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- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 11711-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11711-1-AP, RRID:AB_2081845
- Product name
- GAR1 antibody
- Antibody type
- Polyclonal
- Description
- GAR1 antibody (Cat. #11711-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.
TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
Proteomic analyses reveal new features of the box H/ACA RNP biogenesis.
Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex.
Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence.
PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins.
A primary cilium in oligodendrocytes: a fine structure signal of repairs in thalamic Osmotic Demyelination Syndrome (ODS).
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H/ACA riboproteins, in gastric and colorectal cancers.
A spectrum of oncocytic lesions in the parotid gland of a patient with sarcoidosis.
Qin J, Garus A, Autexier C
Human molecular genetics 2024 Feb 1;33(4):318-332
Human molecular genetics 2024 Feb 1;33(4):318-332
TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
Klump BM, Perez GI, Patrick EM, Adams-Boone K, Cohen SB, Han L, Yu K, Schmidt JC
Cell reports 2023 Jun 27;42(6):112577
Cell reports 2023 Jun 27;42(6):112577
Proteomic analyses reveal new features of the box H/ACA RNP biogenesis.
Schlotter F, Mérouani S, Flayac J, Kogey V, Issa A, Dodré M, Huttin A, Branlant C, Bertrand E, Labialle S, Vandermoere F, Verheggen C, Massenet S
Nucleic acids research 2023 Apr 24;51(7):3357-3374
Nucleic acids research 2023 Apr 24;51(7):3357-3374
Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex.
Han C, Sun LY, Luo XQ, Pan Q, Sun YM, Zeng ZC, Chen TQ, Huang W, Fang K, Wang WT, Chen YQ
Cell reports 2022 Mar 29;38(13):110421
Cell reports 2022 Mar 29;38(13):110421
Human dyskerin binds to cytoplasmic H/ACA-box-containing transcripts affecting nuclear hormone receptor dependence.
Zacchini F, Venturi G, De Sanctis V, Bertorelli R, Ceccarelli C, Santini D, Taffurelli M, Penzo M, Treré D, Inga A, Dassi E, Montanaro L
Genome biology 2022 Aug 22;23(1):177
Genome biology 2022 Aug 22;23(1):177
PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins.
Savelyev NV, Shepelev NM, Lavrik OI, Rubtsova MP, Dontsova OA
Frontiers in cell and developmental biology 2021;9:621134
Frontiers in cell and developmental biology 2021;9:621134
A primary cilium in oligodendrocytes: a fine structure signal of repairs in thalamic Osmotic Demyelination Syndrome (ODS).
Gilloteaux J, Bouchat J, Bielarz V, Brion JP, Nicaise C
Ultrastructural pathology 2021 Mar 4;45(2):128-157
Ultrastructural pathology 2021 Mar 4;45(2):128-157
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
MacNeil DE, Lambert-Lanteigne P, Qin J, McManus FP, Bonneil E, Thibault P, Autexier C
Molecular and cellular biology 2021 Mar 24;41(4)
Molecular and cellular biology 2021 Mar 24;41(4)
Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
Bergstrand S, Böhm S, Malmgren H, Norberg A, Sundin M, Nordgren A, Farnebo M
Cell death & disease 2020 Apr 17;11(4):238
Cell death & disease 2020 Apr 17;11(4):238
Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.
Lin P, Mobasher ME, Hakakian Y, Kakarla V, Naseem AF, Ziai H, Alawi F
Histochemistry and cell biology 2015 Dec;144(6):543-58
Histochemistry and cell biology 2015 Dec;144(6):543-58
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H
Molecular cell 2013 Jan 24;49(2):339-45
Molecular cell 2013 Jan 24;49(2):339-45
Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H/ACA riboproteins, in gastric and colorectal cancers.
Kim MS, Kim SS, Yoo NJ, Lee SH
Pathology 2012 Oct;44(6):576-7
Pathology 2012 Oct;44(6):576-7
A spectrum of oncocytic lesions in the parotid gland of a patient with sarcoidosis.
Ziad F, Sinha S, White J, Pandya H
Pathology 2012 Oct;44(6):574-6
Pathology 2012 Oct;44(6):574-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 11711-1-AP(GAR1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GAR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GAR1. This antibody recognizes human,mouse,rat antigen. The GAR1 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GAR1 (IP:11711-1-AP, 3ug; Detection:11711-1-AP 1:300) with A375 cells lysate 6000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin cancer using 11711-1-AP(GAR1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin cancer using 11711-1-AP(GAR1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
