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- Product number
- 10641-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10641-1-AP, RRID:AB_2240520
- Product name
- TDP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TDP1 antibody (Cat. #10641-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death.
Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.
Spike-In Proteome Enhances Data-Independent Acquisition for Thermal Proteome Profiling.
Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer.
TDP1 is required for efficient non-homologous end joining in human cells.
Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.
Rubio-Contreras D, Hidalgo-García D, Angulo-Jiménez C, Granado-Calle E, Sabio-Bonilla M, Ruiz JF, Gómez-Herreros F
Cell death & disease 2025 Nov 28;16(1):862
Cell death & disease 2025 Nov 28;16(1):862
Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.
Yang X, Liu L, Yu Z, Chen Y, Xu S, Liu M, Wang M, Guo H, Zhang Z, Shan B, Cai S, Pan M, Zhang J, Wang F, Zheng Y
Cell death discovery 2025 Jul 1;11(1):297
Cell death discovery 2025 Jul 1;11(1):297
Spike-In Proteome Enhances Data-Independent Acquisition for Thermal Proteome Profiling.
Wang Q, Chen Q, Lin Y, He D, Ji H, Tan CSH
Analytical chemistry 2024 Dec 10;96(49):19695-19705
Analytical chemistry 2024 Dec 10;96(49):19695-19705
Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer.
Flörkemeier I, Hillmann JS, Weimer JP, Hildebrandt J, Hedemann N, Rogmans C, Dempfle A, Arnold N, Clement B, Bauerschlag DO
International journal of molecular sciences 2022 Sep 10;23(18)
International journal of molecular sciences 2022 Sep 10;23(18)
TDP1 is required for efficient non-homologous end joining in human cells.
Li J, Summerlin M, Nitiss KC, Nitiss JL, Hanakahi LA
DNA repair 2017 Dec;60:40-49
DNA repair 2017 Dec;60:40-49
Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.
Perego P, Cossa G, Tinelli S, Corna E, Carenini N, Gatti L, De Cesare M, Ciusani E, Zunino F, Luison E, Canevari S, Zaffaroni N, Beretta GL
Biochemical pharmacology 2012 Jan 1;83(1):27-36
Biochemical pharmacology 2012 Jan 1;83(1):27-36
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TDP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TDP1. This antibody recognizes human, mouse, rat antigen. The TDP1 antibody has been validated for the following applications: ELISA, WB analysis.
