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- Antibody Data
- Antigen structure
- References [154]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 20582-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20582-1-AP, RRID:AB_10695760
- Product name
- PERK/EIF2AK3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PERK/EIF2AK3 antibody (Cat. #20582-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis.
Hijacking ERAD for targeted degradation of transmembrane proteins.
Protein Kinase R-like Endoplasmic Reticulum Kinase-Mediated ER-Mitochondria Coupling Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells Under Inflammatory Stimuli.
African swine fever virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway.
Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells.
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
An acute increase in systemic bile acid levels in rats treated with tunicamycin.
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
HBV Precore G1896A Mutation Promotes Malignancy of Hepatocellular Carcinoma by Activating Endoplasmic Reticulum Stress to Enhance Aerobic Glycolysis.
Short-term high-dose gemcitabine induces PERK-mediated immunogenic cell death and potentiates antitumor immunity in bladder cancer.
B4GALT3 as a Key Glycosyltransferase Gene in Multiple Myeloma Progression: Insights From Bioinformatics, Machine Learning, and Experimental Validation.
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Mechanistic and target study of anthraquinone modifier KA-4c triggering endoplasmic reticulum stress to inhibit triple-negative breast cancer cells.
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.
Transcriptional regulation of solute carrier family 6 member 9 gene.
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation.
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways.
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction.
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma.
Glycosylation of ceramide synthase 6 is required for its activity.
Caveolin 1 in bovine liver is associated with fatty acid-induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development.
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice.
Perfluorooctane sulfonate causes HK-2 cell injury through ferroptosis and endoplasmic reticulum stress pathways.
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation.
Design, synthesis, and biological evaluation of N(1)-(2-(adamantan-1-yl)-1H-indol-5-yl)-N(2)-(substituent)-1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress.
ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction.
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay.
Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL.
SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress.
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
The EMC acts as a chaperone for membrane proteins.
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Effect of 1-DNJ on Oxidative Stress-Induced Apoptosis in Porcine Ovarian GCs Through Modulation of the PERK-ATF4/MFN2 Signaling Pathway.
Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.
eIF2B localization and its regulation during the integrated stress response is cell-type specific.
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules.
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Doxorubicin‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways.
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model.
African swine fever virus maintains de novo global cellular protein synthesis and inhibits stress granules formation via dephosphorylating eIF2α.
Rolapitant treats lung cancer by targeting deubiquitinase OTUD3.
Ciprofloxacin is a novel anti-ferroptotic antibiotic.
Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury.
PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury.
Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells.
Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
TUDCA inhibits EV71 replication by regulating ER stress signaling pathway and suppressing autophagy.
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Suppressing Endoplasmic Reticulum Stress Alleviates LPS-Induced Acute Lung Injury via Inhibiting Inflammation and Ferroptosis.
Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.
Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin.
Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes.
Classification related to immunogenic cell death predicts prognosis, immune microenvironment characteristics, and response to immunotherapy in lower-grade gliomas.
Cadmium-induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH-SY5Y cells.
RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy.
RNA Interference against ATP as a Gene Therapy Approach for Prostate Cancer.
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota.
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.
The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
NTRK1-mediated protection against manganese-induced neurotoxicity and cell apoptosis via IGF2 in SH-SY5Y cells.
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.
ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy.
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma.
A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway.
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells.
Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1/miR-377-3p pathway.
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.
sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Peste des petits ruminants virus induces ERS-mediated autophagy to promote virus replication.
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Resveratrol attenuates inflammation and apoptosis through alleviating endoplasmic reticulum stress via Akt/mTOR pathway in fungus-induced allergic airways inflammation.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study.
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Interleukin-10 Mitigates Doxorubicin-Induced Endoplasmic Reticulum Stress as Well as Cardiomyopathy.
Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats.
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress.
Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.
Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway.
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Cytotoxic BODIPY-Appended Half-Sandwich Iridium(III) Complex Forms Protein Adducts and Induces ER Stress.
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.
GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis.
Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway.
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
GRHL2 Upregulation Predicts a Poor Prognosis and Promotes the Resistance of Serous Ovarian Cancer to Cisplatin.
The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy.
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage.
Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Pseudorabies virus infection inhibits stress granules formation via dephosphorylating eIF2α.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.
Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K/Akt pathway.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture.
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction.
Protective effect of resveratrol against nigrostriatal pathway injury in striatum via JNK pathway.
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.
Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.
Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Zhu Y, Zhao W, Li W, Wang J, Chen H, Wang Z, Wang X, Chen X
Journal of advanced research 2026 Mar;81:673-687
Journal of advanced research 2026 Mar;81:673-687
Hijacking ERAD for targeted degradation of transmembrane proteins.
Song H, Wang W, Mei T, Zheng H, Ning K, Liu X, Cheung S, Cao Z, Sheng D, Mai X, Zhu H, Guo G, Liu S, Wei R, Wang Q, Cao Y, Ding Y, Fei Y, Liu R, Hattori M, Sheng C, Lu B
Cell 2026 Mar 19;189(6):1768-1784.e24
Cell 2026 Mar 19;189(6):1768-1784.e24
Protein Kinase R-like Endoplasmic Reticulum Kinase-Mediated ER-Mitochondria Coupling Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells Under Inflammatory Stimuli.
