress-Induced Hypertension.
Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.
DNAJC5 promotes cisplatin resistance in epithelial ovarian cancer by autophagy induced by the BiP/IRE1α/XBP1 endoplasmic reticulum stress pathway.
One day of environment-induced heat stress causes injury to the murine kidney.
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Identification and validation of BCL11A as a neural and immune vulnerability factor in pancreatic adenocarcinoma.
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy.
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies.
METTL9 mediated N1-Histidine methylation of SLC39A7 confers ferroptosis resistance and inhibits adipogenic differentiation in mesenchymal stem cells.
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
Maternal high-fat diet impairs cognitive performance by altering hippocampal GRP78/PERK axis and BDNF expression in adult female rat offspring: the potential protective role of N acetylcysteine.
Arsenic enhances endoplasmic reticulum stress via YTHDC1/AKR1C3 aix to promote the malignant transformation of human urothelial cells.
Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models.
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2.
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation.
Schisandra chinensis lignans exerts endocannabinoids-like antidepressive effect: The phagocytotic relationship of activated CB2R-mediated M2 microglia and "stressed-but-viable" neuron.
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity.
Effects of psychosocial stress on myocardial injury by modulating endoplasmic reticulum stress-induced autophagy and inflammation.
CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.
FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis.
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD.
A study on the mechanism by which BCAT1 influences the formation of intracranial aneurysms by regulating autophagy through endoplasmic reticulum stress.
KLF10-IN-1 Attenuates RPE Cell Apoptosis and Experimental Diabetic Retinopathy Via the KLF10/PERK/eIF2α/ATF4/CHOP Pathway.
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Dimethyl fumarate improves non-alcoholic fatty liver disease by regulating SIRT1 signal to inhibit MAMs over-enrichment.
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Melatonin protects against cadmium-induced endoplasmic reticulum stress and ferroptosis through activating Nrf2/HO-1 signaling pathway in mice lung.
Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells.
PERK/Sestrin2 Signaling Pathway Mediated Autophagy Regulates Human Cardiomyocytes Apoptosis Induced by Traffic-Related PM(2.5) and Diverse Constituents.
Deactivation of the Unfolded Protein Response Aggravated Renal AA Amyloidosis in HSF1 Deficiency Mice.
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens.
Carboplatin restricts peste des petits ruminants virus replication by suppressing the STING-mediated autophagy.
Pharmacologic activation of activating transcription factor 6 contributes to neuronal survival after spinal cord injury in mice.
Dendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response.
ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats.
Dahuang Huanglian Xiexin Decoction ameliorates obesity via modulating adipocyte differentiation and lipid degradation through inhibiting endoplasmic reticulum stress.
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
1,25-D3 ameliorates ischemic brain injury by alleviating endoplasmic reticulum stress and ferroptosis: Involvement of vitamin D receptor and p53 signaling.
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Leukocyte infiltration and cross-talk with cardiomyocytes exploit intracellular stress pathways in dilated cardiomyopathy of idiopathic origin.
One day of environment-induced heat stress damages the murine myocardium.
PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis.
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.
Inhibition of GZMB activity ameliorates cognitive dysfunction by reducing demyelination in diabetic mice.
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux.
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Prenatal inflammation exposure accelerates lung cancer tumorigenesis in offspring mouse: possible links to IRE1α/XBP1-mediated M2-like polarization of TAMs and PD-L1 up-expression.
CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway.
Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress.
FUS and METTL3 collaborate to regulate RNA maturation, preventing unfolded protein response and promoting gastric cancer progression.
miR-421-mediated suppression of FGF13 as a novel mechanism ameliorates cardiac hypertrophy by inhibiting endoplasmic reticulum stress.
MicroRNA-15b promotes cardiac ischemia injury by the inhibition of Mitofusin 2/PERK pathway.
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis.
Identification and experimental verification of a biomarker by combining the unfolded protein response with the immune cells in colon cancer.
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.
Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway.
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
SMN haploinsufficiency promotes ischemia/ reperfusion-induced AKI-to-CKD transition by endoplasmic reticulum stress activation.
Seneca Valley Virus Degrades STING via PERK and ATF6-Mediated Reticulophagy.
Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma.
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway.
Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis.
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner.
PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma.
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells.
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice.
Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin.
Treponema pallidum lipoprotein Tp0768 promotes the migration and adhesion of THP-1 cells to vascular endothelial cells through stress of the endoplasmic reticulum and the NF-κB/HIF-1α pathway.
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Jianpi-Qingchang decoction alleviates ulcerative colitis by modulating endoplasmic reticulum stress-related autophagy in intestinal epithelial cells.
Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway.
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period.
ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy.
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation.
Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart.
Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Targeting PERK mediated endoplasmic reticulum stress attenuates neuroinflammation and alleviates lipopolysaccharide-induced depressive-like behavior in male mice.
Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.
Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication.
α-Ketoglutarate Restores Intestinal Barrier Function through Promoting Intestinal Stem Cells-Mediated Epithelial Regeneration in Colitis.
Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy.
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress.
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.
Role of Ero1α in cognitive impairment induced by chronic hypoxia.
Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells.
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
STING1 is essential for an RNA-virus triggered autophagy.
Mitochondrial oxidative phosphorylation is dispensable for survival of CD34(+) chronic myeloid leukemia stem and progenitor cells.
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Porcine Circovirus 2 Manipulates the PERK-ERO1α Axis of the Endoplasmic Reticulum To Favor Its Replication by Derepressing Viral DNA from HMGB1 Sequestration within Nuclei.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells.
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.
Dihydroartemisinin exposure impairs porcine ovarian granulosa cells by activating PERK-eIF2α-ATF4 through endoplasmic reticulum stress.
ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.
Protective effects of pterostilbene against hepatic damage, redox imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress in weanling piglets.
Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.
Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes.
Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36.
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.
MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.
Porcine Circovirus Type 2 Induces ORF3-Independent Mitochondrial Apoptosis via PERK Activation and Elevation of Cytosolic Calcium.
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway.
Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells.
Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.
PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Zhang Z, Tan M, Liu X, Wang W, Chen X, Peng C, Zhao S, Wu L
Cell stress & chaperones 2026 May;31(3):100163
Cell stress & chaperones 2026 May;31(3):100163
Subchronic exposure to decabromodiphenyl ethane impairs cognitive function and induces neuronal ferroptosis via disruption of mitochondria-associated endoplasmic reticulum membranes.
