16610-1-AP

antibody from Proteintech Group

Targeting: ATAD3B KIAA1273, TOB3

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

16610-1-AP

Provider

Proteintech Group

Product name

ATAD3A/B antibody

Antibody type

Polyclonal

Description

KD/KO validated ATAD3A/B antibody (Cat. #16610-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications.

Gonzalez CD, Nissanka N, Van Booven D, Griswold AJ, Moraes CT
The Journal of biological chemistry 2024 Apr;300(4):107128

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Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.

Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A
Molecular cell 2023 Oct 19;83(20):3740-3753.e9

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Analysis of Radiation Toxicity in Mammalian Cells Stably Transduced with Mitochondrial Stat3.

Zanin A, Meneghetti G, Menilli L, Tesoriere A, Argenton F, Mognato M
International journal of molecular sciences 2023 May 4;24(9)

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Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.

Chen L, Dong J, Liao S, Wang S, Wu Z, Zuo M, Liu B, Yan C, Chen Y, He H, Meng Q, Song Z
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408

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Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.

Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D
Nature communications 2022 Nov 7;13(1):6704

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miRNA-27a Transcription Activated by c-Fos Regulates Myocardial Ischemia-Reperfusion Injury by Targeting ATAD3a.

Bao Y, Qiao Y, Yu H, Zhang Z, Yang H, Xin X, Chen Y, Guo Y, Wu N, Jia D
Oxidative medicine and cellular longevity 2021;2021:2514947

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ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.

Arguello T, Peralta S, Antonicka H, Gaidosh G, Diaz F, Tu YT, Garcia S, Shiekhattar R, Barrientos A, Moraes CT
Cell reports 2021 Dec 21;37(12):110139

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ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.

Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283

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OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.

Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940

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Novel ATAD3A recessive mutation associated to fatal cerebellar hypoplasia with multiorgan involvement and mitochondrial structural abnormalities.

Peralta S, González-Quintana A, Ybarra M, Delmiro A, Pérez-Pérez R, Docampo J, Arenas J, Blázquez A, Ugalde C, Martín MA
Molecular genetics and metabolism 2019 Dec;128(4):452-462

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ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.

Peralta S, Goffart S, Williams SL, Diaz F, Garcia S, Nissanka N, Area-Gomez E, Pohjoismäki J, Moraes CT
Journal of cell science 2018 Jul 4;131(13)