Wang Y, Li Y, Jin Y, Luo Z, Liu R
International dental journal 2026 Jun;76(3):109440
International dental journal 2026 Jun;76(3):109440
African swine fever virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Hou YP, Yang JK, Wang Y, Xia T, Wu X
Veterinary microbiology 2026 Jun;317:111013
Veterinary microbiology 2026 Jun;317:111013
Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway.
Wang Y, Zhao M, Liu S, Zheng R, Gao T
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Ginseng Polysaccharides Protect Against Endoplasmic Reticulum Stress-Induced Damage via PI3K/Akt Signalling Pathway in Bovine Ovarian Granulosa Cells.
Wang H, Fang Y, Huang L, Yang X, Ma X, Lyu Y, Jing G, Ding H, Liu H, Lyu W
Cells 2026 Jan 17;15(2)
Cells 2026 Jan 17;15(2)
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
Yang JK, Huang S, Hou YP, Yuan HF, Wang Y, Li M, Cao LB, Xia T, Shu HB, Wu X
The Journal of biological chemistry 2026 Apr;302(4):111333
The Journal of biological chemistry 2026 Apr;302(4):111333
An acute increase in systemic bile acid levels in rats treated with tunicamycin.
Yokoyama F, Yamada R, Yamazaki H, Maeda H, Ishizuka S
Bioscience, biotechnology, and biochemistry 2026 Apr 22;90(5):663-670
Bioscience, biotechnology, and biochemistry 2026 Apr 22;90(5):663-670
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
Yang X, Zheng J, Wang X, Cai H, Yu J
Ageing and neurodegenerative diseases 2025;5(3)
Ageing and neurodegenerative diseases 2025;5(3)
HBV Precore G1896A Mutation Promotes Malignancy of Hepatocellular Carcinoma by Activating Endoplasmic Reticulum Stress to Enhance Aerobic Glycolysis.
Zhao B, Qiao H, Gao Z, Zhao Y, Wang W, Cui Y, Li F, Wang Y, Guo Z, Chuai X, Chiu S
MedComm 2025 Sep;6(9):e70365
MedComm 2025 Sep;6(9):e70365
Short-term high-dose gemcitabine induces PERK-mediated immunogenic cell death and potentiates antitumor immunity in bladder cancer.
Xiong W, Liu Y, Yang H, Zhang B, Zhang X, Du Y, Wang H, Zhang X, Luo Y, Ha H, Fu Y, Zhang B, Zhang H, Lu J, Shang P, Yue Z
International immunopharmacology 2025 Sep 23;162:115057
International immunopharmacology 2025 Sep 23;162:115057
B4GALT3 as a Key Glycosyltransferase Gene in Multiple Myeloma Progression: Insights From Bioinformatics, Machine Learning, and Experimental Validation.
Yang A, Ke M, Feng L, Yang Y, Chen J, Zeng Z
Molecular carcinogenesis 2025 Oct;64(10):1595-1608
Molecular carcinogenesis 2025 Oct;64(10):1595-1608
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Mechanistic and target study of anthraquinone modifier KA-4c triggering endoplasmic reticulum stress to inhibit triple-negative breast cancer cells.
Yang Y, Xu S, Chen Q, Zhao Y, Li X, Li J, Hou H, Li D
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168020
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168020
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.
Zhao G, Qi J, Li F, Ma H, Wang R, Yu X, Wang Y, Qin S, Wu J, Huang C, Ren H, Zhang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2411020
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2411020
Transcriptional regulation of solute carrier family 6 member 9 gene.
Kirii M, Yoshida Y, Takashima S, Uchio-Yamada K, Oh-Hashi K
Molecular biology reports 2025 Jun 3;52(1):540
Molecular biology reports 2025 Jun 3;52(1):540
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation.
Zhang X, Yang M, Lv D, Zhang Y, Xie Y, He M, Fan Y, Li X, Jallow F, Li F, Deng D
Placenta 2025 Jun 26;167:204-215
Placenta 2025 Jun 26;167:204-215
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Li XJ, Huang KX, Wang KX, Liu R, Wang DC, Liang YR, Hao EJ, Wang Y, Guo HM
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways.
Li X, Chen Y, Su L, He J
Diseases (Basel, Switzerland) 2025 Jul 7;13(7)
Diseases (Basel, Switzerland) 2025 Jul 7;13(7)
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction.
Wei W, Wang H, Fu L, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156870
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156870
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma.
Li X, Lu F, Zhou J, Li X, Li Y, Ye W, Li J, Yang L, Tang S, Zhou Y, Yin S, Gao Y, Shang H, Chao T, Cheng X, Chu Q, Wang W
Cell death & disease 2025 Jul 11;16(1):512
Cell death & disease 2025 Jul 11;16(1):512
Glycosylation of ceramide synthase 6 is required for its activity.