Sun Y, Xiong F, Wu L, Liu Z, Liu P, Li W, Zhang J, Sun R
Journal of hazardous materials 2026 May 15;509:142036
Journal of hazardous materials 2026 May 15;509:142036
Inhibition of α-1,3-mannosyltransferase sensitizes head and neck squamous cell carcinomas to cetuximab via endoplasmic reticulum stress.
Hao Y, Deng G, Li B, Cheng L, Wang S, Yang Z
Cell stress & chaperones 2026 Mar;31(2):100153
Cell stress & chaperones 2026 Mar;31(2):100153
ASCC3 promotes chemosensitivity in colorectal cancer cells.
Tu A, Martyn RDC, Cui S, Batenburg NL, Fayyazi R, Di Pastena F, Berthiaume L, Singh K, Saleem R, Scott GR, Berg T, Audet-Walsh É, Steinberg GR, Zhu XD
Scientific reports 2026 Mar 17;16(1)
Scientific reports 2026 Mar 17;16(1)
Lycopene ameliorates swainsonine-induced autophagy in rat renal tubular epithelial cells via the endoplasmic reticulum stress UPR pathway.
Wang P, Tang L, Yang L, Zhang C, Yin H, Hou S, Shao Y, Qu Y, Lu H
Research in veterinary science 2026 Jun;205:106164
Research in veterinary science 2026 Jun;205:106164
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Zhao Q, Zhang HJ, Han MM, Abiti J, Dong YJ, Wang JN, Lu JT, Wang W, Zhang X, Geng SL, Qiu LL, Wang XY, Hua ZC, Wang TY, Jia YL
Synthetic and systems biotechnology 2026 Jun;12:197-208
Synthetic and systems biotechnology 2026 Jun;12:197-208
LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells.
Hou X, Wang Y, Chen Y, Zhong P, Wang G, Li B, Lu B, Jiang H, Ning S
Oncology reports 2026 Jan;55(1)
Oncology reports 2026 Jan;55(1)
5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.
Li A, Xu S, Fan J, Liu J, Song X, Cao L, Gong Z, Lu X
Cell reports. Medicine 2026 Jan 20;7(1):102537
Cell reports. Medicine 2026 Jan 20;7(1):102537
Ageing promotes metastasis via activation of the integrated stress response.
Patel AAH, Dzanan JJ, Ali KX, Eklund EA, Alvarez SW, Raj D, Dankis M, Altinönder I, Schwarz M, Le Gal K, Bedel E, El Zowalaty AE, Jonasson E, Albatrok H, Gul N, Bossowski JP, Pillai R, Micke P, Botling J, Akyürek LM, Angeletti D, Sayin SI, Härtlova A, Papagiannakopoulos T, Olofsson Bagge R, Ståhlberg A, Hallqvist A, Wiel C, Sayin VI
Nature 2026 Apr;652(8112):1339-1348
Nature 2026 Apr;652(8112):1339-1348
METTL18 ensures pancreatic function by maintaining proper translation and proteostasis.
Shimazu T, Gowa M, Kataoka A, Suzuki T, Tomuro K, Shichino Y, Dohmae N, Iwasaki S, Shinkai Y
Molecular metabolism 2026 Apr;106:102337
Molecular metabolism 2026 Apr;106:102337
Advanced oxidation protein products exacerbate osteoarthritis progression by disrupting stress granules assembly via endoplasmic reticulum stress.
Jiang W, Wang Q, Zhang X, Qi B, Liang Y, Li D, Yi C
Free radical biology & medicine 2026 Apr 18;251:440-453
Free radical biology & medicine 2026 Apr 18;251:440-453
Vitamin D receptor (ApaI/BsmI) polymorphisms, human leukocyte antigen-DQB2/DRB3 sub-alleles, and endoplasmic reticulum stress: unravelling their interplay in the pathogenesis of Graves' disease in a tertiary care centre.
Haldar AK, Roy A, Dastidar R, Banerjee SK, Talukdar D, Basu A, Kumar S, Sikder K
Molecular biology reports 2026 Apr 16;53(1)
Molecular biology reports 2026 Apr 16;53(1)
Neuroimaging and molecular mechanism of action of Cang-ai volatile oil in the treatment of vascular cognitive impairment.
Chen B, Liang B, Li W, Wang L, Wang J, Xiong L, Gao F
Frontiers in neuroscience 2025;19:1688649
Frontiers in neuroscience 2025;19:1688649
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Zha L, Cui L, Mei J, Pu J, Hao J, Fan X, Wang H, Fang H, Ma Y
Journal of inflammation research 2025;18:12929-12948
Journal of inflammation research 2025;18:12929-12948
Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes.
Zhao W, Chen L, Qing J, Zhao Z, Xiong L, Tong P, Huang Z, Chen Y
Frontiers in cellular and infection microbiology 2025;15:1667023
Frontiers in cellular and infection microbiology 2025;15:1667023
Shockwave-driven activation of endoplasmic reticulum stress in osteoblasts to enhance bone formation under osteoporotic conditions.
Luo D, Chen Q, Xiao Z, Feng C, Hu R, Wang Y, Zhu C, Yang X, Liu L, Li X, Zhu X, Song Y, Zhang X
Regenerative biomaterials 2025;12:rbaf069
Regenerative biomaterials 2025;12:rbaf069
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.
Zhang X, Wang Y, Wang J, Zhang Y, Li R, Wang X, Ge X, Ye Q, Ji J, Fei D, Wang Q
Journal of advanced research 2025 Sep;75:377-388
Journal of advanced research 2025 Sep;75:377-388
Unveiling the HSP90 inhibitor mediated effects on endoplasmic reticulum stress and redox signaling:from a cancer inhibitor to retinal degeneration catalyst.
Liu Y, Li S, Wang K, Wang Y, Wang Y, Zhang C, Wu H, Wang G, Qin F, Song Z, Tao Y
Free radical biology & medicine 2025 Sep;237:176-194
Free radical biology & medicine 2025 Sep;237:176-194
RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs.
Chen Y, Wang Y, Shen S, Zhang L, Liu J, Yan X, Peng H, Xu Z
European journal of medical research 2025 Sep 26;30(1):859
European journal of medical research 2025 Sep 26;30(1):859
Mechanistic insights into fluoride-induced reproductive toxicity in female ovine animals: Mitochondrial dysfunction and ER stress-driven apoptosis in ovine granulosa cells.
