BS60365
antibody from Bioworld Technology, Inc
Targeting: SCN8A
CerIII, CIAT, MED, NaCh6, Nav1.6, PN4
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60365 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Na+ CP type VIIIÏ« polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human Na+ CP type VIIIÏ«.
- Description
- The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIÏ«) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming Ï« subunit, a noncovalently associated ÉÇ1 subunit and a disulfide-linked ÉÇ2 subunit. The two ÉÇ subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The Ï« subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIÏ« subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of Na+ CP type VIII¦Á pAb at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Raw264.7 cell lysateLane3:H9C2 cell lysate