Straus AJ, Mavodza G, Senkal CE
Journal of lipid research 2025 Jan;66(1):100715
Journal of lipid research 2025 Jan;66(1):100715
Caveolin 1 in bovine liver is associated with fatty acid-induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development.
Li M, Zhao B, Wang J, Zhang H, Yang Y, Song S, Psifidi A, Wu W, Loor JJ, Xu C
Journal of dairy science 2025 Jan;108(1):1007-1021
Journal of dairy science 2025 Jan;108(1):1007-1021
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Yu Z, Wang X, Hu Y, Wang X, Zhu Z, Xu X, Wang Y, Zhang A
Balkan medical journal 2025 Jan 2;42(1):27-36
Balkan medical journal 2025 Jan 2;42(1):27-36
CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice.
Hao R, Gao X, Lu Q, Zhao T, Lu X, Zhang F, Pei Y, Lang J, Liu H, Song J, Zhang Z
Journal of affective disorders 2025 Jan 15;369:547-558
Journal of affective disorders 2025 Jan 15;369:547-558
Perfluorooctane sulfonate causes HK-2 cell injury through ferroptosis and endoplasmic reticulum stress pathways.
Yan S, Ma H, Ren Y, Wang P, Liu D, Ding N, Liu Y, Chen Q, Ren S, Mou Y
Toxicology and industrial health 2025 Feb;41(2):73-82
Toxicology and industrial health 2025 Feb;41(2):73-82
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation.
Lu W, Yang Y, Gao S, Wu J, Sun X
Experimental eye research 2025 Feb;251:110222
Experimental eye research 2025 Feb;251:110222
Design, synthesis, and biological evaluation of N(1)-(2-(adamantan-1-yl)-1H-indol-5-yl)-N(2)-(substituent)-1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress.
Hu H, Wen F, Zhen T, Zhang M, Qin J, Huang J, Chen Z, Yu M, Hu S, Fang M, Zeng JZ
Bioorganic chemistry 2025 Feb;155:108113
Bioorganic chemistry 2025 Feb;155:108113
ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction.
Tao X, Zhang Y, Pang J, Liao Z, Chen G, Zhong X, Cao X, Lin Y, Guan D, Tian Y, Hao L, Zhao R, Cao Z
Pharmacological research 2025 Dec;222:108029
Pharmacological research 2025 Dec;222:108029
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Yang W, Jia M, Zhou F, Zhang M, Qu S, Zeng C, Zhu X, Gu S, Xuan J, Liu Z, Zen K
Autophagy 2025 Dec;21(12):2792-2808
Autophagy 2025 Dec;21(12):2792-2808
Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay.
Gu M, Chen Z, Chen Y, Li Y, Wang H, Feng YR, Zheng P, Huang C
Journal of pharmaceutical analysis 2025 Dec;15(12):101318
Journal of pharmaceutical analysis 2025 Dec;15(12):101318
Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.
Yang Y, Li M, Wang J, Zhang H, Chang R, Zhao B, Aernouts B, Huang Q, Xu C
Journal of dairy science 2025 Dec;108(12):13919-13937
Journal of dairy science 2025 Dec;108(12):13919-13937
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL.
Mandleywala K, Ulrich S, da Silva-Diz V, Sharma P, Thai C, Kim O, Aleksandrova M, Chung G, Eggers C, Lütjohann D, Kulkarni T, Singh A, Elena Díaz-Rubio M, Wierer M, Leidel SA, Su X, White EP, Rabinowitz JD, Morscher RJ, Herranz D
bioRxiv : the preprint server for biology 2025 Dec 23;
bioRxiv : the preprint server for biology 2025 Dec 23;
SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress.
Ying Q, Chen Y, Shen L, Xu Y, Tian R
Nature communications 2025 Dec 19;17(1):911
Nature communications 2025 Dec 19;17(1):911
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Zhao L, He Z, Sun Y, Sun M, Liu Z, Zhou Z, Qi L, Luo Y, Ji Y, Liang T
Nature communications 2025 Dec 10;17(1):525
Nature communications 2025 Dec 10;17(1):525
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Xu J, Hu M, Li Y, Gong H, Zhang X, He Z, Xiao C, Yang C, Zeng J
Cell biology international 2025 Aug;49(8):1042-1055
Cell biology international 2025 Aug;49(8):1042-1055
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Feng X, Du Y, Lv Y, Wei X, Cui C, Qin Y, Lu B, Chen Z, Ouyang K, Chen Y, Wei Z, Huang W, He Y, Qin Y
Viruses 2025 Aug 31;17(9)
Viruses 2025 Aug 31;17(9)
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Xie X, Tong W, Xie Y, Jiang H, Jiang A, Huang J, Liu Z, Yu J
Cell death & disease 2025 Aug 28;16(1):655
Cell death & disease 2025 Aug 28;16(1):655
The EMC acts as a chaperone for membrane proteins.