Ma T, Jiang D, Liu W, Li Z, Gao K, Zhang Y
Ecotoxicology and environmental safety 2025 Sep 15;303:118830
Ecotoxicology and environmental safety 2025 Sep 15;303:118830
PDZD8 Dysregulation Mediates RVLM Neuronal Hyperexcitation Via Activation of Ca(2+)-Calpain-2 Signaling in Stress-Induced Hypertension.
Liu T, Wang L, Tong L, Ren Z, Zhao B, Liu H, Lu W, Zhang H, Zhang S, Du D
Molecular neurobiology 2025 Oct;62(10):12539-12558
Molecular neurobiology 2025 Oct;62(10):12539-12558
Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.
Qian C, Hu C, Xu Y, Xu W, Wang Z, Gan W, Tang W, Huang L, Samorodov AV, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e00741
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e00741
DNAJC5 promotes cisplatin resistance in epithelial ovarian cancer by autophagy induced by the BiP/IRE1α/XBP1 endoplasmic reticulum stress pathway.
Huang S, Chen L, Chen Y, Lu S, Yang B, Chen Y, Zhao W, Zhao S
Scientific reports 2025 Oct 2;15(1):34323
Scientific reports 2025 Oct 2;15(1):34323
One day of environment-induced heat stress causes injury to the murine kidney.
Roths M, Michael A, Schlader ZJ, Selsby JT
Experimental physiology 2025 Oct 2;
Experimental physiology 2025 Oct 2;
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Tong Y, Li Y, Bi Y, Liu Y, Peng X, He B, Wang X
Life sciences 2025 Oct 1;378:123830
Life sciences 2025 Oct 1;378:123830
Identification and validation of BCL11A as a neural and immune vulnerability factor in pancreatic adenocarcinoma.
Chen A, Wang J, Yang J, Wang Y, Wu C, Yang H, Fan Y, Gao Q, Hu Y, Li X, Zou X
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167988
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167988
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Zhang C, Wang H, He Z, He J, Wang F, Yan S, Sheng Y, Yuan N, Chen Y, Xu X, Huang Y, Hu R, Wang M, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound.
Hou W, Shang X, Hao X, Pan C, Zheng Z, Zhang Y, Deng X, Chi R, Liu J, Guo F, Sun K, Xu T
Journal of orthopaedic translation 2025 May;52:233-248
Journal of orthopaedic translation 2025 May;52:233-248
Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy.
Yin ZY, He SM, Zhang XY, Yu XC, Sheng KX, Fu T, Jiang YX, Xu L, Hu BX, Zhang JB, Li YY, Wang Q, Zhang BB, Qi YM, Adu-Amankwaah J, Zhou XY, Qi Q, Zhang B, Li CL
Acta pharmacologica Sinica 2025 May;46(5):1445-1461
Acta pharmacologica Sinica 2025 May;46(5):1445-1461
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549
International journal of biological macromolecules 2025 May;310(Pt 4):143549
Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies.
Li X, Yong J, Zhao B, Zhu Y, Luo J, Sheng J, Tian Y
Food research international (Ottawa, Ont.) 2025 May;209:116196
Food research international (Ottawa, Ont.) 2025 May;209:116196
METTL9 mediated N1-Histidine methylation of SLC39A7 confers ferroptosis resistance and inhibits adipogenic differentiation in mesenchymal stem cells.
Jin J, Li Q, Zhang Y, Ji P, Wang X, Zhang Y, Yuan Z, Jiang J, Tian G, Cai M, Feng P, Wu Y, Wang P, Liu W
Molecular medicine (Cambridge, Mass.) 2025 May 26;31(1):206
Molecular medicine (Cambridge, Mass.) 2025 May 26;31(1):206
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Ning Q, Liu J, Liu S, Zou Q, Li K, Li Z
International immunopharmacology 2025 May 16;155:114610
International immunopharmacology 2025 May 16;155:114610
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Zhang S, Chen Y, Yang R, Ye L, Chen H, Jiang L, Bai D, Wu D
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
Zhao L, Dong X, Guo B, Song J, Bi H
Materials today. Bio 2025 Jun;32:101896
Materials today. Bio 2025 Jun;32:101896
Maternal high-fat diet impairs cognitive performance by altering hippocampal GRP78/PERK axis and BDNF expression in adult female rat offspring: the potential protective role of N acetylcysteine.
Bakirhan EG, Yanilmaz EMB, Tüfekci KK, Bakirhan F, Susam S
Journal of molecular histology 2025 Jun 7;56(3):189
Journal of molecular histology 2025 Jun 7;56(3):189
Arsenic enhances endoplasmic reticulum stress via YTHDC1/AKR1C3 aix to promote the malignant transformation of human urothelial cells.
Chen C, Tong M, Chang Y, Li X, Wang J, Chen L, Huang C, Huang H, Zhao L
Toxicology letters 2025 Jul;410:199-210
Toxicology letters 2025 Jul;410:199-210
Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models.
Song J, Han B, Du X, Chen H, Li M, Tang Z, Xu C, Wei W, Jia F, Wang X, Sun S, Zhong D
Free radical biology & medicine 2025 Jul;234:141-150
Free radical biology & medicine 2025 Jul;234:141-150
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
Huang Y, Zhang Y, Liu Y, Jin Y, Yang H
The Journal of biological chemistry 2025 Jan;301(1):108111
The Journal of biological chemistry 2025 Jan;301(1):108111
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2.
Gan L, Jiang Q, Huang D, Wu X, Zhu X, Wang L, Xie W, Huang J, Fan R, Jing Y, Tang G, Li XD, Guo J, Yin S
Nature chemical biology 2025 Jan;21(1):80-90
Nature chemical biology 2025 Jan;21(1):80-90
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation.
Lu W, Yang Y, Gao S, Wu J, Sun X
Experimental eye research 2025 Feb;251:110222
Experimental eye research 2025 Feb;251:110222
Schisandra chinensis lignans exerts endocannabinoids-like antidepressive effect: The phagocytotic relationship of activated CB2R-mediated M2 microglia and "stressed-but-viable" neuron.
Wang J, Du H, Li M, Yan T, Jia Y
Journal of ethnopharmacology 2025 Feb 27;342:119385
Journal of ethnopharmacology 2025 Feb 27;342:119385
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Zhang R, Zhang Z, Xie L, Yu Z, Gao R, Zhang ZR, Zhang Y, Wei X, Chen Y, Jiao S, Gao Y, Guo JP
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity.
