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- References [12]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 19107-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19107-1-AP, RRID:AB_10638642
- Product name
- ALPK1 antibody
- Antibody type
- Polyclonal
- Description
- ALPK1 antibody (Cat. #19107-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Immune function analysis in a pediatric patient with a de novo ALPK1 gene mutation.
ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke.
NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats.
Alpha protein kinase 1 knockout mitigates microglial pyroptosis and cognition deficits in ADP-heptose-stimulated mice.
The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.
ALPK1 Expressed in IB4-Positive Neurons of Mice Trigeminal Ganglions Promotes MIA-Induced TMJ pain.
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.
Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway.
ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.
Chuan X, Ren A, Hu S, Li Q, Zhu Y, Zhang P, Wang L, Du Q, Li H, Chen Y, Huang P, Du Z
Frontiers in immunology 2025;16:1622079
Frontiers in immunology 2025;16:1622079
ALPK1 signaling pathway activation by HMGB1 drives microglial pyroptosis and ferroptosis and brain injury after acute ischemic stroke.
Du O, Yan YL, Yang HY, Yang YX, Wu AG, Guo YK, Li K, Qiao G, Du JR, Long FY
International immunopharmacology 2025 Mar 6;149:114229
International immunopharmacology 2025 Mar 6;149:114229
NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats.
Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L
Communications biology 2025 Jan 2;8(1):2
Communications biology 2025 Jan 2;8(1):2
Alpha protein kinase 1 knockout mitigates microglial pyroptosis and cognition deficits in ADP-heptose-stimulated mice.
Zou X, Du O, Yang YR, Yang YX, Zheng ZX, Li MY, Wu AG, Du JR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 15;39(3):e70371
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 15;39(3):e70371
The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.
Zhao J, Feng Y, Liu X, Li H, Guo H, Ke J, Long X
Journal of cellular and molecular medicine 2024 Apr;28(7):e18172
Journal of cellular and molecular medicine 2024 Apr;28(7):e18172
ALPK1 Expressed in IB4-Positive Neurons of Mice Trigeminal Ganglions Promotes MIA-Induced TMJ pain.
Zhu T, Li H, Chen Y, Jia X, Ma X, Liu X, Feng Y, Ke J
Molecular neurobiology 2023 Nov;60(11):6264-6274
Molecular neurobiology 2023 Nov;60(11):6264-6274
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Liu X, Li Y, Zhao J, Hu Z, Fang W, Ke J, Li W, Long X
International immunopharmacology 2023 Nov;124(Pt A):110781
International immunopharmacology 2023 Nov;124(Pt A):110781
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
Liu X, Zhao J, Jiang H, Li H, Feng Y, Ke J, Long X
Journal of dental research 2022 Nov;101(12):1499-1509
Journal of dental research 2022 Nov;101(12):1499-1509
Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.
Li JY, Zheng ZX, Liu L, Du O, Yu NW, Zou Y, Seong SY, Du JR
International immunopharmacology 2022 Dec;113(Pt A):109330
International immunopharmacology 2022 Dec;113(Pt A):109330
Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway.
Ding F, Luo X, Tu Y, Duan X, Liu J, Jia L, Zheng P
Frontiers in immunology 2021;12:705751
Frontiers in immunology 2021;12:705751
ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.
Williams LB, Javed A, Sabri A, Morgan DJ, Huff CD, Grigg JR, Heng XT, Khng AJ, Hollink IHIM, Morrison MA, Owen LA, Anderson K, Kinard K, Greenlees R, Novacic D, Nida Sen H, Zein WM, Rodgers GM, Vitale AT, Haider NB, Hillmer AM, Ng PC, Shankaracharya, Cheng A, Zheng L, Gillies MC, van Slegtenhorst M, van Hagen PM, Missotten TOAR, Farley GL, Polo M, Malatack J, Curtin J, Martin F, Arbuckle S, Alexander SI, Chircop M, Davila S, Digre KB, Jamieson RV, DeAngelis MM
Genetics in medicine : official journal of the American College of Medical Genetics 2019 Sep;21(9):2103-2115
Genetics in medicine : official journal of the American College of Medical Genetics 2019 Sep;21(9):2103-2115
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 19107-1-AP(ALPK1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human hepatocirrhosis using 19107-1-AP(ALPK1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ALPK1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ALPK1. This antibody recognizes human, mouse, rat antigen. The ALPK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