Klose CJ, Meighen-Berger KM, Kulke M, Parr M, Steigenberger B, Zacharias M, Frishman D, Feige MJ
Nature communications 2025 Aug 2;16(1):7097
Nature communications 2025 Aug 2;16(1):7097
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Wang C, Liu Z, Xie X, Li Y, Sun L
Tissue & cell 2025 Apr;93:102646
Tissue & cell 2025 Apr;93:102646
Effect of 1-DNJ on Oxidative Stress-Induced Apoptosis in Porcine Ovarian GCs Through Modulation of the PERK-ATF4/MFN2 Signaling Pathway.
Xing W, Li M, Wang B, Huo L, Tian W, Ge F, Shen M, Sun L, Liu J, Yu S
Antioxidants (Basel, Switzerland) 2025 Apr 11;14(4)
Antioxidants (Basel, Switzerland) 2025 Apr 11;14(4)
Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.
Yang L, Wu J, Zhang F, Zhang L, Zhang X, Zhou J, Pang J, Xie B, Xie H, Jiang Y, Peng J
Experimental neurology 2024 Sep;379:114853
Experimental neurology 2024 Sep;379:114853
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.
Tan Y, Huang Z, Jin Y, Wang J, Fan H, Liu Y, Zhang L, Wu Y, Liu P, Li T, Ran J, Tian H, Lam SM, Liu M, Zhou J, Yang Y
Nature communications 2024 Sep 27;15(1):8273
Nature communications 2024 Sep 27;15(1):8273
eIF2B localization and its regulation during the integrated stress response is cell-type specific.
Hanson FM, Ribeiro de Oliveira MI, Cross AK, Allen KE, Campbell SG
iScience 2024 Sep 20;27(9):110851
iScience 2024 Sep 20;27(9):110851
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Li Y, Wang Y, Jiang Z, Yang C, Wu Y, Wu A, Zhang Q, Liu X, Xiao B, Feng Y, Wu J, Liang Z, Yuan Z
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules.
Qi X, Zhao R, Yao X, Liu Q, Liu P, Zhu Z, Tu C, Gong W, Li X
International journal of biological macromolecules 2024 Nov;279(Pt 2):135274
International journal of biological macromolecules 2024 Nov;279(Pt 2):135274
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Shen R, Zhou J, Xin L, Zhou HB, Huang J
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Doxorubicin‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways.
Malik A, Bagchi AK, Jassal DS, Singal PK
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model.
Cheng Z, Liu Z, Liu C, Yang A, Miao H, Bai X
International immunopharmacology 2024 May 10;132:112061
International immunopharmacology 2024 May 10;132:112061
African swine fever virus maintains de novo global cellular protein synthesis and inhibits stress granules formation via dephosphorylating eIF2α.
Gao H, Gao X, Liu X, Luo Y, Zhong J, Liu J, Yan L, Wang H, Gong L, Zhang G, Zheng Z, Sun Y
Veterinary microbiology 2024 Mar;290:109988
Veterinary microbiology 2024 Mar;290:109988
Rolapitant treats lung cancer by targeting deubiquitinase OTUD3.
Du T, Gu Q, Zhang Y, Gan Y, Liang R, Yang W, Lu Y, Xu C, Wu J, Ma R, Cao H, Jiang J, Wang J, Feng J
Cell communication and signaling : CCS 2024 Mar 27;22(1):195
Cell communication and signaling : CCS 2024 Mar 27;22(1):195
Ciprofloxacin is a novel anti-ferroptotic antibiotic.
Chen F, Tang H, Lin J, Kang R, Tang D, Liu J
Heliyon 2024 Jun 15;10(11):e32571
Heliyon 2024 Jun 15;10(11):e32571
Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury.
Huang M, Wang J, Zhai M, Liu J, Zhu Y, Zhang Y, Zhao J, Wang H, Sun J, Yu H, Liu C
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166885
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166885
PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
Sachan V, Le Dévéhat M, Roubtsova A, Essalmani R, Laurendeau JF, Garçon D, Susan-Resiga D, Duval S, Mikaeeli S, Hamelin J, Evagelidis A, Chong M, Paré G, Chernetsova E, Gao ZH, Robillard I, Ruiz M, Trinh VQ, Estall JL, Faraj M, Austin RC, Sauvageau M, Prat A, Kiss RS, Seidah NG
Metabolism: clinical and experimental 2024 Jan;150:155736
Metabolism: clinical and experimental 2024 Jan;150:155736
Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury.
Li Z, Wang B, Tian L, Zheng B, Zhao X, Liu R
Inflammation 2024 Feb;47(1):376-389
Inflammation 2024 Feb;47(1):376-389
Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells.
Su X, Chen H, Xiang H, Ke H, Dong C, Song Q, Zhou J, Jiang Q, Wang Y, Chen L, Yang S
Redox report : communications in free radical research 2024 Dec;29(1):2416825
Redox report : communications in free radical research 2024 Dec;29(1):2416825
Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.
Ke H, Su X, Dong C, He Z, Song Q, Song C, Zhou J, Liao W, Wang C, Yang S, Xiong Y
Redox report : communications in free radical research 2024 Dec;29(1):2391139
Redox report : communications in free radical research 2024 Dec;29(1):2391139
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE(-/-) mice via MBOAT2-mediated endoplasmic reticulum stress.