Jin S, Yan M, Liu Y, Zhang S, Song H, Cao C, Li Y, Sun G, Ye L, Chen J, Han W, Li L, Chang Q
Autophagy 2025 Dec;21(12):2614-2632
Autophagy 2025 Dec;21(12):2614-2632
Effects of psychosocial stress on myocardial injury by modulating endoplasmic reticulum stress-induced autophagy and inflammation.
Gao X, Huang G, Hao R, Wang L, Ma A, Zhang Z, Zhao T
iScience 2025 Dec 19;28(12):114022
iScience 2025 Dec 19;28(12):114022
CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.
Wang Y, Chen X, You G, Yu S, Chen C, Lian R, Diao L, Li Y, Yin T
Journal of translational medicine 2025 Dec 17;24(1):98
Journal of translational medicine 2025 Dec 17;24(1):98
FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis.
Qin K, Zhang H, Shi Y, Wu R, Wu C, Wu Y, He C, Han Z, Luo Y, Fang Y, Yan X, Wang X, Li M, Li A, Liu S, Li Q
NPJ precision oncology 2025 Dec 14;10(1):19
NPJ precision oncology 2025 Dec 14;10(1):19
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD.
Li M, Ou Q, Qin Q, Chen J, Yang S, Zhao J, Meng H, Li X, Xu P, Ye C, Wang X
Nature communications 2025 Dec 12;16(1):11092
Nature communications 2025 Dec 12;16(1):11092
A study on the mechanism by which BCAT1 influences the formation of intracranial aneurysms by regulating autophagy through endoplasmic reticulum stress.
Liu S, Guan H, Wang F
International immunopharmacology 2025 Dec 10;167:115667
International immunopharmacology 2025 Dec 10;167:115667
KLF10-IN-1 Attenuates RPE Cell Apoptosis and Experimental Diabetic Retinopathy Via the KLF10/PERK/eIF2α/ATF4/CHOP Pathway.
Hu W, Yang H, Zhu Q, Zheng G, Tan J, Lin Y, Wang Y, Tu Y, Zhou Q
Investigative ophthalmology & visual science 2025 Dec 1;66(15):25
Investigative ophthalmology & visual science 2025 Dec 1;66(15):25
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Xu J, Hu M, Li Y, Gong H, Zhang X, He Z, Xiao C, Yang C, Zeng J
Cell biology international 2025 Aug;49(8):1042-1055
Cell biology international 2025 Aug;49(8):1042-1055
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Li J, Zhang G, Sun Z, Jiang M, Jia G, Liu H, Liu N, Shi L, Zhang L, Nie L, Zhang Y, Fu Y
Biomaterials 2025 Aug;319:123201
Biomaterials 2025 Aug;319:123201
Dimethyl fumarate improves non-alcoholic fatty liver disease by regulating SIRT1 signal to inhibit MAMs over-enrichment.
Zhang R, Zhang Q, Cui Z, Huang B, Wang Y, Ma H
European journal of pharmacology 2025 Aug 5;1000:177693
European journal of pharmacology 2025 Aug 5;1000:177693
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Feng X, Du Y, Lv Y, Wei X, Cui C, Qin Y, Lu B, Chen Z, Ouyang K, Chen Y, Wei Z, Huang W, He Y, Qin Y
Viruses 2025 Aug 31;17(9)
Viruses 2025 Aug 31;17(9)
Melatonin protects against cadmium-induced endoplasmic reticulum stress and ferroptosis through activating Nrf2/HO-1 signaling pathway in mice lung.
Huang Z, Xu R, Wan Z, Liu C, Li J, He J, Li L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Apr;198:115324
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Apr;198:115324
Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells.
Erzurumlu Y, Catakli D
Cannabis and cannabinoid research 2025 Apr;10(2):258-276
Cannabis and cannabinoid research 2025 Apr;10(2):258-276
PERK/Sestrin2 Signaling Pathway Mediated Autophagy Regulates Human Cardiomyocytes Apoptosis Induced by Traffic-Related PM(2.5) and Diverse Constituents.
Tian J, Niu Z, Yang H, Wang C, Guan L, Zhao L, Shi D, Zhang Z
International journal of molecular sciences 2025 Apr 17;26(8)
International journal of molecular sciences 2025 Apr 17;26(8)
Deactivation of the Unfolded Protein Response Aggravated Renal AA Amyloidosis in HSF1 Deficiency Mice.
Liu W, Xia S, Yao F, Huo J, Qian J, Liu X, Bai L, Song Y, Qian J
Molecular and cellular biology 2024;44(5):165-177
Molecular and cellular biology 2024;44(5):165-177
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296
International journal of biological sciences 2024;20(11):4277-4296
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens.
Shi Y, Gao Z, Xu B, Mao J, Wang Y, Liu Z, Wang J
Frontiers in pharmacology 2024;15:1440877
Frontiers in pharmacology 2024;15:1440877
Carboplatin restricts peste des petits ruminants virus replication by suppressing the STING-mediated autophagy.
Zhang R, Hu Z, Wei D, Li R, Li Y, Zhang Z
Frontiers in veterinary science 2024;11:1383927
Frontiers in veterinary science 2024;11:1383927
Pharmacologic activation of activating transcription factor 6 contributes to neuronal survival after spinal cord injury in mice.
Chang Y, Chen L, Zhang M, Zhang S, Liu R, Feng S
Journal of neurochemistry 2024 Sep;168(9):3221-3234
Journal of neurochemistry 2024 Sep;168(9):3221-3234
Dendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response.
Joseph J, Premeaux TA, Tandon R, Murphy EL, Bruhn R, Nicot C, Herrera BB, Lemenze A, Alatrash R, Baffour Tonto P, Ndhlovu LC, Jain P
Viruses 2024 Sep 10;16(9)
Viruses 2024 Sep 10;16(9)
ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats.
Jia W, Li C, Chen H, Wang X, Liu Y, Shang W, Wang B, Meng W, Guo Y, Zhu L, Wang D, Zhou D, Zhao B, Wei L
Neurochemistry international 2024 Oct;179:105834
Neurochemistry international 2024 Oct;179:105834
Dahuang Huanglian Xiexin Decoction ameliorates obesity via modulating adipocyte differentiation and lipid degradation through inhibiting endoplasmic reticulum stress.
