BS2156

antibody from Bioworld Technology, Inc

Targeting: EIF2AK3 PEK, PERK

Immunocytochemistry

Immunohistochemistry

Antibody data

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Validation data

Product number: BS2156 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS2156, RRID:AB_1663588
Product name: PERK (R87) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 56-102 of Human PERK.
Description: An interferon-inducible, RNA-dependent protein serine /threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the Ï« subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2Ï« on serine-51 results in inhibition of translation. The serine /threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. PERK is a type I transmembrane protein located in the endoplasmic reticulum (ER) that contains a kinase domain similar to the kinase domain of PKR. PERK is activated in response to ER stress and phosphorylates eIF-2Ï«, thus inhibiting the translation of mRNA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

EIF2AK3 protein structure - BS2156 shown in red.