Yu B, Yuan C, Chen J, Zhou Z, Zhang Y, Su M, Wei D, Wu P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Dec;1869(8):159559
TUDCA inhibits EV71 replication by regulating ER stress signaling pathway and suppressing autophagy.
Wang S, Liu R, Zhou Y, Xu J, Su A, Zheng D
Diagnostic microbiology and infectious disease 2024 Dec;110(4):116500
Diagnostic microbiology and infectious disease 2024 Dec;110(4):116500
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Yuan C, Yu B, Li L, Chen J, Qin W, Zhou Z, Su M, Wang D, Zhang Y, Wu Q, He C, Wei D
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
Suppressing Endoplasmic Reticulum Stress Alleviates LPS-Induced Acute Lung Injury via Inhibiting Inflammation and Ferroptosis.
Wang S, Xu F, Liu H, Shen Y, Zhang J, Hu L, Zhu L
Inflammation 2024 Aug;47(4):1067-1082
Inflammation 2024 Aug;47(4):1067-1082
Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.
Chen M, Wen J, Qiu Y, Gao X, Zhang J, Lin Y, Wu Z, Lin X, Zhu A
Toxins 2024 Aug 24;16(9)
Toxins 2024 Aug 24;16(9)
Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin.
Lin H, Guo X, Liu J, Tang Y, Chen L, Chen H, Zhao Y, Wang L, Li H, Yu J, Yao P
Molecular nutrition & food research 2024 Apr;68(7):e2300343
Molecular nutrition & food research 2024 Apr;68(7):e2300343
Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes.
Cui K, Li Z
Frontiers in endocrinology 2023;14:1164112
Frontiers in endocrinology 2023;14:1164112
Classification related to immunogenic cell death predicts prognosis, immune microenvironment characteristics, and response to immunotherapy in lower-grade gliomas.
Kuang Y, Jiang B, Zhu H, Zhou Y, Huang H, Li C, Zhang W, Li X, Cao Y
Frontiers in immunology 2023;14:1102094
Frontiers in immunology 2023;14:1102094
Cadmium-induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH-SY5Y cells.
Li Z, Shi Y, Wang Y, Qi H, Chen H, Li J, Li L
Environmental toxicology 2023 Sep;38(9):2219-2227
Environmental toxicology 2023 Sep;38(9):2219-2227
RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress.
Cremer T, Voortman LM, Bos E, Jongsma ML, Ter Haar LR, Akkermans JJ, Talavera Ormeño CM, Wijdeven RH, de Vries J, Kim RQ, Janssen GM, van Veelen PA, Koning RI, Neefjes J, Berlin I
The EMBO journal 2023 Sep 18;42(18):e111252
The EMBO journal 2023 Sep 18;42(18):e111252
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
You M, Li S, Yan S, Yao D, Wang T, Wang Y
Environment international 2023 Oct;180:108228
Environment international 2023 Oct;180:108228
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy.
Yan M, Wang J, Wang H, Zhou J, Qi H, Naji Y, Zhao L, Tang Y, Dai Y
Journal of translational medicine 2023 Oct 8;21(1):701
Journal of translational medicine 2023 Oct 8;21(1):701
RNA Interference against ATP as a Gene Therapy Approach for Prostate Cancer.
Chen S, Ma J, Xiao Y, Zhou D, He P, Chen Y, Zheng X, Lin H, Qiu F, Yuan Y, Zhong J, Li X, Pan X, Fang Z, Wang C
Molecular pharmaceutics 2023 Oct 2;20(10):5214-5225
Molecular pharmaceutics 2023 Oct 2;20(10):5214-5225
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota.
Li K, Wu J, Xu S, Li X, Zhang Y, Gao X-j
Microbiology spectrum 2023 Oct 17;11(5):e0191423
Microbiology spectrum 2023 Oct 17;11(5):e0191423
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627
World journal of gastroenterology 2023 May 7;29(17):2616-2627
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Zhong X, Wang Y, Liu D, Liang Y, Liu W, Huang Y, Xie L, Cao W, Xu Y, Chen L
Neuroscience 2023 May 1;517:117-127
Neuroscience 2023 May 1;517:117-127
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
Zheng Y, Dai H, Chen R, Zhong Y, Zhou C, Wang Y, Zhan C, Luo J
Journal of cellular physiology 2023 Mar;238(3):582-596
Journal of cellular physiology 2023 Mar;238(3):582-596
Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H
NPJ Parkinson's disease 2023 Mar 7;9(1):35
NPJ Parkinson's disease 2023 Mar 7;9(1):35
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Li Y, She W, Guo T, Huang T, Liu Y, Liu P, Xu X, Wang X, Wang M, Yu C, Liu Y, Wei Y
Biochemical pharmacology 2023 Feb;208:115404
Biochemical pharmacology 2023 Feb;208:115404
Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.