Hao L, Li M, Gu H, Li J
Prostaglandins & other lipid mediators 2024 Oct;174:106874
Prostaglandins & other lipid mediators 2024 Oct;174:106874
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Ji Y, Li C, Wan S, Dong Z, Liu C, Guo L, Shi S, Ci M, Xu M, Li Q, Hu H, Cui H, Liu Y
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
1,25-D3 ameliorates ischemic brain injury by alleviating endoplasmic reticulum stress and ferroptosis: Involvement of vitamin D receptor and p53 signaling.
Song T, Li J, Xia Y, Hou S, Zhang X, Wang Y
Cellular signalling 2024 Oct;122:111331
Cellular signalling 2024 Oct;122:111331
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Xuan W, Wu X, Zheng L, Jia H, Zhang X, Zhang X, Cao B
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Leukocyte infiltration and cross-talk with cardiomyocytes exploit intracellular stress pathways in dilated cardiomyopathy of idiopathic origin.
Talukdar D, Haldar AK, Kumar S, Dastidar R, Basu A, Roy A, Sarkar S, Dey S, Sikder K
Molecular biology reports 2024 Oct 24;51(1):1090
Molecular biology reports 2024 Oct 24;51(1):1090
One day of environment-induced heat stress damages the murine myocardium.
Roths M, Rudolph TE, Krishna S, Michael A, Selsby JT
American journal of physiology. Heart and circulatory physiology 2024 Oct 1;327(4):H978-H988
American journal of physiology. Heart and circulatory physiology 2024 Oct 1;327(4):H978-H988
PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis.
Chen Y, Fang B, Liu X, Bai W, Liu P, Duan Z, Lu T, Zhang Q, Dong W, Zhang Y
Biomolecules 2024 Nov 29;14(12)
Biomolecules 2024 Nov 29;14(12)
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.
Fan B, Li Y, Wang Y, Yang S, Peng Q, Qian J, Wang C, Zhang X, Xu H, Liu S, He W, Zhang G, Zhu X, Li Y, Zhao Y, Hu M, Wang W, Zhou J, Guo R, He K, Li B
Nucleic acids research 2024 Nov 27;52(21):13174-13191
Nucleic acids research 2024 Nov 27;52(21):13174-13191
Inhibition of GZMB activity ameliorates cognitive dysfunction by reducing demyelination in diabetic mice.
Yang ZZ, Liu WQ, Yu HD, Yu SX, Li YR, Wang YF, Yao TF, Li WZ, Sun D, Niu L, Liu XZ, Zuo ZF
Free radical biology & medicine 2024 Nov 20;225:53-62
Free radical biology & medicine 2024 Nov 20;225:53-62
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux.
Tian X, Ou Y, Shi S, Zhou Q, Long S, Xiang Y, Zhao W, Long D
Toxics 2024 Nov 11;12(11)
Toxics 2024 Nov 11;12(11)
Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.
Kang H, Hu Q, Yang Y, Huang G, Li J, Zhao X, Zhu L, Su H, Tang W, Wan M
ACS nano 2024 May 28;18(21):13885-13898
ACS nano 2024 May 28;18(21):13885-13898
(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.
Zhang X, Huo Z, Jia X, Xiong Y, Li B, Zhang L, Li X, Li X, Fang Y, Dong X, Chen G
Food & function 2024 May 20;15(10):5450-5465
Food & function 2024 May 20;15(10):5450-5465
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Long C, Shen L, Zheng X, Li D, Wang X, Yu C, Wu S, Wei G
Genes & diseases 2024 Mar;11(2):935-951
Genes & diseases 2024 Mar;11(2):935-951
Prenatal inflammation exposure accelerates lung cancer tumorigenesis in offspring mouse: possible links to IRE1α/XBP1-mediated M2-like polarization of TAMs and PD-L1 up-expression.
Ma J, Tan J, Zhang W, Bai M, Liu K
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):88
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):88
CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy.
Qi Z, Bai X, Wu L, Zhang P, Guo Z, Yu Y
Journal of translational medicine 2024 Jun 6;22(1):538
Journal of translational medicine 2024 Jun 6;22(1):538
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway.
Zhang QQ, Chen Q, Cao P, Shi CX, Zhang LY, Wang LW, Gong ZJ
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Feb;23(1):43-51
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Feb;23(1):43-51
Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress.
Wu Q, Liu C, Liu D, Wang Y, Qi H, Liu X, Zhang Y, Chen H, Zeng Y, Li J
The Science of the total environment 2024 Feb 20;912:169260
The Science of the total environment 2024 Feb 20;912:169260
FUS and METTL3 collaborate to regulate RNA maturation, preventing unfolded protein response and promoting gastric cancer progression.
Liu D, Ding B, Liu G, Yang Z
Clinical and experimental medicine 2024 Dec 21;25(1):15
Clinical and experimental medicine 2024 Dec 21;25(1):15
miR-421-mediated suppression of FGF13 as a novel mechanism ameliorates cardiac hypertrophy by inhibiting endoplasmic reticulum stress.
Zhi Y, Duan Y, Zhang Y, Hu H, Hu F, Wang P, Liu B, Wang C, Liu D, Gu G
European journal of pharmacology 2024 Dec 15;985:177085
European journal of pharmacology 2024 Dec 15;985:177085
MicroRNA-15b promotes cardiac ischemia injury by the inhibition of Mitofusin 2/PERK pathway.
Zhang W, Zhang M, Ma J, Yao Y, Jiang Y, Huo Q, Jin S, Ji D, Zhao Y, Liu X, Sun H, Xu C, Zhang R
Biochemical pharmacology 2024 Aug;226:116372
Biochemical pharmacology 2024 Aug;226:116372
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis.
Cheng L, Wang X, Liu A, Zhu Y, Cheng H, Yu J, Gong L, Liu H, Shen G, Liu L
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3493-3512
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3493-3512
Identification and experimental verification of a biomarker by combining the unfolded protein response with the immune cells in colon cancer.
Ma Y, Zhang J, Wei C, Wang F, Ji H, Zhao J, Wang D, Zhang X, Tang D
BMC cancer 2024 Aug 8;24(1):978
BMC cancer 2024 Aug 8;24(1):978
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Li J, Liu Q, Liu S, Xin H, Zhang X, Guo N
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.