Wu H, Zhang Y, Liang J, Wu J, Zhang Y, Su H, Zhang Q, Shen Y, Shen S, Wang L, Zou X, Hang C, Zhang S, Lv Y
Translational oncology 2023 Dec;38:101792
Translational oncology 2023 Dec;38:101792
The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Luo G, Aldridge K, Chen T, Aslot V, Kim BG, Han EH, Singh N, Li S, Xiao TS, Sporn MB, Letterio JJ
Molecular oncology 2023 Dec;17(12):2526-2545
Molecular oncology 2023 Dec;17(12):2526-2545
NTRK1-mediated protection against manganese-induced neurotoxicity and cell apoptosis via IGF2 in SH-SY5Y cells.
Zhang C, Jiao B, Cao X, Zhang W, Yu S, Zhang K, Zhang M, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115889
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115889
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Xie F, Qu J, Lin D, Feng K, Tan M, Liao H, Zeng L, Xiong Q, Huang J, Chen W
Molecular biology reports 2023 Dec 12;51(1):10
Molecular biology reports 2023 Dec 12;51(1):10
Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.
Cui X, Yao M, Feng Y, Li C, Li Y, Guo D, He S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027
ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy.
Mo W, Liu S, Zhao X, Wei F, Li Y, Sheng X, Cao W, Ding M, Zhang W, Chen X, Meng L, Yao S, Diao W, Wei H, Guo H
Advanced healthcare materials 2023 Aug;12(21):e2300191
Advanced healthcare materials 2023 Aug;12(21):e2300191
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Xie Y, Mei X, Shi W
Journal of cellular and molecular medicine 2023 Apr;27(7):982-990
Journal of cellular and molecular medicine 2023 Apr;27(7):982-990
Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma.
Liu G, Guan Y, Liu Y, Wang Y, Zhang J, Liu Y, Liu X
BioMed research international 2022;2022:5489553
BioMed research international 2022;2022:5489553
A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway.
Yuan H, Zhao Z, Guo Z, Ma L, Han J, Song Y
International journal of biological sciences 2022;18(13):4853-4868
International journal of biological sciences 2022;18(13):4853-4868
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)
Cancers 2022 Sep 23;14(19)
Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells.
Sun YN, Ma YN, Jia XQ, Yao Q, Chen JP, Li H
Current medical science 2022 Oct;42(5):958-965
Current medical science 2022 Oct;42(5):958-965
Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1/miR-377-3p pathway.
Fu C, Qiu Z, Huang Y, Lin Q, Jin L, Tu H, Ye J, Zheng C, Zhong W, Ma D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113551
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113551
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Wang R, Shang Y, Chen B, Xu F, Zhang J, Zhang Z, Zhao X, Wan X, Xu A, Wu L, Zhao G
Cell death & disease 2022 Oct 6;13(10):851
Cell death & disease 2022 Oct 6;13(10):851
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Peng S, Zhao D, Li Q, Wang M, Zhang S, Pang K, Huang J, Lu F, Chen H, Zhang W
Cells 2022 Nov 2;11(21)
Cells 2022 Nov 2;11(21)
Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.
Li J, Huang L, Xiong W, Qian Y, Song M
Biochemical and biophysical research communications 2022 May 7;603:35-40
Biochemical and biophysical research communications 2022 May 7;603:35-40
sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Zhu L, Li B, Chen D, Chen N, Xu L, Li Q, Chen X
Life sciences 2022 May 1;296:120438
Life sciences 2022 May 1;296:120438
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Peste des petits ruminants virus induces ERS-mediated autophagy to promote virus replication.
Wen B, Yang L, Guo J, Chang W, Wei S, Yu S, Qi X, Xue Q, Wang J
Veterinary microbiology 2022 Jul;270:109451
Veterinary microbiology 2022 Jul;270:109451
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Wang P, Liu D, Yan S, Liang Y, Cui J, Guo L, Ren S, Chen P
Toxics 2022 Jul 29;10(8)
Toxics 2022 Jul 29;10(8)
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Bai Y, Wang M, Yang Y, Liu X, Chen Q, Guo Z
Cell biology international 2022 Feb;46(2):192-202
Cell biology international 2022 Feb;46(2):192-202
Resveratrol attenuates inflammation and apoptosis through alleviating endoplasmic reticulum stress via Akt/mTOR pathway in fungus-induced allergic airways inflammation.
Wang S, Gong L, Mo Y, Zhang J, Jiang Z, Tian Z, Shao C
International immunopharmacology 2022 Feb;103:108489
International immunopharmacology 2022 Feb;103:108489
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study.
Xu Q, Zhao T, Ri H, Ye J, Zhao W, Zhang Y, Ye L
Environmental toxicology 2022 Dec;37(12):2924-2936
Environmental toxicology 2022 Dec;37(12):2924-2936
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.
Wen C, Ruan Q, Li Z, Zhou X, Yang X, Xu P, Akuetteh PDP, Xu Z, Deng J
British journal of cancer 2022 Dec;127(12):2108-2117
British journal of cancer 2022 Dec;127(12):2108-2117
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Ma G, Zhao Z, Qu Y, Cai F, Liu S, Liang H, Zhang R, Deng J
Cell death discovery 2022 Dec 16;8(1):493
Cell death discovery 2022 Dec 16;8(1):493
Interleukin-10 Mitigates Doxorubicin-Induced Endoplasmic Reticulum Stress as Well as Cardiomyopathy.
Malik A, Bagchi AK, Jassal DS, Singal PK
Biomedicines 2022 Apr 13;10(4)
Biomedicines 2022 Apr 13;10(4)
Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats.
Zhang Y, Weng Y, Wang D, Wang R, Wang L, Zhou J, Shen S, Wang H, Wang Y
Oxidative medicine and cellular longevity 2021;2021:7382900
Oxidative medicine and cellular longevity 2021;2021:7382900
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Du Y, Zhong F, Cheng H, Li T, Chen Y, Tan P, Huang M, Liang T, Liu Y, Xia X, Fu W
Oxidative medicine and cellular longevity 2021;2021:4628050
Oxidative medicine and cellular longevity 2021;2021:4628050
Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress.
Li F, Geng X, Lee H, Wills M, Ding Y
Frontiers in cellular neuroscience 2021;15:598230
Frontiers in cellular neuroscience 2021;15:598230
Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.
Liu Z, Liao T, Yang N, Ding L, Li X, Wu P, Wang P
Frontiers in pharmacology 2021;12:739644
Frontiers in pharmacology 2021;12:739644
Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway.
Xiang H, Shao M, Lu Y, Wang J, Wu T, Ji G
Frontiers in pharmacology 2021;12:690736
Frontiers in pharmacology 2021;12:690736
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Liu T, Li T, Chen X, Li Z, Feng M, Yao W, Wan L, Zhang C, Zhang Y
Journal of neuroinflammation 2021 Sep 16;18(1):211
Journal of neuroinflammation 2021 Sep 16;18(1):211
Cytotoxic BODIPY-Appended Half-Sandwich Iridium(III) Complex Forms Protein Adducts and Induces ER Stress.
Ramos R, Gilles JF, Morichon R, Przybylski C, Caron B, Botuha C, Karaiskou A, Salmain M, Sobczak-Thépot J
Journal of medicinal chemistry 2021 Nov 25;64(22):16675-16686
Journal of medicinal chemistry 2021 Nov 25;64(22):16675-16686
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, Accornero F, Sargent MA, Molkentin JD
Nature communications 2021 Jun 24;12(1):3928
Nature communications 2021 Jun 24;12(1):3928
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Yang M, Kuang M, Wang G, Ali I, Tang Y, Yang C, Li Y, Li L
Molecular immunology 2021 Jul;135:388-397
Molecular immunology 2021 Jul;135:388-397
MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
Zhao S, Yuan C, Tuo X, Zhou C, Zhao Q, Shen T
Chemosphere 2021 Jan;263:127868
Chemosphere 2021 Jan;263:127868
Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Jin H, Hou J, Meng X, Ma T, Wang B, Liu Z, Sha X, Ding J, Han X
Ecotoxicology and environmental safety 2021 Jan 15;208:111748
Ecotoxicology and environmental safety 2021 Jan 15;208:111748
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.
Liu YN, Mu YD, Wang H, Zhang M, Shi YW, Mi G, Peng LX, Chen JH
Toxicology 2021 Dec;464:152989
Toxicology 2021 Dec;464:152989
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
Huang L, Liu Q, Zhou T, Zhang J, Tian Q, Zhang Q, Wei W, Wu H
International immunopharmacology 2021 Dec;101(Pt A):108281
International immunopharmacology 2021 Dec;101(Pt A):108281
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.
Chen Y, Hu M, Deng F, Wang P, Lin J, Zheng Z, Liu Y, Dong L, Lu X, Chen Z, Zhou J, Zuo D
Cell calcium 2021 Dec;100:102477
Cell calcium 2021 Dec;100:102477
GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis.
Zhu T, Jiang X, Xin H, Zheng X, Xue X, Chen JL, Qi B
Veterinary research 2021 Dec 20;52(1):148
Veterinary research 2021 Dec 20;52(1):148
Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway.
Wang Z, Feng F, He H, Wu Q, Gu C, Hrovat J, Peng W, Xu Y, Han D, Yang P, Zhou X, Li J, Shan J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Aug;89:153599
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Aug;89:153599
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Ma D, Liu X, Zhang JJ, Zhao JJ, Xiong YJ, Chang Q, Wang HY, Su P, Meng J, Zhao YB
Frontiers in cardiovascular medicine 2020;7:592550
Frontiers in cardiovascular medicine 2020;7:592550
GRHL2 Upregulation Predicts a Poor Prognosis and Promotes the Resistance of Serous Ovarian Cancer to Cisplatin.
Nie Y, Ding Y, Yang M
OncoTargets and therapy 2020;13:6303-6314
OncoTargets and therapy 2020;13:6303-6314
The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy.
Xu X, Chen B, Huang Q, Wu Y, Liang T
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:2583-2592
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:2583-2592
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Liu Y, Wen D, Gao J, Xie B, Yu H, Shen Q, Zhang J, Jing W, Cong B, Ma C
Brain research bulletin 2020 Sep;162:73-83
Brain research bulletin 2020 Sep;162:73-83
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Yang L, Zhou X, Sun J, Lei Q, Wang Q, Pan D, Ding M, Ding Y
Cell death & disease 2020 Sep 17;11(9):766
Cell death & disease 2020 Sep 17;11(9):766
Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Yao X, Li K, Liang C, Zhou Z, Wang J, Wang S, Liu L, Yu CL, Song ZB, Bao YL, Zheng LH, Sun Y, Wang G, Huang Y, Yi J, Sun L, Li Y
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Song Q, He Z, Li B, Liu J, Liu L, Liao W, Xiong Y, Song C, Yang S, Liu Y
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage.