Wang J, Wang W, Zhang J, Xiao F, Li Z, Xu P, Wang H, Du H, Liu S, Li H, Zhang X, Chen S, Gao Z, Wang S, Wang J, Song M
Communications biology 2024 Aug 27;7(1):1054
Communications biology 2024 Aug 27;7(1):1054
Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway.
Tang H, Chen F, Gao W, Cai X, Lin Z, Kang R, Tang D, Liu J
iScience 2024 Aug 16;27(8):110598
iScience 2024 Aug 16;27(8):110598
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.
Wu Y, Gong X, Shen J, Zhu K
Journal of advanced research 2024 Apr;58:117-128
Journal of advanced research 2024 Apr;58:117-128
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Cui Y, Zhang W, Yang P, Zhu S, Luo S, Li M
Free radical biology & medicine 2023 Sep;206:33-49
Free radical biology & medicine 2023 Sep;206:33-49
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Erzurumlu Y, Muhammed MT
Cellular signalling 2023 Sep;109:110745
Cellular signalling 2023 Sep;109:110745
SMN haploinsufficiency promotes ischemia/ reperfusion-induced AKI-to-CKD transition by endoplasmic reticulum stress activation.
Qian X, Li J, Bian S, Zhu D, Guo Q, Bian F, Jiang G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23276
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23276
Seneca Valley Virus Degrades STING via PERK and ATF6-Mediated Reticulophagy.
Bai L, Zhang R, Zheng H, Zhang Z, Zhang Z, Li Y
Viruses 2023 Nov 3;15(11)
Viruses 2023 Nov 3;15(11)
Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma.
Huang Y, Yan H, Zhang B, Zhu G, Yu J, Xiao X, He W, Chen Y, Gao X, She Z, Li M, Yuan J
Marine drugs 2023 Nov 21;21(12)
Marine drugs 2023 Nov 21;21(12)
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway.
Yu Y, Yang A, He X, Wu B, Wu Y, Li Y, Nie S, Xu B, Wang H, Yu G
Journal of inflammation (London, England) 2023 Nov 1;20(1):36
Journal of inflammation (London, England) 2023 Nov 1;20(1):36
Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis.
Yi H, Duan Y, Song R, Zhou Y, Cui Y, Liu C, Mao Z, Hu J, Zhou F
Experimental neurology 2023 May;363:114348
Experimental neurology 2023 May;363:114348
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Erzurumlu Y, Aydogdu E, Dogan HK, Catakli D, Muhammed MT, Buyuksandic B
Cellular signalling 2023 Mar;103:110577
Cellular signalling 2023 Mar;103:110577
Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner.
Wang X, Wang L, Geng L, Tanaka N, Ye B
International journal of molecular sciences 2023 Mar 19;24(6)
International journal of molecular sciences 2023 Mar 19;24(6)
PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma.
Kang L, Wang D, Shen T, Liu X, Dai B, Zhou D, Shen H, Gong J, Li G, Hu Y, Wang P, Mi X, Zhang Y, Tan X
Cell death & disease 2023 Mar 11;14(3):193
Cell death & disease 2023 Mar 11;14(3):193
Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells.
Erzurumlu Y, Catakli D, Dogan HK
Journal of natural medicines 2023 Jun;77(3):572-583
Journal of natural medicines 2023 Jun;77(3):572-583
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.
Zhou F, Gao H, Shang L, Li J, Zhang M, Wang S, Li R, Ye L, Yang S
Journal of experimental & clinical cancer research : CR 2023 Jun 19;42(1):150
Journal of experimental & clinical cancer research : CR 2023 Jun 19;42(1):150
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.
Kuang H, Sun X, Liu Y, Tang M, Wei Y, Shi Y, Li R, Xiao G, Kang J, Wang F, Peng J, Xu H, Zhou F
The FEBS journal 2023 Jul;290(14):3664-3687
The FEBS journal 2023 Jul;290(14):3664-3687
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Erzurumlu Y, Dogan HK, Cataklı D
Steroids 2023 Jul;195:109238
Steroids 2023 Jul;195:109238
Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice.
Wu J, Li J, Wu Y, Yang M, Chen Y, Wang N, Wang J, Yuan Z, Yi J, Yang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113811
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113811
Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin.
Nie X, Ma B, Liu L, Yuan X, Li M, Liu Y, Hou Y, Yang Y, Xu J, Wang Y
International journal of molecular sciences 2023 Jul 20;24(14)
International journal of molecular sciences 2023 Jul 20;24(14)
Treponema pallidum lipoprotein Tp0768 promotes the migration and adhesion of THP-1 cells to vascular endothelial cells through stress of the endoplasmic reticulum and the NF-κB/HIF-1α pathway.
Zhou X, Tang Y, Cao T, Ning L, Li Y, Xie X, Hu Y, He B, Peng B, Liu S
Molecular microbiology 2023 Jan;119(1):86-100
Molecular microbiology 2023 Jan;119(1):86-100
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Erzurumlu Y, Dogan HK, Catakli D
Molecular biology reports 2023 Feb;50(2):1253-1265
Molecular biology reports 2023 Feb;50(2):1253-1265
Jianpi-Qingchang decoction alleviates ulcerative colitis by modulating endoplasmic reticulum stress-related autophagy in intestinal epithelial cells.
Qiao D, Liu X, Zhang Y, Zhang Z, Tang Y, Chen Q, Shi Y, Chen Y, Tang Z, Dai Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114133
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114133
Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway.
Wang W, Guan J, Feng Y, Liu S, Zhao Y, Xu Y, Xu H, Fu F
Toxics 2023 Feb 27;11(3)
Toxics 2023 Feb 27;11(3)
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928
Translational stroke research 2023 Dec;14(6):910-928
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period.
Tüfekci KK, Tatar M, Terzi F, Bakirhan EG
Journal of chemical neuroanatomy 2023 Dec;134:102348
Journal of chemical neuroanatomy 2023 Dec;134:102348
ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy.
Song S, Hu T, Shi X, Jin Y, Liu S, Li X, Zou W, Wang C
International journal of molecular sciences 2023 Dec 18;24(24)
International journal of molecular sciences 2023 Dec 18;24(24)
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X
Life sciences 2023 Aug 15;327:121698
Life sciences 2023 Aug 15;327:121698
PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation.
Chen W, E Q, Sun B, Zhang P, Li N, Fei S, Wang Y, Liu S, Liu X, Zhang X
Cell death & disease 2023 Aug 15;14(8):524
Cell death & disease 2023 Aug 15;14(8):524
Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart.
Peng C, Yang S, Yang F, Xiong Z, Liu Q, Liao S, Huang K, Wan W, Cao H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113660
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113660
Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.
Tao Y, Geng Y, Dang W, Xu X, Zhao H, Zou L, Li Y
Frontiers in endocrinology 2022;13:856331
Frontiers in endocrinology 2022;13:856331
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Zhang L, Li C, Fu L, Yu Z, Xu G, Zhou J, Shen M, Feng Z, Zhu H, Xie T, Zhou L, Zhou X
PeerJ 2022;10:e12759
PeerJ 2022;10:e12759
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis.
Sun S, Han Y, Zhang C, Liu H, Wang B, Cao S, Yuan Q, Wei S, Chen Y
Frontiers in cell and developmental biology 2022;10:827714
Frontiers in cell and developmental biology 2022;10:827714
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Su H, Mei Y, Luo S, Wu H, He Y, Shiraishi Y, Hu P, Cohen RA, Tong X
British journal of pharmacology 2022 Oct;179(20):4778-4791
British journal of pharmacology 2022 Oct;179(20):4778-4791
Targeting PERK mediated endoplasmic reticulum stress attenuates neuroinflammation and alleviates lipopolysaccharide-induced depressive-like behavior in male mice.
Xu XF, Shi MM, Luo MY, Liu DD, Guo DM, Ling C, Zhong XL, Xu Y, Cao WY
International immunopharmacology 2022 Oct;111:109092
International immunopharmacology 2022 Oct;111:109092
Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway.
Liu P, Zu F, Chen H, Yin X, Tan X
Cellular & molecular biology letters 2022 Oct 8;27(1):87
Cellular & molecular biology letters 2022 Oct 8;27(1):87
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.
Zhang R, Lin H, You Q, Zhang Z, Bai L, Chen F, Zhu X, Zhang Z, Li Y
Journal of virology 2022 Oct 26;96(20):e0137522
Journal of virology 2022 Oct 26;96(20):e0137522
Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication.
Deng Z, Sun R, Han X, Zhang Y, Zhou Y, Shan Y, Xu J, Li X, He F, Fang W
Journal of virology 2022 Nov 23;96(22):e0127422
Journal of virology 2022 Nov 23;96(22):e0127422
α-Ketoglutarate Restores Intestinal Barrier Function through Promoting Intestinal Stem Cells-Mediated Epithelial Regeneration in Colitis.
Si X, Song Z, Liu N, Jia H, Liu H, Wu Z
Journal of agricultural and food chemistry 2022 Nov 2;70(43):13882-13892
Journal of agricultural and food chemistry 2022 Nov 2;70(43):13882-13892
Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy.
Zhang Z, Qiao D, Zhang Y, Chen Q, Chen Y, Tang Y, Que R, Chen Y, Zheng L, Dai Y, Tang Z
Molecular nutrition & food research 2022 Mar;66(5):e2100791
Molecular nutrition & food research 2022 Mar;66(5):e2100791
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Wu J, Yang C, Yang M, Liang Z, Wu Y, Kong X, Fan H, Wang S, Ning C, Xiao W, Jin Y, Yi J, Yuan Z
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats.
Zheng J, Liao Y, Xu Y, Mo Z
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
Clinical and experimental pharmacology & physiology 2022 Jul;49(7):719-730
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.
Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L
International journal of molecular sciences 2022 Jan 25;23(3)
International journal of molecular sciences 2022 Jan 25;23(3)
Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress.
Chen KY, Chen YJ, Cheng CJ, Jhan KY, Wang LC
Biomolecules 2022 Jan 21;12(2)
Biomolecules 2022 Jan 21;12(2)
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Wang Q, Zhou L, Wang J, Su D, Li D, Du Y, Yang G, Zhang G, Chu B
Viruses 2022 Feb 15;14(2)
Viruses 2022 Feb 15;14(2)
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.
Bian Y, Xue M, Guo X, Jiang W, Zhao Y, Zhang Z, Wang X, Hu Y, Zhang Q, Dun W, Zhang L
Pharmaceutical biology 2022 Dec;60(1):1801-1811
Pharmaceutical biology 2022 Dec;60(1):1801-1811
Role of Ero1α in cognitive impairment induced by chronic hypoxia.
Zhang N, Shentu Y, Zhu M, Wang H, Yin X, Du C, Xue F, Fan J, Gong Y, Fan X
Brain research 2022 Dec 15;1797:148117
Brain research 2022 Dec 15;1797:148117
Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells.
Wei W, Li Y, Wang C, Gao S, Zhao Y, Yang Z, Wang H, Gao Z, Jiang Y, He Y, Zhao L, Gao H, Yao X, Hu Y
Pharmacological research 2022 Aug;182:106285
Pharmacological research 2022 Aug;182:106285
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB
Autophagy 2022 Aug;18(8):1801-1821
Autophagy 2022 Aug;18(8):1801-1821
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
Peng X, Su S, Zeng J, Xie K, Yang X, Xian G, Xiao Z, Zhu P, Zheng S, Xu D, Zeng Q
Free radical biology & medicine 2022 Aug 1;188:404-418
Free radical biology & medicine 2022 Aug 1;188:404-418
STING1 is essential for an RNA-virus triggered autophagy.
Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2022 Apr;18(4):816-828
Autophagy 2022 Apr;18(4):816-828
Mitochondrial oxidative phosphorylation is dispensable for survival of CD34(+) chronic myeloid leukemia stem and progenitor cells.
Yan JS, Yang MY, Zhang XH, Luo CH, Du CK, Jiang Y, Dong XJ, Wang ZM, Yang LX, Li YD, Xia L, Lu Y
Cell death & disease 2022 Apr 20;13(4):384
Cell death & disease 2022 Apr 20;13(4):384
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Alfred N, Qian B, Qin X, Yin X, Prajapati M, Dou Y, Li Y, Zhang Z
Frontiers in veterinary science 2021;8:645571
Frontiers in veterinary science 2021;8:645571
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.
Zhao L, Li H, Gao Q, Xu J, Zhu Y, Zhai M, Zhang P, Shen N, Di Y, Wang J, Chen T, Huang M, Sun J, Liu C
Frontiers in pharmacology 2021;12:609693
Frontiers in pharmacology 2021;12:609693
Porcine Circovirus 2 Manipulates the PERK-ERO1α Axis of the Endoplasmic Reticulum To Favor Its Replication by Derepressing Viral DNA from HMGB1 Sequestration within Nuclei.