Fan C, Feng J, Tang C, Zhang Z, Feng Y, Duan W, Zhai M, Yan Z, Zhu L, Feng L, Zhu H, Luo E
Stem cell research & therapy 2020 Oct 15;11(1):442
Stem cell research & therapy 2020 Oct 15;11(1):442
Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.
Yao Y
Molecular medicine reports 2020 Mar;21(3):1059-1070
Molecular medicine reports 2020 Mar;21(3):1059-1070
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Chen X, Ji S, Si J, Zhang X, Wang X, Guo Y, Zou X
Molecular medicine reports 2020 Dec;22(6):5243-5250
Molecular medicine reports 2020 Dec;22(6):5243-5250
Pseudorabies virus infection inhibits stress granules formation via dephosphorylating eIF2α.
Xu S, Chen D, Chen D, Hu Q, Zhou L, Ge X, Han J, Guo X, Yang H
Veterinary microbiology 2020 Aug;247:108786
Veterinary microbiology 2020 Aug;247:108786
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Lu F, Lu B, Zhang L, Wen J, Wang M, Zhang S, Li Q, Shu F, Sun Y, Liu N, Peng S, Zhao Y, Dong S, Zhao D, Lu F, Zhang W
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, Wang Z, Tan N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109188
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109188
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Li F, Zhang Y, Lu X, Shi J, Gong Q
Life sciences 2019 Oct 1;234:116739
Life sciences 2019 Oct 1;234:116739
Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.
Cui Y, Wang Y, Liu G
International journal of molecular medicine 2019 May;43(5):2015-2023
International journal of molecular medicine 2019 May;43(5):2015-2023
Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K/Akt pathway.
Zhou MF, Feng ZP, Ou YC, Peng JJ, Li K, Gong HD, Qiu BH, Liu YW, Wang YJ, Qi ST
CNS neuroscience & therapeutics 2019 May;25(5):562-574
CNS neuroscience & therapeutics 2019 May;25(5):562-574
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)
Cells 2019 May 31;8(6)
Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Zhang LK, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z, Wang M
Journal of virology 2019 May 15;93(10)
Journal of virology 2019 May 15;93(10)
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Jin HZ, Fang YY, Jin QG, Fang N
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Li SS, Jiang WL, Xiao WQ, Li K, Zhang YF, Guo XY, Dai YQ, Zhao QY, Jiang MJ, Lu ZJ, Wan R
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
Gu M, Zhao P, Zhang S, Fan S, Yang L, Tong Q, Ji G, Huang C
British journal of pharmacology 2019 Apr;176(7):847-863
British journal of pharmacology 2019 Apr;176(7):847-863
Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture.
Duan YM, Jin Y, Guo ML, Duan LX, Wang JG
Journal of Cancer 2018;9(15):2723-2733
Journal of Cancer 2018;9(15):2723-2733
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction.
Niu X, Zhang J, Ni J, Wang R, Zhang W, Sun S, Peng Y, Bai M, Zhang Z
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Protective effect of resveratrol against nigrostriatal pathway injury in striatum via JNK pathway.
Li D, Liu N, Zhao L, Tong L, Kawano H, Yan HJ, Li HP
Brain research 2017 Jan 1;1654(Pt A):1-8
Brain research 2017 Jan 1;1654(Pt A):1-8
Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707
Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.
Liu Z, Shi Q, Song X, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Sep 19;29(9):1510-8
Chemical research in toxicology 2016 Sep 19;29(9):1510-8
Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.
Zhang W, Chen L, Shen Y, Xu J
Toxicology in vitro : an international journal published in association with BIBRA 2016 Oct;36:186-196
Toxicology in vitro : an international journal published in association with BIBRA 2016 Oct;36:186-196
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu K, Sun H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.
Szaflarski W, Fay MM, Kedersha N, Zabel M, Anderson P, Ivanov P
Oncotarget 2016 May 24;7(21):30307-22
Oncotarget 2016 May 24;7(21):30307-22
Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells.
Li W, Cao F, Li J, Wang Z, Ren Y, Liang Z, Liu P
Molecular medicine reports 2016 Dec;14(6):5334-5342
Molecular medicine reports 2016 Dec;14(6):5334-5342
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23
Drug design, development and therapy 2015;9:5911-23
Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress.
Wang ZS, Xiong F, Xie XH, Chen D, Pan JH, Cheng L
BMC nephrology 2015 Mar 31;16:44
BMC nephrology 2015 Mar 31;16:44
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 20582-1-AP(PERK antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PERK antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PERK. This antibody recognizes human antigen. The PERK antibody has been validated for the following applications: ELISA, WB, IHC analysis.