Sun R, Deng Z, Han X, Zhang Y, Zhou Y, Shan Y, Fang W, Li X
Journal of virology 2021 Sep 9;95(19):e0100921
Journal of virology 2021 Sep 9;95(19):e0100921
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Sun Y, Zhang L, Lu B, Wen J, Wang M, Zhang S, Li Q, Shu F, Lu F, Liu N, Peng S, Zhao Y, Dong S, Lu F, Zhang W, Wang Y
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606
Autophagy 2021 Nov;17(11):3592-3606
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
Yen IC, Tu QW, Chang TC, Lin PH, Li YF, Lee SY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111504
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111504
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Zhu Q, Liu Z, Wang Y, Song E, Song Y
Journal of hazardous materials 2021 Jun 5;411:124958
Journal of hazardous materials 2021 Jun 5;411:124958
Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.
Lai YH, Lee PY, Lu CY, Liu YR, Wang SC, Liu CC, Chang YC, Chen YH, Su CC, Li CY, Liu PL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21200
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21200
Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells.
Liu X, Wang Z, Wang X, Yan X, He Q, Liu S, Ye M, Li X, Yuan Z, Wu J, Yi J, Wen L, Li R
Toxicology and applied pharmacology 2021 Dec 1;432:115753
Toxicology and applied pharmacology 2021 Dec 1;432:115753
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes.
Hiller H, Beachy DE, Lebowitz JJ, Engler S, Mason JR, Miller DR, Kusmarteva I, Jacobsen LM, Posgai AL, Khoshbouei H, Oram RA, Schatz DA, Hattersley AT, Bodenmiller B, Atkinson MA, Nick HS, Wasserfall CH
Diabetes 2021 Aug;70(8):1885-1897
Diabetes 2021 Aug;70(8):1885-1897
Dihydroartemisinin exposure impairs porcine ovarian granulosa cells by activating PERK-eIF2α-ATF4 through endoplasmic reticulum stress.
Luo Y, Guo Q, Zhang L, Zhuan Q, Meng L, Fu X, Hou Y
Toxicology and applied pharmacology 2020 Sep 15;403:115159
Toxicology and applied pharmacology 2020 Sep 15;403:115159
ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.
Liu C, Zhang A
Environmental toxicology 2020 Oct;35(10):1100-1113
Environmental toxicology 2020 Oct;35(10):1100-1113
Protective effects of pterostilbene against hepatic damage, redox imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress in weanling piglets.
Zhang H, Chen Y, Li Y, Jia P, Ji S, Chen Y, Wang T
Journal of animal science 2020 Oct 1;98(10)
Journal of animal science 2020 Oct 1;98(10)
Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.
Yuan F, Jiang H, Yin H, Jiang X, Jiao F, Chen S, Ying H, Chen Y, Zhai Q, Guo F
Nature communications 2020 Jun 5;11(1):2847
Nature communications 2020 Jun 5;11(1):2847
Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes.
Chen KY, Chen YJ, Cheng CJ, Jhan KY, Wang LC
Parasites & vectors 2020 Jun 18;13(1):317
Parasites & vectors 2020 Jun 18;13(1):317
Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36.
Yang B, Qin Q, Xu L, Lv X, Liu Z, Song E, Song Y
Chemical research in toxicology 2020 Jun 15;33(6):1497-1507
Chemical research in toxicology 2020 Jun 15;33(6):1497-1507
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.
Su W, Tai Y, Tang SH, Ye YT, Zhao C, Gao JH, Tuo BG, Tang CW
World journal of gastroenterology 2020 Jul 28;26(28):4094-4107
World journal of gastroenterology 2020 Jul 28;26(28):4094-4107
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N
Scientific reports 2020 Feb 7;10(1):2160
Scientific reports 2020 Feb 7;10(1):2160
Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.
Chen ZJ, Chen JX, Wu LK, Li BY, Tian YF, Xian M, Huang ZP, Yu RA
Biomedical and environmental sciences : BES 2019 Jan;32(1):1-10
Biomedical and environmental sciences : BES 2019 Jan;32(1):1-10
MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.
Xu K, Han B, Bai Y, Ma XY, Ji ZN, Xiong Y, Miao SK, Zhang YY, Zhou LM
Cell death & disease 2019 Feb 15;10(3):152
Cell death & disease 2019 Feb 15;10(3):152
Porcine Circovirus Type 2 Induces ORF3-Independent Mitochondrial Apoptosis via PERK Activation and Elevation of Cytosolic Calcium.
Zhang Y, Sun R, Geng S, Shan Y, Li X, Fang W
Journal of virology 2019 Apr 1;93(7)
Journal of virology 2019 Apr 1;93(7)
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.
Niu X, Zhang J, Ling C, Bai M, Peng Y, Sun S, Li Y, Zhang Z
The Journal of international medical research 2018 May;46(5):1717-1733
The Journal of international medical research 2018 May;46(5):1717-1733
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)
Marine drugs 2018 Mar 26;16(4)
Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway.
Liu C, Fu Q, Mu R, Wang F, Zhou C, Zhang L, Yu B, Zhang Y, Fang T, Tian F
Brain research 2018 Dec 15;1701:246-254
Brain research 2018 Dec 15;1701:246-254
Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells.
Tang C, Lei H, Zhang J, Liu M, Jin J, Luo H, Xu H, Wu Y
Cancer biology & therapy 2018 Aug 3;19(8):715-721
Cancer biology & therapy 2018 Aug 3;19(8):715-721
Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.
Shao J, Yin Y, Yin X, Ji L, Xin Y, Zou J, Yao Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(2):788-800
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(2):788-800
PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Xu X, Cui Y, Cao L, Zhang Y, Yin Y, Hu X
Experimental and therapeutic medicine 2017 May;13(5):1993-1999
Experimental and therapeutic medicine 2017 May;13(5):1993-1999
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Xu D, Su C, Song X, Shi Q, Fu J, Hu L, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Jun 15;28(6):1326-37
Chemical research in toxicology 2015 Jun 15;28(6):1326-37
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 24390-1-AP( EIF2AK3 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EIF2AK3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EIF2AK3. This antibody recognizes human antigen. The EIF2AK3 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
